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Dr. Bill Andrews Interviewed by John Murrieta of the Science-Based Species Channel

Dr. Bill Andrews Interviewed by John Murrieta of the Science-Based Species Channel

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Bill Andrews
John Murrieta


John Murrieta of the channel Science-Based Species interviewed Dr. Bill Andrews, the U.S. Transhumanist Party’s Biotechnology Advisor, in October 2018. Watch this interview on YouTube here.

In this video, Dr. Andrews discusses the research he does at Sierra Sciences with the aim to reverse aging and extend lifespans by extending telomeres, as well as the forthcoming gene-therapy clinical trial by Libella Gene Therapeutics.

This interview with recorded by U.S. Transhumanist Party Secretary Bobby Ridge at the Fifth Enlightenment Salon, hosted by U.S. Transhumanist Party Chairman Gennady Stolyarov II.

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018

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Gennady Stolyarov II
Ray Kurzweil


The Stolyarov-Kurzweil Interview has been released at last! Watch it on YouTube here.

U.S. Transhumanist Party Chairman Gennady Stolyarov II posed a wide array of questions for inventor, futurist, and Singularitarian Dr. Ray Kurzweil on September 21, 2018, at RAAD Fest 2018 in San Diego, California. Topics discussed include advances in robotics and the potential for household robots, artificial intelligence and overcoming the pitfalls of AI bias, the importance of philosophy, culture, and politics in ensuring that humankind realizes the best possible future, how emerging technologies can protect privacy and verify the truthfulness of information being analyzed by algorithms, as well as insights that can assist in the attainment of longevity and the preservation of good health – including a brief foray into how Ray Kurzweil overcame his Type 2 Diabetes.

Learn more about RAAD Fest here. RAAD Fest 2019 will occur in Las Vegas during October 3-6, 2019.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form.

Watch the presentation by Gennady Stolyarov II at RAAD Fest 2018, entitled, “The U.S. Transhumanist Party: Four Years of Advocating for the Future”.

Advocating for the Future – Panel at RAAD Fest 2017 – Gennady Stolyarov II, Zoltan Istvan, Max More, Ben Goertzel, Natasha Vita-More

Advocating for the Future – Panel at RAAD Fest 2017 – Gennady Stolyarov II, Zoltan Istvan, Max More, Ben Goertzel, Natasha Vita-More

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Gennady Stolyarov II
Zoltan Istvan
Max More
Ben Goertzel
Natasha Vita-More


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, moderated this panel discussion, entitled “Advocating for the Future”, at RAAD Fest 2017 on August 11, 2017, in San Diego, California.

Watch it on YouTube here.

From left to right, the panelists are Zoltan Istvan, Gennady Stolyarov II, Max More, Ben Goertzel, and Natasha Vita-More. With these leading transhumanist luminaries, Mr. Stolyarov discussed subjects such as what the transhumanist movement will look like in 2030, artificial intelligence and sources of existential risk, gamification and the use of games to motivate young people to create a better future, and how to persuade large numbers of people to support life-extension research with at least the same degree of enthusiasm that they display toward the fight against specific diseases.

Learn more about RAAD Fest here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form.

Watch the presentations of Gennady Stolyarov II and Zoltan Istvan from the “Advocating for the Future” panel.

Transhumanism and a Cure for Depression – Article by Arin Vahanian

Transhumanism and a Cure for Depression – Article by Arin Vahanian

Arin Vahanian


In the quest to transcend humankind’s limits and take humanity to its next level of development physically, mentally, emotionally and socially, much is written and discussed about topics such as life extension and human augmentation. And this is for good reason, as humans have strived, since the beginning of time, to overcome their limits, do more, and be better. This includes, of course, living longer and healthier, which is among the most noble of all human goals.

However, in the midst of all this, there is a topic that is seldom discussed in Transhumanist circles, and that is the topic of depression, a condition which, according to the World Health Organization (WHO), affects more than 300 million people worldwide.

Making matters worse is the fact that depression is the leading cause of disability worldwide, a major contributor to disease, and in some cases, leads to suicide.

Given these facts, one would think more should be done to combat the plague of depression, but alas, we appear to be stuck with outdated treatments for a condition that cripples large segments of humanity and for many, threatens the very possibility of living longer and healthier.

Contrary to what many people may believe, an individual suffering from depression cannot simply “snap out of it,” and there is, as of yet, no established cure for depression, as there is for diseases such as smallpox. Indeed, depression is a particularly thorny problem to solve for many reasons, which include the fact that diagnosing it isn’t as cut and dried as other conditions, but also that the treatments for it have thus far not been very efficacious.

Those treatments include pharmacological (selective serotonin reuptake inhibitors, or SSRIs, such as Paxil, Prozac, and Zoloft), non-pharmacological (cognitive behavioral therapy), and technological (cranial electrotherapy stimulation) solutions. However, if we are honest with ourselves, the data reveals that what we have been doing hasn’t been very effective, given that depression is on the rise worldwide. According to the WHO, the total estimated number of people living with depression worldwide increased by 18.4 percent between 2005 and 2015 to 322 million. Even if this increase is due to better and more accurate diagnoses, the incidence of depression isn’t decreasing, which is cause for concern.

