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Advocating for the Future – Panel at RAAD Fest 2017 – Gennady Stolyarov II, Zoltan Istvan, Max More, Ben Goertzel, Natasha Vita-More

Advocating for the Future – Panel at RAAD Fest 2017 – Gennady Stolyarov II, Zoltan Istvan, Max More, Ben Goertzel, Natasha Vita-More

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Gennady Stolyarov II
Zoltan Istvan
Max More
Ben Goertzel
Natasha Vita-More


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, moderated this panel discussion, entitled “Advocating for the Future”, at RAAD Fest 2017 on August 11, 2017, in San Diego, California.

Watch it on YouTube here.

From left to right, the panelists are Zoltan Istvan, Gennady Stolyarov II, Max More, Ben Goertzel, and Natasha Vita-More. With these leading transhumanist luminaries, Mr. Stolyarov discussed subjects such as what the transhumanist movement will look like in 2030, artificial intelligence and sources of existential risk, gamification and the use of games to motivate young people to create a better future, and how to persuade large numbers of people to support life-extension research with at least the same degree of enthusiasm that they display toward the fight against specific diseases.

Learn more about RAAD Fest here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form.

Watch the presentations of Gennady Stolyarov II and Zoltan Istvan from the “Advocating for the Future” panel.

A Biohacker’s Letter to Santa – Article by Elena Milova

A Biohacker’s Letter to Santa – Article by Elena Milova

Elena Milova


Editor’s Note: Happy Holidays! If Santa Claus were real, life extension would be the greatest gift that he could possibly give. Elena Milova convincingly illustrates why in this letter, originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Gennady Stolyarov II, Chairman, U.S. Transhumanist Party, December 21, 2018

Dear Santa,
My name is Elena Milova, and I am from Moscow, Russia. I am a science popularizer, biohacker, and public health advocate in the field of aging and longevity. I am 39, single, and without children, but if you think that I am reaching out to you to ask for a CRISPR-designed baby, I am not. I believe that this type of wish is rather in the pile of letters from China. I am not asking you for a particular health improvement, as one could not wish for a better HOMA-IR (mine is 0.40, because I greatly reduced fast carbs) or total cholesterol level (below 4 mmol/L). I am fine without a new smartphone, too.

The thing that I am going to ask you for is much more tricky to get. I want everyone on Earth to realize that biological aging is amenable to medical intervention and that treatments targeting various mechanisms of aging are already in human clinical trials. 7.6 billion minds, one idea. That is my only wish.

Why this is so important to me

You have probably noticed yourself that your clientele is changing over time. There are more and more people over 60 in the world, and I assume that the number of wishes for recovery from this or that age-related disease are spiking higher every year. This must be a problem for you, as for many diseases of old age, there is still no effective treatment that would actually help to cure people. It must be frustrating to not be able to fulfill a sincere wish of a good person, especially when a child asks for her grandparents to recover so that they can walk and throw snowballs together.

Source: United Nations, Department of Economic and Social Affairs, Population Division (2017). World Population Prospects 2017 – Data Booklet (ST/ESA/SER.A/401)

By 2050, the elderly will be a quarter of the global population, and these people will likely be suffering from several chronic diseases at once, gradually losing their health, independence and dignity. For so many people, being a burden on their families because of their deteriorating health is unacceptable, which is why the number of suicides in this age group is so high.

Is aging an invisible problem?

The numbers of these voluntary deaths are very upsetting, but what is even more upsetting is that diseases of old age are the major cause of death worldwide and aging kills around 100,000 people every day. This is the population of a small city. Imagine what would happen if everyone in a city like Cambridge, Massachusetts were to die in one day. I bet that there would be a lot of media attention and that thousands of experts would be on television discussing the potential causes of death and ways of preventing this tragedy in the future. Let’s say that the next day, another city becomes deadly peaceful. Take the Russian city of Domodedovo, which has its own airport. Everyone dead. People in neighboring cities would probably be frightened, and some charismatic politicians would be trying to calm down the public and promising to do something about all these deaths. The next day, this happens to yet another city, maybe in India. Then another one in Australia. It would not take long before G20 would set up an urgent conference call to set up an international commission and allocate money and scientists to investigate and solve the problem.

                                                                                                                                              Source: WHO website

Guess what? This type of thing never happens in relation to aging, because people dying from it are spread around the globe, so the disaster does not make the headlines. The public only notices the problem when an actor, scientist, or other significant public figure dies from an age-related disease – most often heart disease, stroke, or cancer. Do you want an example? “Santa Claus, age 90, dies from a heart attack: a critical blow to the industry of giftmaking.”

Sorry, sorry. I didn’t mean to scare you, but you get the point, right? From looking at your pictures, I could suspect that you might have some minor problems with glucose metabolism, but your extensive physical activity during gift delivery should be compensating for that, so you should be fine. For other people aged 60 and older, aging is an ever-increasing problem. Here, we come to the other important issue.

What is aging? How it can be addressed?

You see, aging is the accumulation of damage that happens due to normal bodily functions. This damage builds up over time, normal cell functions erode, and, at some point, this leads to the manifestation of age-related diseases. Normal operations, damage accumulation, disease, more damage, aggravation of disease, death. Simple.

It turns out that at the beginning of this century, British scientist Aubrey de Grey published an article in which he described several types of damage done by aging. He suggested the heretical idea of targeting these damages with medical interventions instead of trying to cure the symptoms of each age-related disease. He argued that age-related diseases are only a consequence of damage accumulation and that it would be much more effective to address the root causes.

The seed that Dr. de Grey dropped into the fertile soil of scholarship produced nice fruit in 2013, which is when a group of famous researchers of aging published The Hallmarks of Aging, a paper in which they described nine types of damage that accumulate with age and could be made into new therapeutic targets.

Comparison of a mouse treated with senolytics (at right) and a same-age mouse of the control group (at left). Source: Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., … & Khazaie, K. (2016). Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature, 530(7589), 184.

There were other fruits as well: animal studies have definitively proven that even only addressing one type of damage can extend the healthy period of life, postpone age-related diseases, keep animals more active, and, as a positive side effect, extend lifespan. It is worms that hold the best record so far, as tweaking some of their longevity-related genes has allowed them to live 10 times longer. The results in mice are also impressive – the researchers can extend both their healthy period of life and lifespan by 30-35%. Honestly, I find myself jealous of these mice, sometimes. I would not mind adding another 30% of youthful and healthy years to my life, even if I would have to take some pills or get some regular injections.

Can we control aging in humans?

You see, Santa, where I am going with this. I am sure that you sometimes leave gifts under the trees of people who work for the FDA. Accumulating a critical mass of knowledge about interventions against murine aging made it possible to develop the same type of interventions for people. Now, drugs and therapies addressing some of the root mechanisms of aging are in official human clinical trials. At some point, some of these trials will be successful, and drugs and therapies targeting aging itself will come to market.

If you don’t believe me, here is the short list of people whose chimneys’ stacks are the best source of additional information on the topic: George Church, Anthony Atala, Judy Campisi, Vadim Gladyshev, Maria Blasco, Michael West, Vera Gorbunova, Irina Conboy, Kelsey Moody, Brian Kennedy, Linda Partridge, Alexey Moskalev, Cynthia Kenyon, Claudio Franceschi, Alex Zhavoronkov, Nir Barzilai, and, of course, Aubrey de Grey. He wears a great beard, so you have more in common with gerontologists than you would think.

