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Benchmark Database of Lifespan-Extending Drugs Announced – Press Release by Biogerontology Research Foundation

Benchmark Database of Lifespan-Extending Drugs Announced – Press Release by Biogerontology Research Foundation

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Note from the Editor: The following Press Release was originally published on EurekAlert! Science News by the Biogerontology Research Foundation. In accord with the U.S. Transhumanist Party’s open support of longevity science – in particular, Article V and Article VI of the Transhumanist Bill of Rights (v. 2.0) – we affirm our support by republishing the Press Release below.

~ B.J. Murphy, Director of Social Media, United States Transhumanist Party, March 16, 2017


Benchmark database of lifespan-extending drugs announced

Finding: The majority of age-related pathways have yet to be targeted pharmacologically

BIOGERONTOLOGY RESEARCH FOUNDATION

Scientists from the Biogerontology Research Foundation (BGRF) and University of Liverpool have announced a landmark database of lifespan-extending drugs and compounds called DrugAge. The database has 418 compounds, curated from studies spanning 27 different model organisms including yeast, worms, flies and mice. It is the largest such database in the world at this time. Significantly, the study found that the majority of age-related pathways have not yet been targeted pharmacologically, and that the pharmacological modulation of aging has by and large focused upon a small subset of currently-known age-related pathways. This suggests that there is still plenty of scope for the discovery of new lifespan-extending and healthspan-extending compounds.

DrugAge is the latest of a number of valuable resources freely available on the Human Aging Genomic Resources (HAGR) website created and maintained by the Integrative Genomics of Ageing Group at the University of Liverpool, led by Biogerontology Research Foundation Trustee Joao Pedro de Magalhaes, in collaboration with many other scientists worldwide, including BGRF Chief Science Officer and CEO of Insilico Medicine, Alex Zhavoronkov, PhD. Other resources available through HAGR include GenAge (a database of age and longevity-related genes in humans and model organisms), AnAge (a database on ageing, longevity records and life-history featuring over 4000 species), GenDR (a database of genes associated with the life extending effects of dietary restriction), and LongevityMap (a database of over 2000 human genes and genetic variations associated with longevity).

“DrugAge is the latest database created by Joao Pedro de Magalhaes, a world leader in the application of advanced bioinformatics and integrated computational approaches to biogerontology and ageing research. I am confident that it will gain widespread use in the ageing research community, and represents a significant milestone along the way to the coming paradigm shift in modern healthcare away from single disease treatment and toward geroprotective multi-disease prevention,” said Dmitry Kaminskiy, Managing Trustee of the Biogerontology Research Foundation.

The database is freely available to the public, and is searchable according to compound name, species and effect on lifespan. The data can be presented as both tables and interactive charts. Functional enrichment analysis of the targets of the database’s compounds was performed using drug-gene interaction data, which revealed a modest but statistically significant correlation between the cellular targets of the database’s compounds and known age-related genes.

The database encompasses the earlier efforts published by the BGRF scientists, Joao Pedro de Magalhaes, PhD and Alex Zhavoronkov, PhD as an open resource called Geroprotectors.org. The publication is available at http://www.aging-us.com/article/100799 .

“DrugAge represents a landmark resource for use in the biogerontology community. It is the largest database of lifespan-extending compounds compiled to date, and will surely come to be recognized as an extremely valuable resource for biogerontologists. Analysis performed using the database has already revealed interesting trends, including a modest but statistically significant overlap between lifespan-extending drugs and known age-related genes, a strong correlation between average/median lifespan changes and maximum lifespan changes, a strong correlation between the lifespan-extending effects of compounds between males and females, and perhaps most significantly that most known age-related pathways have yet to be targeted pharmacologically. More broadly, an understanding of the comparative effects of geroprotectors upon the lifespan of a variety of different model organisms is important both for basic research into the biology of ageing, demonstration of lifespan plasticity via modulation of a variety of distinct biomolecular targets as proof to regulators that healthspan extension is a viable paradigm for disease treatment and prevention, and for the eventual clinical translation of potential geroprotectors,” said Franco Cortese, Deputy Director and Trustee of the Biogerontology Research Foundation.

“Besides introducing the DrugAge database to the larger scientific community, this paper’s overarching significance lies in the finding that the large majority of known age-related pathways have not yet been targeted pharmacologically, and that we are in a very real sense at the starting line of the search for pharmacological agents capable of extending lifespan and healthspan via the modulation of known age-related pathways. There is still very much left to learn,” said Joao Pedro de Magalhaes, PhD, a Trustee of the Biogerontology Research Foundation (BGRF) and a Principal Investigator at the University of Liverpool’s Integrative Genomics of Aging Group (IGAG).

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The paper ‘The DrugAge database of ageing-related drugs’ has been published in the journal Aging Cell.