Given these statistics, it is time to do something other than what has been done before. It is time for a new approach and a new way of thinking when it comes to treating and curing depression. Transhumanism may offer that light at the end of the tunnel. Indeed, Transhumanism may very well be humanity’s best hope for a cure for depression, because it leaves no stone unturned in the quest to live a life of fewer limits, as well as improved health, and greater happiness and fulfillment. Imagine what could be done to solve depression if we approached treatment and a cure not in the standard ways, but by harnessing the full power of science and technology to do whatever it takes to assist the hundreds of millions of people who are suffering.

For instance, why is the technology of deep brain stimulation approved for treating Parkinson’s Disease, which, according to the Parkinson’s Foundation, affects 10 million people worldwide, but not approved for treating depression, which affects more than 300 million people globally? Scientific and technological breakthroughs should be leveraged to relieve the suffering of all people, and not just a few. This is the promise of Transhumanism – that all humans are worthy of a cure for what ails them, and therefore, all people inflicted with depression should get the help they need so that they can transcend the condition that threatens to wreck their lives.

Why is it that the most commonly-prescribed treatments for post-traumatic stress disorder (PTSD), which are the SSRIs Paxil and Zoloft, require daily dosing for many weeks to months, and have little to no effect in curing PTSD? On the other hand, MDMA-assisted psychotherapy, conducted by the Multidisciplinary Association for Psychedelic Studies (MAPS), has been proven to treat PTSD successfully in two to three sessions, yet it remains illegal as a Schedule 1 drug. This is the promise of Transhumanism – that we should look for creative, out-of-the-box ways to relieve suffering, which includes pharmacological, non-pharmacological, technological, and scientific methods.

If we are really serious about curing depression, as opposed to just putting bandages on a gaping wound in humanity’s well-being, we will have to do much more than we are doing right now, and we will have to reassess the way we are treating depression.

But why focus on depression, besides the fact that it destroys the lives of many millions of people and the treatments so far have been ineffective in curing it? Because depression does not care whether you are young or old, whether you are black or white, whether you are rich or poor, and whether you are physically healthy or not. Depression is an equal-opportunity destroyer of life. While heart attacks and pancreatic cancer may end lives quickly, depression ends lives slowly, ruthlessly robbing people of their happiness, sadistically stripping away their dignity, and mercilessly beating and drowning them in a dark, dreary swamp with little hope for a better future.

It is inhuman to ignore the plight of those suffering from depression and to give up the fight for a brighter, happier future for every individual on Earth. Transhumanism not only offers hope for a better future through inspiring and motivating humans to transcend their limits, but it also encourages us to look at problems from many different angles, and to dedicate our efforts toward actually resolving the challenges that humanity is facing.

Many Transhumanists are, understandably, focused on life extension and reversing aging, since life is the most precious thing we have. But life is a lot less beautiful when one is trapped in an inescapable labyrinthine nightmare, enfeebling one’s mind and tormenting one with endless movie-like scenes of their perceived past failures. In a sense, some people with depression feel there is not much point in attempting to extend their lives when they are continuously engulfed in profound sadness.

But the truth of the matter is that it is not people suffering from depression who have failed; it is we as a society who have failed them.

One of the ways we can rectify this situation and offer a real solution for those battling depression is by advocating for and creating breakthrough technologies and medicines that will successfully treat and cure this dreadful condition that has ruined so many precious, promising lives. Transhumanism is not just about advocating for life extension, it is also about advocating for a better quality of life through leveraging advances in science and technology to treat conditions such as depression.

Arin Vahanian is Director of Marketing for the U.S. Transhumanist Party.

The First Step Toward Reversing Aging and Curing Disease – Article by Arin Vahanian

The First Step Toward Reversing Aging and Curing Disease – Article by Arin Vahanian

Arin Vahanian


The dawn of every new year brings renewed hope and numerous promises made by individuals across the world to improve their lot in life, whether through increased exercise, a new diet, or a career change. However, according to extensive research conducted on the topic, most of these resolutions are seldom kept long-term, and many people eventually revert back to old habits and modes of thought.

While failing to keep a promise to oneself to find a new job may not have catastrophic consequences for that person, an entire society or parts of the world falling short of goals such as reversing climate change may have disastrous implications for the rest of the world.

However, this article isn’t necessarily about saving the world. It’s about a topic that is very near and dear to me; specifically, personal responsibility, especially when it comes to longevity.

Whether we read about this topic, discuss it with others, watch interviews with experts and laypeople, or read polls, almost everyone would agree that the idea of living longer and healthier is very appealing to them.

Why is it, then, that observing people’s actions reveals that many of us do things that will prevent us from living longer and healthier? Why do so many people who claim longevity is important to them turn around and engage in behaviors such as overeating, smoking tobacco products, not exercising regularly, and so on?

Thankfully, there are some people out there who take longevity and health seriously, and these individuals eagerly follow new developments and hope for the scientific breakthroughs that will finally reverse aging and cure debilitating diseases that have plagued humankind for so long.