Listen to these people tell their families about their research, and you will get my point. We are on the edge of a revolution in rejuvenation biotechnology. Yet, most people don’t know about it and don’t realize what kind of potential benefit this advancement holds for them and for our aging society as a whole. Most importantly, as they know nothing, they have no say in decision making. How can people possibly speed up the pace of aging research if they don’t realize that aging is amenable to intervention? How can they foster technology transfer and local production of the cures for aging, such as senolytics, in their countries? How can they control prices and make future distribution and access equal? How can they ensure that old people in their families, who need these new treatments the most, would get them sooner?

Knowledge is power. We hear this in almost every interview, and you should be hearing it every Christmas from the researchers of aging, too. They have golden brains; the only thing they need is an appropriate amount of funding to solve the problem of aging more quickly. A strong public movement for aging research could be a game changer and could act as leverage to allocate government funding towards researching and developing treatments that target the underlying mechanisms of aging.

Ending aging and age-related diseases is possible

It is obvious that you are a kind person, Santa. You are perceptive and generous; you know what people want, and you try to give them what they want. However, if you don’t help me with my information campaign, in a couple of decades from now, you will be delivering billions of adult diapers and wheelchairs all over the globe. Wouldn’t it be nicer if you were to pile these up in your warehouse to be covered in dust while you give people therapies and drugs that prevent aging and wipe age-related diseases out of human lives? Just imagine how much happier people would be if they could remain healthy and independent, enjoy full and productive lives, achieve more, and stay with their families and friends for longer.

I was a good girl the whole year, attending scientific conferences, interviewing researchers, speaking at public events, and supporting our partners and colleagues in every way I could, even if that much socializing makes me suffer from an introvert’s hangover. I was eating healthy food and promoting evidence-based means to slow down aging among my relatives and friends. I deserve a nice Christmas gift.

All you have to do is to let everyone on the planet know that aging is amenable to intervention and that treatments addressing the root causes of aging are currently being created. For real. That would make me the happiest creature on the planet. Thank you in advance!

Sincerely, Elena

Instead of a conclusion

I am 39 years old, and I am an agnostic. There is not much evidence that Santa Claus exists. However, I do believe that miracles happen: the miracles that we create with our own hands. You who are reading these words (thanks for getting this far, by the way!) possess this special power, too. Use it! Let people around you know that science is close to bringing aging under medical control, and let’s build a world where healthy longevity for everyone is a reality.

As a devoted advocate of rejuvenation technologies since 2013, Elena Milova is providing the community with a systemic vision how aging is affecting our society. Her research interests include global and local policies on aging, demographic changes, public perception of the application of rejuvenation technologies to prevent age-related diseases and extend life, and related public concerns. Elena is a co-author of the book Aging prevention for all (in Russian, 2015) and the organizer of multiple educational events helping the general public adopt the idea of eventually bringing aging under medical control.

Transhumanist Bill of Rights – Results of Vote and Version 3.0

Transhumanist Bill of Rights – Results of Vote and Version 3.0

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Gennady Stolyarov II


The U.S. Transhumanist Party conducted its tenth vote of the members on December 2 through December 9, 2018. Official ballot options can be found here.

Detailed results of the voting have been tabulated here. Where more than two options existed, the winning result was selected based on the ranked-preference method with instant runoffs.

As a result, Version 3.0 of the Transhumanist Bill of Rights was compiled on the basis of the members’ decisions. Version 3.0 augments and supersedes Version 2.0, while retaining the original intent of Version 2.0.

The resulting Version 3.0 of the Transhumanist Bill of Rights is permanently hosted here. Its text is also reproduced below.

Note: It is important to keep in mind that the Transhumanist Bill of Rights is not a policy platform but rather a member-driven expression of ideals for a transhumanist society. No individual is bound to it (indeed, its new Article I states this explicitly), it is not static, and it is subject to further amendments if/when member recommendations arise and meet with significant demand.  Anyone who sees this version can always give feedback on the U.S. Transhumanist Party website (including on this thread) and/or Facebook page. The official U.S. Transhumanist Party Platform can be found here.


Transhumanist Bill of Rights – Version 3.0

Version 1.0 written by Zoltan Istvan – Delivered to the U.S. Capitol on December 14, 2015

Version 2.0 developed by members of the U.S. Transhumanist Party – Adopted via Electronic Vote on December 25-31, 2016 – Integrated from Voting Preferences on January 4, 2017

Version 3.0 developed by members of the U.S. Transhumanist Party – Adopted via Electronic Vote on December 2-9, 2018 – Integrated from Voting Preferences on December 12, 2018

[NOTE: The Transhumanist Bill of Rights is not static and is open to further amendments via future votes of U.S. Transhumanist Party members. To suggest a specific amendment, you may make a post on this thread or e-mail Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, here. Proposed amendments that receive sufficient member demand will be considered for inclusion on future ballots.]

Preamble

Whereas science and technology are now radically changing human beings and may also create future forms of advanced sapient and sentient life, transhumanists establish this TRANSHUMANIST BILL OF RIGHTS to help guide and enact sensible policies in the pursuit of life, liberty, security of person, and happiness.

As used in this TRANSHUMANIST BILL OF RIGHTS, the term “sentient entities” encompasses:
        (i) Human beings, including genetically modified humans;
        (ii) Cyborgs;
        (iii) Digital intelligences;
        (iv) Intellectually enhanced, previously non-sapient animals;
       (v) Any species of plant or animal which has been enhanced to possess the capacity for intelligent thought; and
        (vi) Other advanced sapient life forms.

Sentient entities are defined by information-processing capacity such that this term should not apply to non-self-aware lifeforms, like plants and slime molds. Biological processing substrates are referred to as using an “analogue intelligence”, whereas purely electronic processing substrates are referred to as “digital intelligence”, and processing substrates that utilize quantum effects would be considered “quantum intelligence”.

Sentience is ranked as Level 5 information integration according to the following criteria:

