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Evolution Won’t Stop Aging Any Time Soon, but Medicine Might – Article by Sedeer el-Showk

Evolution Won’t Stop Aging Any Time Soon, but Medicine Might – Article by Sedeer el-Showk

Sedeer el-Showk


Editor’s Note: The U.S. Transhumanist Party publishes this article by Sedeer el-Showk, originally featured by our allies at Lifespan.io, in order to highlight the fallacious nature of many media outlets’ responses to a recent study about the “invariant rate of aging”. As Mr. el-Showk eloquently explains, this study does not refute or undermine the possibility of pursuing the reversal of biological aging, but simply suggests that this needs to be done through medical and technological means, and that without such means, overcoming the limitations of the current maximum human lifespan would not be feasible. Many of us in the longevity advocacy community have known this for a long time already, but it is important to spread accurate information to prevent an unjustified decline in public confidence in the feasibility of radical life extension.

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, July 25, 2021


Aging is not unstoppable, despite misinterpretations of the new study.

A new study [1] about the ‘invariant rate of ageing’ has led to reports that aging is unstoppable and that we cannot cheat death. However, this reporting is based on a misunderstanding of what the study actually says.

The misinterpretations

The study shows that “immortality and everlasting youth are the stuff of myths,” according to The Guardian. The article goes on to say that “an unprecedented study has now confirmed that we probably cannot slow the rate at which we get older because of biological constraints.” Other outlets published similar conclusions, with Futurism saying that the study shows “an ‘invariant rate of aging’ that won’t slow down”.

These reporters seem to have gotten tripped up on the idea of an ‘invariant rate’, which has the key implication that biological constraints determine the rate of human aging. This led to the conclusion that aging is fixed, inevitable, and immutable, but that’s not at all what the study shows, as the paper itself directly says.

What the study actually says

The study aimed to investigate the ‘invariant rate of ageing’ hypothesis, which proposes that the rate of aging is fixed within a species. The idea is that aging has evolved in concert with a suite of other traits, such as birth rate and metabolic rate, and this concerted evolution has led to the rate of aging being relatively fixed within a species.

In this context, ‘fixed’ is used as the opposite of ‘plastic’. It doesn’t mean ‘set in stone’. It means there’s relatively limited variation in this trait within a species because biological factors have a stronger effect on it than environmental factors. A good example might be the number of digits on a limb – environmental factors don’t really affect it, and there’s very little (but some) variation.

To test this hypothesis, the researchers created a statistical model of the age-specific risk of death in species from seven primate genera. They used data from various studies to set the parameters of their model, which is how they tested the amount of variation.

The model included parameters for infant and juvenile mortality, age-independent mortality, and senescent mortality. Variation in the biological rate of aging would be reflected in the senescent mortality parameter, since it captures what we normally think of as ‘aging’, while the infant and juvenile morality parameter reflects the misfortune of dying young.

The study’s first finding is that most of the gain in human lifespan so far has come from reducing mortality at younger ages. There’s also variation in the infant and juvenile mortality parameter, both between societies and at different times.

This also shows up in the relationship between life expectancy and lifespan equality. Media reports generally got this part of the study right, and you can look at the report on SciTechDaily to get more details about these findings.

Unlike the infant and juvenile mortality parameter, the senescent mortality parameter varied very little within each species. In fact, changing this parameter in their model shifted the mortality and demographic data of one species to look like another.

Changing the other parameters led to minor shifts in age distribution, but changing senescent mortality made it look like data from a different species. What this means is that within a given species, biological factors are the ultimate determinants of longevity.

Changing the environment to reduce mortality at younger ages (as we have in most parts of the world) affects demographics, increasing life expectancy and lifespan equality. However, accomplishing more than that will require tackling the evolved biological constraints on lifespan.

This study, therefore, doesn’t show that the rate of aging cannot be changed; it shows that there’s a limit to how much change can be realized without biological interventions, which is precisely the challenge that longevity research aims to overcome.

The paper itself closes on that note, though you wouldn’t know it from the way it’s been covered: “It remains to be seen if future advances in medicine can overcome the biological constraints that we have identified here, and achieve what evolution has not.”

Abstract

Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.

Conclusion

Ultimately, this wasn’t a study about longevity or the inevitability of aging. It was research to understand what affects the rate of aging – how much it results from evolved biological processes versus the effects of the environment. That’s important science not only for longevity research but also for evolutionary biology. It’s undoubtedly valuable, but unfortunately, its message has been misconstrued.

Far from showing that aging is inevitable, this research instead demonstrates that, ultimately, we’ll run out of environmental improvements and will have to turn to biological interventions to affect aging.

Literature

[1] Colchero, F. et al. The long lives of primates and the ‘invariant rate of ageing’ hypothesis. Nature Communications (2021), doi: 10.1038/s41467-021-23894-3

Sedeer el-Showk became a professional science writer after finishing a degree in biology. He also writes poetry and science fiction and fantasy, and somehow juggles an ever-growing list of hobbies from programming to knitting to gardening. Eternal curiosity and good fortune have taken him to many parts of the world, but he’s settled in Helsinki, Finland for the moment. He hopes he’ll never stop learning new things.

The Unnatural Objection to Life Extension – Article by Arin Vahanian

The Unnatural Objection to Life Extension – Article by Arin Vahanian

Arin Vahanian


Of all the objections to life extension, perhaps the most banal one yet is the argument that it is not natural for humans to want to live longer and healthier than they currently do. Of course, not only does this actually go against human nature itself, but it is also an insult to the immense progress we have made in improving the human condition throughout the course of history. In fact, this opposition to life extension also flies in the face of the entire medical industry, which is focused on keeping people alive, and any other industry that contributes to the betterment of the human condition, of which there are many. The fact is, opposing life extension is what is unnatural, because it is a natural human desire to want to survive, and to continue living in a healthy manner.

And let me be clear – just because something is natural does not make it good. It doesn’t take a genius to understand that getting poisoned by a plant, mauled by a wild animal, drowned by a tsunami, or crushed by a landslide are scenarios that are to be avoided at all costs. That these sorts of events are now relatively rare speaks volumes about the progress we have made in battling the destructive forces of nature.

Similarly, cancer, heart attacks, and strokes are natural too, yet no one would say that these conditions are desirable or good. In fact, many billions of dollars and resources are spent on finding a cure for these diseases, and for good reason – these diseases are deadly and contribute to massive suffering and pain.

To be sure, the environment is precious and should be protected. After all, to be able to walk through a forest and appreciate the flora and fauna is refreshing. Being able to visit a beach and feel the cool ocean breeze on one’s skin on a late summer afternoon is lovely. However, we should also be very wary of romanticizing nature, mostly because nature is entirely indifferent to the human condition. Indeed, nature does not care one bit about our happiness or fulfillment. Earthquakes, tornadoes, tsunamis and hurricanes are part of nature, but no sane person would argue that these events are positive or that we should experience more of them.

Just because something exists in nature does not make it desirable or good. Conversely, just because something was developed outside of nature does not make it undesirable or bad. In fact, more often than not, science and technology have contributed to massively improving the quality of life for human beings. Imagine how much worse life would be without electricity, life-saving medicines, medical procedures, and computer technology.

How many people now would say that the tuberculosis vaccine, stents, or pacemakers are bad and should be abolished? Of course, all these discoveries were “unnatural,” but no sane person would wish to be inflicted with a deadly infectious disease or suffer a heart attack.

But going back to talking about the environment, climate change is a very real threat to planet Earth and humanity, and we should do all we can to protect our planet, the human race, and members of the animal kingdom. However, the solution to climate change is not going to arrive automatically as part of a natural process. Neither is the answer to stop evolving as a species or to stop all technological innovation and progress and revert to the Dark Ages, and in turn have humanity experience economic collapse and widespread suffering. In fact, humanity’s best hope for battling climate change will likely come from science and technology.

Further, attempting to control nature is what has allowed us to come up with inventions such as indoor plumbing, safe and comfortable shelter, and weather forecasts, all of which have improved the quality of life dramatically. Suppose that we had just let nature run its course in these scenarios. I don’t think I need to spell out what would have happened to humans had we allowed that to happen.

But even after we have thoroughly debunked this ridiculous objection to life extension, critics may then move on to other objections, such as the idea that a human life is already long enough, or that we may become bored if we were to live longer, or that the Earth will become overpopulated. Fortunately, we have answers to these objections as well. And what about the argument that sickness and death are inevitable and that we should just accept things the way they are? This topic deserves its own discussion, but for the moment we can respond by saying that catching an infectious disease and dying at the age of 20 or 30 was once the way things used to be, but it is fortunately no longer the case.

