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20 Cutting-Edge Biotechnologies in Development Today – Article by Logan Thrasher Collins

20 Cutting-Edge Biotechnologies in Development Today – Article by Logan Thrasher Collins

Logan Thrasher Collins


I have compiled a list of some of today’s most exciting, cutting-edge biotechnologies! Some of these technologies are emerging, and some of them are already prevalent in a translational context.

1. CRISPR-Cas systems: revolutionary for gene editing, gene therapy, fundamental biology, diagnostics, and more.
2. Gene therapy: enables cures for genetic diseases and powerful treatments for many cancers, may eventually treat polygenic disorders, ameliorate aging, and even enhance human biology (e.g., provide radiation resistance to astronauts). Synergy with CRISPR-Cas technologies will greatly aid gene therapy.
3. DNA origami: paves the way for new nanomedicines, biocatalysts, biosensors, imaging probes, diagnostics, data storage methods, biocomputing, and more.
4. Computational protein engineering: paves the way for new nanomedicines, biocatalysts, biosensors, diagnostics, biomaterials, imaging probes, and more.
5. Immunotherapy: enables cures for many cancers, treatments for autoimmune diseases, and more.
6. Computational protein structure prediction: revolutionizes drug discovery and basic biology, synergizes with computational protein engineering.
7. Spatial transcriptomics: method for interrogation of cell and tissue biology in a holistic and multidimensional fashion to deeply understand health and disease, may lead to dramatic insights on aging, cognition, and pathology.
8. Optogenetics: powerful tool for understanding cellular physiology and neural circuits, may greatly enhance brain-machine interfacing (with the help of gene therapy).
9. Expansion microscopy: physically enlarges biological samples to multiply resolution. Making major strides in connectomics, vastly enhancing study of spatial organization of cells and tissues in general, synergizing with spatial transcriptomics.
10. Longevity medicines: pharmacological, gene therapy, and other methods of treating aging may extend human lifespan and dramatically reduce the prevalence of most aging-related diseases.
11. Bioprinting: produces replacement tissue and may enable manufacturing of replacement organs. Also greatly aids study of tissue biology and provides platforms for drug testing.
12. Organ-on-a-chip systems: may greatly reduce the need for animal models in research, helping to understand organ microenvironments and organ physiology in general, serving as platform for drug testing and discovery.
13. Organoids: may greatly reduce the need for animal models in research, helping to understand organ physiology (especially in context to 3D structure and function), serving as platforms for drug testing and discovery, contributing to understanding of cognition, aiding understanding of developmental biology.
14. Cryo-EM and cryo-ET: rivaling x-ray crystallography for solving high-resolution protein structures and is much easier than x-ray crystallography (especially for certain problematic samples), giving 3D images of cellular environments at sufficient resolution to see some macromolecular structural details, preserves sample integrity better than other methods.
15. Phage therapy: enables versatile and potent treatment of bacterial infections, may save the world from antibiotic resistance.
16. Synchrotron x-ray nanotomography: rapid 3D imaging in one or two colors, may help map brain structure much more rapidly than other methods. This could lead to superior brain-inspired AI and robotics, treatments for brain disease, and whole-brain simulations.
17. Tissue clearing with light-sheet microscopy: facilitates 3D imaging of tissues and even whole organs, leading to much better understanding of biological function, aids connectomics.
18. Predictive systems biology models: transforming vast biological datasets into parameters for large-scale simulations which give valuable insights. Some key examples are kinetic signaling network simulations, molecular dynamics simulations, and biophysical neuronal network simulations.
19. Injectable electronics: minimally invasive method of delivering brain-machine interface hardware, may lead to widespread biomedical and nonmedical adoption of brain-machine interfaces.
20. Minimal cells: may transform understanding of cellular physiology, may act as a superior biomanufacturing platform, may act as a superior platform for cell therapy, and more.
***

Logan Thrasher Collins is a U.S. Transhumanist Party member, futurist, synthetic biologist, author, and innovator. When he was 16, he invented a new antimicrobial protein, OpaL (Overexpressed protein aggregator Lipophilic). He next developed a bacterial conjugation delivery system for the gene encoding OpaL. His synthetic biology research has been published as a first-author journal article in ACS Biochemistry: “Design of a De Novo Aggregating Antimicrobial Peptide and a Bacterial Conjugation-Based Delivery System.” In addition, his synthetic biology research has been recognized at numerous venues including TEDxMileHigh, the Intel International Science and Engineering Fair (ISEF), the International BioGENEius Challenge at the BIO International Convention, and at the American Society for Microbiology General Meeting. At Intel ISEF 2014, his synthetic biology research won 1st place in microbiology and best of category in microbiology ($8,000) as well as the Dudley R. Herschbach award. The latter included a trip to take part in the Nobel Prize ceremonies via the Stockholm International Youth Science Seminar (SIYSS). As part of the honors at Intel ISEF, a minor planet was officially named Logancollins.