  • Level 0 – No information integration: Inanimate objects; objects that do not modify themselves in response to interaction – e.g., rocks, mountains.
  • Level 1 – Non-zero information integration: Sensors – anything that is able to sense its environment – e.g., photo-diode sense organs, eyes, skin.
  • Level 2 – Information manipulation: Systems that include feedback that is non-adaptive or minimally adaptive – e.g., plants, basic algorithms, the system that interprets the output from a photo-diode to determine its on/off state (a photo diode itself cannot detect its own state). Level 2 capabilities include the following:
  1. Expression of emotion;
  2. Expression of sensory pleasure;
  3. Taste aversion.
  • Level 3 – Information integration – Awareness: Systems that include adaptive feedback, can dynamically generate classification – e.g., deep-learning AI, chickens, animals that are able to react to their environment, have a model of their perception but not the world. This level describes animals acting on instinct and unable to classify other animals into more types than “predator”, “prey”, or “possible mate”. Level 3 capabilities include the following:
  1. Navigational detouring (which requires an being to pursue a series of non-rewarding intermediate goals in order to obtain an ultimate reward); Examples: documentation of detouring in jumping spiders (Jackson and Wilcox 1998), motivational trade-off behavior in hermit crabs (Elwood and Appel 2009);
  2. Emotional fever (an increase in body temperature in response to a supposedly stressful situation — gentle handling, as operationalized in Cabanac’s experiments).
  • Level 4 – Awareness + World model: Systems that have a modeling system complex enough to create a world model: a sense of other, without a sense of self – e.g., dogs. Level 4 capabilities include static behaviors and rudimentary learned behavior.
  • Level 5 – Awareness + World model + Primarily subconscious self model = Sapient or Lucid: Lucidity means to be meta-aware – that is, to be aware of one’s own awareness, aware of abstractions, aware of one’s self, and therefore able to actively analyze each of these phenomena. If a given animal is meta-aware to any extent, it can therefore make lucid decisions. Level 5 capabilities include the following:
  1. The “sense of self”;
  2. Complex learned behavior;
  3. Ability to predict the future emotional states of the self (to some degree);
  4. The ability to make motivational tradeoffs.
  • Level 6 – Awareness + World model + Dynamic self model + Effective control of subconscious: The dynamic sense of self can expand from “the small self” (directed consciousness) to the big self (“social group dynamics”). The “self” can include features that cross barriers between biological and non-biological – e.g., features resulting from cybernetic additions, like smartphones.
  • Level 7 – Global awareness – Hybrid biological-digital awareness = Singleton: Complex algorithms and/or networks of algorithms that have capacity for multiple parallel simulations of multiple world models, enabling cross-domain analysis and novel temporary model generation. This level includes an ability to contain a vastly larger amount of biases, many paradoxically held. Perspectives are maintained in separate modules, which are able to dynamically switch between identifying with the local module of awareness/perspective or the global awareness/perspective. Level 7 capabilities involve the same type of dynamic that exists between the subconscious and directed consciousness, but massively parallelized, beyond biological capacities.

Article I. All sentient entities are hereby entitled to pursue any and all rights within this document to the degree that they deem desirable – including not at all. All sentient entities are entitled, to the extent of their individual decisions, to all the rights and freedoms set forth in this TRANSHUMANIST BILL OF RIGHTS, without distinction of any kind, such as race, color, sex, gender, language, religion, political or other opinion, national, social, or planetary origin, property, birth (including manner of birth), biological or non-biological origins, or other status. Furthermore, no distinction shall be made on the basis of the political, jurisdictional, or international status of the country or territory to which a sentient entity belongs, whether it be independent, trust, non-self-governing, or under any other limitation of sovereignty. In the exercise of their rights and freedoms, all sentient entities shall be subject only to such limitations as are determined by law solely for the purpose of securing due recognition and respect for the rights and freedoms of others and of meeting the just requirements of morality, public order, and the general welfare in a democratic society, which may not undermine the peaceful prerogatives of any individual sentient entity. These rights and freedoms may in no case be exercised contrary to the purposes and principles of this TRANSHUMANIST BILL OF RIGHTS.

Article II. The enumeration in this TRANSHUMANIST BILL OF RIGHTS of certain rights shall not be construed to deny or disparage any other rights retained by sentient entities.

Article III. All sentient entities shall be granted equal and total access to any universal rights to life. All sentient entities are created free and equal in dignity and rights. They are endowed with reason and conscience and should act towards one another in a spirit of brotherhood (without necessitating any particular gender or implying any particular biological or non-biological origin or composition).

Article IV. Sentient entities are entitled to universal rights of ending involuntary suffering, making personhood improvements, and achieving an indefinite lifespan via science and technology. The right of ending involuntary suffering does not refer to euthanasia but rather to the application of technology to eliminate involuntary suffering in still-living beings, while enabling their lives to continue with improved quality and length.

Article V. No coercive legal restrictions should exist to bar access to life extension and life expansion for all sentient entities. Life expansion includes life extension, sensory improvements, and other technologically driven improvements of the human condition that might be achieved in the future.

Article VI. Involuntary aging shall be classified as a disease. All nations and their governments will actively seek to dramatically extend the lives and improve the health of their citizens by offering them scientific and medical technologies to overcome involuntary aging.

Article VII. All sentient entities should be the beneficiaries of a system of universal health care. A system of universal health care does not necessitate any particular means, policy framework, source, or method of payment for delivering health care. A system of universal health care may be provided privately, by governments, or by some combination thereof, as long as, in practice, health care is abundant, inexpensive, accessible, and effective in curing diseases, healing injuries, and lengthening lifespans.

Article VIII. Sentient entities are entitled to the freedom to conduct research, experiment, and explore life, science, technology, medicine, and extraterrestrial realms to overcome biological limitations of humanity. Such experimentation will not be carried out on any sapient being, without that being’s informed consent. Sentient entities are also entitled to the freedom to create cybernetic artificial organs, bio-mechatronic parts, genetic modifications, systems, technologies, and enhancements to extend lifespan, eradicate illness, and improve all sentient life forms. Any such creations that demonstrate sapience cannot be considered property and are protected by the rights presented herein.

Article IX. Legal safeguards should be established to protect individual free choice in pursuing peaceful, consensual life-extension science, health improvements, body modification, and morphological enhancement. While all individuals should be free to formulate their independent opinions regarding the aforementioned pursuits, no hostile cultural, ethnic, or religious perspectives should be entitled to apply the force of law to erode the safeguards protecting peaceful, voluntary measures intended to maximize the number of life hours citizens possess.

Article X. Sentient entities agree to uphold morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not harm others.

This right includes the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient has the right to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

Morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

However, the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms inflicted upon others. Furthermore, any sentient entity is also recognized to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

Article XI.  An altered, augmented, cybernetic, transgenic, anthropomorphic, or avatar sentient entity, whether derived from or edited by science, comprised of or conjoined with technology, has the right to exist, form, and join the neo-civilization.

Article XII.  All sentient entities are entitled to reproductive freedom, including through novel means such as the creation of mind clones, monoparent children, or benevolent artificial general intelligence. All sentient entities of full age and competency, without any limitation due to race, nationality, religion, or origin, have the right to marry and found a family or to found a family as single heads of household. They are entitled to equal rights as to marriage, during marriage, and at its dissolution. Marriage shall be entered into only with the free and full consent of the intending spouses. All families, including families formed through novel means, are entitled to protection by society and the State. All sentient entities also have the right to prevent unauthorized reproduction of themselves in both a physical and a digital context. Privacy and security legislation should be enacted to prevent any individual’s DNA, data, or other information from being stolen and duplicated without that individual’s authorization.

Article XIII. No sentient entity shall be subjected to arbitrary interference with his, her, or its privacy, family, home, or correspondence, nor to attacks upon his, her, or its honor and reputation. Every sentient entity has the right to the protection of the law against such interference or attacks. All sentient entities have privacy rights to personal data, genetic material, digital, biographic, physical, and intellectual enhancements, and consciousness. Despite the differences between physical and virtual worlds, equal protections for privacy should apply to both physical and digital environments. Any data, such as footage from a public security camera, archived without the consent of the person(s) about whom the data were gathered and subject to legal retention, shall be removed after a period of seven (7) years, unless otherwise requested by said person(s).

Article XIV. No sentient entity shall be subjected to arbitrary arrest, detention or exile. Sousveillance laws should be enacted to ensure that all members of peaceful communities feel safe, to achieve governmental transparency, and to provide counter-balances to any surveillance state. For instance, law-enforcement officials, when interacting with the public, should be required to wear body cameras or similar devices continuously monitoring their activities.

Article XV. All sentient entities, with the exception only of those in legal detention, have the right to private internet access without such access being prohibited or circumvented by either private corporations or governmental bureaucracy.