The fact is that it is entirely natural for humans to want to live longer and healthier. Indeed, it is what we have been trying to do since the dawn of time. It is human nature to want to survive and thrive. For the first time in human history, we have the potential to overcome nature itself. Limiting ourselves to what is natural means we deny ourselves the opportunity to be better and to do better. Dying at 20 years of age due to cholera, measles, or malaria wasn’t our destiny as human beings, and therefore we overcame infectious illnesses and significantly increased our life expectancy. Now, we are at a crossroads where we get to decide if we wish to continue suffering for years and then dying due to aging-related illnesses such as dementia, heart disease, and cancer, or, whether we will dedicate this next stage of human development to overcoming these horrific illnesses.

Of course, even after admitting that aging-related illnesses and natural disasters are devastating and should be avoided at all costs, opponents of life extension may still argue that they are entitled to oppose life extension. Of course, they are entitled to their beliefs, no matter how faulty their reasoning and logic may be, but we supporters of life extension are also entitled to advocate for the defeat of aging-related illnesses and to improve the human condition through advancements in science and technology, even if these advancements are not part of nature.

I would urge those who oppose life extension technologies because they are unnatural to revisit their stance after burying a loved one who dies from cancer, or after witnessing a calamitous natural disaster that destroys entire towns and kills thousands of people.

If nature held all the solutions to life, then we would not need to build earthquake-resistant buildings, we would not need to develop anti-cancer drugs, and we would not need spend money, time, and resources on reducing human suffering and improving the human condition.

Nature is how we started as human beings, but nature is not where we need to end.

Arin Vahanian is Vice-Chairman of the U.S. Transhumanist Party. 

20 Cutting-Edge Biotechnologies in Development Today – Article by Logan Thrasher Collins

20 Cutting-Edge Biotechnologies in Development Today – Article by Logan Thrasher Collins

Logan Thrasher Collins


I have compiled a list of some of today’s most exciting, cutting-edge biotechnologies! Some of these technologies are emerging, and some of them are already prevalent in a translational context.

1. CRISPR-Cas systems: revolutionary for gene editing, gene therapy, fundamental biology, diagnostics, and more.
2. Gene therapy: enables cures for genetic diseases and powerful treatments for many cancers, may eventually treat polygenic disorders, ameliorate aging, and even enhance human biology (e.g., provide radiation resistance to astronauts). Synergy with CRISPR-Cas technologies will greatly aid gene therapy.
3. DNA origami: paves the way for new nanomedicines, biocatalysts, biosensors, imaging probes, diagnostics, data storage methods, biocomputing, and more.
4. Computational protein engineering: paves the way for new nanomedicines, biocatalysts, biosensors, diagnostics, biomaterials, imaging probes, and more.
5. Immunotherapy: enables cures for many cancers, treatments for autoimmune diseases, and more.
6. Computational protein structure prediction: revolutionizes drug discovery and basic biology, synergizes with computational protein engineering.
7. Spatial transcriptomics: method for interrogation of cell and tissue biology in a holistic and multidimensional fashion to deeply understand health and disease, may lead to dramatic insights on aging, cognition, and pathology.
8. Optogenetics: powerful tool for understanding cellular physiology and neural circuits, may greatly enhance brain-machine interfacing (with the help of gene therapy).
9. Expansion microscopy: physically enlarges biological samples to multiply resolution. Making major strides in connectomics, vastly enhancing study of spatial organization of cells and tissues in general, synergizing with spatial transcriptomics.
10. Longevity medicines: pharmacological, gene therapy, and other methods of treating aging may extend human lifespan and dramatically reduce the prevalence of most aging-related diseases.
11. Bioprinting: produces replacement tissue and may enable manufacturing of replacement organs. Also greatly aids study of tissue biology and provides platforms for drug testing.
12. Organ-on-a-chip systems: may greatly reduce the need for animal models in research, helping to understand organ microenvironments and organ physiology in general, serving as platform for drug testing and discovery.
13. Organoids: may greatly reduce the need for animal models in research, helping to understand organ physiology (especially in context to 3D structure and function), serving as platforms for drug testing and discovery, contributing to understanding of cognition, aiding understanding of developmental biology.
14. Cryo-EM and cryo-ET: rivaling x-ray crystallography for solving high-resolution protein structures and is much easier than x-ray crystallography (especially for certain problematic samples), giving 3D images of cellular environments at sufficient resolution to see some macromolecular structural details, preserves sample integrity better than other methods.
15. Phage therapy: enables versatile and potent treatment of bacterial infections, may save the world from antibiotic resistance.
16. Synchrotron x-ray nanotomography: rapid 3D imaging in one or two colors, may help map brain structure much more rapidly than other methods. This could lead to superior brain-inspired AI and robotics, treatments for brain disease, and whole-brain simulations.
17. Tissue clearing with light-sheet microscopy: facilitates 3D imaging of tissues and even whole organs, leading to much better understanding of biological function, aids connectomics.
18. Predictive systems biology models: transforming vast biological datasets into parameters for large-scale simulations which give valuable insights. Some key examples are kinetic signaling network simulations, molecular dynamics simulations, and biophysical neuronal network simulations.
19. Injectable electronics: minimally invasive method of delivering brain-machine interface hardware, may lead to widespread biomedical and nonmedical adoption of brain-machine interfaces.
20. Minimal cells: may transform understanding of cellular physiology, may act as a superior biomanufacturing platform, may act as a superior platform for cell therapy, and more.
***

Logan Thrasher Collins is a U.S. Transhumanist Party member, futurist, synthetic biologist, author, and innovator. When he was 16, he invented a new antimicrobial protein, OpaL (Overexpressed protein aggregator Lipophilic). He next developed a bacterial conjugation delivery system for the gene encoding OpaL. His synthetic biology research has been published as a first-author journal article in ACS Biochemistry: “Design of a De Novo Aggregating Antimicrobial Peptide and a Bacterial Conjugation-Based Delivery System.” In addition, his synthetic biology research has been recognized at numerous venues including TEDxMileHigh, the Intel International Science and Engineering Fair (ISEF), the International BioGENEius Challenge at the BIO International Convention, and at the American Society for Microbiology General Meeting. At Intel ISEF 2014, his synthetic biology research won 1st place in microbiology and best of category in microbiology ($8,000) as well as the Dudley R. Herschbach award. The latter included a trip to take part in the Nobel Prize ceremonies via the Stockholm International Youth Science Seminar (SIYSS). As part of the honors at Intel ISEF, a minor planet was officially named Logancollins.

As the Chief Technology Officer (CTO) at Conduit Computing, Mr. Collins is leading a supercomputing project which has allowed visualization of how the constituent proteins of SARS-CoV-2 interact inside of cells to build whole viruses.

Visit Logan Thrasher Collins’s website here.

The Overpopulation Myth – Article by Arin Vahanian

The Overpopulation Myth – Article by Arin Vahanian

Arin Vahanian


Of all the objections to life extension, one of the most pernicious is that there are too many people on Earth. Indeed, this objection in particular is rather harmful not just because it appears to advocate for suffering and death, but also because it appears to be a valid objection on a surface level.

Visions of mass starvation, billions of people living in deplorable conditions, and wars over resources, help fuel the popularity of this objection. However fascinating these sorts of overly dramatic, sensational Hollywood scenarios may seem to some people, believing in the inevitability of these scenarios would be ignoring the countless ways that science and technology have allowed us, time and again, to exceed our limitations, improve health outcomes, and create a better environment for humanity to thrive in.

There are many reasons why these dreadful scenarios continue to exist in peoples’ minds. One of the reasons why doomsday thinking has managed to remain a part of our zeitgeist is because the entertainment industry is addicted to it, constantly proliferating nightmarish scenarios of technology being a destructive force hell-bent on the devastation of humanity and the world. A less obvious reason is also because some well-meaning influential people have been fabulously wrong and have continued to double-down on being wrong over the years.

Biologist Paul Ehrlich famously said in 1968 that “The battle to feed all of humanity is over. In the 1970s hundreds of millions of people will starve to death in spite of any crash programs embarked upon now. At this late date nothing can prevent a substantial increase in the world death rate.”