 

Results of Platform Vote #2 and Adopted Sections

Results of Platform Vote #2 and Adopted Sections

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Gennady Stolyarov II


The U.S. Transhumanist Party conducted its third vote of the members and the second vote on its platform planks on February 16 through February 22, 2017. Official ballot options can be found here.

Detailed results of the voting have been tabulated here. Options were selected based on the ranked-preference method with instant runoffs.

As a result, the following sections of Article III of the U.S. Transhumanist Party Constitution were adopted.

Section VI: The United States Transhumanist Party upholds morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not directly harm others.

The United States Transhumanist Party considers morphological freedom to include the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient should be entitled to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

The United States Transhumanist Party also recognizes that morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

The United States Transhumanist Party is focused on the rights of all sapient individuals to do as they see fit with themselves and their own reproductive choices.

However, the United States Transhumanist Party holds that the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms directly inflicted upon others. Furthermore, the United States Transhumanist Party recognizes any sentient entity to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

The United States Transhumanist Party recognizes the ethical obligations of sapient beings to be the purview of those individual beings, and holds that no other group, individual, or government has the right to limit those choices – including genetic manipulation or other biological manipulation or any other modifications up to and including biological manipulation, mechanical manipulation, life extension, reproductive choice, reproductive manipulation, cryonics, or other possible modifications, enhancements, or morphological freedoms. It is only when such choices directly infringe upon the rights of other sapient beings that the United States Transhumanist Party will work to develop policies to avoid potential infringements.

Section VII:  The United States Transhumanist Party strongly supports and emphasizes all values and organized efforts related to the cultivation of science, reason, intelligence, and rational thinking.

The United States Transhumanist Party places no reliance upon any and all sources of information that cannot stand up to rational scrutiny.

The United States Transhumanist Party places no reliance upon any individual, organization, or belief system that intentionally distorts empirically verifiable evidence, including but not limited to scientific and historical evidence, to serve its own agenda.

The United States Transhumanist Party places no reliance upon any position or belief system that contains arguments built upon logical fallacies (with exemption granted to arguments containing both fallacious and logically defensible premises).

Section VIII: The United States Transhumanist Party supports maximum individual liberty to engage in scientific and technological innovation for the improvement of the self and the human species. In particular, the United States Transhumanist Party supports all rationally, scientifically grounded research efforts for curing diseases, lengthening lifespans, achieving functional, healthy augmentations of the body and brain, and increasing the durability and youthfulness of the human organism. The United States Transhumanist Party holds that all such research efforts should be rendered fully lawful and their products should be made fully available to the public, as long as no individual is physically harmed without that individual’s consent or defrauded by misrepresentation of the effects of a possible treatment or substance.

Section IX: The United States Transhumanist Party supports all emerging technologies that have the potential to improve the human condition – including but not limited to autonomous vehicles, electric vehicles, economical solar power, safe nuclear power, hydroelectricity, geothermal power, applications for the sharing of durable goods, artificial intelligence, biotechnology, nanotechnology, robotics, rapid transit, 3D printing, vertical farming, electronic devices to detect and respond to trauma, and beneficial genetic modification of plants, animals, and human beings.

Section X: The United States Transhumanist Party advocates the construction of a self-repairing, self-maintaining smart infrastructure which incorporates the distribution of energy, communications, and clean potable water to every building.

Transhumanism, Meet Business – Article by Alcott Evans

Transhumanism, Meet Business – Article by Alcott Evans

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Alcott Evans


Being the tech and business enthusiast that I am, I have a weekly subscription for Bloomberg Businessweek, so the latest issue arrived in the mailbox yesterday.

After checking through the front-page index which provides headlines for every major topic, I noticed the title “Do-It-Yourself Transhumanism” under the Technology section of the magazine. The article can be read online here.

“Harbisson, whose U.K. passport shows he’s the first legally recognized cyborg, was born colorblind. He designed his antenna—which translates colors into one of 360 musical tones he’s memorized—back in 2003 with help from a cyberneticist. At first, he connected it to headphones and a laptop. Eventually, he persuaded a surgeon to drill into his skull, implant a chip, and fuse the antenna to his occipital bone.”

The field of human augmentation is rapidly becoming its own corporate industry, and many can openly assert that it already is its own industry; plastic surgery and liposuctions are becoming more and more common as we speak. As time passes and technological breakthroughs become more prominent, we will move from surgically fixing asymmetrical faces and other human cosmetic desires to programming “nanobots” which can dive into our bodies to perform the same tasks with relative ease.

Even in today’s early stage of mental and physical augmentations, we can clearly see the industry growing rapidly as individuals seek freedom of expression, a right granted to us by the Universal Declaration of Human Rights.

