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Dr. Bill Andrews and U.S. Transhumanist Party Chairman Gennady Stolyarov II Discuss Transhumanism and RAADfest at Sierra Sciences

Dr. Bill Andrews and U.S. Transhumanist Party Chairman Gennady Stolyarov II Discuss Transhumanism and RAADfest at Sierra Sciences

Gennady Stolyarov II
Bill Andrews


On October 12, 2019, Brent Nally recorded this discussion between Dr. Bill Andrews – the Biotechnology Advisor of the U.S. Transhumanist Party / Transhuman Party – and U.S. Transhumanist Party / Transhuman Party Chairman Gennady Stolyarov II regarding recent news in the field of longevity (including pet longevity), techniques to slow down the rate of telomere shortening, changes to public perceptions of aging and longevity, transhumanism and technologies of life enhancement, and how to be rigorous and appropriately skeptical when evaluating various ideas and hypotheses in medicine.

Watch this discussion here and be on the lookout for a special visitor from a different species!

Become a member of the U.S. Transhumanist Party / Transhuman Party here for free, no matter where you reside.

Show Notes by Brent Nally

0:35 Dr. Andrews links:

Facebook: https://facebook.com/telomere.bill.andrews;

Linkedin: https://linkedin.com/in/william-h-andrews-5455b45/;

Wikipedia: https://en.wikipedia.org/wiki/William_H._Andrews_(biologist);

Sierra Sciences Website: https://sierrasci.com/;

Sierra Sciences YouTube Channel: https://www.youtube.com/channel/UCB9UFIxyD9VUHjuNQzpLzeA

1:08 Brent’s RAADfest 2019 YouTube playlist. Go to RAADfest primarily to network https://www.raadfest.com/

2:35 USTP concluded its presidential primary elections: watch Gennady Stolyarov II & Johannon Ben Zion at RAADfest 2019; watch Brent interview Mr. Ben Zion at RAADfest 2019; watch Brent interview Mr. Ben Zion and his VP running mate Charlie Kam at RAADfest 2019.

3:10 Bill’s dog Dash makes his cameo appearance.

4:35 Long-distance running and recovery.

7:20 Bill hosted a pet-longevity panel at RAADfest 2019.

12:15 Quacks and charlatans have discredited human longevity for centuries.

13:26 How has the public’s perception of human aging changed in the last decade?

15:10 Buy Bill’s 2 books: Curing Aging and Telomere Lengthening. See Brent’s book review of Telomere Lengthening: Curing all diseases including cancer & aging by Dr. Bill Andrews

15:25 Inflammation is the number one cause of human aging.

16:47 Do fun activities, meditate, practice yoga, eat a healthy diet, reduce stress to decrease the rate of telomere shortening.

18:48 Caldwell Esselstyn – Wikipedia

19:10 Watch Brent’s interview with Dr. Sandy Kaufmann.

21:33 Funding is needed to cure human aging and all chronic diseases.

24:03 Bill is hoping the telomerase gene therapy clinical study by Libella Gene Therapeutics (which is scheduled to start in November 2019) will show age reversal in the human Alzheimer’s patient in every measurable way.

24:18 Mice telomerase gene therapy study by Dr. by Ron DePinho

26:13 Animals age in different ways.

30:35 Life enhancement should be our focus.

33:08 Most humans living in the 1st world have been transhumanists for quite some time.

35:38 Nanobots

38:02 Get involved in the longevity movement in any way you can – follow thought leaders; donate.

39:40 Dr. Jason Williams

40:30 A race to cure human aging is a great idea to educate people.

43:26 Watch Brent’s interview with USTP Presidential candidate Johannon Ben Zion.

45:15 Spinal-cord repair, prosthetics, stem cells, etc.

51:01 Bill is impressed by stem-cell therapies but warns of charlatans. Watch Brent’s playlist on stem cells.

52:38 Use PubMed to do a meta-analysis of scientific peer-reviewed studies.

Brent Nally Interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II at Sierra Sciences

Brent Nally Interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II at Sierra Sciences

Gennady Stolyarov II
Brent Nally


On October 12, 2019, U.S. Transhumanist Party Chairman Gennady Stolyarov II spoke with Brent Nally at the venerable Sierra Sciences headquarters in Reno, Nevada. They discussed developments in the U.S. Transhumanist Party, fitness, health, and longevity – among other subjects.

Watch the interview here.

Become a member of the U.S. Transhumanist Party / Transhuman Party here for free, no matter where you reside.

