Browsed by
Tag: press release

Bioquark, Inc., and Lakmus LLC Announce Research Collaboration to Study Novel Biopharmaceuticals for Healthy Longevity Enhancement – Press Release by Ira Pastor

Bioquark, Inc., and Lakmus LLC Announce Research Collaboration to Study Novel Biopharmaceuticals for Healthy Longevity Enhancement – Press Release by Ira Pastor

logo_bg

Ira Pastor


Bioquark, Inc., and Lakmus LLC, announce a multi-disciplinary research collaboration to study age-reversal / longevity-enhancing bio-pharmaceutical development with the FSBI Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, and the Pavlov Institute of Physiology of the Russian Academy of Sciences.

Bioquark, Inc., (http://www.bioquark.com) a life sciences company focused on the development of novel bio-products for regeneration, disease reversion, and healthy aging, and Moscow-based Lakmus LLC, a diversified investment company with business interests in pharmacies, restaurants, and real estate, announced a multi-disciplinary research collaboration with the FSBI Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences (http://www.academpharm.ru/), and the Pavlov Institute of Physiology of the Russian Academy of Sciences (http://www.infran.ru/), to jointly study the pharmacotherapeutic longevity-enhancement properties of its combinatorial regenerative biologic candidates.

“We are very excited about this continued collaboration with Lakmus,” said Ira S. Pastor, CEO, Bioquark Inc. “The disciplined development of our combinatorial biologic candidates (Bioquantines) for healthy longevity enhancement, represents another important step in our continued evolution as a company focused on a broad range of therapeutic products and services in the regenerative healthcare space.”

Throughout the 20th century, natural products formed the basis for a majority of all pharmaceuticals, biologics, and consumer healthcare products used by patients around the globe, generating trillions of dollars of wealth. However, many scientists believe we have only touched the surface with what the natural world, and its range of organisms, which from a health and wellness perspective are much further advanced than human beings, has to teach us.

The integration of a complex set of newer research disciplines, including interkingdom signaling, semiochemical communication, and evolutionary biology, as well as significant recent activity in the areas of the microbiome, are highlighting a myriad of new ways that non-human bio-products can affect the human genome for positive transitions in health and wellness dynamics.

“Bioquark has spent several years studying the natural ability of many species to turn back biological time in order to maintain health, fitness, and survival, developing a broad understanding of the combinatorial biochemical approaches they use to control nested hierarchies of disease (i.e., gene, cell, tissue, organism, environment),” said Dr. Sergei Paylian, Founder, CSO, and President, Bioquark Inc. “This research initiative is one more step in the path in allowing humans to recapture these capabilities to effectively counter our unfortunate progression into aging, disease, and degeneration.”

About Bioquark, Inc.

Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.

Read about Mr. Ira S. Pastor here.

Benchmark Database of Lifespan-Extending Drugs Announced – Press Release by Biogerontology Research Foundation

Benchmark Database of Lifespan-Extending Drugs Announced – Press Release by Biogerontology Research Foundation

logo_bg


Note from the Editor: The following Press Release was originally published on EurekAlert! Science News by the Biogerontology Research Foundation. In accord with the U.S. Transhumanist Party’s open support of longevity science – in particular, Article V and Article VI of the Transhumanist Bill of Rights (v. 2.0) – we affirm our support by republishing the Press Release below.

~ B.J. Murphy, Director of Social Media, United States Transhumanist Party, March 16, 2017


Benchmark database of lifespan-extending drugs announced

Finding: The majority of age-related pathways have yet to be targeted pharmacologically

BIOGERONTOLOGY RESEARCH FOUNDATION

Scientists from the Biogerontology Research Foundation (BGRF) and University of Liverpool have announced a landmark database of lifespan-extending drugs and compounds called DrugAge. The database has 418 compounds, curated from studies spanning 27 different model organisms including yeast, worms, flies and mice. It is the largest such database in the world at this time. Significantly, the study found that the majority of age-related pathways have not yet been targeted pharmacologically, and that the pharmacological modulation of aging has by and large focused upon a small subset of currently-known age-related pathways. This suggests that there is still plenty of scope for the discovery of new lifespan-extending and healthspan-extending compounds.