Looking at this statement more than 50 years later, Paul Ehrlich wasn’t just wrong, he was completely wrong. None of his Malthusian predictions even came close to being true. I suppose that supporters of this sort of doomsday thinking will say in response that even though Ehrlich has been wrong for decades, he will one day be right. Even if a broken clock is right twice a day, we shouldn’t base the future of humanity on such faulty thinking. While it is possible for these horrific scenarios to come true, it does not mean that these scenarios are destiny. Humanity has weathered challenges and difficulties en route to coming up with amazing technological and medical innovations that have improved the quality of life for billions of people. And while challenges such as climate change should be taken very seriously, the fact that these challenges exist does not mean that humanity is doomed. It simply means that we need to make adjustments and to utilize science and technology to their fullest in order to resolve these threats.

Further, rather than extrapolate wildly and bring forth doomsday scenarios, we should bring forth data and facts to support our arguments. As I mentioned in a previous article, according to The World Bank and the International Institute for Applied Systems Analysis, the worldwide population growth rate is slowing down and is projected to eventually stabilize and begin falling. Nowhere is this more apparent than in countries such as Germany, Italy, Spain, China, Russia, and even the United States, where birth rates are below the 2.1 live births per woman required to just maintain population equilibrium. Additionally, even countries such as India, which used to have a very high birth rate, have seen huge declines in birth rates in recent years. Finally, according to a study published in the Lancet, the global population is expected to peak at 9.73 billion in 2064, before dropping to 8.79 billion in 2100. As a result, more than 23 countries are likely to see their populations halve by the end of this century. This includes countries such as Spain, Italy, Ukraine, and China.

Even if the above trends were somehow reversed, and human beings suddenly began reproducing more, we would be able to accommodate the increased population through solutions such as seasteading, vertical farming, 3D printing, and nanotechnology. Indeed, these technologies, and more, are among the many that would allow us to overcome limitations and alleviate potential threats resulting from an increased population. And I have not even begun speaking about space exploration.

The simple fact is that there is no fixed number of people who should be living on Earth at any given moment. In fact, we should rightfully be laughed out of the room if we asked the question, “What should the world’s population be?” We may as well ask how long a piece of string is. How many people is too many people? Further, how does one decide how many people is too many? Do you see how absurd this sort of thinking is? Even if we were to run detailed calculations on how many people the Earth could accommodate at any given point in time, what is true right now may not be true later, as planet Earth is dynamic, human beings are dynamic, and the forces of physics are dynamic. More importantly, we would be ignoring the awesome power of technology to allow us to do more, with less.

Therefore, let us move away from the pessimism, the doomsday scenarios, and the lack of vision, and move toward data, facts, science, and technological innovations that have allowed us, and will continue to allow us, to accommodate the needs of humanity. This does not mean that we should ignore challenges and perils and hope that everything will work out in the end. It does mean, however, that we should recognize the threats humanity is facing, and then take swift, concerted action toward eliminating those threats by using advancements in science, technology, and modern medicine.

But to go back to the topic, and frame the argument in a simpler way, one might want to ask proponents of the overpopulation myth whether they would have wanted their own parents to hold the same views about there being too many people on Earth. Of course, such critics of life extension would never want this to be the case, because it would mean that they themselves would not exist.

I would urge those who are critical of life extension to refrain from trying to decide how many people should be living on Earth. Indeed, rather than playing judge, jury, and executioner, I would recommend them to take a look in the mirror and appreciate the tremendous gift they were given – the gift of life. Had their parents held the faulty belief that there are too many people on Earth, these critics wouldn’t be able to offer their criticisms now. I am not suggesting that people should not offer valid criticisms of life extension. Nor am I suggesting that we gloss over the present and future challenges the Earth is facing. I am suggesting, however, that critics provide data, facts, and valid arguments to support their conclusions, rather than paint doomsday scenarios and claim that there are “too many people already.”  Indeed, the next time you hold a loved one in your arms, think about how you would feel if this person had never been born, or if this person was mercilessly ripped away from you.

So far, the likes of Thomas Malthus and Paul Ehrlich have been completely wrong with their predictions, though it is possible for them and others like them, to be right someday. However, we should not take pleasure in being right, we should take pleasure in being better people. Being right is not what is important – being able to actualize oneself, improve the human condition, and make the world a better place to live, is what is important. And we cannot do that if we extrapolate wildly, spread fear, and insist that humanity is doomed. The truth is that humanity’s future hasn’t even been written yet. But when we do write it, we should do so utilizing the best that science and technology have to offer, in order to improve the human condition.  Overpopulation, calamity, and starvation are not destiny – but human improvement is, and has been, since the dawn of time.

Arin Vahanian is the Vice-Chairman of the U.S. Transhumanist Party. 

Judge, Jury and Executioner Syndrome – Article by Arin Vahanian

Judge, Jury and Executioner Syndrome – Article by Arin Vahanian

Arin Vahanian


The topic of life extension seems to bring forth strong emotions from people. While living longer and healthier is a goal that nearly all people say they have, there are critics of life extension who have become quite vociferous in their opposition to extending the human lifespan.  The truth is, living a longer and healthier life shouldn’t be controversial at all. After all, it is what we humans have been trying to do since day one.

However, when the topic turns to living a healthy life indefinitely, critics seem to come out of the woodwork, citing various reasons why humans should not live radically longer. While each of the major objections to life extension deserves its own space (and its own rebuttal), one objection, in particular, is rankling in its lack of substance – that human beings already live long enough.

As ridiculous as this objection is, we need to address it, not only because of the amount of damage it does to humanity by limiting life-extension research, but also because it causes unnecessary pain and suffering. People who present this objection have what I like to call “Judge, Jury, and Executioner Syndrome.”

I can’t imagine that people in the 14th century suffering and then dying from the Bubonic Plague at age 20 or 30 would have considered their life to have been “long enough.” In the same way, nor could I imagine that someone would actually find declining and then dying from an aging-related disease such as dementia at age 75 to be desirable.

But how long is long enough? Is it 40 years, like it used to be in 19th-century England? Or is it 82 years, as it is in modern-day Japan? Or is it 100 years?

It is difficult to answer this question, because there is no correct answer to the question.

However, rather than going down a rabbit hole, the best way to answer such critics is to ask them why they get to decide how long people should live. Of course, they have no right whatsoever to decide how long the human lifespan should be. This should end the conversation right then and there, but sadly, in some cases, it does not.

To go further, one might want to ask these critics whether they believe their parents or grandparents, if they are still alive, have lived too many years and whether they would want them to die quickly because they have already lived “long enough.” Or, even better, we should ask critics of life extension how many years they think their children should live (if they have children). Of course, no one, other than a psychopath, would wish such suffering and death upon their loved ones.

Therefore, it appears that people who oppose life extension on the basis that humans already live long enough, tend to only hold this view toward other people, and not themselves or their loved ones. This seems to me to be horribly cruel, not to mention illogical. However, we should not consider those who claim they are satisfied with the 82-year lifespan for themselves, as being nobler or more altruistic than other people. After all, they are still trying to play judge, jury, and executioner!

The argument that human beings already live long enough attacks the very core of what it means to be human. Human beings are designed to want to survive, and to continue living. Otherwise, we would have stopped trying to live longer a long time ago, and as a consequence, we would have stopped trying to find cures for diseases such as cancer, heart disease, or diabetes. The very fact that we are so dedicated to finding cures for conditions that have ravaged humanity is proof that we are dedicated to living longer and healthier. There is no rule that says that human beings can only live until 100 years old, or that they are not allowed to try to live longer.

Of course, just as no one may decide how long the human lifespan should be, neither should we force those who do not want to live longer and healthier, to live longer and healthier. This is a personal choice that everyone must make for themselves. But opponents of life extension do not have the right, nor do they have the ability, fortunately, to decide how long the human lifespan should be.

Even if there is some unalterable limit to how long a human lifespan can be, wouldn’t it be better to come to this conclusion and obtain closure after conducting medical and scientific research, rather than hastily quitting, and in the process, damning all of humanity to pain, suffering, and death, solely to satisfy a falsely held belief that humans already live long enough?

I understand that no matter what I may be arguing in this article, there will always be people who do not want to live much longer and healthier than they do now, for whatever reason. While I respect their decision to not want to extend their own life, I also ask them to respect my wishes to live longer and healthier. Surely this seems like a fair position to take.

There is absolutely no reason at all to apologize for wanting to live a healthy life indefinitely. No one should be asking, “Why do you want to live longer?” Rather, we should be asking, “How can we live longer and healthier?” This sort of inclusive, optimistic, and honest approach will go a long way toward removing some of the obstacles to life extension, thus putting humanity just a bit closer to attaining what it has been seeking since the beginning of time – to live a longer, healthier life.

Arin Vahanian is the Vice-Chairman of the U.S. Transhumanist Party. 

