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2020 New Year’s and New Decade’s Message by Victor Bjoerk

2020 New Year’s and New Decade’s Message by Victor Bjoerk

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Victor Bjoerk


Picture of the M87 Black Hole – First-ever image of a black hole and a major accomplishment of the 2010s

Happy New Year and Decade, everyone!

I celebrated it this year in San Francisco, as I managed to get an opportunity in aging research here. I’ve always celebrated in Sweden before, with relatives or friends, and the last years’ celebrations have been with AI researcher Anders Sandberg. However, I’m certainly not stuck to any routine to mark it, and who knows where one may be in the future, if one may celebrate it in space even!

I still recall thinking about what would happen in the future back in 1999. Although, of course, our time calculation is completely arbitrary and not rooted in anything the universe cares about, we nonetheless like to set certain dates of when X event will happen when writing the history of humanity.

Back then I was a small child, and while I lacked a particular interest in aging research, I certainly read a lot of popular science and liked to think about what would happen during the upcoming millennia. Certainly, genetic enhancement of humans was high on that list and its happening now! Look, for example, at Luxturna and Zolgensma, the 2 approved gene therapies so far.

We should all be very happy to be alive now instead of during the previous 4 billion years life has existed. It’s been the best decade in history, ever. We have not only the basic logistics for keeping most people alive on a day-to-day basis with a good quality of life, but this also leads to a lot of spare time to develop technology.

Back in about 2008, when working in a nursing home as a teenager, I realized that I did not want to end up in that state within the next few decades. I did not feel that age-related disease belonged in an otherwise advanced high-tech society that respected human rights reasonably well. Since then, on most days, I’ve probably read new scientific papers on the topic, I went to university and studied molecular biology, I became director of Heales – which is a scientific think tank in Brussels – and set up the biannual EHA (Eurosymposium on Healthy Aging) conference series together with Sven Bulterijs.

I never intended to become a scientist for the sake of it; I just want to get the biggest problem in the history of humanity solved.

There are a lot of reasons for optimism. The 2010s saw unprecedented investment in this area, and many therapeutic aging interventions emerged. Among the ones most well-known are innovations in clearing senescent cells with senolytic drugs, leading to aging reversal.

So I just hope this trajectory of advancement continues as the public also becomes more informed. I’ve learnt that hype comes in cycles; lots of buzzwords and overoptimistic speculation flow around, but eventually also real products come out of the research (yes, even in biotechnology). The question is when enough therapies can be put together into an old person and systemically bring that person back to youth.

So I wish everyone a happy new year and decade, whatever your pursuits are, hoping that at the end of this decade we can summarize it, saying that we did what was possible.

I hope everyone had a fun celebration!

Victor Bjoerk has worked for the Gerontology Research Group, the Longevity Reporter, and the Fraunhofer-Institut für Zelltherapie und Immunologie. He has promoted awareness throughout Europe of emerging biomedical research and the efforts to reverse biological aging. He is now a molecular biologist and working for BioAge in San Francisco. 

New Decade’s Message for the 2020s by USTP Chairman Gennady Stolyarov II

New Decade’s Message for the 2020s by USTP Chairman Gennady Stolyarov II

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Gennady Stolyarov II


As 2019 draws to a close, Gennady Stolyarov II, Chairman of the United States Transhumanist Party / Transhuman Party and Editor-in-Chief of The Rational Argumentator, expresses hope that humankind will emerge from the “Crazy Years” and offers ten concrete resolutions for human achievement during the 2020s. This message was recorded on December 31, 2019, and is available for viewing here.

As 2019 draws to a close, let us bid farewell and good riddance to a decade which could, in retrospect be referred to using the prophetic Robert Heinlein term, “The Crazy Years” – a turbulent, conflicted decade during which, while glimmers of hope appeared on multiple fronts of technological advancement, society and culture have clearly declined due to the rise of incivility, tribalism, authoritarianism, identity politics, and mass breakdowns of sanity. It is no secret that I had hoped for humankind to have been farther along the path of advancement by now than it has actually come. The great conflict of our decade – between the marvels that have been built by the creative and rational higher faculties of the human mind and the biases, fallacies, vulnerabilities, and atrocities spawned by its darkest evolved recesses – between the Apollonian heights and the Dionysian depths of human nature – will carry on into the 2020s and perhaps beyond. To win this conflict, those of us who desire a brighter future need to advocate for more progress, faster innovation, greater rationality, higher standards of civility and morality, and a long-term outlook that seeks to cultivate the best in human beings.