As the Chief Technology Officer (CTO) at Conduit Computing, Mr. Collins is leading a supercomputing project which has allowed visualization of how the constituent proteins of SARS-CoV-2 interact inside of cells to build whole viruses.

Visit Logan Thrasher Collins’s website here.

Opinions From Around the World: Obah Isaac Ebuka – 3D-Printing Organs for Transplant

Opinions From Around the World: Obah Isaac Ebuka – 3D-Printing Organs for Transplant

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Obah Isaac Ebuka


Editor’s Note: It is extremely important that supporters of transhumanism understand the opinions of peoples from every nation. I, Kimberly Forsythe, decided to reach out to people from other cultures and asked them to give me their opinions on the topic of transhumanist tech. My goal is to better understand why some may object to the idea based on various cultural differences.

As I receive the essays, I will publish them. My hope is that we can work together to build more international bridges and achieve progress that works for as many people as possible. This essay regarding the promises of 3D-printing of organs and the remaining challenges of implementing this technology was written by Obah Isaac Ebuka. 

~ Kimberly Forsythe, Member, United States Transhumanist Party, December 13, 2020


3D-Printing Organs for Transplant

What if it was possible to mass-produce organs – to grow hearts and lungs in a lab, readily accessible by the hundreds of thousands of patients waiting for organs? The affirmative answer to that question has been the goal of many researchers over the years, and their results are very promising.

The Promise of 3D-Printing

In 1988, a researcher modified a basic HP inkjet printer into using cells instead of regular ink and used the printer to write on a surface using cytoscribing technology. Now in 2019, scientists in Israel have been able to print a miniature human heart complete with contracting blood vessels using human cells. A lot of work and technology through the years led up to this incredible feat of human bio-engineering.

3D-printing organs is still not completely perfected, but the technology at present shows that it is possible. Current biotechnology makes it possible to print incredibly complex organ scaffold structures that mimic the structures of human organs and tissues with high anatomical precision using synthetic but biocompatible materials. These scaffolds can then be used as the spatial matrix on which cells can be built upon to create life-sized vascularized organs that possess the vital microstructures of real organs.

Current Challenges for Bioprinting

Biological Complexity

There are still many challenges to bioprinting that are yet to be addressed. One of these is that human organs are more incredibly complex than current technology can create. It might have been possible to create a miniature heart with the major aortae and coronary arteries, but scientists have yet to replicate vessel structures like the millions of capillary networks which are micrometers in diameter and essential to the life of organs.

Also, organs are much more than their structures and shapes. There a lot of details about organs that we are yet to understand such as how certain genes, hormones, and other factors in the body interact with organs and vice versa. An example of this is how the heart is an endocrine organ and not simply a blood pumper. So a true heart replacement also has to be able to create Atrial Natriuretic Peptides (ANP), which lower blood pressure.

Practicability

Hindrances from a bioengineering perspective aren’t the only things to worry about. It is also very challenging to design clinical trials that will test the longevity and compatibility of these experimental organs in humans. There is also the challenge of securing sustainable sources of cells, biocompatible material, as well as large-scale manufacturing capabilities needed for 3D-printing to be a viable and affordable replacement for real organ transplants.

Ethnic and Religious beliefs

Ethnicity and religious belief inhibit technological changes. In Nigeria, a country in western Africa, some groups of religious fanatics believe that each organ is sacred and would not have their organs changed. This view is not only shared in Nigeria particularly, but it is commonplace and widespread for natives to abhor mending or replacing what they come to see as natural.

Proposed solutions to these barriers

Natives should be enlightened. They should be taught the need for bioprinting organs, seeing that the ultimate aim is to save lives.

Author: Obah Isaac Ebuka

Abuja, Nigeria.

Twitter handle: @AiTweet01