2021 New Year’s Message by Victor Bjoerk

2021 New Year’s Message by Victor Bjoerk

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Victor Bjoerk


2021 has arrived, and it’s time for my yearly New Year’s message!

Since we all know how the world has been affected this year, there’s no point in mentioning the virus, but quite a few things happened for me.

At the beginning of this year and spring I was living in San Francisco and working on aging at BioAge. However, BioAge had to temporarily shut down because of COVID, but this wasn’t a big deal for me since I was able to transfer to Ichor Therapeutics in Syracuse, New York, which remained operational. So I got to work at two awesome leading biotech companies in the Longevity field, where I gained a lot of specific know-how which I am very grateful for!

I returned to Europe a few weeks ago, and shortly I’ll have some more exciting things to announce that I will be working on!

So yes, a lot of lemons were handed out this year worldwide, but I felt I did a decent job at making lemonade out of them. I’m a very positive person with a grand vision of wiping out all age-related disease within the next few decades, so that everybody can live as long as they want in a 25-year old body.

Some do not have that approach, they think “Longevity” means some slight health improvement by diet/exercise. Others study some aspect of aging because they want a PhD and some academic credentials (using aging as an excuse to refer to for that); however, this causes a generalized lack of a big-picture perspective for what’s going to work.

That is not me. I robustly and consistently keep up the interest until the mission is fully accomplished. In my personal roadmap I’ve developed for impacting aging, I emphasize the transdisciplinary scientific fields that are going to produce good outcomes (that may be hidden as, e.g.,“proteomics” rather than explicitly stated as “anti-aging”).

I also put an equal weight on the “business aspect” here, since your impact won’t be that big without the correct biotech business know-how, especially as AI and robotics wipe out the lab workers. Drug development and clinical trials are complex fields with 15-20 years from initial discovery to approved product. In addition, raising capital and advocacy to the public are as important as knowing the basic biology itself.

A lot of things in history have also been grotesquely mismanaged and squandered because of predictable human error, not because of the intrinsic difficulty of the science itself. There are a lot of golden nuggets laying around the labs in the world right now, and lots of resources and techniques are at our fingertips, but how will they be combined and implemented into an individual in order to cure them from aging? And how will this cocktail of interventions that forms the ultimate cure of aging be implemented across the world just like the efforts currently underway with the COVID vaccine?

A lot of setbacks are reversible and temporary, such as a lack of money and success or whatever people feel this year has caused them; aging is profoundly more serious.

During the year I read, as usual, many hundreds of scientific papers to keep up with the aging field, and also I have several publications I’ve produced, coming out now during 2021 (unfortunately peer-review takes time). I participated in many aging conferences, including one in Curacao, which meant a week of swimming in the tropics (how enjoyable!).

So yes, I felt I did many things well despite the challenges. Of course, things could always have been done better in retrospect, but that’s what one always says.

My New Year’s celebration this year isn’t very special because of all restrictions, but I wish you all a happy new year!

I have some typical New Year’s resolutions like getting fitter (but not motivating with all gyms and pools being closed, so some coaching is required), and of course continuing with the aging mission. So I’ll leave the question now to the reader: What have you done this year, and what good do you feel you can do for next year?

Victor Bjoerk has worked for the Gerontology Research Group, the Longevity Reporter, the Fraunhofer-Institut für Zelltherapie und Immunologie, BioAge, and Ichor Therapeutics. He has promoted awareness throughout Europe of emerging biomedical research and the efforts to reverse biological aging. In his honor the U.S. Transhumanist Party organized the Victor Run 2020 Virtual Race on June 5-7, 2020. 

Why I Hope to Be Alive at 75 – Article by Steve Hill

Why I Hope to Be Alive at 75 – Article by Steve Hill

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Steve Hill


Editor’s Note: In this article, originally published on November 13, 2020, by our allies at the Life Extension Advocacy Foundation (LEAF), Steve Hill explains why the attitude of Joe Biden’s new advisor on COVID-19 strategy, Ezekiel Emanuel, is supremely counterproductive. Emanuel infamously wrote in 2014 that he hopes to die at age 75. Given that COVID-19 is a disease whose toll is greatly amplified by biological aging, Emanuel’s statements render him uniquely ill-suited  to remedy the ravages of the ongoing pandemic. Moreover, his pessimism toward what life is like at age 75 is no longer justified, in light of emerging medical advances that could enable rejuvenation and biological youthfulness for those who are in late middle age today. Perhaps, if he sees these advances become a reality in the not-too-distant future, Emanuel might change his mind regarding the desirability of longer lifespans.

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, November 17, 2020


2020 has been a strange year for a variety of reasons, but the societal changes that the COVID-19 pandemic has created are probably the strangest. However, it is perhaps even stranger that Dr. Ezekiel Emanuel has been appointed to advise Joe Biden on COVID strategy.

Emanuel is best known for writing a controversial article in the October 2014 edition of The Atlantic, headlined “Why I Hope to Die at 75”, in which he strongly rejects the desire to live beyond the age of 75 and expresses his opinion that continuing to live after such an age is meaningless.

Living too long is also a loss. It renders many of us, if not disabled, then faltering and declining, a state that may not be worse than death but is nonetheless deprived.

Needless to say, I strongly disagree with this baffling point of view and am somewhat concerned that someone who thinks this way of his own life, and presumably the lives of others, may be appointed to a position of influence for a disease whose primary risk group is the elderly. This seems almost as foolhardy as spending a vacation weekend in a caravan with Hannibal Lecter.

Emanuel listed quite a few methods by which people extend their lives and stated that they were a “valiant effort to cheat death and prolong life as long as possible,” but his response to them was, “I reject this aspiration. I think this manic desperation to endlessly extend life is misguided and potentially destructive.”

Age is the #1 risk factor for COVID

The scientific evidence clearly shows that the primary risk factor for contracting and dying from COVID-19 is age, with people over the age of 75 at particularly high risk. This is due to the decline of the immune system, which becomes increasingly weak and dysfunctional with age in a process known as immunosenescence.

Globally, the strategy has been to try to shield these vulnerable people as best as possible due to their weakened immune systems and limit their exposure to the disease while vaccines are developed.

Needless to say, I find Biden’s nomination of him to address a disease that mostly affects seniors ironic in itself, given that he thinks the lives of most people beyond 75 are pointless and that they don’t live meaningful lives and would be better off embracing death rather than desperately trying to extend them. Therefore, I hope for the sake of the older people in our society that he has rethought his priorities.

Why I hope to be alive at 75

Predictably, there is already a storm raging on social media around his appointment, so there is no purpose to adding more fuel to that fire. Instead, I am going to talk about why the future of aging could be very different to the grim picture that Emanuel paints.

At age 63, he is getting closer to the age at which he thinks life is pointless, and I believe that a large reason why he is so pessimistic about life beyond 75, whether he realizes it or not, is based on the current state of medicine. This line of reasoning does not take into account how medicine, and in particular how we treat aging could change in the next decade or two.

Current medicine does a great job at keeping people alive for longer, but they often have to live with one or more chronic diseases. Given that, I am not surprised that Emanuel is not enamored with living a long life, especially as that could entail being disabled, bed-bound, or otherwise suffering a poor quality of life as the result of debilitating age-related diseases.

Thankfully, the world healthcare strategy is slowly starting to shift to one of prevention over cure, but right now, the typical approach is to play whack-a-mole with diseases. As one pops up, it is treated, then the next, and the next, and so on. This strategy works great for infectious diseases, but it is an exercise in futility and diminishing returns when applied to the chronic diseases of aging.

However, things could be different in the not so distant future, and being 75 could see the majority of people far more fit, healthy, and vibrant than ever before in human history thanks to advances in aging research. Therapies that directly target aging could potentially make people biologically younger (in particular their immune systems) and much more able to withstand COVID-19 and other diseases.

As explained on LEAF’s What is Aging? page, aging consists of multiple processes (“hallmarks”) that gradually cause damage to organs and tissues and lead to age-related diseases. Rejuvenation biotechnology is advanced medical technology that directly addresses any of the various aging processes in order to restore tissue and organ function to a more youthful state, thereby ameliorating, delaying, or preventing age-related diseases. Let’s take a brief look at some of the promising near-future research that could bear fruit by the time Emanuel reaches 75 and perhaps change his mind.

Rejuvenating the immune system

The decline of the immune system is a key reason why the elderly are most susceptible to infectious diseases such as COVID, and there has been considerable interest in the rejuvenation of the immune system in recent years.