As the winds of fortune shift, some of us individually will rise, and others will fall. This certainly was the case this past decade. In so many respects, for me, it has been marked by colossal achievements and improvements, but also tectonic shifts in my own life which were not of my initiative – to which I needed to respond and adapt and preserve what I valued in the aftermath. Reflecting back on the end of 2009, and comparing it to today, I realize that absolutely everything about the circumstances of my life is now different… and yet I myself am essentially the same. I believe that it is this core of myself, this fundamentally constant and consistent identity, which has carried me through the crises and enabled me to defy adversity and arise stronger every time – to pursue new endeavors and take on new roles while remaining the same essential individual, to learn from the empirical evidence before me while maintaining the same convictions and understanding of the good. The events of the 2010s have illustrated for me that, indeed, peace and stability in life must ultimately come from within – although it is not a matter of withdrawal into the self or mere self-affirmation, as some popular creeds would claim. Rather, it is the self that must devise and implement solutions to the crises of the day while pursuing consistent improvement in as many dimensions as possible, and preserving that essential core intact.

It is beyond our power to live a decade over again, but we can harness the best of its aftermath and turn the coming decade into a superior and more rational one. Some of us will create resolutions as individuals, and then pursue plans of varying degrees of specificity and likelihood of success. But perhaps it is best to consider the resolutions we would wish to have for humankind as a whole. It is all well and good, of course, to wish for progress and prosperity, but it is also well-known that the resolutions which have the greatest likelihood of succeeding are those which are accompanied by concrete indicators of fulfillment. Therefore, I propose the following ten resolutions for humankind during the decade of the 2020s, which will enable us to empirically identify whether or not they have been fulfilled at the decade’s end.

  1. Construct the next world’s tallest building – because humankind must always reach higher.
  2. Build a base on the Moon – because it is time to colonize other worlds.
  3. Land a human on Mars – because it is time to expand beyond our orbit.
  4. Establish the first fully operational seastead communities – because it is time for human habitation to expand beyond land and for jurisdictional experimentation to resume in earnest.
  5. Have at least one person live beyond 120 years again – mathematically possible given that 10 of today’s supercentenarians are 114 or older; it is time to begin to approach Jeanne Calment’s longevity record of 122 years once more.
  6. Cut all world nuclear-weapon stockpiles in half – more than this has been done before, and so this is really quite a modest goal, but it is imperative to reverse the trajectory of the current arms race. Complete nuclear disarmament by all powers would, of course, be preferable, to finally dispel the “MAD” cloud of annihilation looming over our species.
  7. Compose 100 tonal symphonies – because it is time to rediscover beauty.
  8. Develop medically effective cures for every type of cancer – because, really, it is decades past time.
  9. End the decade with 50 percent of all vehicles on the road at level 2 autonomy or greater – because road deaths are a travesty and should become a relic of a barbaric past.
  10. Experience at least one year in which no country is at war with any other, with “war” including armed insurgencies and terrorist attacks – because national, ethnic, religious, and ideological warfare needs to be relegated to the past.

Of course, there are many worthwhile objectives not encompassed above, and it is my hope that efforts to reach those goals will also advance in parallel. You may have a list of ten resolutions for humankind that differs from mine, but they may be compatible nonetheless. The overarching aim, however, is to restore humanity’s much-needed confidence in progress, to emerge from the postmodern swamp of self-doubt and deconstruction and return to the heights of ennobling ambition and creation. Concrete benchmarks to track our progress can also serve the dual purpose of motivating people everywhere to undertake great tasks. A certain President has expressed the desire to make America great again, but I would venture to say that he has not selected the proper means for doing so. I challenge everyone during the next decade to make the world great again and demonstrate that the most impressive achievements and the most lasting solutions to our age-old problems are still to come. This is the message of transhumanism, and I hope that it can become the theme of the next decade – so that when I speak to you again at the decade’s end, we can reflect upon the wonders that have been built.

Join the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside. Apply here in less than a minute. 