However, the first step toward curing disease and reversing the process of aging does not start with the chemists who come up with new medicines or the gerontologists who study aging or the governments that fund projects; it starts with the individual.

If you don’t believe me, simply take a closer look the next time you are at a restaurant or supermarket and observe what many people are purchasing and putting in their bodies. You may well be shocked at the sorts of things we are consuming on a daily basis. Several decades ago, there was a fear that humanity would face starvation on a global scale, but that threat never materialized. In fact, we now have far more food than we know what to do with. Indeed, our problem isn’t that we do not have enough food, it is that we have too much food, and too much of what we consume is unhealthy, thus reducing our life span and health span.

Even if we may not want to admit it, the first step toward living a longer and healthier life is entirely in our hands.  The actions we take on a daily basis determine, in no small part, whether we can put ourselves in a situation to take advantage of the advances in medicine and technology that may cure us of disease and reverse the process of aging in our bodies and minds.

In my humble opinion, it is irresponsible for someone to neglect their health and well-being while at the same time waiting and hoping for a cure for aging or disease. There is, currently, no magic pill one can take that will cure them of poor health or magically reverse aging. Thus, the impetus is on each person to do all they can to take care of themselves and their health, while the organizations and individuals that are working on curing disease and reversing aging come up with the requisite scientific and technological breakthroughs. In fact, we could even argue that in addition to managing one’s health and diet very closely, we should do more to support the organizations and individuals dedicated to curing disease and reversing senescence, but that is perhaps another topic for another time.

Of course, by focusing on personal responsibility, I do not wish to ignore the numerous situational and socioeconomic factors that may contribute to people being unable to fully take responsibility for their health. Some people, due to conditions such as extreme poverty, are not in a position to take control of their lives in the way those of us in developed countries are able to. Similarly, though, I do not wish to ignore the plight of many residents of developed countries who face hardships (of the medical variety or otherwise) every day that prevent them from fully taking the advice in this article. Life is not black-and-white, but rather, gray, and I would never advocate for the law of the jungle in any society.

Thus, I also want to make clear that we as a society should do whatever we can to ensure that people who need medical care receive the care that they need, in a cost-effective and dignified manner. In a world of abundance, there is no reason why people suffering from curable conditions (or otherwise) should go untreated, and no reason why anyone should be bankrupted by medical bills. However, these are not the persons I have dedicated this article to. A tragedy of modern life is that so many people are easily able to make changes in their life that would lead to a healthier and longer life, but instead choose to not do so, and continue engaging in destructive behaviors.

Regardless of your views on disease and aging, it is not unreasonable to say that we should, at the very least, do whatever is in our power to take care of our own health.

Therefore, the next time you think about gorging yourself on donuts and guzzling the soda offered at the next company party, you might want to reconsider, because what many people are eating and drinking is literally killing them.

The next time you decide to sit at home and watch TV instead of doing 20 minutes of light exercise at the park or the gym, remember that lethargy has consequences.

The next time you tell yourself “I’ll quit smoking someday,” or “I’ll start exercising when I have more time,” please pause for a moment and ask yourself whether you are really being honest.

I do not wish to insinuate that we should try to be perfect all the time when it comes to health, diet, and exercise. Indeed, there is no way to get it right all the time, and the occasional piece of cake or glass of beer won’t derail your journey toward good health if you’re consistently and methodically taking good care of yourself. Rather, what I believe we should strive for is doing the best that we can on a daily basis, and if we need to make minor changes, to take small steps toward improvement every day.

There is a famous quote attributed to Mahatma Gandhi that goes, “You must be the change you wish to see in the world.” I agree wholeheartedly, and would add that we must be the change we wish to see in ourselves. Because no one is more responsible for your own personal well-being than you. And no one can do as much for your own longevity as you can.

Arin Vahanian is Director of Marketing for the U.S. Transhumanist Party.

What President Trump Should Focus on Instead of the Border Wall – Article by Alex Lightman

What President Trump Should Focus on Instead of the Border Wall – Article by Alex Lightman

Alex Lightman


Editor’s Note: The U.S. Transhumanist Party is home to many innovative thinkers who offer more forward-looking and far superior policy solutions than those pursued by either of the major political parties in the United States. This brief article by Alex Lightman, Campaign Director for the California Transhumanist Party, is an example of how even a few constructive, inspiring, big-picture ideas by transhumanists could revolutionize politics for the better and help us construct the next era of our civilization. What could Donald Trump be focusing on instead of his brinksmanship over an unnecessary border wall? Mr. Lightman explores the alternatives here.  

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, December 24, 2018


I am stunned by this Presidency. If I were President of the United States, I would be obsessively focused on:

 1. Space Migration – Setting up permanent bases and thriving colonies on the moon (for Helium 3, one shuttle load of which could cleanly power the entire US for a few weeks) and Mars (as a base for jumping off to other worlds and mining the asteroid belt).

2. Intelligence Increase – I would focus on raising average IQ from what I believe to be 87 to over 106, equal to the highest national average in Asia. IQ can be raised by 19 points within six weeks.

3. Life Extension – Average life expectancy in the US has dropped three years in a row after 114 years of steady increase that DOUBLED life expectancy. The USA ranks in the 25-50 range in key health measures, including infant mortality. I think a smart Presidency could boost average life expectancy by 5-15 years.