Show Notes by Brent Nally

3:15 Brent Nally’s RAADfest 2019 YouTube playlist: https://www.youtube.com/playlist?list=PLGjySL94COVSO3hcnpZq-jCcgnUQIaALQ

4:24 Go to RAADfest primarily to network: https://www.raadfest.com/

6:28 People Unlimited website: https://peopleunlimitedinc.com/

6:30 The Coalition for Radical Life Extension website: https://www.rlecoalition.com/

7:20 We need to increase your healthspan to increase your lifespan.

9:01 Watch Bill Andrews and Gennady discussing transhumanism and radical life extension: https://www.youtube.com/watch?v=U7GJrVBp8FQ

13:35 Gennady just ran the Lakeside Marathon at Lake Tahoe the day before, October 11, 2019.

19:30 Do whatever type of exercise that you enjoy. Don’t push yourself to the point of exhaustion where you’re throwing up or getting injured or not having fun because that’s bad for your telomeres.

24:10 Audit your own thoughts daily as a meditation to recognize your limiting beliefs.

26:15 How Gennady became Chairman of the U.S. Transhumanist Party

29:35 How the 9 USTP presidential candidates competed using a “ranked preference” approach

32:07 43 articles are currently in the 3rd version of the Transhumanist Bill of Rights: https://transhumanist-party.org/tbr-3/

34:27 https://transhumanist-party.org/

35:40 We should be more concerned with ideas rather than people. We’re in an “ideas” economy.

36:28 Politicians are more followers than leaders.

40:27 3 core ideals of USTP: https://transhumanist-party.org/values/

41:40 Gennady shares more details about how his role as chairman may evolve.

44:28 Positives and negatives of centralization and decentralization

49:15 Sophia the AI robot: https://www.hansonrobotics.com/sophia/

51:30 Truth is sometimes stranger than fiction. Try to educate others about transhumanism.

55:30 Ray Kurzweil points out that technology growth and stock market growth are separate. Here’s Brent talking to Ray in February 2011: https://www.youtube.com/watch?v=3TuVn…

57:37 Join the USTP: https://transhumanist-party.org/membership/

58:40 USTP Twitter: https://twitter.com/USTranshumanist; USTP LinkedIn: https://www.linkedin.com/company/19118856/; Gennady’s online magazine – The Rational Argumentator: http://www.rationalargumentator.com/index/

1:01:14 Gennady, Bill Andrews, and Brent ran about 8.4 miles the next morning above Carson City, NV on the Upper Clear Creek Trail.

1:02:15 Don’t forget to subscribe, like, comment on this video, and share on your social media accounts!

U.S. Transhumanist Party Chairman Gennady Stolyarov II on the Debt Nation Show – Refutation of Malicious and False Allegations from the Conspiracy-Theorist Site Biohackinfo

U.S. Transhumanist Party Chairman Gennady Stolyarov II on the Debt Nation Show – Refutation of Malicious and False Allegations from the Conspiracy-Theorist Site Biohackinfo

Gennady Stolyarov II
Steele Archer


In an important conversation with Steele Archer on the Debt Nation show, which took place on October 14, 2019, U.S. Transhumanist Party / Transhuman Party Chairman Gennady Stolyarov II refutes many of the baseless, false, and malicious allegations regarding the USTP Electronic Primary election, which were made by the yellow-journalism site Biohackinfo. Watch the discussion between Mr. Stolyarov and Mr. Archer here.

In addition, many of the successes of the USTP election process were discussed, as well as possibilities for improvement and aspirations for the Ben Zion 2020 Presidential campaign. Watch this video to get the facts regarding what happened during the election, as well as what the USTP stands for and our prospects for growing the transhumanist movement in 2020 and beyond.

The USTP election was the most open and transparent process possible, with detailed disclosure of the results – including anonymized individual votes – and external validation of the results through the open-source Instant-Runoff Voting Tool. The election was honest and fair on all sides, and only genuine USTP members attempted to vote. A full report on the results can be found here, with supporting details in this spreadsheet and the input into the Instant-Runoff Voting Tool available here.

We need to reject the echo-chamber of contrived allegations and move forward by promoting transhumanism in positive ways!