How 2020 Can Be the Year of Transhumanist Politics in America: USTP Chairman Gennady Stolyarov II Interviewed by Steele Archer on the Debt Nation Show

How 2020 Can Be the Year of Transhumanist Politics in America: USTP Chairman Gennady Stolyarov II Interviewed by Steele Archer on the Debt Nation Show

Gennady Stolyarov II
Steele Archer


On November 24, 2019, U.S. Transhumanist Party / Transhuman Party Chairman Gennady Stolyarov II spoke extensively with Steele Archer on the Debt Nation show regarding recent transhumanist political developments and possibilities to come in 2020, including how 2020 can shape up to become the year of transhumanism in American politics, across the conventional spectrum, with Zoltan Istvan running as a Republican, Andrew Yang running as a Democrat, several Libertarian candidates sympathetic to a highly technological future – with their supporters having the potential to be drawn to the Transhumanist Presidential campaign of Johannon Ben Zion, who will remain in the race all the way to the general election, long after all the other parties’ primaries have concluded.

Watch this conversation here.

Also discussed were subjects such as how transhumanism can give a new sense of purpose and rekindle the belief in progress among Americans, how transhumanism can inaugurate a more rational politics, which seeks creative solutions to replace wedge issues with win-win outcomes, and the key points from the USTP Chairman’s Third Anniversary Message and how they will be implemented so as to further enhance and grow the USTP.

Join the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside. Click here to apply in less than a minute.

 

Brent Nally Interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II at Sierra Sciences

Brent Nally Interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II at Sierra Sciences

Gennady Stolyarov II
Brent Nally


On October 12, 2019, U.S. Transhumanist Party Chairman Gennady Stolyarov II spoke with Brent Nally at the venerable Sierra Sciences headquarters in Reno, Nevada. They discussed developments in the U.S. Transhumanist Party, fitness, health, and longevity – among other subjects.

Watch the interview here.

Become a member of the U.S. Transhumanist Party / Transhuman Party here for free, no matter where you reside.

Show Notes by Brent Nally

3:15 Brent Nally’s RAADfest 2019 YouTube playlist: https://www.youtube.com/playlist?list=PLGjySL94COVSO3hcnpZq-jCcgnUQIaALQ

4:24 Go to RAADfest primarily to network: https://www.raadfest.com/

6:28 People Unlimited website: https://peopleunlimitedinc.com/

6:30 The Coalition for Radical Life Extension website: https://www.rlecoalition.com/

7:20 We need to increase your healthspan to increase your lifespan.

9:01 Watch Bill Andrews and Gennady discussing transhumanism and radical life extension: https://www.youtube.com/watch?v=U7GJrVBp8FQ

13:35 Gennady just ran the Lakeside Marathon at Lake Tahoe the day before, October 11, 2019.

19:30 Do whatever type of exercise that you enjoy. Don’t push yourself to the point of exhaustion where you’re throwing up or getting injured or not having fun because that’s bad for your telomeres.

24:10 Audit your own thoughts daily as a meditation to recognize your limiting beliefs.

26:15 How Gennady became Chairman of the U.S. Transhumanist Party

29:35 How the 9 USTP presidential candidates competed using a “ranked preference” approach

32:07 43 articles are currently in the 3rd version of the Transhumanist Bill of Rights: https://transhumanist-party.org/tbr-3/

34:27 https://transhumanist-party.org/

35:40 We should be more concerned with ideas rather than people. We’re in an “ideas” economy.

36:28 Politicians are more followers than leaders.

40:27 3 core ideals of USTP: https://transhumanist-party.org/values/

41:40 Gennady shares more details about how his role as chairman may evolve.

44:28 Positives and negatives of centralization and decentralization

49:15 Sophia the AI robot: https://www.hansonrobotics.com/sophia/

51:30 Truth is sometimes stranger than fiction. Try to educate others about transhumanism.

55:30 Ray Kurzweil points out that technology growth and stock market growth are separate. Here’s Brent talking to Ray in February 2011: https://www.youtube.com/watch?v=3TuVn…

57:37 Join the USTP: https://transhumanist-party.org/membership/

58:40 USTP Twitter: https://twitter.com/USTranshumanist; USTP LinkedIn: https://www.linkedin.com/company/19118856/; Gennady’s online magazine – The Rational Argumentator: http://www.rationalargumentator.com/index/

1:01:14 Gennady, Bill Andrews, and Brent ran about 8.4 miles the next morning above Carson City, NV on the Upper Clear Creek Trail.