4. Acceleration of Innovation – just implementing the 200-page national innovation plan I was paid to write by the Obama White House would do this. It’s ready to implement and there is nothing comparable to it ever tried by any nation in history.

5. Smart Green Augmented Cities – I can’t understand why Donald Trump, real-estate developer, doesn’t use some of the $20-25 trillion he has to play with during a four-year term to create a novel, brilliant, beautiful, state-of-the-art city that sets a new high standard and serves as an archetype and living laboratory for all future cities.

Instead, the Border Wall is where his head is.

If I were him, I would ask someone like me, “Why are the people from Mexico and Central America coming? What can we do to make their countries successful?” I spent $300,000 or so of my own money figuring this out, and I shared the results with Mexico’s Secretary of Agriculture, Secretary of Energy, and Director of Sustainability, and they all said my plan made sense.

My point isn’t that I am the only one with a plan. When you are the US government, you can hire thousands of people like me and have them come up with thousands of possible solutions and then implement these solutions.

Trump claims that his art form is the art of the deal. A deal that helped Mexico and Central America be successful would be easy to strike with Democrats.

Alex Lightman, Campaign Director for the California Transhumanist Party, has 25 years of management and social innovation experience and 15 years of chairman and chief executive experience. He is an award-winning inventor with multiple U.S. patents issued or pending and author of over one million published words, including the first book on 4G wireless, and over 150 articles in major publications. He chaired and organized 17 international conferences with engineers, scientists, and government officials since 2002, with the intention of achieving policy breakthroughs related to innovation. He is a world-class innovator and recipient of the first Economist magazine Readers’ Choice Award for “The Innovation that will Most Radically Change the World over the Decade 2010 to 2020” (awarded Oct. 21, 2010, out of 4,000 initial suggestions and votes over 5 months from 200 countries, and from 32 judges). He is the recipient of the 2nd Reader’s Award (the posthumous recipient announced 10/21/2011 was Steve Jobs). He is also the winner of the only SGI Internet 3D contest (both Entertainment and Grand Prize) out of 800 contestants.

Social innovation work includes repeatedly putting almost unknown technologies and innovation-accelerating policies that can leverage the abilities of humanity into the mainstream of media, business, government, foundations, and standards bodies, including virtual reality, augmented reality, Internet Protocol version 6, and 4G wireless broadband, open spectrum, technology transfer to developing countries, unified standards, crowd-sourcing, and collective intelligence, via over 40 US government agencies, over 40 national governments, and via international entities including the United Nations and the North Atlantic Treaty Organization (NATO).

Political credentials include a national innovation plan entitled “The Acceleration of American Innovation” for the White House Office of Science and Technology Policy, work for U.S. Senator Paul E. Tsongas (D-MA) and on several state campaigns and U.S. presidential campaigns for Democratic candidates (Gary Hart, Richard Gephardt), presentations to the United Nations, and advisory services to the governments of Bahrain, United Arab Emirates, New Zealand, Australia, Philippines, Japan, China, Korea, and India, as well as to the U.S. Congress, the White House (via the Office of Management and Budget), the U.S. Joint Chiefs of Staff, the Defense Information Systems Agency, and the North Atlantic Treaty Organization (NATO). Mr. Lightman is trained as an engineer at MIT and as a prospective diplomat and policy analyst at Harvard’s Kennedy School of Government.

A Biohacker’s Letter to Santa – Article by Elena Milova

A Biohacker’s Letter to Santa – Article by Elena Milova

Elena Milova


Editor’s Note: Happy Holidays! If Santa Claus were real, life extension would be the greatest gift that he could possibly give. Elena Milova convincingly illustrates why in this letter, originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Gennady Stolyarov II, Chairman, U.S. Transhumanist Party, December 21, 2018

Dear Santa,
My name is Elena Milova, and I am from Moscow, Russia. I am a science popularizer, biohacker, and public health advocate in the field of aging and longevity. I am 39, single, and without children, but if you think that I am reaching out to you to ask for a CRISPR-designed baby, I am not. I believe that this type of wish is rather in the pile of letters from China. I am not asking you for a particular health improvement, as one could not wish for a better HOMA-IR (mine is 0.40, because I greatly reduced fast carbs) or total cholesterol level (below 4 mmol/L). I am fine without a new smartphone, too.

The thing that I am going to ask you for is much more tricky to get. I want everyone on Earth to realize that biological aging is amenable to medical intervention and that treatments targeting various mechanisms of aging are already in human clinical trials. 7.6 billion minds, one idea. That is my only wish.

Why this is so important to me

You have probably noticed yourself that your clientele is changing over time. There are more and more people over 60 in the world, and I assume that the number of wishes for recovery from this or that age-related disease are spiking higher every year. This must be a problem for you, as for many diseases of old age, there is still no effective treatment that would actually help to cure people. It must be frustrating to not be able to fulfill a sincere wish of a good person, especially when a child asks for her grandparents to recover so that they can walk and throw snowballs together.