DrugAge is the latest of a number of valuable resources freely available on the Human Aging Genomic Resources (HAGR) website created and maintained by the Integrative Genomics of Ageing Group at the University of Liverpool, led by Biogerontology Research Foundation Trustee Joao Pedro de Magalhaes, in collaboration with many other scientists worldwide, including BGRF Chief Science Officer and CEO of Insilico Medicine, Alex Zhavoronkov, PhD. Other resources available through HAGR include GenAge (a database of age and longevity-related genes in humans and model organisms), AnAge (a database on ageing, longevity records and life-history featuring over 4000 species), GenDR (a database of genes associated with the life extending effects of dietary restriction), and LongevityMap (a database of over 2000 human genes and genetic variations associated with longevity).

“DrugAge is the latest database created by Joao Pedro de Magalhaes, a world leader in the application of advanced bioinformatics and integrated computational approaches to biogerontology and ageing research. I am confident that it will gain widespread use in the ageing research community, and represents a significant milestone along the way to the coming paradigm shift in modern healthcare away from single disease treatment and toward geroprotective multi-disease prevention,” said Dmitry Kaminskiy, Managing Trustee of the Biogerontology Research Foundation.

The database is freely available to the public, and is searchable according to compound name, species and effect on lifespan. The data can be presented as both tables and interactive charts. Functional enrichment analysis of the targets of the database’s compounds was performed using drug-gene interaction data, which revealed a modest but statistically significant correlation between the cellular targets of the database’s compounds and known age-related genes.

The database encompasses the earlier efforts published by the BGRF scientists, Joao Pedro de Magalhaes, PhD and Alex Zhavoronkov, PhD as an open resource called Geroprotectors.org. The publication is available at http://www.aging-us.com/article/100799 .

“DrugAge represents a landmark resource for use in the biogerontology community. It is the largest database of lifespan-extending compounds compiled to date, and will surely come to be recognized as an extremely valuable resource for biogerontologists. Analysis performed using the database has already revealed interesting trends, including a modest but statistically significant overlap between lifespan-extending drugs and known age-related genes, a strong correlation between average/median lifespan changes and maximum lifespan changes, a strong correlation between the lifespan-extending effects of compounds between males and females, and perhaps most significantly that most known age-related pathways have yet to be targeted pharmacologically. More broadly, an understanding of the comparative effects of geroprotectors upon the lifespan of a variety of different model organisms is important both for basic research into the biology of ageing, demonstration of lifespan plasticity via modulation of a variety of distinct biomolecular targets as proof to regulators that healthspan extension is a viable paradigm for disease treatment and prevention, and for the eventual clinical translation of potential geroprotectors,” said Franco Cortese, Deputy Director and Trustee of the Biogerontology Research Foundation.

“Besides introducing the DrugAge database to the larger scientific community, this paper’s overarching significance lies in the finding that the large majority of known age-related pathways have not yet been targeted pharmacologically, and that we are in a very real sense at the starting line of the search for pharmacological agents capable of extending lifespan and healthspan via the modulation of known age-related pathways. There is still very much left to learn,” said Joao Pedro de Magalhaes, PhD, a Trustee of the Biogerontology Research Foundation (BGRF) and a Principal Investigator at the University of Liverpool’s Integrative Genomics of Aging Group (IGAG).

###

The paper ‘The DrugAge database of ageing-related drugs’ has been published in the journal Aging Cell.

 

U.S. Transhumanist Party Endorses the Restricting First Use of Nuclear Weapons Act of 2017

U.S. Transhumanist Party Endorses the Restricting First Use of Nuclear Weapons Act of 2017

logo_bg


Note from the Chairman: In accord with Article III, Section IV, of the U.S. Transhumanist Party Platform, which recognizes the dire existential threat that nuclear weapons pose to sapient life on Earth and advocates the complete dismantlement and abolition of all nuclear weapons everywhere, as rapidly as possible, the U.S. Transhumanist Party endorses the Restricting First Use of Nuclear Weapons Act of 2017, proposed by U.S. Representative Ted Lieu and U.S. Senator Edward Markey. While the proposal by Representative Lieu and Senator Markey to restrict the first use of nuclear weapons is much more modest than complete disarmament, it is also a basic and common-sense measure to prevent the United States Federal Government from acting as the aggressor in a potentially civilization-ending war. As such, the passage of this act would be a welcome first step on the path toward peace and nuclear disarmament.

For more information, please read the press release of January 24, 2017, from Representative Lieu and Senator Markey below.