1:02:15 Don’t forget to subscribe, like, comment on this video, and share on your social media accounts!

Gennady Stolyarov II and Johannon Ben Zion Discuss a Transhumanist Vision for U.S. Policy

Gennady Stolyarov II and Johannon Ben Zion Discuss a Transhumanist Vision for U.S. Policy

Gennady Stolyarov II
Johannon Ben Zion


Johannon Ben Zion of the Futurist New Deal Podcast interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II regarding the U.S. Transhumanist Party’s recent efforts, visions for the future of American politics, technological progress and technological Singularities, the importance of life-extension advocacy, open-source approaches to innovation, and overcoming challenges such as information overload and overly slow and cumbersome approval processes for innovative medical treatments. Mr. Stolyarov and Mr. Ben Zion also discussed in general terms the upcoming USTP Presidential Primary Election, for which voting will open on September 22, 2019.

This interview was filmed in Burbank, California, on August 24, 2019, following the Wellness and Longevity Seminar that was hosted there to mark the publication of The Transhumanism Handbook.

References

– “Progress in the Politics of Abundance” – Presentation by Gennady Stolyarov II
U.S. Transhumanist Party Discussion Panel – Burbank, California – August 24, 2019
The Transhumanism Handbook
– “The United States Transhumanist Party and the Politics of Abundance” – Mr. Stolyarov’s chapter in “The Transhumanism Handbook” – available for free download
Free Transhumanist Symbols
Futurist New Deal Podcast videos
Johannon Ben Zion – Candidate in the 2019 U.S. Transhumanist Party / Transhuman Party Presidential Primary

Join the U.S. Transhumanist Party for free, no matter where you reside. Those who join by September 22, 2019, will be eligible to vote in the Presidential Primary.

U.S. Transhumanist Party Discussion Panel – Burbank, California – August 24, 2019

U.S. Transhumanist Party Discussion Panel – Burbank, California – August 24, 2019

Johannon Ben Zion
Gennady Stolyarov II
Arin Vahanian
Charles Holsopple


On August 24, 2019, many leading transhumanists gathered in Burbank, California, to commemorate the publication of The Transhumanism Handbook. Subsequent to the seminar and book-signing event marking that occasion, the U.S. Transhumanist Party / Transhuman Party (USTP) held a discussion panel hosted by Chairman Gennady Stolyarov II and featuring Director of Marketing Arin Vahanian and USTP Presidential Primary candidates Johannon Ben Zion and Charles Holsopple. Subjects of conversation included assessments of the public’s receptiveness to transhumanist ideas, approaches toward spreading transhumanism, common misconceptions and challenges to overcome, as well as the upcoming Presidential primary election, for which voting will begin on September 22, 2019.

Find out more about The Transhumanism Handbook.

Join the U.S. Transhumanist Party for free, no matter where you reside. Those who join by September 22, 2019, will be eligible to vote in the upcoming USTP Presidential Primary.

See the USTP Platform here.

Read Mr. Stolyarov’s chapter in The Transhumanism Handbook – entitled “The United States Transhumanist Party and the Politics of Abundance” – for free here.

Progress in the Politics of Abundance – Presentation by Gennady Stolyarov II

Progress in the Politics of Abundance – Presentation by Gennady Stolyarov II

Gennady Stolyarov II


Gennady Stolyarov II, Chairman of the United States Transhumanist Party / Transhuman Party (USTP), delivered this presentation, entitled “Progress in the Politics of Abundance“, during the August 24, 2019, Wellness and Longevity Seminar in Burbank, California, to commemorate the publication of The Transhumanism Handbook. Mr. Stolyarov spoke to update the audience on recent USTP activities in 2019 since the writing of his chapter, entitled “The United States Transhumanist Party and the Politics of Abundance” which is available for free download.

Some of the subjects addressed in Mr. Stolyarov’s presentation are the necessity and challenges of overcoming the evolved mindset of scarcity – the zero-sum mentality – in politics, the USTP’s #IAmTranshuman campaign, its successful effort to amend Nevada Assembly Bill 226 to remove the prohibition against voluntary microchip implantation, and its Transhumanist Symbols project, of which the products are freely available here.

The presentation slides are not fully visible in the video but can be accessed and downloaded here.

Find out more about The Transhumanism Handbook.