Announcement of Third and Fourth Virtual Debates Among U.S. Transhumanist Party Presidential Candidates – Gennady Stolyarov II Interviewed by Steele Archer of Debt Nation

Announcement of Third and Fourth Virtual Debates Among U.S. Transhumanist Party Presidential Candidates – Gennady Stolyarov II Interviewed by Steele Archer of Debt Nation

Gennady Stolyarov II
Steele Archer


On September 10, 2019, U.S. Transhumanist Party / Transhuman Party Chairman Gennady Stolyarov II was again interviewed by Steele Archer of Debt Nation, this time to discuss the two forthcoming official final virtual debates of the U.S. Transhumanist Party Presidential primary season.

Watch the interview here.

3rd Virtual Debate: Candidates Forsythe, Harris, Haywire, Holsopple, and Kerecz – Saturday, September 14, 2019, at 5:00 p.m. U.S. Pacific Time – See more details here.

4th Virtual Debate: Candidates Ben Zion, Schattke, Taylor, and Vrillon – Tuesday, September 17, 2019 at 6:30 p.m. U.S. Pacific Time – See more details here.

The Debt Nation show will co-host the debates, which will be livestreamed from The Unshackled YouTube channel.

Remember to join the U.S. Transhumanist Party for free before September 21, 2019, in order to be eligible to vote in the Electronic Presidential Primary that follows. Join here, no matter where you reside.

Gennady Stolyarov II and Johannon Ben Zion Discuss a Transhumanist Vision for U.S. Policy

Gennady Stolyarov II and Johannon Ben Zion Discuss a Transhumanist Vision for U.S. Policy

Gennady Stolyarov II
Johannon Ben Zion


Johannon Ben Zion of the Futurist New Deal Podcast interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II regarding the U.S. Transhumanist Party’s recent efforts, visions for the future of American politics, technological progress and technological Singularities, the importance of life-extension advocacy, open-source approaches to innovation, and overcoming challenges such as information overload and overly slow and cumbersome approval processes for innovative medical treatments. Mr. Stolyarov and Mr. Ben Zion also discussed in general terms the upcoming USTP Presidential Primary Election, for which voting will open on September 22, 2019.

This interview was filmed in Burbank, California, on August 24, 2019, following the Wellness and Longevity Seminar that was hosted there to mark the publication of The Transhumanism Handbook.

References

– “Progress in the Politics of Abundance” – Presentation by Gennady Stolyarov II
U.S. Transhumanist Party Discussion Panel – Burbank, California – August 24, 2019
The Transhumanism Handbook
– “The United States Transhumanist Party and the Politics of Abundance” – Mr. Stolyarov’s chapter in “The Transhumanism Handbook” – available for free download
Free Transhumanist Symbols
Futurist New Deal Podcast videos
Johannon Ben Zion – Candidate in the 2019 U.S. Transhumanist Party / Transhuman Party Presidential Primary

Join the U.S. Transhumanist Party for free, no matter where you reside. Those who join by September 22, 2019, will be eligible to vote in the Presidential Primary.

Gennady Stolyarov II Interviews James Strole Regarding RAAD Fest 2019 and Life-Extension Advocacy

Gennady Stolyarov II Interviews James Strole Regarding RAAD Fest 2019 and Life-Extension Advocacy

James Strole
Gennady Stolyarov II
Johannon Ben Zion


On Tuesday, July 16, 2019, U.S. Transhumanist Party Chairman Gennady Stolyarov II invited James Strole of the Coalition for Radical Life Extension and People Unlimited to discuss the upcoming RAAD Fest 2019 in Las Vegas on October 3-6, 2019 – the fourth RAAD Fest in history – https://www.raadfest.com/ – and the first in a new venue. Mr. Stolyarov and Mr. Strole discussed the importance of unity in the transhumanist and life-extensionist movements, as well as what opportunities for education and inspiration RAAD Fest will offer to those who wish to live longer and healthier. They also addressed audience questions and were briefly joined by Johannon Ben Zion, Chairman of the Arizona Transhumanist Party. Watch the interview on YouTube here.

Become a member of the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside. Apply here in less than a minute.

Watch some of the U.S. Transhumanist Party’s prior appearances at RAAD Fests in 2017 and 2018 below.