Alcott Evans is a member of the U.S. Transhumanist Party and submitted this article as a guest post.

Official Ballot Options for Platform Vote #2

Official Ballot Options for Platform Vote #2

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The 7-day electronic voting period on the second set of five proposed platform planks of the U.S. Transhumanist Party will occur from 12:01 a.m. U.S. Pacific Time on February 16, 2017, to 12:01 a.m.  U.S. Pacific Time on February 23, 2017. All members of the U.S. Transhumanist Party who have applied before 12:01 a.m. on February 16, 2017, will be eligible to vote, as long as they have expressed agreement with the three Core Ideals of the Transhumanist Party or have otherwise been rendered eligible to vote at the discretion of the Chairman.

All members who are eligible to vote will be sent a link to an electronic submission form whereby they will be able to cast their ballot.

When you are voting, it is strongly recommended that you keep this page of official ballot options and the submission form open simultaneously in different windows so that you can reference the relevant options as you vote on them. Due to space limitations, the submission form does not list the entire text of all the options.

It is also recommended that you set aside at least fifteen minutes to consider and vote on all of the options and read their text closely, as some of the options contain minor variations upon other options. 

For most questions, electronic voting is  conducted by a ranked-preference method on individual articles where more options are possible than would be accommodated by a simple “Yes” or “No” vote. Members should keep in mind that the ranked-preference method eliminates the incentives for strategic voting – so members are encouraged to vote for the options that reflect their individual preferences as closely as possible, without regard for how other members might vote.

Results of the voting will be tabulated during late February 2017, with the intent to announce the results approximately 7 days after all votes have been submitted.

NOTE: The titles of the questions and potential Sections are descriptive and informational only and will not appear in the final adopted platform planks (which will be incorporated into Article III of the U.S. Transhumanist Party Constitution). They are intended as concise guides to the subject matter of the questions and potential Sections. Likewise, the letters assigned to Sections within this ballot will not reflect the numbering of the final adopted provisions, which will depend on which Sections are selected by the membership.

NOTE II: The inclusion of any proposals on this ballot does not indicate any manner of endorsement for those proposals by the U.S. Transhumanist Party at this time – except to place those proposals before the members to determine the will of the members with regard to whether or not the U.S. Transhumanist Party Platform should incorporate any given proposal.

 


 

Voter Identification

E-mail address

Provide the same e-mail address you used to register for U.S. Transhumanist Party membership. Your ballot will be cross-referenced to our membership rolls, and only ballots with matching e-mail addresses will be counted.

What is your name?

At minimum, first and last name are required, unless you are publicly known by a single-name pseudonym which is not itself a common name. Your identity will not be publicly disclosed by the Transhumanist Party, unless you choose and/or authorize its disclosure. Only other members of the Transhumanist Party will be able to see *that* you voted, but not *how* you voted. The nature of the selections made by the members may be disclosed, but, if they are, each individual vote will not be associated with the identity of the voter but rather will be presented in an anonymized manner.

Navigate the Options

Question I. Section E2-A. Morphological Freedom
Question II. Additional Text of Section E2-A. Reproductive Choice
Question III. Additional Text of Section E2-A. Ethical Obligations as Individual, Not Collective Purview
Question IV. Preceding Mention of Not Harming Others by the Word “Directly”
Question V. Section E2-B. Pro-Intelligence / Pro-Science Position
Question VI. Additional Text of Section E2-B. Unfavorable Treatment of Sources That Cannot Stand Up to Scrutiny
Question VII. Additional Text of Section E2-B. Nature of Scrutiny to Be Used to Justify Reliance
Question VIII. Additional Text of Section E2-B. Unfavorable Treatment of Entities That Intentionally Distort Evidence
Question IX. Additional Text of Section E2-B. Manner of Verifiability of Evidence
Question X. Additional Text of Section E2-B. Unfavorable View of Logical Fallacies
Question XI. Section E2-C. Liberty to Innovate
Question XII. Section E2-D. Support for Emerging Technologies
Question XIII. Section E2-E. Smart Infrastructure

Proposed Platform Sections

Question I. Section E2-A. Morphological Freedom. 

Rank-order the Section E2-A Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E2-A-1. [Based on Section VI of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party advocates for morphological freedom – the right of an individual to alter the appearance, composition, and prospects of his, her, or its organism, as long as such changes do not harm others.

☐ Option E2-A-2. [Platform Adaptation of Article X of the Transhumanist Bill of Rights, Version 2.0]

The United States Transhumanist Party upholds morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not harm others.

The United States Transhumanist Party considers morphological freedom to include the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient should be entitled to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

The United States Transhumanist Party also recognizes that morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

However, the United States Transhumanist Party holds that the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms inflicted upon others. Furthermore, the United States Transhumanist Party recognizes any sentient entity to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

 Option E2-A-NO. No Section of this sort.