Join the U.S. Transhumanist Party for free, no matter where you reside. Those who join by September 22, 2019, will be eligible to vote in the upcoming USTP Presidential Primary.

Gennady Stolyarov II Interviews James Strole Regarding RAAD Fest 2019 and Life-Extension Advocacy

Gennady Stolyarov II Interviews James Strole Regarding RAAD Fest 2019 and Life-Extension Advocacy

James Strole
Gennady Stolyarov II
Johannon Ben Zion


On Tuesday, July 16, 2019, U.S. Transhumanist Party Chairman Gennady Stolyarov II invited James Strole of the Coalition for Radical Life Extension and People Unlimited to discuss the upcoming RAAD Fest 2019 in Las Vegas on October 3-6, 2019 – the fourth RAAD Fest in history – https://www.raadfest.com/ – and the first in a new venue. Mr. Stolyarov and Mr. Strole discussed the importance of unity in the transhumanist and life-extensionist movements, as well as what opportunities for education and inspiration RAAD Fest will offer to those who wish to live longer and healthier. They also addressed audience questions and were briefly joined by Johannon Ben Zion, Chairman of the Arizona Transhumanist Party. Watch the interview on YouTube here.

Become a member of the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside. Apply here in less than a minute.

Watch some of the U.S. Transhumanist Party’s prior appearances at RAAD Fests in 2017 and 2018 below.

RAAD Fest 2017

The U.S. Transhumanist Party – Pursuing a Peaceful Political Revolution for Longevity – August 11, 2017

RAAD Fest 2018

The U.S. Transhumanist Party: Four Years of Advocating for the Future – Gennady Stolyarov II at RAAD Fest 2018 – September 21, 2018

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018 – September 21, 2018

U.S. Transhumanist Party Meeting at RAAD Fest 2018 – September 22, 2018

Andrés Grases Interviews Gennady Stolyarov II on Transhumanism and the Transition to the Next Technological Era – September 23, 2018

Register for RAAD Fest 2019 here

The United States Transhumanist Party and the Politics of Abundance – Essay by Gennady Stolyarov II in “The Transhumanism Handbook”

The United States Transhumanist Party and the Politics of Abundance – Essay by Gennady Stolyarov II in “The Transhumanism Handbook”

Gennady Stolyarov II


U.S. Transhumanist Party / Transhuman Party Chairman Gennady Stolyarov II’s essay “The United States Transhumanist Party and the Politics of Abundance” is available in the newly published master compilation, The Transhumanism Handbook, edited by Newton Lee, the California Transhumanist Party Chairman and U.S. Transhumanist Party Education and Media Advisor, and published by Springer Nature. This book is a milestone publication in transhumanist thought, and the U.S. Transhumanist Party / Transhuman Party encourages everyone to purchase it and read it in full. Fortunately, Mr. Stolyarov is able to share his own chapter – 60 pages within the book – for free download here: https://transhumanist-party.org/wp-content/uploads/2019/07/Stolyarov_USTP_Politics_of_Abundance.pdf.

Read “The United States Transhumanist Party and the Politics of Abundance” for a detailed explanation of the premises behind transhumanist politics and what the U.S. Transhumanist Party stands for. This essay is current through year-end 2018, and various other significant developments have occurred since then. However, this essay should give readers a strong impression of the USTP’s values, operating procedures, areas of focus, and aspirations for the future.

Abstract: “The depredations of contemporary politics and the majority of our era’s societal problems stem from the scarcity of material resources and time. However, numerous emerging technologies on the horizon promise to dramatically lift the present-day constraints of scarcity. The United States Transhumanist Party, in advocating the accelerated development of these technologies and seeking to influence public opinion to embrace them, is forging a new political paradigm rooted in abundance, rather than scarcity. This new approach is simultaneously more ambitious and more civil than the status quo. Here I illustrate the distinguishing features of the Transhumanist Party’s mode of operation, achievements, and plans for the future.”

Purchase the Transhumanism Handbook on Amazon here.

Become a member of the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside. Click here.

Click on the image of the first page above to read the essay in full. 