Source: United Nations, Department of Economic and Social Affairs, Population Division (2017). World Population Prospects 2017 – Data Booklet (ST/ESA/SER.A/401)

By 2050, the elderly will be a quarter of the global population, and these people will likely be suffering from several chronic diseases at once, gradually losing their health, independence and dignity. For so many people, being a burden on their families because of their deteriorating health is unacceptable, which is why the number of suicides in this age group is so high.

Is aging an invisible problem?

The numbers of these voluntary deaths are very upsetting, but what is even more upsetting is that diseases of old age are the major cause of death worldwide and aging kills around 100,000 people every day. This is the population of a small city. Imagine what would happen if everyone in a city like Cambridge, Massachusetts were to die in one day. I bet that there would be a lot of media attention and that thousands of experts would be on television discussing the potential causes of death and ways of preventing this tragedy in the future. Let’s say that the next day, another city becomes deadly peaceful. Take the Russian city of Domodedovo, which has its own airport. Everyone dead. People in neighboring cities would probably be frightened, and some charismatic politicians would be trying to calm down the public and promising to do something about all these deaths. The next day, this happens to yet another city, maybe in India. Then another one in Australia. It would not take long before G20 would set up an urgent conference call to set up an international commission and allocate money and scientists to investigate and solve the problem.

                                                                                                                                              Source: WHO website

Guess what? This type of thing never happens in relation to aging, because people dying from it are spread around the globe, so the disaster does not make the headlines. The public only notices the problem when an actor, scientist, or other significant public figure dies from an age-related disease – most often heart disease, stroke, or cancer. Do you want an example? “Santa Claus, age 90, dies from a heart attack: a critical blow to the industry of giftmaking.”

Sorry, sorry. I didn’t mean to scare you, but you get the point, right? From looking at your pictures, I could suspect that you might have some minor problems with glucose metabolism, but your extensive physical activity during gift delivery should be compensating for that, so you should be fine. For other people aged 60 and older, aging is an ever-increasing problem. Here, we come to the other important issue.

What is aging? How it can be addressed?

You see, aging is the accumulation of damage that happens due to normal bodily functions. This damage builds up over time, normal cell functions erode, and, at some point, this leads to the manifestation of age-related diseases. Normal operations, damage accumulation, disease, more damage, aggravation of disease, death. Simple.

It turns out that at the beginning of this century, British scientist Aubrey de Grey published an article in which he described several types of damage done by aging. He suggested the heretical idea of targeting these damages with medical interventions instead of trying to cure the symptoms of each age-related disease. He argued that age-related diseases are only a consequence of damage accumulation and that it would be much more effective to address the root causes.

The seed that Dr. de Grey dropped into the fertile soil of scholarship produced nice fruit in 2013, which is when a group of famous researchers of aging published The Hallmarks of Aging, a paper in which they described nine types of damage that accumulate with age and could be made into new therapeutic targets.

Comparison of a mouse treated with senolytics (at right) and a same-age mouse of the control group (at left). Source: Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., … & Khazaie, K. (2016). Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature, 530(7589), 184.

There were other fruits as well: animal studies have definitively proven that even only addressing one type of damage can extend the healthy period of life, postpone age-related diseases, keep animals more active, and, as a positive side effect, extend lifespan. It is worms that hold the best record so far, as tweaking some of their longevity-related genes has allowed them to live 10 times longer. The results in mice are also impressive – the researchers can extend both their healthy period of life and lifespan by 30-35%. Honestly, I find myself jealous of these mice, sometimes. I would not mind adding another 30% of youthful and healthy years to my life, even if I would have to take some pills or get some regular injections.

Can we control aging in humans?

You see, Santa, where I am going with this. I am sure that you sometimes leave gifts under the trees of people who work for the FDA. Accumulating a critical mass of knowledge about interventions against murine aging made it possible to develop the same type of interventions for people. Now, drugs and therapies addressing some of the root mechanisms of aging are in official human clinical trials. At some point, some of these trials will be successful, and drugs and therapies targeting aging itself will come to market.

If you don’t believe me, here is the short list of people whose chimneys’ stacks are the best source of additional information on the topic: George Church, Anthony Atala, Judy Campisi, Vadim Gladyshev, Maria Blasco, Michael West, Vera Gorbunova, Irina Conboy, Kelsey Moody, Brian Kennedy, Linda Partridge, Alexey Moskalev, Cynthia Kenyon, Claudio Franceschi, Alex Zhavoronkov, Nir Barzilai, and, of course, Aubrey de Grey. He wears a great beard, so you have more in common with gerontologists than you would think.

Listen to these people tell their families about their research, and you will get my point. We are on the edge of a revolution in rejuvenation biotechnology. Yet, most people don’t know about it and don’t realize what kind of potential benefit this advancement holds for them and for our aging society as a whole. Most importantly, as they know nothing, they have no say in decision making. How can people possibly speed up the pace of aging research if they don’t realize that aging is amenable to intervention? How can they foster technology transfer and local production of the cures for aging, such as senolytics, in their countries? How can they control prices and make future distribution and access equal? How can they ensure that old people in their families, who need these new treatments the most, would get them sooner?

