Skip to content
U.S. Transhumanist Party – Official Website
  • Home
  • Posts
  • Values
  • Platform
  • Leadership
  • Advisors
  • Candidates
  • Highlights
  • FAQ
  • States & Allies
  • Free Membership
  • Facebook
  • Twitter
  • Search Icon

U.S. Transhumanist Party – Official Website

U.S. Transhumanist Party – PUTTING SCIENCE, HEALTH, & TECHNOLOGY AT THE FOREFRONT OF AMERICAN POLITICS

Benchmark Database of Lifespan-Extending Drugs Announced – Press Release by Biogerontology Research Foundation

Benchmark Database of Lifespan-Extending Drugs Announced – Press Release by Biogerontology Research Foundation

March 16, 2017 Biogerontology Research Foundation Comments 0 Comment

logo_bg


Note from the Editor:Β The following Press Release was originally published on EurekAlert! Science News by the Biogerontology Research Foundation. In accord with the U.S. Transhumanist Party’s open support of longevity science – in particular, Article V and Article VI of the Transhumanist Bill of Rights (v. 2.0) – we affirm our support by republishing the Press Release below.

~ B.J. Murphy, Director of Social Media, United States Transhumanist Party, March 16, 2017


Benchmark database of lifespan-extending drugs announced

Finding: The majority of age-related pathways have yet to be targeted pharmacologically

BIOGERONTOLOGY RESEARCH FOUNDATION

Scientists from the Biogerontology Research Foundation (BGRF) and University of Liverpool have announced a landmark database of lifespan-extending drugs and compounds called DrugAge. The database has 418 compounds, curated from studies spanning 27 different model organisms including yeast, worms, flies and mice. It is the largest such database in the world at this time. Significantly, the study found that the majority of age-related pathways have not yet been targeted pharmacologically, and that the pharmacological modulation of aging has by and large focused upon a small subset of currently-known age-related pathways. This suggests that there is still plenty of scope for the discovery of new lifespan-extending and healthspan-extending compounds.

DrugAge is the latest of a number of valuable resources freely available on the Human Aging Genomic Resources (HAGR) website created and maintained by the Integrative Genomics of Ageing Group at the University of Liverpool, led by Biogerontology Research Foundation Trustee Joao Pedro de Magalhaes, in collaboration with many other scientists worldwide, including BGRF Chief Science Officer and CEO of Insilico Medicine, Alex Zhavoronkov, PhD. Other resources available through HAGR include GenAge (a database of age and longevity-related genes in humans and model organisms), AnAge (a database on ageing, longevity records and life-history featuring over 4000 species), GenDR (a database of genes associated with the life extending effects of dietary restriction), and LongevityMap (a database of over 2000 human genes and genetic variations associated with longevity).

“DrugAge is the latest database created by Joao Pedro de Magalhaes, a world leader in the application of advanced bioinformatics and integrated computational approaches to biogerontology and ageing research. I am confident that it will gain widespread use in the ageing research community, and represents a significant milestone along the way to the coming paradigm shift in modern healthcare away from single disease treatment and toward geroprotective multi-disease prevention,” said Dmitry Kaminskiy, Managing Trustee of the Biogerontology Research Foundation.

The database is freely available to the public, and is searchable according to compound name, species and effect on lifespan. The data can be presented as both tables and interactive charts. Functional enrichment analysis of the targets of the database’s compounds was performed using drug-gene interaction data, which revealed a modest but statistically significant correlation between the cellular targets of the database’s compounds and known age-related genes.

The database encompasses the earlier efforts published by the BGRF scientists, Joao Pedro de Magalhaes, PhD and Alex Zhavoronkov, PhD as an open resource called Geroprotectors.org. The publication is available at http://www.aging-us.com/article/100799 .

“DrugAge represents a landmark resource for use in the biogerontology community. It is the largest database of lifespan-extending compounds compiled to date, and will surely come to be recognized as an extremely valuable resource for biogerontologists. Analysis performed using the database has already revealed interesting trends, including a modest but statistically significant overlap between lifespan-extending drugs and known age-related genes, a strong correlation between average/median lifespan changes and maximum lifespan changes, a strong correlation between the lifespan-extending effects of compounds between males and females, and perhaps most significantly that most known age-related pathways have yet to be targeted pharmacologically. More broadly, an understanding of the comparative effects of geroprotectors upon the lifespan of a variety of different model organisms is important both for basic research into the biology of ageing, demonstration of lifespan plasticity via modulation of a variety of distinct biomolecular targets as proof to regulators that healthspan extension is a viable paradigm for disease treatment and prevention, and for the eventual clinical translation of potential geroprotectors,” said Franco Cortese, Deputy Director and Trustee of the Biogerontology Research Foundation.

“Besides introducing the DrugAge database to the larger scientific community, this paper’s overarching significance lies in the finding that the large majority of known age-related pathways have not yet been targeted pharmacologically, and that we are in a very real sense at the starting line of the search for pharmacological agents capable of extending lifespan and healthspan via the modulation of known age-related pathways. There is still very much left to learn,” said Joao Pedro de Magalhaes, PhD, a Trustee of the Biogerontology Research Foundation (BGRF) and a Principal Investigator at the University of Liverpool’s Integrative Genomics of Aging Group (IGAG).

###

The paper ‘The DrugAge database of ageing-related drugs’ has been published in the journal Aging Cell.