Why I Am Future-Positive on My Birthday – Article by Steve Hill

Why I Am Future-Positive on My Birthday – Article by Steve Hill

Steve Hill


Editor’s Note: The U.S. Transhumanist Party features this article by our guest Steve Hill, originally published by the Life Extension Advocacy Foundation (LEAF) on June 7th, 2019. In this article, Mr. Hill discusses how he feels great about being over 40 years old, instead of the depressing feeling that many tend to have on their birthdays, because he is very aware of how close medical science is to curing age-related diseases. He goes on in discuss, in his opinion, two of the most promising research methods being sought by various companies to defeat age-related diseases.

~ Bobby Ridge, Assistant Editor, July 7, 2019


Not so long ago, it was my 44th birthday, and I’ve finally decided to write something that I’ve been reflecting on for a while. To some people, a birthday is a cause for celebration; for others, it is viewed as a bad thing.

Yes, if you take the negative view, you could see it as simply a reminder of being another year older and another year closer to the grave. However, this is not how I see it; in fact, I think quite the opposite. I see it as another year closer to our goal: the defeat of age-related diseases due to the progress of rejuvenation biotechnology that offers longer and healthier lives.

From my point of view, viewing birthdays, or, indeed, the passing of time, as a positive or negative thing is largely a question of knowledge and understanding of the aging research field, which ties in with what I want to address today.

Knowledge is power

During my work as a journalist, people often ask me how things are progressing in the field. This is, of course, a perfectly reasonable and understandable question to ask. While I am always more than happy to talk about the field and answer this question, I also urge people to delve deeper into the field so that they can learn and evaluate for themselves rather than simply taking my word for it.

Our website, including the Rejuvenation Roadmap, is a good resource to start learning and to hear the latest news, as are places such as FightAging and the SENS Research Foundation website. Conferences such as Ending Age-Related Diseases and Undoing Aging are also valuable places to learn more about what is happening in the field.

Sometimes, I encounter people outside, but also fairly frequently within, the community who can be somewhat pessimistic about the field and its progress. It is perfectly natural to be cautious about the unknown, but there comes a point at which caution becomes unwarranted pessimism. The “Science Will Not Defeat Aging in My Lifetime, so Why Bother?” argument is a classic example of this, and much of this is caused by a lack of knowledge and understanding of the field.

The Latin phrase scientia potentia est, meaning “knowledge is power”, is particularly apt here. Knowledge and understanding allow us to better evaluate a situation or a proposal and reach a conclusion. It is hard to reach an accurate conclusion about anything without all the facts in place, yet I often see people doing it. Of course, there are always people who will not put in the time and effort required to learn about a topic properly, so they make predictions without all the facts, but there really isn’t much we can do about these people.

However, as advocates and supporters, we can do our best to learn about such things ourselves, and this will also come in useful when speaking to others about the field, as there is nothing like having a good understanding of the topic to help you convey it to others. That does not mean you need to become a biologist and understand things to such deep levels but even a solid understanding of the basics can be a huge help when it comes to engaging with others on the subject and also for understanding where we are currently progress wise.

Future-positive

This relates to a second question people often tend to ask me, which is if I think that they or we have a chance of living long enough to see these technologies arrive.

Obviously, no one can predict the future, so this question, by its very nature, is a tricky one to answer. I generally avoid being too specific on the timeframe in which we will reach the goal of longer lives through science, but I am optimistic that people in my age group, even perhaps older, have a reasonable chance of making the cut.

The reason that I am generally optimistic about the future is mostly that, as a journalist who speaks to hundreds of researchers, each focused on a part of the puzzle, I get an almost unique picture of the field. I can see the broader landscape and how and where things in the field or related fields connect or may connect in the future. A breakthrough in a related medical field may not have immediately apparent utility in aging research at first glance, but a deeper look could reveal hidden potential.

This fairly unique insight, combined with the knowledge that I have collected over the years working in the field, makes me fairly optimistic about the future and my place in it. As I have said a number of times in the past, the defeat of age-related diseases will not suddenly happen overnight; there is unlikely to be a single moment at which humanity goes from having no choice about aging to having control. It is far more likely that there will be steady progress, with incremental breakthroughs along the road, that will ultimately reach the goal.

Reasons to be cheerful

I would like to touch upon two of the most promising therapies that I am most interested in and believe may have a big impact in the near future (10-20 years) and that may help pave the way for major changes to how society thinks about and treats aging. Both of these therapies directly address one of the nine proposed causes of aging and thus if they work they have the potential to be transformative in healthcare. Of course, there are more therapies in development and at various stages of progress which also address the other causes of aging but these two are what I am most enthusiastic about presently. I urge you to explore the provided links to resources and learn more about each one.