Article XVI. All sentient entities are equal before the law and are entitled without any discrimination to equal protection of the law. All sentient entities are entitled to equal protection against any discrimination in violation of this TRANSHUMANIST BILL OF RIGHTS and against any incitement to such discrimination.All sentient entities should be protected from discrimination based on their physical form in the context of business transactions and law enforcement.

Article XVII. All sentient entities have the right to life, liberty and security of person. All sentient entities have the right to defend themselves from attack, in both physical and virtual worlds.

Article XVIII. Societies of the present and future should afford all sentient entities sufficient basic access to wealth and resources to sustain the basic requirements of existence in a civilized society and function as the foundation for pursuits of self-improvement. This includes the right to a standard of living adequate for the health and well-being of oneself and one’s family, including food or other necessary sources of energy, clothing, housing or other appropriate shelter, medical care or other necessary physical maintenance, necessary social services, and the right of security in the event of involuntary unemployment, sickness, disability, loss of family support, old age, or other lack of livelihood in circumstances beyond the sentient entity’s control. Present and future societies should ensure that their members will not live in poverty solely for being born to the wrong parents. All children and other recently created sentient entities, irrespective of the manner or circumstances of their creation, shall enjoy the same social protection. Each sentient entity, as a member of society, has the right to social security and is entitled to realization, through national effort and international co-operation and in accordance with the organization and resources of each State, of the economic, social, and cultural rights indispensable for his, her, or its dignity and the free development of his, her, or its personality.

Article XIX. Irrespective of whether or not technology will eventually replace the need for the labor of sentient entities, all sentient entities should be the beneficiaries of an unconditional universal basic income, whereby the same minimum amount of money or other resources is provided irrespective of a sentient entity’s life circumstances, occupations, or other income sources, so as to provide a means for the basic requirements of existence and liberty to be met.

Article XX. Present and future societies should provide education systems accessible and available to all in pursuit of factual knowledge to increase intellectual acuity; promote critical thinking and logic; foster creativity; form an enlightened collective; attain health; secure the bounty of liberty for all sentient entities for our posterity; and forge new ideas, meanings, and values. All sentient entities have the right to education. Education shall be free, at least in the elementary and fundamental stages. Technical and professional education shall be made generally available, and higher education shall be equally accessible to all on the basis of merit. Education shall be directed to the full development of the sentient entity’s personality and to the strengthening of respect for all sentient entities’ rights and fundamental freedoms. It shall promote understanding, tolerance, and friendship among all nations, racial, religious, and other sentient groups – whether biological, non-biological, or a combination thereof – and shall further the maintenance of peace. Parents and other creators of sentient entities have a prior right to choose the kind of education that shall be given to their children or other recently created sentient entities which have not yet developed sufficient maturity to select their own education.

Article XXI. All sentient entities are entitled to join their psyches to a collective noosphere in an effort to preserve self-consciousness in perpetuity. The noosphere is the sphere of human thought and includes, but is not limited to, intellectual systems in the realm of law, education, philosophy, technology, art, culture, and industry. All sentient entities have the right to participate in the noosphere using any level of technology that is conducive to constructive participation.

Article XXII. Sentient entities will take every reasonable precaution to prevent existential risks, including those of rogue artificial intelligence, asteroids, plagues, weapons of mass destruction, bioterrorism, war, and global warming, among others.

Article XXIII. All nations and their governments will take all reasonable measures to embrace and fund space travel, not only for the spirit of adventure and to gain knowledge by exploring the universe, but as an ultimate safeguard to its citizens and transhumanity should planet Earth become uninhabitable or be destroyed.

Article XXIV. Transhumanists stand opposed to the post-truth culture of deception. All governments should be required to make decisions and communicate information rationally and in accordance with facts. Lying for political gain or intentionally fomenting irrational fears among the general public should entail heavy political penalties for the officials who engage in such behaviors.

Article XXV. No sentient entity shall be held in slavery or involuntary servitude; slavery and the slave trade shall be prohibited in all their forms.

Article XXVI. No sentient entity shall be subjected to torture or to treatment or punishment that is cruel, degrading, inhuman, or otherwise unworthy of sentience or sapience.

Article XXVII. Each sentient entity has the right to recognition everywhere as a person before the law.

Article XXVIII. All individual sentient entities have the right to an effective remedy by the competent local, national, international, or interplanetary tribunals for acts violating the fundamental rights granted them by the constitution, by law, and/or by this TRANSHUMANIST BILL OF RIGHTS.

Article XXIX. All individual sentient entities are entitled in full equality to a fair and public hearing by an independent and impartial tribunal, in the determination of their individual rights and obligations and of any criminal charge against them.

Article XXX. All individual sentient entities charged with a penal offence have the right to be presumed innocent until proved guilty according to law in a public trial at which they individually have had all the guarantees necessary for their defense. No sentient entity shall be held guilty of any penal offence on account of any act or omission which did not constitute a penal offence, under national or international law, at the time when it was committed. Nor shall a heavier penalty be imposed than the one that was applicable at the time the penal offence was committed.

Article XXXI. All sentient entities have the right to freedom of movement and residence within the borders of each state. Each individual sentient entity has the right to leave any country, including his, her, or its own, and to return to his, her, or its country.

Article XXXII. All sentient entities have the right to seek and to enjoy in other countries asylum from persecution. This right may not be invoked in the case of prosecutions genuinely arising from non-political crimes or from acts contrary to the purposes and principles of this TRANSHUMANIST BILL OF RIGHTS.

Article XXXIII. All sentient entities have the right to a nationality. No sentient entity shall be arbitrarily deprived of his, her, or its nationality nor denied the right to change his, her, or its nationality.

Article XXXIV. All sentient entities have the right to own property alone as well as in association with others. No one shall be arbitrarily deprived of his, her, or its property.

Article XXXV. All sentient entities have the right to freedom of thought, conscience and religion; this right includes freedom to change one’s religion or belief, and freedom, either alone or in community with others and in public or private, to manifest one’s religion or belief in teaching, practice, worship, and observance. This right also includes freedom not to have a religion and to criticize or refuse to engage in any religious practice or belief without adverse legal consequences.

Article XXXVI. All sentient entities have the right to freedom of opinion and expression; this right includes freedom to hold opinions without interference and to seek, receive, and impart information and ideas through any media and regardless of frontiers.

Article XXXVII. All sentient entities have the right to freedom of peaceful assembly and association. No sentient entity may be compelled to belong to an association.

Article XXXVIII. All sentient entities have the right to take part in the government of their countries, directly or through freely chosen representatives. All sentient entities have the right of equal access to public service in their countries. The will of the constituent sentient entities shall be the basis of the authority of government; this will shall be expressed in periodic and genuine elections which shall be by universal and equal suffrage of sentient entities and shall be held by secret vote or by equivalent free voting procedures.

Article XXXIX. All sentient entities have the right to work, to free choice of employment, and to just and favorable conditions of work, as long as employment is offered or considered economically necessary in the sentient entity’s proximate society and contemporary epoch. All sentient entities who choose to work have the right to equal pay for equal work. All sentient entities who choose to work have the right to just and favorable remuneration, ensuring for themselves and their families an existence worthy of human dignity, and supplemented, if necessary, by other means of social protection, such as a universal basic income. All sentient entities have the right to form and join trade unions for the protection of their interests; however, no sentient entity may be compelled to join a trade union as a condition of employment.