Dr. Greg Fahy from intervene immune has had some early success with thymus rejuvenation in a small human pilot study and demonstrated that it is possible to cause the thymus, which shrinks and loses its capacity to produce immune T cells during aging, to regrow and resume production of those cells. Dr. Fahy is now moving forward into a larger-scale study, and if the results continue to be positive, it is not hard to imagine that thymus regrowth could become a staple of helping the elderly stay healthy.

Another example of immune rejuvenation is currently being developed by Samumed, a biotechnology company that is developing drugs that target the Wnt pathway to restore it to youthful function. The Wnt pathway is a key pathway that regulates the function of our stem cells and ensures that they supply our tissues and organs with new cells to replace losses from injury, disease, and wear and tear.

If successful, this approach would allow the body to resume efficient repair of tissues, and it would replenish aged and failing tissues and organs with fresh, healthy cells supplied by the rejuvenated stem cells.

Therapeutic plasma exchange

Researchers Irina and Mike Conboy at UC Berkeley have been researching blood factors and their role in aging for over two decades. During that time, they have identified a number of factors present in aged blood that appear to regulate aging.

These factors are also present in younger people, but in typically far lower amounts, and tend to serve useful functions. However, during aging, the levels of these proteins become deregulated, and they often rise to detrimental levels and cause damage to the body, which typically involves preventing stem cells from working and tissue from regenerating.

Decades’ worth of research from the Conboy lab has shown that, in mice at least, it is possible to filter out these harmful pro-aging blood factors and bring them back down to a level similar to younger animals. When this happens, the result is rejuvenation of tissues and the reversal of some of the aspects of aging, making the mice more youthful.

This approach uses an already approved technique known as therapeutic plasma exchange to filter and calibrate these key factors and could be readily modified for human use. Should the results seen in animals translate to humans using this approach, it would have a profound effect on our health as we age and potentially delay, prevent, or even reverse some age-related diseases.

Conclusion

These are only some of the examples of why healthy life expectancy could rise significantly in the near future, and there are plenty of reasons to remain future positive. This is the future direction of medicine and healthcare that we support at Lifespan.io, a world where being 75 does not mean you are thrown on the scrap heap and where people like Emanuel will no longer feel that life has no meaning. I am confident that in such a world, being 75 would not be the burden he thinks it will be, and this is why I hope to be alive at 75.

Steve Hill serves on the Life Extension Advocacy Foundation (LEAF) Board of Directors and is the Editor-in-Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 500 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, along with attending various medical industry conferences. His work has been featured in H+ Magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep Me Prime, and New Economy Magazine. Steve has a background in project management and administration, which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.

Petition by Biogerontology Global to Declare Aging the Top Global Risk

Petition by Biogerontology Global to Declare Aging the Top Global Risk

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Biogerontology Global


Editor’s Note: The U.S. Transhumanist Party encourages its members to support the petition created by our allies at Biogerontology Global, which aims to declare aging the largest global risk. The U.S. Transhumanist Party holds significant life extension as its first Core Ideal, and biological aging is the greatest barrier to significant life extension. Overcoming biological aging through the progress of science and technology is therefore the greatest moral imperative of our time.

 ~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, August 21, 2020

Sign this petition on Change.org here


TL;DR: You have a terminal disease and so does everyone you love. Human aging kills more people (100,000 per day), causes more suffering, and harms society more than anything else – by a large margin. Scientific discoveries and technological advancements are making it clearer by the day that given enough funding and effort, human aging can be cured. In other words, we should cure aging and we can cure aging. For that to happen, however, a large cultural shift must take place in favor and support of the idea – which currently faces significant opposition and neglect. The Global Risks Report is an annual publication released by the World Economic Forum that ranks global risks. It is read by a large portion of world leaders and citizens alike. If human aging were to top this list of risks or, at the very least, make the cut, it would help the world see aging as an urgent threat and potentially save the life of whomever is reading this. Sign this petition if you want to help declare aging the top global risk.

Detailed Description:

Each year, the World Economic Forum, with support from Marsh and McLennan Companies, releases a Global Risks Report. This report, as the name suggests, includes detailed analyses and rankings of the greatest threats facing the world each year. Each major threat is referred to as a risk. The two-part centerpiece of this report consists of a ranking of the top 5 risks in terms of likelihood, and another ranking of the top 5 risks in terms of impact. There are also “trends”. Per the World Economic Forum, a “trend” is defined as a long-term pattern that is currently evolving and that could contribute to amplifying global risks and/or altering the relationship between them. Simply put, trends are not seen as the major global threats, but instead as factors that may influence them. In past years “population ageing” has sometimes been recognized as a trend, but nothing more.

The purpose of this petition is to get the World Economic Forum to not only recognize human aging as a global risk but as the global risk. Human aging kills approximately 100,000 people per day. In developed countries, 90% of all deaths are at the hands of age-related disease. How could it be that the largest cause of human death (by an immense margin) is not seen as the most pressing issue in the world? Not to mention, the amount of human suffering caused by the diseases of old age is arguably unparalleled. Why is this mass suffering and death justified rather than fought?

In 2020, the top 5 global risks in terms of likelihood were all environmental. Solving aging would significantly lessen these risks. Without human aging, people would not be planning to die. They would have a stake in the long-term future of the environment. This radical sociological shift could be the push humanity needs to start consistently making environmentally beneficial decisions. Overpopulation should not be a concern, as we have more than enough land and resources to accommodate a much larger population on planet Earth. More efficient methods of resource allocation are the remedy for current problems that are often falsely attributed to a growing global population. Additionally, emerging agricultural technologies such as hydroponics, which can boost crop yields by up to 11 times, and vertical farming, which can further maximize that factor, will continue to make it even easier to feed more people.

Without human aging, we would no longer have such a substantial portion of society that is sick and unable to work or enjoy the activities that they so loved in their youth. This could work wonders for global productivity. Not to mention, people who are not gripped by old age and stay in the workforce much longer than they do now would become more experienced than the workers of today, boosting global productivity even further.

People would be happier in a world without death by aging. They would have much more time with their loved ones. They would be able to have and achieve long-term goals without the inevitability of death by aging to get in the way. They would have the time to live fuller lives. Happier societies commit less crime, so that is another societal ill that curing aging could help dismantle.

Many of humanity’s greatest threats are directly or indirectly the result of human aging. If we were to solve aging, many of the global risks mentioned in past Global Risks Reports would no longer be major issues.

We tend to think of death by aging as an inevitability of life. However, scientists in the field of biogerontology (the study of biological aging), billionaire businesspeople and philanthropists, technologists, and many other professionals/activists are working to make death by aging optional. Science and technology have already drastically improved lifespan and health in recent years by a considerable margin; however, it can do more. The molecular mechanisms by which we age (The Hallmarks of Aging) have been identified by scientists. Interventions such as senolytic drugs have already been proven to counteract some of these mechanisms. Cellular pathways have been genetically modified to extend the lifespans of model organisms to the equivalent of 500 human years. Google has launched and given over a billion dollars to its subsidiary, Calico, which researches aging. Many other companies and nonprofits, including the SENS Research Foundation and Methuselah Foundation, are tackling aging or its subparts. Growing support and advancement makes it clear that humanity will cure aging eventually, but so many people die each day of aging that eventually is not good enough. We must cure aging as soon as possible to save ourselves and those we love.

This petition recognizes that a cultural shift at every level of society is necessary for leaders and organizations in this space to garner enough support to cure human aging within our lifetimes. If this petition were to succeed, that cultural shift would come easier. Between the large portions of world leaders and citizens that read and respect the Global Risks Report, many more people would recognize aging as a problem they can solve and should solve if the report were to name aging as a global risk. This would lead to increased funding to cure aging, more talented scientists and technologists joining the space, and a greater opportunity to cure aging within our lifetimes!

Aging is objectively the largest global risk to humanity in terms of likelihood and impact. We ask that the World Economic Forum recognize this and act accordingly.

Sign this petition to help forge a better existence for yourself, your loved ones, and all of humanity.

Learn more at @biogerontology on Instagram.

Proposal for Argentina to Declare a Mandate for Longer Life Spans and the Reasonable Treatment of Aging as an Ailment

Proposal for Argentina to Declare a Mandate for Longer Life Spans and the Reasonable Treatment of Aging as an Ailment

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A National Techno-Progressive Policy Proposal for Argentina to Declare a Mandate for Longer Life Spans and the Reasonable Treatment of Aging as an Ailment

Respectfully Submitted to the Ministry of Health of Argentina

The United States Transhumanist Party (USTP) has been associated with public health initiatives and emerging-technology policymaking since 2014; we have many State-level parties, associates, partner organizations, and foreign ambassadors around the world. At this time in history and out of a sense of duty to the future, we are compelled to submit this public-policy proposal designed to not only enhance the public health and prosperity of Argentina, but also to make it a model for techno-optimistic progress around the world.