Senolytics

No list of promising technologies would be complete without talking about the senescent cell-clearing drugs and therapies known as senolytics. Senescent cells are aged or damaged cells that should destroy themselves via a process known as apoptosis but, for various reasons, do not do so; instead, they hang around, sending out inflammatory signals that harm nearby healthy cells, block effective tissue repair, and contribute to numerous age-related diseases.

One proposed solution to these problem cells is to remove them by causing them to enter apoptosis, as originally intended, by using senolytic drugs and therapies. Removing these cells in mouse studies has produced some remarkable results, with mice often living healthier and longer lives as well as reversing some aspects of aging.

The race is now on to bring these drugs to people, and a number of companies are developing them right now. So far, UNITY Biotechnology has seen the most progress, and the company is already conducting human trials of its lead candidate drug (UBX0101) for the treatment of osteoarthritis. It has another candidate drug (UBX1967) closely behind; this drug is poised to enter human trials for the treatment of age-related macular degeneration, diabetic macular edema, diabetic retinopathy, and glaucoma. Based on recent comments from UNITY, we are anticipating the initial results of human trials in the next few months; hopefully, the news will be positive.

With the number of companies working on these therapies, it is fair to be optimistic about their potential to address multiple age-related diseases given that senescent cells are a proposed root cause of aging. You can also check out the Rejuvenation Roadmap to see which companies are working on senolytics and how they are progressing.

Partial cellular reprogramming

Cells can be reverted back to an earlier developmental state, known as induced pluripotency, using reprogramming factors, and this process effectively makes aged cells functionally young again in many ways. Ever since its first discovery, there has been a great deal of interest in this area of aging research.

The problem with inducing pluripotency is that the cell loses its identity and forgets what cell type it currently is, as it becomes a new kind of cell capable of being guided into changing into any other cell type, much like our cells during development. This is great for early human development, but as adults, having our cells forget what they are is bad news. Therefore, researchers have wondered if it is possible to reset a cell’s age without resetting its cell memory, and the answer appears to be yes!

Thankfully, during the reprogramming of a cell back to pluripotency, the cell’s age is one of the first things to be reset before the cell memory is wiped, and it appears possible to partially reprogram the cell so that only aging is reset. We have talked about the potential of partial cellular reprogramming and how it is similar to hitting the reset button on aging in a previous article, but, needless to say, if we can find a way to safely partially reprogram our cells, it could have a dramatic impact on how we age and may allow us to remain more youthful and healthy.

In terms of progress, partial reprogramming has already been demonstrated in mice, and now a number of groups, including Turn.Bio, the Salk Institute, Life Biosciences, Youthereum Genetics, and AgeX, are developing therapies based on partial reprogramming, which is essentially the resetting of cells’ epigenetic states (what genes are expressed) from an aged profile to a more youthful one, again directly targeting one of the proposed root causes of aging.

This approach is likely to be quite a few years away, but I think it is plausible that it could be in human trials in the next decade, and it is probably the approach that interests me the most in the field.

In closing

The truth is we cannot predict the future because it is not set in stone, so we cannot be totally certain if or when rejuvenation technologies will arrive. The best we can do is learn as much as we can about the field and try to reach a reasonable conclusion based on the situation as it is now.

The field is advancing steadily, and we should be optimistic but not complacent about progress. We should be mindful of being too negative and, equally, of being too positive without ample justification. Blind optimism is as bad as blind pessimism, and we should always strive for informed optimism.

That said, given the progress being made, I am optimistic about my chances based on the evidence to date. This is why I do not mind birthdays and why I find them positive experiences rather than negative ones. Arm yourself with knowledge, and perhaps you too will agree with me and understand why I am future positive.

Steve Hill serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 500 articles on the topic as well as attending various medical industry conferences. In 2019 he was listed in the top 100 journalists covering biomedicine and longevity research in the industry report – Top-100 Journalists covering advanced biomedicine and longevity, created by the Aging Analytics Agency. His work has been featured in H+ Magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Keep Me Prime, and New Economy Magazine. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project. In 2015 he led the Major Mouse Testing Program (MMTP) for the International Longevity Alliance and in 2016 helped the team of the SENS Research Foundation to reach their goal for the OncoSENS campaign for cancer research.