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, January 29, 2017

 


Congressman Lieu, Senator Markey Introduce the Restricting First Use of Nuclear Weapons Act of 2017

Press Release by Congressman Ted Lieu & Senator Edward J. Markey

WashingtonToday, Congressman Ted W. Lieu (D | Los Angeles County) and Senator Edward J. Markey (D-Massachusetts) introduced the Restricting First Use of Nuclear Weapons Act of 2017.  This legislation would prohibit the President from launching a nuclear first strike without a declaration of war by Congress. The crucial issue of nuclear “first use” is more urgent than ever now that President Donald Trump has the power to launch a nuclear war at a moment’s notice.

Upon introduction of this legislation, Mr. Lieu issued the following statement:

“It is a frightening reality that the U.S. now has a Commander-in-Chief who has demonstrated ignorance of the nuclear triad, stated his desire to be ‘unpredictable’ with nuclear weapons, and as President-elect was making sweeping statements about U.S. nuclear policy over Twitter. Congress must act to preserve global stability by restricting the circumstances under which the U.S. would be the first nation to use a nuclear weapon. Our Founders created a system of checks and balances, and it is essential for that standard to be applied to the potentially civilization-ending threat of nuclear war. I am proud to introduce the Restricting First Use of Nuclear Weapons Act of 2017 with Sen. Markey to realign our nation’s nuclear weapons launch policy with the Constitution and work towards a safer world.”

Upon introduction of this legislation, Senator Markey issued the following statement:

“Nuclear war poses the gravest risk to human survival. Yet, President Trump has suggested that he would consider launching nuclear attacks against terrorists. Unfortunately, by maintaining the option of using nuclear weapons first in a conflict, U.S. policy provides him with that power. In a crisis with another nuclear-armed country, this policy drastically increases the risk of unintended nuclear escalation. Neither President Trump, nor any other president, should be allowed to use nuclear weapons except in response to a nuclear attack. By restricting the first use of nuclear weapons, this legislation enshrines that simple principle into law. I thank Rep. Lieu for his partnership on this common-sense bill during this critical time in our nation’s history.”

Support for the Restricting First Use of Nuclear Weapons Act of 2017:

William J. Perry, Former Secretary of Defense – “During my period as Secretary of Defense, I never confronted a situation, or could even imagine a situation, in which I would recommend that the President make a first strike with nuclear weapons—understanding that such an action, whatever the provocation, would likely bring about the end of civilization.  I believe that the legislation proposed by Congressman Lieu and Senator Markey recognizes that terrible reality.  Certainly a decision that momentous for all of civilization should have the kind of checks and balances on Executive powers called for by our Constitution.”

Tom Z. Collina, Policy Director of Ploughshares Fund – “President Trump now has the keys to the nuclear arsenal, the most deadly killing machine ever created. Within minutes, President Trump could unleash up to 1,000 nuclear weapons, each one many times more powerful than the Hiroshima bomb. Yet Congress has no voice in the most important decision the United States government can make. As it stands now, Congress has a larger role in deciding on the number of military bands than in preventing nuclear catastrophe.”

Derek Johnson, Executive Director of Global Zero – “One modern nuclear weapon is more destructive than all of the bombs detonated in World War II combined. Yet there is no check on a president’s ability to launch the thousands of nuclear weapons at his command. In the wake of the election, the American people are more concerned than ever about the terrible prospect of nuclear war — and what the next commander-in-chief will do with the proverbial ‘red button.’ That such devastating power is concentrated in one person is an affront to our democracy’s founding principles. The proposed legislation is an important first step to reining in this autocratic system and making the world safer from a nuclear catastrophe.”

Megan Amundson, Executive Director of Women’s Action for New Directions (WAND) – “Rep. Lieu and Sen. Markey have rightly called out the dangers of only one person having his or her finger on the nuclear button. The potential misuse of this power in the current global climate has only magnified this concern. It is time to make real progress toward lowering the risk that nuclear weapons are ever used again, and this legislation is a good start.”

Jeff Carter, Executive Director of Physicians for Social Responsibility – “Nuclear weapons pose an unacceptable risk to our national security. Even a “limited” use of nuclear weapons would cause catastrophic climate disruption around the world, including here in the United States. They are simply too profoundly dangerous for one person to be trusted with the power to introduce them into a conflict. Grounded in the fundamental constitutional provision that only Congress has the power to declare war, the Restricting First Use of Nuclear Weapons Act of 2017 is a wise and necessary step to lessen the chance these weapons will ever be used.”

Diane Randall, Executive Secretary of the Friends Committee on National Legislation (Quakers) – “Restricting first-use of nuclear weapons is an urgent priority. Congress should support the Markey-Lieu legislation.”

###