RAAD Fest 2017

The U.S. Transhumanist Party – Pursuing a Peaceful Political Revolution for Longevity – August 11, 2017

RAAD Fest 2018

The U.S. Transhumanist Party: Four Years of Advocating for the Future – Gennady Stolyarov II at RAAD Fest 2018 – September 21, 2018

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018 – September 21, 2018

U.S. Transhumanist Party Meeting at RAAD Fest 2018 – September 22, 2018

Andrés Grases Interviews Gennady Stolyarov II on Transhumanism and the Transition to the Next Technological Era – September 23, 2018

Register for RAAD Fest 2019 here

U.S. Transhumanist Party Chairman Gennady Stolyarov II and Tobias Teufel Discuss Science, Technology, Politics, and Transhumanism

U.S. Transhumanist Party Chairman Gennady Stolyarov II and Tobias Teufel Discuss Science, Technology, Politics, and Transhumanism

Tobias Teufel
Gennady Stolyarov II


On July 9, 2019, U.S. Transhumanist Party Chairman Gennady Stolyarov II conversed with Tobias Teufel, a transhumanist from Germany and Allied Member of the U.S. Transhumanist Party, regarding a variety of subjects – including a comparison / contrast of the voting systems in Germany and the United States, robotics, 3D printing, space colonization, life extension, possibilities for persuading those who are reluctant to accept emerging technologies, as well as some thoughts that Mr. Teufel had in connection with the recent First Virtual Debate of the U.S. Transhumanist Party’s Presidential primary candidates. Overall, Mr. Teufel shared some excellent insights regarding technological possibilities – including many that are open to ordinary people today – and some promising ways in which the Transhumanist Party can continue to reach out and educate the public about ongoing technological advances and their uses. Watch the conversation on YouTube here.

Become a member of the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside. Apply here in less than a minute.

U.S. Transhumanist Party Chairman Gennady Stolyarov II Speaks with Steele Archer of Debt Nation

U.S. Transhumanist Party Chairman Gennady Stolyarov II Speaks with Steele Archer of Debt Nation

Gennady Stolyarov II
Steele Archer


Watch this wide-ranging discussion between U.S. Transhumanist Party Chairman Gennady Stolyarov II and Steele Archer of the Debt Nation show, addressing a broad array of emerging technologies, the aspirations of transhumanism, and aspects of both broader and more personal economic matters – from the impact of technology on the labor market to how Mr. Stolyarov paid off his mortgage in 6.5 years. This conversation delved into Austrian economics, techno-optimism, cultural obstacles to progress, the work and ideals of the U.S. Transhumanist Party / Transhuman Party, life extension and the “Death is Wrong” children’s book, science fiction, and space colonization – among many other topics.
Dr. Nichola Conlon and James Strole Discuss the Biggest Reported Increase of NAD in Humans

Dr. Nichola Conlon and James Strole Discuss the Biggest Reported Increase of NAD in Humans

Nichola Conlon
James Strole


Dr. Nichola Conlon, Nuchido CEO & Co-founder, spoke with James Strole, Director of the Coalition for Radical Life Extension, about what she’s bringing to RAADfest 2019:
***
Increasing NAD+ levels to a level comparable with people 17 years younger. 
***
NAD is a natural molecule found within every living cell of your body. Without it, your body couldn’t generate the energy it needs to survive or kick-start its natural cell maintenance and repair systems. In its youthful state, your body naturally makes and retains high levels of NAD. But as you age, these levels are not maintained and the amount of NAD in your body drops by 50% every 20 years. This decline has been scientifically linked to the increasing effects of aging.
***
Recent scientific breakthroughs have shown that one of the best ways to combat aging is to maintain high levels of NAD.
***
Nuchido has pioneered the use of systems pharmacology and clinical research to boost and maintain NAD. In a scientific world-first, the team achieved the biggest increase of NAD in humans reported by any scientific group.
***
Hear what she has to share, and meet her at RAADfest 2019, October 3-6:

To find out more and register, visit the RAAD Fest website at https://www.raadfest.com/.


Watch the U.S. Transhumanist Party’s prior appearances at RAAD Fests in 2017 and 2018 below.

RAAD Fest 2017

The U.S. Transhumanist Party – Pursuing a Peaceful Political Revolution for Longevity – August 11, 2017

Advocating for the Future – Panel at RAAD Fest 2017 – Gennady Stolyarov II, Zoltan Istvan, Max More, Ben Goertzel,

RAAD Fest 2018

The U.S. Transhumanist Party: Four Years of Advocating for the Future – Gennady Stolyarov II at RAAD Fest 2018 – September 21, 2018

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018 – September 21, 2018

U.S. Transhumanist Party Meeting at RAAD Fest 2018 – September 22, 2018

Andrés Grases Interviews Gennady Stolyarov II on Transhumanism and the Transition to the Next Technological Era – September 23, 2018

Register for RAAD Fest 2019 here

Steve Hill Interviews Sarah Constantin of The Longevity Research Institute

Steve Hill Interviews Sarah Constantin of The Longevity Research Institute

Sarah Constantin
Steve Hill


Editor’s Note: The U.S. Transhumanist Party features this article by our guest Steve Hill, originally published by our allies at the Life Extension Advocacy Foundation (LEAF) on May 9th, 2018. In this article Mr. Hill interviews Dr. Sarah Constantin, a researcher with a focus on machine learning at The Longevity Research Institute. This is an excellent article, especially if you want to learn more of the hard science behind longevity research. The topics of the interview range from deep learning being applied to pharmacology, to optimal mouse strains, and ideal areas of research to target age-related diseases.