Knowledge is power. We hear this in almost every interview, and you should be hearing it every Christmas from the researchers of aging, too. They have golden brains; the only thing they need is an appropriate amount of funding to solve the problem of aging more quickly. A strong public movement for aging research could be a game changer and could act as leverage to allocate government funding towards researching and developing treatments that target the underlying mechanisms of aging.

Ending aging and age-related diseases is possible

It is obvious that you are a kind person, Santa. You are perceptive and generous; you know what people want, and you try to give them what they want. However, if you don’t help me with my information campaign, in a couple of decades from now, you will be delivering billions of adult diapers and wheelchairs all over the globe. Wouldn’t it be nicer if you were to pile these up in your warehouse to be covered in dust while you give people therapies and drugs that prevent aging and wipe age-related diseases out of human lives? Just imagine how much happier people would be if they could remain healthy and independent, enjoy full and productive lives, achieve more, and stay with their families and friends for longer.

I was a good girl the whole year, attending scientific conferences, interviewing researchers, speaking at public events, and supporting our partners and colleagues in every way I could, even if that much socializing makes me suffer from an introvert’s hangover. I was eating healthy food and promoting evidence-based means to slow down aging among my relatives and friends. I deserve a nice Christmas gift.

All you have to do is to let everyone on the planet know that aging is amenable to intervention and that treatments addressing the root causes of aging are currently being created. For real. That would make me the happiest creature on the planet. Thank you in advance!

Sincerely, Elena

Instead of a conclusion

I am 39 years old, and I am an agnostic. There is not much evidence that Santa Claus exists. However, I do believe that miracles happen: the miracles that we create with our own hands. You who are reading these words (thanks for getting this far, by the way!) possess this special power, too. Use it! Let people around you know that science is close to bringing aging under medical control, and let’s build a world where healthy longevity for everyone is a reality.

As a devoted advocate of rejuvenation technologies since 2013, Elena Milova is providing the community with a systemic vision how aging is affecting our society. Her research interests include global and local policies on aging, demographic changes, public perception of the application of rejuvenation technologies to prevent age-related diseases and extend life, and related public concerns. Elena is a co-author of the book Aging prevention for all (in Russian, 2015) and the organizer of multiple educational events helping the general public adopt the idea of eventually bringing aging under medical control.

Aubrey de Grey – Clinical Trials in Five Years – Interview by Laura Sanz Olacia

Aubrey de Grey – Clinical Trials in Five Years – Interview by Laura Sanz Olacia

logo_bgLaura Sanz Olacia
Aubrey de Grey


Editor’s Note: In this interview originally published by our allies at the Life Extension Advocacy Foundation (LEAF), Laura Sanz Olacia discusses with Dr. Aubrey de Grey his anticipation that treatments aimed at reversing biological aging may enter clinical trials within five years. The U.S. Transhumanist Party is pleased to feature these insights from Dr. de Grey. 

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, December 18, 2018

 


In November, Dr. Aubrey de Grey, a graduate of the University of Cambridge, was in Spain to attend the Longevity World Forum in the city of Valencia, and he gave a press conference organized by his friend, MIT engineer José Luis Cordeiro.

Dr. Aubrey de Grey is the scientific director (CSO) and founder of the SENS Research Foundation. In Madrid and Valencia, Dr. de Grey reaffirmed for Tendencias21 one of his most striking statements of 2018: “In the future, there will be many different medicines to reverse aging. In five years, we will have many of them working in early clinical trials.”

The Longevity World Forum is a congress on longevity and genomics in Europe. It is heir to the first congress in Spain, the International Longevity and Cryopreservation Summit, which was held at the CSIC headquarters in Madrid in May 2017, and Dr. de Grey also participated in that event. In Valencia, his presentation was recieved with interest, and Dr. de Grey explained to this select audience that aging will be treated as a medical problem in the near future. Rather than treating its symptoms using the infectious disease model, the root causes of aging will themselves be treated.

It was published recently on longevityworldforum.com that a therapy to reverse aging will be a reality within five years. What will be its mechanism of action, roughly?

There will not be just one medicine; there will be a lot of different medicines, and they will all have different mechanisms of action. For example, some of them will be stem cells, where we put cells back into the body in order to replace cells that the body is not replacing on its own. Sometimes, they will be drugs that kill cells that we don’t want. Sometimes, they will be gene therapy treatments that give cells new capabilities to break down waste products, for example. Sometimes, they will be vaccines or other immune therapies to stimulate the immune system to eliminate certain substances. Many different things. In five years from now, we will probably have most of that working. I do not think that we will really have it perfect by then; probably, we will still be at the early stages of clinical trials in some of these things. Then, we will need to combine them, one by one, to make sure that they do not affect each other negatively. So, there will still be some way to go. But, yes, I think it’s quite likely that in five years from now, we will have everything, or almost everything, in clinical trials.

Then clinical trials for seven years until it’s perfected. Don’t clinical trials usually take a long time?