Article XL. All sentient entities have the right to rest and leisure commensurate with the physical requirements of those sentient entities for maintaining optimal physical and mental health, including reasonable limitation of working hours and periodic holidays with pay in societies where paid employment is considered economically necessary.

Article XLI. All sentient entities have the right freely to participate in the cultural life of the community, to enjoy the arts, and to share in scientific advancement and its benefits. All sentient entities have the right to the protection of the moral and material interests resulting from any scientific, literary, or artistic production of which they are the authors.

Article XLII. All sentient entities are entitled to a social and international order in which the rights and freedoms set forth in this TRANSHUMANIST BILL OF RIGHTS can be fully realized.

Article XLIII. Nothing in this TRANSHUMANIST BILL OF RIGHTS may be interpreted as implying for any State, group, or sentient entity any right to engage in any activity or to perform any act aimed at the destruction of any of the rights and freedoms set forth herein.

Fifth Enlightenment Salon – Discussions on Longevity, Gene Therapy, Overcoming Disabilities, Animal Lifespans, Education, and Privacy

Fifth Enlightenment Salon – Discussions on Longevity, Gene Therapy, Overcoming Disabilities, Animal Lifespans, Education, and Privacy

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Gennady Stolyarov II
Bill Andrews
James Kohagen
Bobby Ridge
John Murrieta


On October 13, 2018, in the spirit of the Age of Enlightenment and its furtherance today, Gennady Stolyarov II, Bill Andrews, James Kohagen, Bobby Ridge, and John Murrieta met for the fifth interdisciplinary discussion – hosted by Mr. Stolyarov – on science, culture, education, advocacy, and policy. Subjects discussed included the following:

– The recent RAAD Fest 2018 in San Diego
– Developments in the field of gene therapy
– Advances in epidural stimulation for treating and overcoming spinal-cord injuries
– Long-lived organisms and their similarities and dissimilarities to humans
– How animal experiments can become more humane
– How contemporary science still has far to go to accumulate even fairly basic information about certain organisms
– How the study of lifespans can be included in educational curricula starting at early childhood
– Whether privacy will remain in a more technologically interconnected future.

Join the U.S. Transhumanist Party for free, no matter where you reside by filling out an application form that takes less than a minute.

Find out about Death is Wrong – the illustrated children’s book on indefinite life extension.

U.S. Transhumanist Party Meeting at RAAD Fest 2018 – September 22, 2018

U.S. Transhumanist Party Meeting at RAAD Fest 2018 – September 22, 2018


On September 22, 2018, representatives of the U.S. Transhumanist Party met in San Diego, California, during RAAD Fest 2018, in order to provide an overview of recent efforts and future prospects, discuss approaches to advocacy with several leading transhumanist public figures, and field audience questions regarding the transhumanist movement and its goals.

Watch the video of the meeting on YouTube here.

Participants at the meeting included the following individuals:
Gennady Stolyarov II, Chairman, U.S. Transhumanist Party
Arin Vahanian, Director of Marketing, U.S. Transhumanist Party
Newton Lee, Chairman, California Transhumanist Party, U.S. Transhumanist Party Education and Media Advisor
José Luis Cordeiro, U.S. Transhumanist Party Technology Advisor and Foreign Ambassador to Spain
Natasha Vita-More, Member of Los Angeles City Council (1992-1993), Elected on a Transhumanist Platform, Executive Director of Humanity Plus
Bill Andrews, U.S. Transhumanist Party Biotechnology Advisor
Charlie Kam, Director of Networking, California Transhumanist Party
Elizabeth (Liz) Parrish, U.S. Transhumanist Party Advocacy Advisor

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

The Longevity Film Competition – Announcement by SENS Research Foundation, The Healthy Life Extension Society, and International Longevity Alliance

The Longevity Film Competition – Announcement by SENS Research Foundation, The Healthy Life Extension Society, and International Longevity Alliance

SENS Research Foundation
The Healthy Life Extension Society 
International Longevity Alliance


Editor’s Note: The U.S. Transhumanist Party encourages its members to participate in the Longevity Film Competition, whose official website can be found here. The more original attempts exist to convey to the general public the feasibility and desirability of indefinite life extension, and to dispel common misconceptions about it, the sooner we will have the critical mass of public support needed to bring about this most vital goal. 

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party, July 15, 2018


Contest Introduction: 

We are living in very interesting times, times of constant change. The scientific community is telling us that soon we could enjoy much healthier and longer lives thanks to technological advancements happening at an accelerated rate. The future can be bright and healthy, and we want more people to know about this amazing prospect and want them to get involved in this important mission – the mission of healthy longevity.

However, describing something potentially beautiful is not always easy. We think you can help by making a (very) short movie conveying that a longer and healthier life thanks to sustainable medical interventions, will be a very positive thing for citizens and society alike.

Help us spread the word in the right way, help us make sure people understand this is about health and that for the first time in history the possibility of tackling aging is not science fiction, but science fact.

Join us in this crusade by entering our competition presented by the SENS Research Foundation, The Healthy Life Extension Society and the International Longevity Alliance and not only potentially help saving lots of lives, but also win the first prize of $10,000!

We look forward to your ideas on how to better communicate this important message to the world.

– The Longevity Film Competition team

Contest Guidelines: 

Even though putting aging under medical control is probably desirable to most humans, this concept is not always clear to everybody.

One of our goals is to use this competition as a vehicle to clarify and demystify some of the misconceptions we hear very often.

You can choose just one or all of them and explain them in any way you choose, using your own language and ideas.

Misconception #1

“Aging and disease are two separate things.”

CLARIFICATION:

— Aging causes disease, and they should be treated as one. —

As we age, we lose our health. We cannot age and become elderly without eventually getting ill as a result of it. If we live long enough, we will all get sick of one or several of the diseases of aging and eventually succumb to them. When we talk about eliminating aging, we talk about putting this process under medical control so that we don’t have to get sick as we age.

Misconception #2

“If I live to a 150, I will be living for a long time in an old, sick body.”

CLARIFICATION:

— If these new therapies help us live to a 150, it will only be because they will keep us strong and healthy. —

When we talk about extending our lifespan, we are talking about extending our health. The extension of our life will not happen unless we fix the health problems that come with aging. Once we do this, more longevity will happen as a “side benefit” of being healthier. As we said before, we get sick with aging, and that’s why most of humans die of old age.

So, if we will still be alive at 150, this will mean we will have a better control of the aging process through medical interventions – hence we should not be living in an old sick body.

Misconception #3

“Aging is natural, and we shouldn’t tamper with the natural.”

CLARIFICATION:

— Combating aging is a great challenge for Humanity, and we have a long history of getting great benefit from tampering with many natural things. —

It is proven that there are endless ‘unnatural’ things created by humans of enormous value and positive outcomes, and we can imagine only a minuscule number of people who would choose to live without them — especially when it has to do with suffering, disease and death.

A few examples of unnatural things we use all the time without questioning much are: pacemakers, antibiotics (to kill natural bacteria), painkillers, cochlear implants, dialysis, plastic surgery, airplanes (it is not natural for us to fly), hair coloring, prosthetic limbs, contact lenses, birth-control methods, and the list goes on forever.

On the other hand, here are some natural things that are definitely bad for us: earthquakes, hurricanes, mudslides, tornadoes, infectious microorganisms, poisonous plants, predators, venomous creatures, fire, gravity (when we fall), tsunamis, radiation, meteor impacts, etc.

It is time to reason and understand that “natural” doesn’t necessarily mean “good”.

