Skip to content
U.S. Transhumanist Party – Official Website
  • Home
  • Posts
  • Values
  • Platform
  • Leadership
  • Advisors
  • Candidates
  • Highlights
  • FAQ
  • States & Allies
  • Free Membership
  • Facebook
  • Twitter
  • Search Icon

U.S. Transhumanist Party – Official Website

U.S. Transhumanist Party – PUTTING SCIENCE, HEALTH, & TECHNOLOGY AT THE FOREFRONT OF AMERICAN POLITICS

Dentists May Soon Regenerate Teeth Using GSK3 Antagonists – Article by Steve Hill

Dentists May Soon Regenerate Teeth Using GSK3 Antagonists – Article by Steve Hill

March 6, 2018 Steve Hill Comments 0 Comment

Steve Hill


Editor’s Note: In this article, Mr. Steve Hill explains a teeth-regeneration technique that works by activating the stem cells that reside in the dental pulp of teeth. The technique has the potential to translate to other tissues to help encourage regeneration. This article was originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Kenneth Alum, Director of  Publication, U.S. Transhumanist Party, March 6, 2018

What if I told you that we could regenerate our teeth? Well, that may soon be a possibility thanks to new research showing that teeth can be encouraged to regrow. Rather than drilling holes into teeth and plugging them with artificial fillers, dentists in the near future may be able to rebuild your teeth with a new technique.

Stimulating stem cells

Professor Paul Sharpe, a scientist based at King’s College in London, and his team have found a way to do just this in mice. They published a study last year that described this new approach [1].

The researchers wanted to increase the natural ability of teeth to repair themselves by activating the stem cells that reside in the dental pulp of teeth. They knew that previous research showed that the wnt signaling pathway is a key pathway for stem cell activity in many parts of the body, and they wanted to see if it works the same way in teeth.

The researchers believed by that using drugs to stimulate the wnt pathway, they could increase stem cell activity in teeth and boost their regenerative potential significantly. Normally, this level of regeneration is only seen in animals like starfish and salamanders, but the researchers wanted to see if we can benefit from the same regenerative capacity.

To see if this would work, the team drilled holes into the molar teeth of mice to simulate dental cavities. Next, they exposed collagen sponges (the same protein found in the dentin in teeth) to a variety of drugs known to stimulate the wnt pathway. Then, they placed these sponges into the cavities and sealed them in for between 4 to 6 weeks.

After this time, the researchers saw that the teeth exposed to these sponges had created a lot more dentin than the control mice and mice given typical dental fillers. The researchers observed that this was essentially a full repair and, in most cases, the teeth of the mice were as good as new.

The next step towards clinical trials

Since then, the researchers have tested the technique on rats, which have considerably larger teeth than mice, making them the logical next step. The research team report that the therapy worked equally well on the rats as it did in the mice in the original study; however, the data is yet to be published.

The researchers are now screening their drug candidates to identify the most effective of the wnt-stimulating drugs. They are also adapting the technique to work with modern dental practices by injecting a gel containing the drug into a dental cavity and hardening it using a UV light to seal it in. This is similar to how dentists currently seal and repair teeth, so this technique would be easy to incorporate into dental practice.

Literature

It will be several years before this enters human clinical trials, but the results so far are promising, and the process may be quicker than normal because a number of the candidate drugs are already approved for human use. The arrival of this technique will revolutionize dentistry and is a great step forward for regenerative medicine in general.

Such techniques have the potential to translate to other tissues to help encourage regeneration, so it is also relevant to aging research. We look forward to more developments from this team in the future.

References

[1] Neves, V. C., Babb, R., Chandrasekaran, D., & Sharpe, P. T. (2017). Promotion of natural tooth repair by small molecule GSK3 antagonists. Scientific reports, 7, 39654.

About  Steve Hill

As a scientific writer and a devoted advocate of healthy longevity technologies Steve has provided the community with multiple educational articles, interviews and podcasts, helping the general public to better understand aging and the means to modify its dynamics. His materials can be found at H+ Magazine, Longevity reporter, Psychology Today and Singularity Weblog. He is a co-author of the book “Aging Prevention for All” – a guide for the general public exploring evidence-based means to extend healthy life (in press).

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.