As such the USTP humbly submits this proposal to the Minister of Health of Argentina to work together to assure the prevention of future pandemics and jointly tackle broader health concerns with life extension as its goal. It is our intention with this proposal to encourage the Minister of Health of Argentina to declare a mandate for longer life spans and the reasonable treatment of aging as an ailment.

Purpose: This declaration promises to generate accolades from the global community for the Minister of Health particularly and Argentina generally as forward-thinking and serious leaders in the future of human welfare and scientific development. It will ensure that Argentina will be recognized as the world’s first techno-optimistic, progressive constitutional democracy. 

Benefit to the Argentine Government from accepting this proposal: The USTP holds that this bold declaration will further enhance Argentina’s status in the Western Hemisphere. Aside from the importance to humanity that this declaration provides in the name of Science, it will act to promote tourism and investment, and to encourage more civic undertakings from an increased interest in Argentine affairs.  

The USTP will be approaching the governments of San Marino and Liechtenstein to persuade them to make similar declarations in the wake of this worldwide pandemic. However, we are reaching out to the home country of Salvador Mazza to champion this cause to inspire other nations to follow your lead and provide citizens with a new level of public health services and longer lives. 

We look forward to your response and the potential of working with Minister Ginés González García and his capable team.

Signed, 

Gennady Stolyarov II, FSA, ACAS, MAAA, CPCU, ARe, ARC, API, AIS, AIE, AIAF, Chairman, United States Transhumanist Party

J. Ben Zion, Vice-Chairman and 2020 U.S. Presidential Candidate, United States Transhumanist Party

Charlie Kam, Director of Longevity Outreach and 2020 U.S. Vice-Presidential Candidate, United States Transhumanist Party

Tom Ross, Director of Media Production, United States Transhumanist Party

Pavel Ilin, Secretary, United States Transhumanist Party

Daniel C. Elton, Ph.D., Director of Scholarship, United States Transhumanist Party

David Shumaker, Director of Applied Innovation, United States Transhumanist Party

Arin Vahanian, Director of Marketing, United States Transhumanist Party

B.J. Murphy, Director of Social Media, United States Transhumanist Party

Dinorah Delfin, Director of Admissions and Public Relations, United States Transhumanist Party

John J. Kerecz, Campaign Director, United States Transhumanist Party

Brent Logan Reitze, Director of Publication, United States Transhumanist Party

Dr. Christian Meniw, United States Transhumanist Party Foreign Ambassador in Argentina

Henry Hoyos, United States Transhumanist Party Foreign Ambassador in Bolivia

Keoma Ferreira Antonio, MSc, Ph.D. Student, Philosopher, United States Transhumanist Party Foreign Ambassador in Brazil

Bill Andrews, Ph.D., President and CEO, Sierra Sciences, Biotechnology Advisor to the United States Transhumanist Party

José Luis Cordeiro, MBA, Ph.D., Technology Advisor to the United States Transhumanist Party, United States Transhumanist Party Foreign Ambassador in Spain

Alexey Kadet, United States Transhumanist Party Foreign Ambassador in Latvia

Ojochogwu Abdul, United States Transhumanist Party Foreign Ambassador in Nigeria

Peter Wang, United States Transhumanist Party Foreign Ambassador in China

Paul A. Spiegel, J.D., Legal Advisor to the United States Transhumanist Party

Micah Redding, Advisor on Religion to the United States Transhumanist Party

Elizabeth Parrish, CEO, BioViva, and Advocacy Advisor to the United States Transhumanist Party

Newton Lee, Chairman, California Transhumanist Party, and Education and Media Advisor to the United States Transhumanist Party

Rich Lee, Biohacking Advisor to the United States Transhumanist Party

Daniel Yeluashvili, Climate Advisor to the Ben Zion 2020 Presidential Campaign

Michael Murray, Director of Environmental Science, California Transhumanist Party

Dr. Efi Roboti, Obstetrician-Gynecologist Surgeon and Member, United States Transhumanist Party

Romina Florencia Cabrera, UNLP-UBA-UM-USAL,  Abogada,  Investigadora-Docente-Asesora-Consultora, Argentina, Chile e Iberoamérica

Raiany Romanni, Harvard Medical School, Member, United States Transhumanist Party

Natasha Vita-More, Ph.D., Executive Director, Humanity+

Maria Entraigues Abramson, Global Outreach Coordinator, SENS Research Foundation

David Kekich, President and CEO, Maximum Life Foundation

Ben Goertzel, Chief Scientist and Chairman, Novamente, LLC, Chairman, OpenCog Foundation, Chair, Humanity+

Sergio Martínez de Lahidalga Tarrero, President, Alianza Futurista

Alex M. Vikoulov, Founder, CEO, and Editor-in-Chief, Ecstadelic Media Group

Michael Hope, Biogerontologist

Matthew Schenk, Geroscientist and Member, United States Transhumanist Party

John Marlowe, Advocate for Rare Disease Research, Regenerative Medicine, and Rejuvenation Biotechnology

Elena Rusyn, Founder, AmpliCell Medical, and Member, United States Transhumanist Party

Joe Bardin, Essayist, Playwright, Communication Strategist, RAADfest Communications Director, and Member, United States Transhumanist Party

Dr. Ilia Stambler, Chairman, Israeli Longevity Alliance

Brent NallyEntrepreneur, Interviewer, Longevity and Health Enthusiast, and Member, United States Transhumanist Party

Didier Coeurnelle, Co-Chair of Heales.org (Healthy Life Extension Society), Vice-Chair of the Association Française Transhumaniste Technoprog, and Member, United States Transhumanist Party

Kelvin Ogba DafiaghorCEO, Ogba Educational Clinic

Osinakachi Akuma Kalu, Founder, Transdisciplinary Agora for Future Discussions, and Member, United States Transhumanist Party

Negash Alamin, Head of CAMIDRCS Nature Media and Member, United States Transhumanist Party

Orji Ama Chinedu, Attorney in Lagos, Nigeria

Victor Bjoerk, Heales.org (Healthy Life Extension Society) and Gerontology Research Group

Martin O’Dea, Partner, Longevity Accelerator, and Member, United States Transhumanist Party

Kevin Perrott, Entrepreneur and Co-Founder, Methuselah Foundation and SENS Research Foundation

Yifei Sun, President and CEO, International Institute for Innovation and Development

Brandon Michael King, Co-Founder and Organizer, Longevity Party United States, Member, United States Transhumanist Party

Eric Schulke, Activist with the Movement for Indefinite Life Extension, Member, United States Transhumanist Party

Maitreya One, Transhumanist Hip-Hop Artist and Member, United States Transhumanist Party

Jennifer Huse, Member, United States Transhumanist Party

Tom Hite, Member, United States Transhumanist Party

Kimberly Forsythe, Member, United States Transhumanist Party

James Kohagen, Member, United States Transhumanist Party

Daud Sheikh, Member, United States Transhumanist Party

Amanda Stoel, Member, United States Transhumanist Party

Montie Adkins, Member, United States Transhumanist Party

Mike DiVerde, Member, United States Transhumanist Party

Chet Fontenot, Member, United States Transhumanist Party

Christopher Browning, Member, United States Transhumanist Party

Nick Dunn, Member, United States Transhumanist Party

Art Ramon, Member, United States Transhumanist Party

Renato Galindo Caceres, Member, United States Transhumanist Party

Marcus Dreitzler, Member, United States Transhumanist Party

Alexander Taylor Clayton, Member, United States Transhumanist Party

Jason Geringer, Member, United States Transhumanist Party

Dawn Gilroy, Member, United States Transhumanist Party

Adam Perrotta, Member, United States Transhumanist Party

AtmaJodha Singh, Member, United States Transhumanist Party

Andrew Eckley, Member, United States Transhumanist Party

Allen Crowley, USA LTC (Retired), Member, United States Transhumanist Party

Erin Reeve, Member, United States Transhumanist Party

William G. Echevarria Fernandez, Member, United States Transhumanist Party

Brent Ellman, Member, United States Transhumanist Party

Thomas James O’Carroll, Member, United States Transhumanist Party

Luis J. Arroyo, Member, United States Transhumanist Party

Simon Stiel, Member, United States Transhumanist Party

Alexandria Black, Member, United States Transhumanist Party

Michał Szymacha, Member, United States Transhumanist Party

Corbin Stefan, Dosimetrist, Member, United States Transhumanist Party

Anthony Bruce, Member, United States Transhumanist Party

Rima Martin, Member, United States Transhumanist Party

Jiri Jelinek, Member, United States Transhumanist Party

Quinn Cummins-Lune, Member, United States Transhumanist Party, Member, The Futurist Foundation