Misconception #4

“These therapies will only be for the rich.”

CLARIFICATION:

— Healthy longevity therapies are being developed for everybody to access. —

Rejuvenation therapies could be as little reserved for rich people as mobile phones, cars, electricity, or vaccination may have been in the beginning. Like for most technological progress, the research may be complicated and expensive, but once the technology becomes available, it will become available for everybody. One good example is that the first Human Genome took $2.7 billion dollars and almost 15 years to complete. In 2001 the price of sequencing a genome was 100 Million dollars; today is under 1000 dollars, and it will keep going down without a doubt. Humanity has never stopped advancing just because it was harder and less cost-effective in the beginning; if we had thought like that, we would probably not have most of the technology that is available for everybody today. That’s one more reason why it’s so important not to delay the development of these cures.

Official Rules

  1. Concept of film: The submitted piece should show that medical progress for a healthier and longer life is generally a good thing for citizens and society alike. You will achieve this by using the list of common misconceptions provided in the Guidelines section above. You must choose at least one and may also choose all of them.
  2. Length: The length of the film should be a minimum of 1 minute and a maximum of 20 minutes.
  3. Visual art style: All kinds of visuals are allowed:
    Films, computer animations, whiteboard drawings, live action, infographics, stop and motion, cartoons, typography, screencast, etc.
  4. Genre: All genres are allowed. Science, fiction or science-fiction, a story, sad or funny, a docufiction, a documentary, etc.
  5. Copyright: All material used in the video should be original, or you should own the copyright for it. You may not use copyrighted material for which you don’t have the rights. If you fail to follow this rule, your film will be automatically disqualified.
  6. Submission: The submission deadline is 23:59 GMT September 15, 2018. The final work should be uploaded to the Internet, and a link to watch it should be provided to us via email at contact@longevityfilmcompetition.com, together with your last name, first name, and the proposed title of the work. The winners will be announced October 1st (International Longevity Day).
  7. Language: The official language is English. Videos can also be submitted in French, Spanish, Italian, German, Russian and Dutch but would need to have English subtitles.
  8. Work Originality and Permissions: a) Films must be the original work of the applicants, and they must be unpublished before July 1st, 2018. b) If a film is based upon another person’s life or upon a book or other underlying work, applicant(s) must secure any necessary rights to make such adaptations. c) By entering the competition, you represent that you have secured all necessary rights. d) Applicants are solely responsible for obtaining all necessary rights and permissions for third-party materials included in their films, including but not limited to music, trademarks, logos, copyrights, and other intellectual property rights. e) Longevity Film Competition (LFC) expressly disclaims all liability or responsibility for any violations of the foregoing. f) If your submission is selected for a prize, you agree that SENS Research Foundation (SRF), The Healthy Life Extension Society (Heales), and the International Longevity Alliance (ILA) use your movie without restriction to promote the mission of curing the diseases of aging. SRF, Heales and the ILA can show your work on the internet or by all other means. g) SRF, Heales and the ILA are non-profit organizations and may use the films to drive donations from the public, which will be used to advance the mission of healthy longevity. Any funds raised though the films will support scientific research, outreach, and/or education programs.
  9. Selected Films and Winners: a) LFC has no obligation (other than as stated in these rules or on our website) to disclose any of the following information: i) identities of screeners or judges; ii) notes, feedback, or information relating to the submitted project; and/or iii) details regarding the submission review or selection process. b) LFC explicitly disclaims any liability or responsibility for any comments, notes, or opinions expressed about a submission, whether by LFC or by its volunteers.  c) Winners will be announced on October 1st, 2018. The judges’ decision is final. Winners receiving cash prizes are solely responsible for payment of all applicable local, state, and federal taxes.
  10. Legal action: In the event of litigation the competent courts will be those of the Brussels jurisdiction in Belgium.
  11. Additional information: For all issues not mentioned above, the members of the jury will decide. They must decide in equity and with the same rules for all competitors.

COMPETITION LEGAL TERMS

BY SUBMITTING THE MATERIAL PARTICIPANTS  AGREE:

To having read all of the rules, understood, and have complied with these rules.

To warrant that their work is original and that there are no disputes regarding the ownership of their submission.

To warrant that the submitted material does not defame or invade the rights of any person living or dead.

That failure to adhere to the competition rules and regulations will result in disqualification.

That no revisions of materials will be accepted once entry has been submitted.

That to the best of their knowledge, all the statements herein are true and correct.

TO INDEMNIFY, HOLD HARMLESS, AND DEFEND THE COMPETITION, ITS EMPLOYEES, VOLUNTEERS, DIRECTORS, JURORS, REPRESENTATIVES, AND AFFILIATES FROM ALL LIABILITY, CLAIMS, AND DAMAGES IN CONNECTION WITH THE SUBMISSION AND FROM ANY FEES AND EXPENSES, INCLUDING BUT NOT LIMITED TO REASONABLE ATTORNEYS’ FEES, THAT ANY OF THEM MAY INCUR IN CONNECTION THEREWITH.
Fourth Enlightenment Salon – Gennady Stolyarov II, Bill Andrews, Bobby Ridge, and John Murrieta Discuss Transhumanist Outreach and Curing Disabilities

Fourth Enlightenment Salon – Gennady Stolyarov II, Bill Andrews, Bobby Ridge, and John Murrieta Discuss Transhumanist Outreach and Curing Disabilities

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Gennady Stolyarov II
Bill Andrews
Bobby Ridge
John Murrieta


On July 8, 2018, during his Fourth Enlightenment Salon, Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, invited John Murrieta, Bobby Ridge, and Dr. Bill Andrews for an extensive discussion about transhumanist advocacy, science, health, politics, and related subjects. In this first of several installments from the Fourth Enlightenment Salon, the subjects of conversation include the following:

• The U.S. Transhumanist Party’s recent milestone of 1,000 members and what this portends for outreach toward the general public regarding the meaning of transhumanism and the many ways in which emerging technologies help make life better.

• The new channel – Science-Based Species – launched by Bobby Ridge and John Murrieta to spread basic knowledge about transhumanism, key thinkers in the movement, and advances on the horizon.

• How today’s technologies to assist the disabled are already transhumanist in their effects, and how technologies already in development can liberate humans from disability altogether. John Murrieta’s story is one of transhumanism literally saving a life – and one of the most inspiring examples of how transhumanism translates into human well-being now and in the future.

Join the U.S. Transhumanist Party for free, no matter where you reside by filling out an application form that takes less than a minute. Members will also receive a link to a free compilation of Tips for Advancing a Brighter Future, providing insights from the U.S. Transhumanist Party’s Advisors and Officers on some of what you can do as an individual do to improve the world and bring it closer to the kind of future we wish to see.

California Transhumanist Party Leadership Meeting – Presentation by Newton Lee and Discussion on Transhumanist Political Efforts

California Transhumanist Party Leadership Meeting – Presentation by Newton Lee and Discussion on Transhumanist Political Efforts

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Newton Lee
Gennady Stolyarov II
Bobby Ridge
Charlie Kam


The California Transhumanist Party held its inaugural Leadership Meeting on January 27, 2018. Newton Lee, Chairman of the California Transhumanist Party and Education and Media Advisor of the U.S. Transhumanist Party,  outlined the three Core Ideals of the California Transhumanist Party (modified versions of the U.S. Transhumanist Party’s Core Ideals), the forthcoming book “Transhumanism: In the Image of Humans” – which he is curating and which will contain essays from leading transhumanist thinkers in a variety of realms, and possibilities for outreach, future candidates, and collaboration with the U.S. Transhumanist Party and Transhumanist Parties in other States. U.S. Transhumanist Party Chairman Gennady Stolyarov II contributed by providing an overview of the U.S. Transhumanist Party’s current operations and possibilities for running or endorsing candidates for office in the coming years.