It depends. For example, in aging, because there is this progressive accumulation of damage, you could have therapies that slow down the rate at which damage accumulates, or you could have therapies that repair the damage that has already happened. The second type of therapy is what we think is going to be most effective and is going to be easiest to do, and you can see results from that very quickly, like in one or two years. Now, of course, you still want to know what happens later on, but the first thing is to determine whether this is working at all, and as soon as it starts to work, then you can start to make it available. Clinical trials are changing in that way. Historically, clinical trials had to be completed before anybody could get these drugs, but now we are getting new policies; there is a thing called adaptive licensing, which is becoming popular in the US and elsewhere, where the therapy becomes approved at an earlier stage, and then it’s monitored after that.

Beyond the humanitarian perspective of avoiding the pain and suffering that comes with old age, if increasing the years of healthy life in people will significantly reduce health care spending by governments, why don’t they promote research in this area?

You’re absolutely right. It’s quite strange that governments are so short-sighted. But, of course, the real problem is psychological: it’s not just governments that are short-sighted. Almost everybody in the world is short-sighted about this. The reason I believe why that’s true is people still can’t quite convince themselves that it’s going to happen. Since the beginning of civilization, we have known that there is this terrible thing called aging, and we have been desperate to do something about it, to get rid of it. And people have been coming along, ever since the beginning of civilization, saying, “Yes, here’s the solution, here’s the fountain of youth!” And they’ve always been wrong. So, when the next person comes along and says they think they know how to do it, of course, there is going to be some skepticism until they have really shown that it’s true. Of course, if you don’t think it’s going to work, then you’re not going to support the effort financially. It’s very short-sighted, but it’s understandable.

Why do you think that the pharmaceutical industry does not devote its research and development efforts to this area, which causes the death of 100,000 people every day?

Today, the pharmaceutical industry is geared toward keeping old people alive when they are sick. It makes its money that way. It’s not just the pharmaceutical industry, it’s the whole of the medical industry. And so, most people say that they are worried that maybe the pharmaceutical industry will be against these therapies when they do come along. I don’t think that’s true at all. I think they will be in favor because people will be in favor, but people are not really in favor yet. People don’t really trust preventive medicine. They think “Okay if I am not yet sick…” They don’t trust medicine in general; they know that this is experimental. So, when they are not yet sick, they think “Well, I’ll wait until I am sick,” but we can change that. Eventually, people will understand that it’s going to be much more effective to treat yourself before you get sick, and then the whole medical industry will just respond to that; they will make the medicines that people want to pay for.

So you don’t think that they will be against these therapies?

No. They will follow.

But now, they are not focusing their research into this field.

That’s right because they don’t need to. The big pharmaceutical companies don’t really do much of their own research in the first place. They just wait to see what happens, and then they buy small companies.

In the car analogy that you use, you say that a car is built to last 10 or 15 years, but with proper maintenance, it can last up to 100 years. Isn’t this expressing the idea that aging is programmed and that the life of a car is also programmed?

No, it’s not. All of you know that, a long time ago, Henry Ford invented a concept called planned obsolescence, which was a way of building a car so that you could predict pretty accurately how long it would last. But, of course, the only reason that the prediction works is because people are lazy, and they don’t mind replacing their cars, so they only do the minimum amount of maintenance that the law tells them to. The reason that some cars last 100 years is not because those cars were built differently, it’s because there are a few people out there who fall in love with their cars and they don’t want them to get old. So, it really is exactly the same. In the human body, we have aging, because there are certain types of damage that are not automatically repaired when they happen. Of course, many types of damage in the human body are repaired automatically when they happen, so we don’t need medicine for that, but some of them are not. So, if we can develop medicines that do fix those things, it’s exactly the same as with a car.

If aging is not programmed, why do different species have different lifespans?

Because they have different qualities of built-in repair machinery. When I talk about all these types of damage, they are the types of damage that accumulate in the body, and they accumulate because the body does not have ways to repair them. There are massive amounts of other types of damage that I don’t call damage, and the reason I don’t call them damage is because they don’t accumulate. The reason that they don’t accumulate is because we already have built-in machinery to repair them when they happen. So, long-lived species have more comprehensive automatic repair machinery built into them.

Do you think that first we can focus on just replacing organs and restoring their function, and eventually we can eliminate the root causes of aging? Once we reach longevity escape velocity, maybe we can focus on just eliminating it?

We will never be able to stop the body from creating this damage. The body is going to do that because it is intrinsic to metabolism, but the better we get at repairing the damage, the fewer problems we have.

What healthy habits do you follow now?

I don’t do healthy habits. I’m lucky, I don’t need to do anything; I can drink whatever I like and nothing happens. I don’t even do much exercise, and also I don’t get nearly enough sleep, which is probably shortening my life, but it is worth it because I am hastening the defeat of aging, so it is a net positive.

Which generation will live to be a thousand years old? Do you think it is born already?

I think it is very probably born already, yes. But, of course, we cannot know until we get the medicines.

Which country do you think is more aware, or the people is more aware that this is a problem that we need to fix?

I would say Russia.

Russia?

Yeah. Surprising, isn’t it? But when I go to Russia and I talk about all of this, it’s so wonderful; I don’t get any of the uninformed questions, and everyone seems to understand it.

They don’t ask you ethical questions?

That’s right, yeah. They understand that this is a medical problem, it needs to be fixed, and it can be fixed.