~Bobby Ridge, Assistant Editor, June 30, 2019

Today, we have an interview with the Longevity Research Institute, a new group that launched in April 2018. The goal of the Institute is to identify therapies that can demonstrably extend healthy human lifespan by 2030 at the latest.

Searching for longevity

There are dozens of compounds and therapies that have been demonstrated to increase the lifespan of mammals. Recently, there have been some impressive examples of rejuvenation in animals using a variety of approaches, including partial cellular reprogramming, stem cell therapy, and senescent cell removal. More importantly, in many of these studies, age-related diseases have been delayed or even reversed.

Unfortunately, very few of these studies have had independent follow-ups or replication, and that is slowing down progress. The Longevity Research Institute is aiming to bridge the gap between basic science and commercial drug development.

It has chosen the field of aging research as its area of focus for one simple reason: age-related diseases are the leading cause of death globally. Heart disease, stroke, cancer, diabetes, Parkinson’s, Alzheimer’s and many more diseases are all caused by the various processes of aging.

The data from hundreds of animal studies tell us that aging is not a one-way process and that the rate of aging is something we can slow down or even reverse. Experimental results show that we can increase the healthy lifespan of animals significantly and delay the onset of age-related diseases in doing so. If we could translate those findings to humans, we could potentially increase the healthy period of life, known as health span, or even increase our lifespan beyond current norms while remaining healthy.

The majority of aging research consists of basic science that focuses on the mechanisms of aging, studies involving invertebrates like worms or fruit flies, and experiments that examine the effect of therapies on biomarkers of aging. However, the Longevity Research Institute believes that the way to find effective treatments that could translate to humans is by testing interventions on mammals to see if they increase lifespan or if they delay or reverse symptoms of aging, such as frailty, cognitive decline, and the prevalence of age-related diseases. Robust mammalian lifespan studies are quite rare in aging research due to their long duration and thus cost; the Institute believes they are worth doing despite this challenge.

Its philosophy is to be skeptical of results that depend on too many uncertain assumptions, such as particular mechanisms of aging or analogies between invertebrate and human biology. It believes that the closest way to measure the health and lifespan of a human is to measure the same things in mammals.

Replicating and Extending Lifespan Results

The majority of studies that have been shown to increase lifespan are rarely independently replicated to confirm the findings. There are therapies that, decades later, still have had no follow-up, and the Longevity Research Institute would like to change this situation.

To that end, it will be engaged in grant writing to obtain funds so that researchers studying aging will be able to conduct lifespan studies in mice and rats. The Longevity Research Institute also plans to commission its own studies and contract research organizations to carry them out.

It has a long list of promising interventions and is considering becoming involved with carboxyfullerenes, epithalamin, and stem cell transplants, for example. It is also interested in testing combinations of therapies to see if they have synergistic effects.

As translational research on aging is really a new, uncharted territory, the Institute is working with the Interventions Testing Program and METRICS to design reproducible animal studies. As part of that process, it will be testing genetically heterogeneous animals and using blind, randomized studies to reduce bias. A blind experiment is an experiment in which information about the test is hidden from participants, to reduce or eliminate bias, until after a trial outcome is known.

Best practices and transparency

Establishing best practices and protocol for translational aging research is a top priority here, and its work could help set the stage for future translational efforts. If superbly designed research protocols can be designed and made accessible to everyone, then they could be a real help in standardizing aging research and ensuring that the quality of results is the best it can be.

As part of its commitment to transparency and knowledge sharing, a condition of funding projects is that all experimental data will be made freely available to the public, as will pre-registration of experimental designs. The Institute will further protect this open science initiative by using blockchain technology to make immutable, publicly accessible records of everything it does.

We had the opportunity to talk with Sarah Constantin, Ph.D. and one of the key figures at the Longevity Research Institute, about their work. Sarah is a data scientist specializing in machine learning.