Mike Cockrill, Member, United States Transhumanist Party

Zach Richardson, Member, United States Transhumanist Party

Chris McAulay, Member, United States Transhumanist Party

Justin Fontenot, Member, United States Transhumanist Party

Valerie Handlers, Member, United States Transhumanist Party

Jessica Gifford, Member, United States Transhumanist Party

Joshua Gifford, Member, United States Transhumanist Party

Zipporah Naomi Pecot, Member, United States Transhumanist Party

Hugh Ching, BS, MS, ScD

C. JoyBell C., Science Writer

Michael Beight

John Greenwood

Azure Michalak

Ryan Moisik

Kari Alatalo

Billy McCarthy

Fabian Pudlo

Walter H. Crompton

Adam Moser

Steven Mejia

Jeffrey Mercer

Marius Fusariu

Patricia A. Ray

Brett Mvrk

Kris McHale

Audrey Joyce

Mario Thibert

NOTE TO READERS: If you would like to digitally sign this proposal, please indicate this in the comments, or send an e-mail to USTP Chairman Stolyarov here. Please note that, if this is your first instance commenting on this website, your comment will go through moderation, but we will approve it in the near future and add your signature to the list above.

Results of Platform Vote #8 and Adopted Sections on COVID-19 Responses

Results of Platform Vote #8 and Adopted Sections on COVID-19 Responses

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Gennady Stolyarov II


The U.S. Transhumanist Party conducted its fourteenth vote of the members and the eighth vote on its platform planks between March 25 and March 28, 2020. Official ballot options can be found here.

Detailed results of the voting have been tabulated here. In two instances, where no majority was reached in the first round of voting, options were selected based on the ranked-preference method with instant runoffs.

As a result, the following new or amended sections of Article VI of the U.S. Transhumanist Party Constitution were adopted.

These sections are also compiled in a special area of the USTP Platform pertaining to COVID-19 responses.

Watch U.S. Transhumanist Party Chairman Gennady Stolyarov II and Vice-Chairman J. Ben Zion discuss the results of the vote on the Debt Nation show with Steele Archer here.

It is time to reorient the economy and society toward pursuit of public health and longevity. We are already effectively on a war footing, so let us take the war on the offensive against death and disease. Either the world will succumb to this pandemic, or we can turn around the situation to step fully into the Transhuman Era. The U.S. Transhumanist Party is proud to put forward these proactive ideas for winning this war.


Section XCVIII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party advocates for rapid construction of hospitals to begin immediately throughout the United States, with one new hospital constructed for every 50,000 in population. Rapid construction techniques, pioneered in China during the COVID-19 outbreak, should be utilized in the United States to build new hospitals in 10 days or less. However, unlike the rapidly constructed Chinese hospitals, the new hospitals constructed in the United States should become permanent.

The United States Transhumanist Party advocates for immediately waiving any zoning restrictions and building codes that would in any manner delay, prevent, or interfere with such rapid construction of hospitals.

Architectural designs for the rapidly constructed hospitals should:
(i) Be prepared and updated as new and superior building techniques and technologies are developed;
(ii) Include plans for multi-purpose facilities for patient care and research, or protocols for how to flexibly convert patient-care facilities into research facilities and vice versa as the need arises; and
(iii) Include separate entrances and generally separate facilities for patients infected with COVID-19 and all other patients, so as to effectively prevent the spread of COVID-19 to hospital visitors who do not have it.

Once the new permanent hospitals have been established, the United States Transhumanist Party supports a mandate for these hospitals to remain open to patients and fully staffed in perpetuity, regardless of profitability or patient influx. After the COVID-19 outbreak subsides, the new hospitals would provide major additional capacity to respond to epidemics and also conduct research on fighting diseases, including biological aging.

After the construction of the new hospitals, the United States Transhumanist Party supports an indefinite obligation for the U.S. federal government to indefinitely remedy any shortfall in funds to a new hospital in order to prevent its closure. Any hospital receiving such federal assistance shall be limited in the charges it may impose for its services to 110% of the cost of providing such services.

The United States Transhumanist Party supports the construction and retrofit of buildings adjacent to the hospitals, which could be used for any of a variety of unrelated purposes in normal times, but which could rapidly be converted into hospital space in times of pandemics by means of features that enable easy customizability, modularity, and accessibility to patients and medical personnel.

The United States Transhumanist Party views a vast and permanent expansion of hospital capacity as a necessary component of a permanent reorientation of the economy and broader society toward the pursuit of improved public health and widespread life extension. The COVID-19 pandemic has illustrated the extent of the disruption and suffering that can occur if these goals are not made explicit and not supported by guaranteed allocations of resources immune from macroeconomic vicissitudes.

Section XCIX [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports for an immediate, universal, unconditional basic income of at least $1000 per month to be provided to every United States citizen for the duration of the COVID-19 outbreak and its immediate aftermath, without regard for individuals’ means or other sources of income. The priority for this program should be to prevent massive and irreparable economic disruptions to the lives of Americans in the wake of the COVID-19 epidemic.

Section C [Adopted by a vote of the members during March 25-28, 2020]: In recognition of the severe, sudden, and often all-encompassing adverse economic impacts resulting from governmental measures taken to limit the spread of the COVID-19 epidemic, and in the conviction that the principles of justice require that governmental policies – even if necessary, unavoidable, or beneficial on balance – not damage innocent parties without just compensation, the United States Transhumanist Party advocates for the United States federal government to take the following actions:

(i) Fully compensate all adversely affected businesses for all loss of income and property resulting from governmental measures taken to contain the COVID-19 epidemic. The United States Transhumanist Party holds that any businesses receiving such compensation should be
    (a) Prohibited from engaging in buybacks of their own stocks; and
    (b) Prohibited from increasing executive pay if that pay currently exceeds $500,000 per executive per year.

(ii) Fully compensate all individuals who lost their jobs or self-employment income, or suffered a reduction in working hours, as a result of governmental measures taken to contain the COVID-19 epidemic. This compensation shall be in addition to, and not a substitute for, the universal basic income received by those individuals.

Section CI [Adopted by a vote of the members during March 25-28, 2020]: In recognition that the recent screening bottlenecks at United States airports create situations of unacceptable crowding which further contribute to the spread of the COVID-19 epidemic, the United States Transhumanist Party advocates for immediate admittance through security checkpoints of the vast majority travelers currently waiting at airports in the United States. Such travelers may be required to subsequently undergo health screenings at other facilities within the United States within a certain period of time, as long as such screenings do not involuntarily place the individuals being screened in close physical proximity to one another.

Section CII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the recall of all United States military personnel from overseas stations as soon as possible and their deployment for the purpose of rapid hospital construction in the United States, as well as for providing rapid emergency aid and essential infrastructure improvements. Continued military presence abroad only unnecessarily exposes American troops to the risk of infection, while the expertise of American military personnel in crisis response is urgently needed within American borders.

Section CIII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the rapid research into effective cures and vaccines for COVID-19 and the harnessing of synergies from this research to also develop a cure for the common cold and more effective vaccination against influenza. Such research should proceed with no barriers, subject to the researchers’ expression of ethical intentions, and any regulations or processes that would delay the progress of such research should be immediately waived or repealed. In the effort to accelerate progress in this field, the United States Transhumanist Party advocates for an immediate $100 billion funding package for the rapid development of a COVID-19 vaccine, with all volunteers being accepted into human trials as soon as practicable. The United States Transhumanist Party advocates for government funding and ownership of any cure for COVID-19, to be distributed free of charge to those infected with the virus.

Section CIV [Adopted by a vote of the members during March 25-28, 2020]: Because biological aging is the number-one risk factor for mortality and severe complications from COVID-19 infections, as well as infections of virtually every sort, the United States Transhumanist Party emphasizes the importance of reversing biological aging as rapidly as possible and thereby protecting more lives from future pandemics. Accordingly, the United States Transhumanist Party advocates for a permanent, annual $100 billion funding package for anti-aging research, to be immediately distributed to leading research organizations in the field which have in the past specifically identified the defeat and reversal of biological aging as their goals.