Kriorus [the first and only cryonics company in Eurasia] is there right?

Yeah, I know Kriorus, I know the people very well.

Alcor [the world leader in cryonics located in Arizona] is the most expensive.

It gives the best service. I mean, it makes sense to have a very expensive, high-quality service and also less expensive and lower quality service. That is normal.

Where are you currently living?

I live in the United States, but I go everywhere when I am invited to speak and so on.

Laura Sanz Olacia, has a degree in Pharmacy from the Complutense University of Madrid (2015). Between 2016 and 2017 she worked for nine months in different pharmacies in London. She also worked in a pharmacy laboratory compounding medicines and cosmetics in Madrid. More recently she worked in IQVIA as Data Management Analyst. She is very interested in research and, in particular, in the area of ​aging. During her stay in London, she participated in the organization of the Antiaging Conference London 2016, and back in Madrid, she collaborated closely with the organizing committee of the International Longevity and Cryopreservation Summit 2017. She wants to devote her career to doing research in this field.

Health & Wellness: Living Forever – Presentation by Peter Xing at Real Big Things #22

Health & Wellness: Living Forever – Presentation by Peter Xing at Real Big Things #22

Peter Xing


The U.S. Transhumanist Party is pleased to feature this presentation from Peter Xing, co-founder of Transhumanism Australia, an organization allied with the U.S. Transhumanist Party, from the Real Big Things Conference earlier in 2018. This video was originally published on June 13, 2018.

Peter challenges our way of thinking about death by presenting the very real prospect that living forever isn’t just a plot in Hollywood scripts. Walking us through the research developments, Peter shows living into our hundreds (or even thousands) is science non-fiction.

About Peter Xing

“We’re at an inflection point of being able to cure all diseases including the ageing process, solving intelligence, and conquering scarcity to create abundance.”

~ Peter Xing

KPMG’s Tech & Innovation Manager and Co-founder of Transhumanism Australia, Peter Xing, has built a community that educates and invests in scientific research and technologies to enhance the human biological condition. Through nanotech, biotech, and artificial intelligence, Peter seeks to accelerate its research and applications to benefit society and wellbeing through Transhumanism Australia.

Integral Transhumanism – Article by Dinorah Delfin

Integral Transhumanism – Article by Dinorah Delfin

Dinorah Delfin


This article was written by Transhumanist Artist, Writer, & Activist Dinorah Delfin.

“It is easier to build strong children than to repair broken men.” Or, is it?

Integral Transhumanism adopts a framework that accounts for individual and collective enhancement and consciousness expansion through a holistic neurological reprogramming at any stage of one’s emotional, intellectual, and spiritual development. 

Whether it is through genetic enhancement, brain-computer interface, holistic wellness & education, or shamanic entheogenic practices integrated into modern life, Integral Transhumanism advocates for enhanced cognitive and neurological states to achieve heightened spiritual awareness and wisdom. This level of maturity will allow humanity to work towards a sustainable equilibrium between social and natural environments.

Integral Transhumanism takes into account that knowledge or intelligence aren’t sufficient if they don’t entail a holistic integration of scientific reductionism & rationalism, with humanity’s deep-felt intuition and connection to its nonphysical quantum dimensions.

Without an understanding of this vibrational reality, and its social and universal psychological implications, humanity will fail to design cognitive models and policies that are safe and grounded in the maintenance of the common good as it will perpetuate the disconnect between fragmented knowledge and the right course of action. 

To preserve transhumanist ideals’ inherent ethical and altruistic worldview, we must account for a truly holistic integration of mind, body and the collective consciousness. Spiritual Superawareness, therefore, constitutes the highest achievement of Superintelligence.

Albert Einstein once said, “We can’t fix our problems from the same consciousness that created it.” A holistic and sustainable re-engineering of humanity must account for the understanding of consciousness itself to give rise to truly benevolent beings, and new and effective ways to affect change.

One must not fear the evolution of humanity’s inherent technological ingenuity and desire to continue pushing through the boundaries of its limitations, but one should fear ignorance and apathy. 

One must not fear that which we might think as “unnatural” because humans are anything but willful subjects to nature’s way. We don’t tend to label the domestication of plants and animals, education, art, cars, dental floss, eyeglasses, pacemakers, in-vitro fertilization, as “unnatural”, and we don’t necessarily think of “natural” things like plagues, meteorites, parasites, or polio as desirable things either.

One must not fear that advanced enhancement technologies might be initially available to only the wealthy, as such fear is counterproductive towards our efforts to democratize these technologies. Furthermore, enhanced individuals with heightened cognitive and spiritual awareness might actually nurture greater compassion for the have-nots, and reduce, rather than exacerbate, socio-economic tensions.

Integral Transhumanism wishes to harness this growing momentum to help inspire individuals and societies at all stages of maturity towards a more just, beautiful, and holistic expression of its most authentic form. 

#IamTranshuman

Note: This article was inspired by an essay written by Michael Tennison, titled “Integral Transhumanism: The Holistic Leap Forward” (2010).

Ms. Delfin is the Director of Admissions and Public Relations of the U.S. Transhumanist Party.

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