 


Press Releases
Biogerontology Research Foundation, life extension, longevity, press release, science

Post navigation

PREVIOUS
Transhumanist Party Founder Zoltan Istvan to Speak at this Year’s Moogfest
NEXT
Why I Fear Aging – Article by Hayley Harrison

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Social Media

Constitution of the U.S. Transhumanist Party

Transhumanist Bill of Rights – Version 3.0

U.S. Transhumanist Party Facebook Feed

Victor Run Virtual Race – June 4-6, 2021

Free Transhumanist Symbols

Guidelines for Community Conduct

SUBMIT A POST

Recent Posts

  • U.S. Transhumanist Party Virtual Enlightenment Salon with Zack Varkaris – November 27, 2022
  • U.S. Transhumanist Party Virtual Enlightenment Salon with Steele Archer – December 4, 2022
  • U.S. Transhumanist Party Virtual Enlightenment Salon with Tom Ross and Zack Kopp – December 11, 2022
  • The Ethics and Implications of Indefinite Life Extension – Gennady Stolyarov II – Compilation Stream
  • Futuristic Neoclassical Music – Virtual Concert I – Gennady Stolyarov II and Jason Geringer – December 25, 2022
  • Rational Philosophy, Objective Morality, and Free Will – Gennady Stolyarov II – Compilation Stream
  • U.S. Transhumanist Party Virtual Enlightenment Salon with Nonso Nolly – January 8, 2023
  • U.S. Transhumanist Party Virtual Enlightenment Salon with Ian Hale – January 15, 2023
  • Virtual Enlightenment Salon on Hereditary Religion and the Dangers of Religious Indoctrination – January 22, 2023
  • U.S. Transhumanist Party General Discussion Thread for 2023
  • U.S. Transhumanist Party Chairman’s Sixth Anniversary and 2023 New Year’s Message
  • My Smart Stick Invention Prototype – Article by Nonso Nolly
  • Transhumanism: The Challenges of Techno-Scientific Power and Sociological Approach to African Backwardness – Article by Siba Tcha-Mouza
  • The Age of Deferred Aging – Article by J. Lund
  • U.S. Transhumanist Party and Nevada Transhumanist Party Positions on 2022 Nevada Ballot Questions
  • The U.S. Transhumanist Party Endorses Daniel E. Twedt for City Council in Thousand Oaks, California
  • U.S. Transhumanist Party Vote on the Question of Endorsing Daniel E. Twedt for City Council in Thousand Oaks, California
  • Constitution of the New York Transhumanist Party
  • U.S. Transhumanist Party to Participate in RAADfest 2022
  • U.S. Transhumanist Party Regional Liaison Spotlights: Celeste Castaldo and Dinorah Delfin

Recent Comments

  • Dan Kilian on Benefit for U.S. Transhumanist Party Members: Discounts Offered for Treatments from AmpliCell Medical
  • Cheryl Knepper on The U.S. Transhumanist Party Endorses Daniel E. Twedt for City Council in Thousand Oaks, California
  • Carlos on U.S. Transhumanist Party Vote on the Question of Endorsing Daniel E. Twedt for City Council in Thousand Oaks, California
  • Gennady Stolyarov II on Constitution of the New York Transhumanist Party
  • Daniel on U.S. Transhumanist Party Vote on the Question of Endorsing Daniel E. Twedt for City Council in Thousand Oaks, California

Archives

  • January 2023 (11)
  • December 2022 (2)
  • November 2022 (2)
  • October 2022 (3)
  • August 2022 (3)
  • July 2022 (2)
  • May 2022 (6)
  • March 2022 (3)
  • February 2022 (4)
  • January 2022 (7)
  • December 2021 (11)
  • November 2021 (4)
  • October 2021 (5)
  • September 2021 (2)
  • August 2021 (2)
  • July 2021 (4)
  • June 2021 (2)
  • May 2021 (6)
  • April 2021 (7)
  • March 2021 (4)
  • February 2021 (5)
  • January 2021 (6)
  • December 2020 (10)
  • November 2020 (4)
  • October 2020 (2)
  • September 2020 (1)
  • August 2020 (4)
  • July 2020 (5)
  • June 2020 (6)
  • May 2020 (3)
  • April 2020 (3)
  • March 2020 (6)
  • February 2020 (1)
  • January 2020 (6)
  • December 2019 (3)
  • November 2019 (2)
  • October 2019 (9)
  • September 2019 (10)
  • August 2019 (12)
  • July 2019 (18)
  • June 2019 (17)
  • May 2019 (12)
  • April 2019 (8)
  • March 2019 (12)
  • February 2019 (7)
  • January 2019 (13)
  • December 2018 (9)
  • November 2018 (5)
  • October 2018 (9)
  • September 2018 (5)
  • August 2018 (10)
  • July 2018 (13)
  • June 2018 (14)
  • May 2018 (8)
  • April 2018 (8)
  • March 2018 (10)
  • February 2018 (15)
  • January 2018 (17)
  • December 2017 (8)
  • November 2017 (17)
  • October 2017 (19)
  • September 2017 (11)
  • August 2017 (11)
  • July 2017 (16)
  • June 2017 (15)
  • May 2017 (10)
  • April 2017 (7)
  • March 2017 (8)
  • February 2017 (16)
  • January 2017 (8)
  • December 2016 (6)
  • November 2016 (5)

Categories

  • Allied Projects
  • Announcements
  • Art
  • Candidates
  • Discussion Panels
  • Distributed Computing
  • Exposure Periods
  • Foreign Ambassadors
  • General Discussion
  • Guest Articles
  • Inclusion
  • Interviews
  • Official Ballots
  • Petitions
  • Platform
  • Presentations
  • Press Releases
  • Research
  • Sample Ballots
  • Science Fiction
  • Statements
  • Tolerance
  • Virtual Enlightenment Salons
  • Vote Results
  • Working Groups
© 2023   Copyright - U.S. Transhumanist Party - All Rights Reserved | WordPress design: Art Ramon Paintings