Visit the website of the California Transhumanist Party: http://www.californiatranshumanistparty.org/index.html

Read the U.S. Transhumanist Party Constitution: http://transhumanist-party.org/constitution/

Become a member of the U.S. Transhumanist Party for free: http://transhumanist-party.org/membership/

(If you reside in California, this would automatically render you a member of the California Transhumanist Party.)

Exercise is Currently the Best Way to Slow Down Aging – Article by Michael Falk

Exercise is Currently the Best Way to Slow Down Aging – Article by Michael Falk

Michael Falk


Editor’s Note: In this article, Mr. Michael Falk explains how exercising slows down aging. This article was originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Kenneth Alum, Director of  Publication, U.S. Transhumanist Party, January 25, 2018

We have all heard that exercise is good for our health. However, it can not only keep you healthy, it can also slow down some aspects of aging. Some researchers even think that it might be possible to use this knowledge to develop new therapies against aging. While waiting for that to happen, we need to exercise in order to slow down the effects of aging.

How important is it to keep fit?

So, how beneficial is exercising? Well, one of the best studies conducted on this subject showed that women will live 5.6 years longer and men 6.2 years longer if they exercise between 1 and 2.5 hours per week [1]. This makes exercise a better lifestyle choice than any other, at least as long as you’re not counting avoiding downright dangerous behavior, such as smoking.

The main benefits of physical activity may come from better health for the heart. Exercise lessens the risk for many types of heart disease [2]. It is even more beneficial for people who already suffered age-related conditions, including stroke and coronary heart disease, and it is more effective than any known drug in preventing repeated episodes [3].

The key improvements also include increased muscle strength, stronger bones, better weight control, and improved cognitive function. This means less risk of age-related diseases, such as Alzheimer’s disease, as well as lethal falls, which are a major risk for the elderly.

The conclusion is that exercise helps with a lot of different aspects of your health in several ways, and we can summarize its effects as improving quality of life and increasing healthspan.

How much exercise do you need?

More exercise does not always improve outcomes. Professional athletes exercise more than the rest of us, and they generally live longer than the average person [4]. However, correlation isn’t causation, and robust individuals are perhaps more likely to become athletes, instead of the other way around. There could even be negative effects from too much exercise, although that is far from certain.

Even moderate exercise leads to better health. Half an hour a day seems to be enough to see positive effects, and it is also a common recommendation for the minimum amount of exercise you should get. The biggest difference can be seen between people who hardly move around at all and people who get at least a little exercise a few times a week. Taking the stairs and walking short distances is clearly better than nothing. In fact, some studies show that even light activity, such as housework, can have an effect on mortality risk.

It should also be noted that there are different types of exercise and that these could have different benefits. Jogging increases your aerobic ability, which should, among other things, lead to better heart health. Lifting weights is an anaerobic exercise that improves strength and should bring other benefits, such as stronger bones. A lot of research about this has been done already, but so far, we don’t definitively know the optimal amount and type of training for each particular type of person.

Drugs to mimic exercise

Some of the positive effects have to do with the anti-inflammatory processes that occur when exercising [5]. Other mechanisms appear to be involved, although more research on these mechanisms is needed.

Since the advantages of exercise are clear, the idea has occurred to some researchers that it may be possible to mimic the effects of exercise without doing the hard work and getting sweaty. Research is now being conducted using drugs that target the same mechanisms to try to get the same benefits of exercise.

This typically involves adjusting a part of the human metabolism, which is not an easy matter. However, there have been at least some tentative breakthroughs already, and last year, a team found a drug that boosted the endurance of mice by roughly 70 percent [6]. Where this might lead in the future is not clear, but some positive effects may come from this research.

Will exercise lead to longevity?

Even though exercise is beneficial for your health, there is no guarantee it will keep you alive until you reach 100, although staying fit will almost certainly improve your chances. This is why if we want to remain in good health and live longer, we need to develop rejuvenation biotechnology and therapies that address the aging processes directly. That said, if you want to increase your chances of living long enough to see these therapies arrive, then exercise is the best option you have right now.

Literature

[1] Schnohr, P., Lange, P., Scharling, H., & Jensen, J. S. (2006). Long-term physical activity in leisure time and mortality from coronary heart disease, stroke, respiratory diseases, and cancer. The Copenhagen City Heart Study. European Journal of Cardiovascular Prevention & Rehabilitation, 13(2), 173-179.

[2] Jakovljevic, D. G. (2017). Physical activity and cardiovascular aging: Physiological and molecular insights. Experimental Gerontology.

[3] Naci, H., & Ioannidis, J. P. (2013). Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. Bmj, 347, f5577.

[4] Lemez, S., & Baker, J. (2015). Do elite athletes live longer? a systematic review of mortality and longevity in elite athletes. Sports medicine-open, 1(1), 16.

[5] Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M. X., Wall, C. E., … & Auwerx, J. (2017). PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metabolism, 25(5), 1186-1193.

[6] Dimitrov, S., Hulteng, E., & Hong, S. (2017). Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β 2-adrenergic activation. Brain, behavior, and immunity, 61, 60-68.

About Michael Falk

Michael Falk is a communication specialist with 15 years of experience writing about healthcare and technology. He has been an advocate of longevity research since 2013, when he started his longevity blog Unggamma (www.unggammal.se).

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.

Looking Back at 2017: A Year in Rejuvenation Biotechnology – Article by Nicola Bagalà

Looking Back at 2017: A Year in Rejuvenation Biotechnology – Article by Nicola Bagalà

Nicola Bagalà


 

Editor’s Note: In this article, Mr. Nicola Bagalà highlights various events of rejuvenation biotechnology in the year 2017.  This article was originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Kenneth Alum, Director of  Publication, U.S. Transhumanist Party, January 11, 2018

Winter kick-off

This year has been pretty intense, with a lot going on both at LEAF and in the rest of the community. January saw the launch of the LEAF website, shortly followed by both the Lifeboat Foundation and Trust me – I’m a biologist partnering with us. Given that it’s been only a year, we’re amazed at how enthusiastic and supportive the community has been—and how fast it has grown, with nearly 30,000 Facebook followers late in December! We’re also very grateful to our friends at Fight Aging! for their encouragement, support, and appreciation for our work, including honoring us by featuring it on their website!

In February, the CellAge campaign launched in late 2016 concluded successfully, also thanks to the matching fund put together by Longecity. That’s also when LEAF President Keith Comito met Mikhail Batin to discuss the Russian initiative Open Longevity and when Series A funding was announced for LYSOCLEAR, a LysoSENS-based approach to treating macular degeneration.

An eventful spring

The Lifespan Heroes campaign was launched in the spring, and thus far, it has greatly helped us carry out our activities, especially in terms of web development—so thank you to all our generous donors!

In the spring, we also started our advocacy projects with global policymakers. During April 10-15, LEAF Board Director Elena Milova attended a training program conducted by the International Institute on Ageing (INIA) in Saint Petersburg, where she met and interviewed INIA director Dr. Marvin Formosa and former Head of the UN Programs on Ageing Dr. Alexandre Sidorenko.