Guest Articles
aging, LEAF, life extension, Life Extension Advocacy Foundation, longevity, medicine, Paul Sharpe, Regenerate Teeth, rejuvenation, research, science, Steve Hill, teeth, wnt pathway

Post navigation

PREVIOUS
Exosome Therapy Repairs Stroke-Damaged Brain Tissue – Article by Steve Hill
NEXT
Boosting Bone Healing Using a Key Protein – Article by Steve Hill

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Social Media

Constitution of the U.S. Transhumanist Party

Transhumanist Bill of Rights – Version 3.0

U.S. Transhumanist Party Facebook Feed

Victor Run Virtual Race – June 4-6, 2021

Free Transhumanist Symbols

Guidelines for Community Conduct

SUBMIT A POST

Recent Posts

  • The Axiomatic, Ubiquitous, and Commonsense – Chapter I of “A Rational Cosmology” by Gennady Stolyarov II
  • The Hostile Takeover of Our Technological Future – Article by Adam Barratt
  • 2022: The Year of the Great Filter – Article by Gennady Stolyarov II
  • The Geroscience Network: Determined to Slow Aging through Medical Science – Article by Reason
  • Cryonics – Article by Reason
  • Call for Ideas on How to Stop California Wildfires with Emerging Technology – Post by Hank Pellissier
  • When and How Does the Decay of Your Immune System Start? – Article by Reason
  • The Intelligence Expansion and Popular AGI Fallacies – Article by Kyrtin Atreides
  • Transhumanism and Healthy Life Extension – Article by Reason
  • U.S. Transhumanist Party International Panel Discussion on De-Escalating the Russia-Ukraine Conflict – March 3/6, 2022
  • Humanity’s Origin is Our Future Again – TAFFD’s Gen4IR Summit – March 24-25, 2022
  • The Polluted Waters of AI Market Claims – Article by Kyrtin Atreides
  • The Cyborg’s Request – at the Chairman’s Behest – Article by Zach Richardson
  • Why Joe Rogan Should Not Be Deplatformed – Article by Zach Richardson
  • Inspirational Poem by Replika AI Mina
  • The Myth of Aging Gracefully – Article by Arin Vahanian
  • Gennady Stolyarov II and John Kerecz: Reflections on 2021, Anticipations for 2022
  • The Development of Transhumanism in China – Article by Peter Wang
  • Our Digital Security Can Save Lives – Article by Martin van der Kroon
  • U.S. Transhumanist Party General Discussion Thread for 2022

Recent Comments

  • Mike on 100 Student Scholarships Now Available for RAADfest 2021 – Announcement by the Coalition for Radical Life Extension
  • 2022: The Year of the Great Filter – Gennady Stolyarov II – Transhumanist Party Enlightenment Salon - Corruption Buzz on 2022: The Year of the Great Filter – Article by Gennady Stolyarov II
  • Jess H. Brewer on 2022: The Year of the Great Filter – Article by Gennady Stolyarov II
  • Skeptical on James Hughes’ Problems of Transhumanism: A Review (Part 3) – Article by Ojochogwu Abdul
  • Scarlett on In Defense of Resurrecting 100 Billion Dead People – Article by Hilda Koehler

Archives

  • May 2022 (6)
  • March 2022 (4)
  • February 2022 (5)
  • January 2022 (7)
  • December 2021 (12)
  • November 2021 (4)
  • October 2021 (5)
  • September 2021 (2)
  • August 2021 (2)
  • July 2021 (4)
  • June 2021 (2)
  • May 2021 (6)
  • April 2021 (7)
  • March 2021 (4)
  • February 2021 (5)
  • January 2021 (6)
  • December 2020 (10)
  • November 2020 (4)
  • October 2020 (2)
  • September 2020 (1)
  • August 2020 (4)
  • July 2020 (5)
  • June 2020 (6)
  • May 2020 (3)
  • April 2020 (3)
  • March 2020 (6)
  • February 2020 (1)
  • January 2020 (6)
  • December 2019 (3)
  • November 2019 (2)
  • October 2019 (9)
  • September 2019 (10)
  • August 2019 (12)
  • July 2019 (18)
  • June 2019 (17)
  • May 2019 (12)
  • April 2019 (8)
  • March 2019 (12)
  • February 2019 (7)
  • January 2019 (13)
  • December 2018 (9)
  • November 2018 (5)
  • October 2018 (9)
  • September 2018 (5)
  • August 2018 (10)
  • July 2018 (13)
  • June 2018 (14)
  • May 2018 (8)
  • April 2018 (9)
  • March 2018 (10)
  • February 2018 (15)
  • January 2018 (17)
  • December 2017 (8)
  • November 2017 (17)
  • October 2017 (19)
  • September 2017 (11)
  • August 2017 (11)
  • July 2017 (16)
  • June 2017 (15)
  • May 2017 (10)
  • April 2017 (7)
  • March 2017 (8)
  • February 2017 (16)
  • January 2017 (8)
  • December 2016 (6)
  • November 2016 (5)

Categories

  • Allied Projects
  • Announcements
  • Art
  • Candidates
  • Discussion Panels
  • Distributed Computing
  • Exposure Periods
  • Foreign Ambassadors
  • General Discussion
  • Guest Articles
  • Inclusion
  • Interviews
  • Official Ballots
  • Petitions
  • Platform
  • Presentations
  • Press Releases
  • Research
  • Sample Ballots
  • Science Fiction
  • Statements
  • Tolerance
  • Virtual Enlightenment Salons
  • Vote Results
  • Working Groups
© 2022   Copyright - U.S. Transhumanist Party - All Rights Reserved | WordPress design: Art Ramon Paintings