Section CV [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party advocates for the immediate institution of a program of micropayments to everyone participating in citizen-science initiatives, such as Foldit, with the specific aim of developing cures or vaccines for COVID-19. Micropayments should be proportional to the amount of time and/or computing power spent contributing to any given initiative, with additional bounties provided for results with meaningful practical applications.

Section CVI [Adopted by a vote of the members during March 25-28, 2020]: In response to the dire shortage of ventilator components and other crucial equipment in hospitals treating COVID-19 patients, the United States Transhumanist Party advocates for the rapid 3D-printing of additional components through both private and governmental initiatives, as well as the deployment of on-site 3D-printers in every hospital and medical clinic to enable the future production of such components on demand. Immediate bounties should be offered by federal, state, and local government to individuals and businesses capable of producing such components. Policy initiatives should empower individuals and communities to explore the suitability of alternative manufacturing processes to produce needed parts and equipment to deal with the crisis.

Section CVII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party advocates for an immediate allowance for remote learning to satisfy the completion or graduation requirements of all K-12 schools and all publicly funded colleges and universities indefinitely going forward. Not only is physical proximity not necessary for effective learning in light of rapidly advancing technologies allowing immersive interaction at a distance, but the encouragement of remote learning also allows individuals more flexibility in advancing at their own pace and focusing on subjects and skill sets which result in the greatest fulfillment and most improved life prospects. The United States Transhumanist Party advocates for the maximal adoption of diverse homeschooling approaches throughout the United States, suited to the individual aptitudes, preferences, and learning styles of students.

The United States Transhumanist Party also supports refocusing the education system on producing the goods and services necessary to maintain United States independence, including vocational studies in electricity, metalwork, ceramics, auto mechanics, graphic arts, and coding in the classroom.

Section CVIII [Adopted by a vote of the members during March 25-28, 2020]: In recognition that unsanitary living conditions are a primary cause of the spread of COVID-19 and other infectious diseases, the United States Transhumanist Party supports the immediate and mandatory housing of the homeless, achieved by means of the rapid construction of tiny homes, including 3D-printed homes, without regard for building codes or zoning regulations, which must be immediately waived to allow such construction.

Every homeless individual discovered by local authorities would be required to move into a separate small home free of monetary cost and would be granted free conditional title to the home. The conditions of the title would be that the new homeowner would be obligated to perform litter-cleanup and other community-service duties for a specified time period per day under supervision, until and unless he or she is able to find different or better housing independently. The new housing communities would be subject to actively enforced covenants and restrictions prohibiting alcohol and recreational drugs. Such prohibitions will have the side benefit of transitioning the homeless toward meaningful social participation and useful work.

Section CIX [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports establishing a rapid three-month training and certification program for hundreds of thousands medical personnel specifically for responding to the COVID-19 outbreak and other pandemics. While the newly trained medical practitioners would not be full-fledged medical doctors, they would be provided with fundamental knowledge of epidemiology, first aid, sanitary practices, and patient care, including the operation of the devices used to assist severely ill patients. This would greatly supplement the available personnel to respond effectively to the COVID-19 outbreak and also anticipate future pandemics. The new COVID-19 medical responders would be compensated generously and selected from among high-performing students and other populations with demonstrated competence and aptitude for learning. For any first responders with student loans, those loans would be forgiven in exchange for a commitment to serve until the COVID-19 pandemic is eradicated. Those medical responders who remain in their positions afterward will receive continuous training on effective pandemic response so as to be in a superior position to anticipate, prevent, and mitigate future outbreaks.

Section CX [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the immediate deployment of as many COVID-19 diagnostic tests as possible to the general population, with the aim of achieving universal testing of every American, even those without symptoms, free of charge. Universal testing is necessary to understand the true prevalence of COVID-19 infections and the proportion of serious cases and fatalities relative to actual total cases, not merely reported cases. This would enable a true understanding of the extent of the epidemic’s spread as well as how the rates of serious complications and death compare to the common cold and influenza. The United States Transhumanist Party supports generous aid to both private and governmental research teams working in parallel on developing effective testing kits and approaches, particularly those which do not require large numbers of people to congregate.

The United States Transhumanist Party also advocates for COVID-19 testing kits to be developed that could result in tests being self-administered by individuals in their own homes and then mailed to laboratories for evaluation. This would minimize the physical contact of individuals being tested with medical practitioners and other patients.

Section CXI [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party advocates for the establishment of facilities, such as warehouses, where essential supplies would be temporarily stored in large quantities in case of emergencies such as COVID-19. Distributors would supply to these warehouses a large surplus of essential goods, and hospitals, medical research facilities, pharmaceutical companies, and other medical organizations would get their normal supplies, including masks, soap, hand-sanitizer, and common device components, from there in the event of any shortages. In case of an epidemic, there will be enough supplies on hand to provide such institutions for a prolonged period of time.

The essential supplies stored by such facilities would include ready-made hazmat suits that could be distributed to both medical practitioners and the population at large in the event of a highly contagious disease outbreak, along with clear and layperson-friendly instructions of how to put on and use the hazmat suits effectively.

Section CXII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party holds that, as a proactive measure, the United States should spearhead an initiative to collaborate with other wealthy nations, or by means of the World Health Organization (WHO), to set up a financial and material package of supplies and infrastructure to be deployed anywhere in the world in case a pathogen is found that needs to rapidly be contained in a foreign nation. This could be particularly important if the origin country is one that cannot itself manage to contain the outbreak due to poverty or lack of resources. This could help prevent a pathogen from ever coming to the United States.

A committee or part of an existing office should research and collaborate with other nations to learn and establish best or improved practices and update emergency plans accordingly. Likewise such collaborative efforts could establish which practices are not effective and remove those accordingly.

Section CXIII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports efforts by the federal government to begin an initiative in collaboration with businesses to create packages of emergency medical supplies, akin to a first-aid kit box, for civilians to buy for an affordable price, and offered for free to those who fall below the poverty line. Such a package could include advanced face masks, hand-sanitizer, soap, latex gloves, and other important items for effective epidemic response. The kit should come with clear instructions on how and when to use it, as well as instructions regarding self-quarantining and the express notice that the kit should not be re-sold, because the health and safety of everyone depends on the maximum number of people participating. This advance provision of response kits would have the effects of lowering the pressure on supply when there is an emergency and enabling people to be better prepared from the start, thus immediately limiting the spread of a pathogen.

Section CXIV [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the inclusion of education on epidemic crises in the curricula of schools. Science-based instruction on key attributes of epidemics and pandemics, historical instances, and effective responses could be incorporated within related courses, such as biology.

Section CXV [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the immediate and complete repeal of all “certificate of need” laws, which currently, in many jurisdictions, prohibit the construction of new hospitals or the expansion of capacity of existing hospitals, unless “need” is demonstrated using arbitrary criteria overseen by incumbents within the hospital industry. “Certificate of need” laws are entirely deleterious and have no redeeming features of any sort. They constitute pure protectionism for the incomes of incumbents, at the expense of available and affordable health care, especially in times of increased strain, such as pandemics.

Section CXVI [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the development of vaccines under conditions that do not afford patents to the developers but instead compensate the developers in the form of bounties for safe, effective vaccines and their rapid production and deployment. Patents, as grants of exclusive monopoly privilege for as long as twenty years, operate to limit the supply of a vaccine and render it artificially expensive. Bounties and other forms of compensation based on production and distribution of vaccines would be better aligned with the urgent public interest in those vaccines’ rapid availability to the general population.

Section CXVII [Adopted by a vote of the members during March 25-28, 2020]: The United States Transhumanist Party supports the deployment of robots and automated systems wherever possible to assist COVID-19 patients and individuals who are at greater risk for serious complications from COVID-19. These systems could include autonomous vehicles, food-delivery robots and drones, and production robots in as many industries as possible to reduce the human presence in factories while continuing to manufacture many goods necessary for human life and well-being.

Section CXVIII [Adopted by a vote of the members during March 25-28, 2020]: Given the extreme delays, bottlenecks, and expenses created by the mandatory approval processes on the Food and Drug Administration (FDA), the United States Transhumanist Party supports abolishing the FDA and replacing it with a Radical Life Extension Administration (RLEA), whose mandate would be to prioritize the rapid development of potential disease cures, treatments, and vaccines – including any possible cures or vaccines for COVID-19, as well as treatments to mitigate and reverse the disease of biological aging, the major risk factor for COVID-19. The RLEA would allow the marketing and collection of patient data on any potential cure, treatment, or vaccine which has passed affordable safety testing at a reasonably acceptable threshold.