Later in April, the SENS Research Foundation announced a collaboration on a cellular senescence project with the Buck Institute for Research on Aging.

The month of May was busy with conferences and networking; at the International Longevity and Cryopreservation Summit in Madrid, Elena Milova had the opportunity to interview life extension advocate Didier Coeurnelle, London Futurists Chair David Wood, Dr. Jose Luis Cordeiro, Senior Scientist at CONICET Dr. Rodolfo Goya (we hope to support his studies related to Yamanaka factors in 2018 via crowdfunding at Lifespan.io), and SRF’s Chief Science Officer Dr. Aubrey de Grey. Elena herself gave a talk about effective life extension advocacy methodologies; LEAF board member Paul Spiegel also gave a talk about the need for society to adapt to longer lives. In Paris, the International Cell Senescence Association (ICSA) held a conference discussing senescence triggers, physiological functions of senescence, and pathologies and therapies. We announced the event here.

Our Journal Club series was also launched at the end of May, for a total of eight Journal Club episodes this year, which you can watch here. The Journal Club is a monthly science show on which Dr. Oliver Medvedik hosts guests, and this show is supported by our patrons, the Lifespan Heroes. We broadcast this show live to our Facebook Page every month, where we invite the audience to ask questions and join in with the discussion.

Summer news

In the summer, LEAF and MMTP co-hosted a panel featuring Dr. Alexandra Stolzing, Dr. Aubrey de Grey, and Dr. Oliver Medvedik. This live broadcast included discussions about funding, research progress, and advocacy, providing some interesting insights into the field. They were joined by Alen Akhabaev, one of the project donors who supported the MMTP project on Lifespan.io, as well as Steve Hill and Elena Milova from the MMTP and LEAF.

The AgeMeter campaign was launched on Lifespan.io by Elliott Small in July, and in August, we celebrated the first birthday of our crowdfunding platform—you could say Lifespan.io’s birthday present was the MouseAge campaign launched shortly thereafter. The campaign was successful, and the MouseAge app is now ready and expected to be launched shortly. The use of AI is trending more and more in the field of aging research, so this app is certainly only one of many that will be employed in the future.

A great autumn

The autumn has been, without doubt, the busiest time of the year. The Undoing Aging conference was announced by the Forever Healthy Foundation in September, as was a series of small-scale human senolytic pilot studies by Betterhumans. Almost at the same time as the AgeMeter campaign reached 100% of its goal, Dr. Aubrey de Grey joined our SAB (Scientific Advisory Board), shortly followed by Dr. Robert Shmookler Reis. At this time, SRF and the Spiegel Lab launched a collaboration on developing monoclonal antibodies against glucosepane.

September also saw the Basel Life 2017 conference held in Basel, Switzerland, where Dr. Alex Zhavoronkov chaired the Artificial intelligence and block chain in healthcare and the Aging & drug discovery forums. Insilico Medicine’s Young.AI aging-rate tracking app was officially announced at this conference.

Juvenescence by Jim Mellon and Al Chalabi—a thorough, investor-focused introduction to the science of aging and the world of rejuvenation biotech—was published on September 25. LEAF has published two reviews of the book, which you can read here and here.

Open Longevity ICO, a Russian project focused on conducting clinical trials of geroprotective therapies and introducing diagnoses of aging into clinical practice, was launched in September. It is currently entering the second phase of pre-ICO, and we wish Anastasia Egorova’s team good luck.

In October (which is traditionally considered the Longevity Month) we launched the #IAmTheLifespan campaign, inviting all our supporters to make videos describing what brought them to join our cause, and you can watch some of them here. To help out MouseAge, and for Inktober 2017, our volunteer Laura Weston launched a fundraiser offering her beautiful artwork as a reward for donors.

The Pathways to Healthy Longevity 2017 conference was organized on October 15th by Dr. Ilia Stambler, a famous longevity activist, in Bar Ilan University (Israel), with Prof. Nir Barzilai and Prof. Haim Cohen as key speakers.

In late October and early November, the popular YouTube channel Kurzgesagt published End Aging? and Cure Aging?, which were both created with help from the Lifespan.io team. We saw overwhelming support from old and new members of the community, showing that healthy life extension is much more popular with the public than one might think.

As MouseAge reached and surpassed its goal, news started to spread that WHO was planning to leave healthy aging out of the general programme of work 2019-2023; thanks to the advocacy efforts of the community, though, WHO has received plenty of feedback on the issue and may hopefully reconsider.

During November 8-10th, the TransVision conference was held in Brussels. It was organised by Didier Coeurnelle, the head of HEALES, the Healthy Life Extension Society. Among its other objectives, the Technoprogressive declaration presented at the conference mentions the defeat of aging; it’s good to see that this objective is now considered to be of primary importance by a growing number of organisations.

During December, LEAF took part in Project4Awesome; many amazing videos were made to support us, and we’re really grateful to the community for that. It was a truly beautiful display of generosity, and not the only one; thanks to many fantastic donors, including the mysterious Pineapple Fund creator, the SENS Research Foundation has smashed its funding goals for the year. You can read more about the December highlights here.

Coming up in 2018

In 2018, we will be working towards creating more major media collaborations with awesome content creators to spread further awareness about the problem of aging and the upcoming advent of rejuvenation biotechnologies.

Our web development team will be, and in fact already is, working on improving the overall user experience of our followers and scaling our systems up to meet the needs of a larger user base; we experienced a significant growth in this sense after our collaboration videos with Kurzgesagt were published, and we’re most definitely looking forward to this happening again!

Our Journal Club will, of course, continue discussing and providing commentary on the latest aging research news in the company of special guests from the biogerontology world. More livestream events are in the cards too, so keep an eye on our Facebook page, and subscribe if you haven’t already!

As the community grows larger, so does the need to establish and develop regional presences; our next objective will be starting the Russian chapter of LEAF to engage with a wider audience. Aging is a global problem, so the more communities and audiences we can get involved in the fight against age-related diseases, the better.

LEAF will naturally take part in as many events in the healthy longevity world as possible to keep our readers in the loop. A big must is definitely the March 15-17 Undoing Aging conference in Berlin, Germany, as is the April 22-26 Interventions to Extend Healthspan and Lifespan conference in Kazan, Russia. There will certainly be much exciting news to share, so stay tuned!

The Eurosymposium on Healthy Ageing—a scientific conference organized by the European aging research advocacy group HEALES—will be held in Brussels on November 8-10. It is likely that at least a few of the LEAF team will be at the event, and it is sure to be an interesting one.

Finally, of course, more exciting crowdfunding projects are in the works!

About Nicola Bagalà

Nicola Bagalà has been an enthusiastic supporter and advocate of rejuvenation science since 2011. Although his preferred approach to treating age related diseases is Aubrey de Grey’s suggested SENS platform, he is very interested in any other potential approach as well. In 2015, he launched the blog Rejuvenaction to advocate for rejuvenation and to answer common concerns that generally come with the prospect of vastly extended healthy lifespans. Originally a mathematician graduated from Helsinki University, his scientific interests range from cosmology to AI, from drawing and writing to music, and he always complains he doesn’t have enough time to dedicate to all of them which is one of the reasons he’s into life extension. He’s also a computer programmer and web developer. All the years spent learning about the science of rejuvenation have sparked his interest in biology, in which he’s planning to get a university degree.

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.