Your group believes that we need to conduct lifespan studies in mice in order to confirm that something might translate. However, some researchers believe that using multiple biomarkers of aging allows them to project, within a reasonable margin of error, changes to potential lifespan. This is becoming more relevant as the accuracy of biomarkers, and the use of comprehensive biomarker panels, becomes more commonplace. How do you respond to this?

There’s some very interesting stuff going on with biomarkers of aging.  We’re able to predict mortality with AUCs of 0.8-0.9, which is quite good, with aging biomarkers, including things like blood panels of inflammatory and metabolic markers, DNA methylation, and phenotypic markers such as BMI and frailty. Some of these biomarkers are things we’re planning to measure in our animal studies, and they should give us interim results on whether the interventions we’re testing affect the predictors of aging. I still believe that we can be most confident in whether a treatment promotes longevity when we’ve tracked its effects throughout an organism’s lifespan. We do know of examples (such as calorie restriction in primates) in which it’s equivocal whether the treatment extends lifespan but it clearly improves age-related biomarkers, and you have to do a lifespan study to distinguish those cases.

Advances in deep learning and systems pharmacology are allowing us to project interactions and potential therapies far more efficiently than ever before. What are your thoughts on these approaches, and will you be looking to use them in your work?

The deep learning and systems pharmacology approaches are actually where I started in biotech; I did machine learning at Recursion Pharmaceuticals, which is taking those approaches for doing phenotypic screens for genetic disease treatments. I think they’re really useful for drug discovery, at the beginning of the pipeline, where they can enable you to search a wider space of drug candidates. At LRI, we’re starting all the way at the other end of the pipeline, with drugs that have already been tested and shown promise in vivo. However, once we make some progress on those, then yes, it could make sense to start doing some of these machine learning-enabled approaches.

What is the ideal mouse strain for aging research, particularly lifespan studies, in your view?

Well, the Interventions Testing Program at the National Institute of Aging is using three-way heterozygous mouse crosses, which I think is the ideal. A single inbred strain of mouse doesn’t have much genetic diversity, so often what you’re testing is the effect of a treatment on that particular strain of mouse, and the results won’t transfer to another strain.

The use of progeria mice is common in aging research due to the shorter study time, but these models are often criticized as not being representative of true aging; what are your thoughts on the prevalence of progeria mice in aging research, and are they a relevant model for what we are trying to achieve?

I think progeria mice are an imperfect proxy. There are a lot of different kinds of progeria, and they exhibit some but not all of the typical symptoms of natural aging.  I’d have more confidence in studies done on aged mice than progeric mice.

We see that you have a strong commitment to ensuring public access to scientific knowledge. What inspired you to make such a wonderful and strong commitment to open science?

Well, coming from a data science background, I’m hyper-aware of how easy it is to fool yourself with data.  You can massage anything into a spurious result if you test enough hypotheses and pick your subgroups artfully. Really, the best way to guard against that is to share the raw data so that people can run their own analyses. Making science more open is how you make it more trustworthy.

Is there a publically viewable list of the targets that you are interested in testing?

The list is still evolving, but some of the first things we’re looking into testing are carboxyfullerenes, which seem to have neuroprotective and life-extending effects, and epithalamin, which is a pineal gland-derived peptide that’s been reported to extend lifespan and even reduce human mortality. Both of these are sort of in the sweet spot of not being the subject of that much research to date, but what there is is very promising, so the value of information is high.

What is likely to be your first target for studies, and what is the rationale behind your choice?

I think people should know that there’s a lot of low-hanging fruit in aging research — treatments that we have reason to believe might work but that we’d still have to test. The misperceptions are either that life extension is so speculative that we’ll never get there or that we already know how to do it and you just have to take the right supplements to live forever. I think the reality is that we’ll have to do a lot of experimental work, but it’s highly possible that, in time, we might find something that extends healthy lifespan in humans.

We would like to thank Sarah for taking the time to do this interview with us, and we look forward to seeing her team’s progress in the near future.

Steve Hill serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 500 articles on the topic as well as attending various medical industry conferences. In 2019 he was listed in the top 100 journalists covering biomedicine and longevity research in the industry report – Top-100 Journalists covering advanced biomedicine and longevity created by the Aging Analytics Agency. His work has been featured in H+ Magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, and, Keep Me Prime, and New Economy Magazine. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project. In 2015 he led the Major Mouse Testing Program (MMTP) for the International Longevity Alliance and in 2016 helped the team of the SENS Research Foundation to reach their goal for the OncoSENS campaign for cancer research.