Question II. Additional Text of Section E2-A. Reproductive Choice.

If Section E2-A on morphological freedom is adopted, shall the following sentence be integrated into the article?

“The United States Transhumanist Party is focused on the rights of all sapient individuals to do as they see fit with themselves and their own reproductive choices.”

Select one of the following options.

Yes.

No.

Abstain.

Question III. Additional Text of Section E2-A. Ethical Obligations as Individual, Not Collective Purview

If Section E2-A on morphological freedom is adopted, shall the following sentence be integrated into the article?

“The United States Transhumanist Party recognizes the ethical obligations of sapient beings to be the purview of those individual beings, and holds that no other group, individual, or government has the right to limit those choices – including genetic manipulation or other biological manipulation or any other modifications up to and including biological manipulation, mechanical manipulation, life extension, reproductive choice, reproductive manipulation, cryonics, or other possible modifications, enhancements, or morphological freedoms. It is only when such choices directly infringe upon the rights of other sapient beings that the United States Transhumanist Party will work to develop policies to avoid potential infringements.”

Select one of the following options.

Yes.

No.

Abstain.

Question IV. Preceding Mention of Not Harming Others by the Word “Directly”

If any option for Section E2-A on morphological freedom is adopted, shall any mention of not harming others be preceded by the word “directly”? For example, if members vote in the affirmative, then in Option E2-A-1, “as long as such changes do not harm others” would be revised to “as long as such changes do not directly harm others”. In Option E2-A-2, “so long as it does not harm others” would be revised to “so long as it does not directly harm others”.

Select one of the following options.

☐ Yes, add the word “directly”.

☐ No, do not add the word “directly”.

Abstain.

Question VSection E2-B. Pro-Intelligence / Pro-Science Position

Rank-order the Section E2-B Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E2-B-1.  [Based on Section II of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports the spread of a pro-science culture by emphasizing reason and secular values.

☐ Option E2-B-2. [Based on Proposal by Daniel Yeluashvili, Base Text]

The United States Transhumanist Party strongly supports and emphasizes all values and organized efforts related to the cultivation of science, reason, intelligence, and rational thinking.

 Option E2-B-NO. No Section of this sort.

Question VI. Additional Text of Section E2-B. Unfavorable Treatment of Sources That Cannot Stand Up to Scrutiny 

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-1: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon] any and all sources of information that cannot stand up to [Possible Options: academic, rational, factually grounded, objective] scrutiny.

If so, which of the following wording options would you favor for the term to express the U.S. Transhumanist Party’s unfavorable outlook toward the aforementioned sources of information?

Rank-order the options you support. “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesuse “condemns”.

☐ Yes, use “disavows”.

☐ Yes, use “disregards”.

☐ Yes, use “disapproves of”.

☐ Yes, use “frowns upon”.

☐ Yes, use “places no reliance upon”.

☐ No, do not include such a clause at all.

Question VII. Additional Text of Section E2-B. Nature of Scrutiny to Be Used to Justify Reliance

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-1: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon] any and all sources of information that cannot stand up to [Possible Options: academic, rational, factually grounded, objective] scrutiny.

If so, which of the following wording options would you favor for the term to express the kind of scrutiny to which information should be able to stand up?

Rank-order the options you support. “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesuse “academic”.

☐ Yesuse “rational”.

☐ Yesuse “factually grounded”.

☐ Yesuse “objective”.

☐ No, do not include such a clause at all.

Question VIII. Additional Text of Section E2-B. Unfavorable Treatment of Entities That Intentionally Distort Evidence

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-2: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon – Same as choice for Question VI] any [Candidate entities for inclusion in the list: individual, organization, belief system] that intentionally distorts [Possible Options: academically, empirically, factually, objectively] verifiable evidence to serve its own agenda, including but not limited to [Candidate adjectives for inclusion in the list: scientific, historical, political, journalistic] evidence.

If so, which of the following entities do think should be included in the list of entities to be considered unfavorably if they engage in the distortion being described, and what sort of evidence do you think should be included in the list of evidence whose distortion the U.S. Transhumanist Party would oppose?

Select all the options you support. (You can select multiple options for this question.) “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesinclude “individual”.

☐ Yesinclude “organization”.

☐ Yesinclude “belief system”.

☐ Yesinclude “scientific” evidence.

☐ Yesinclude “historical” evidence.

☐ Yesinclude “political” evidence.

☐ Yesinclude “journalistic” evidence.

☐ No, do not include such a clause at all.

Question IX. Additional Text of Section E2-B. Manner of Verifiability of Evidence

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-2: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon – Same as choice for Question VI] any [Candidate entities for inclusion in the list: individual, organization, belief system] that intentionally distorts [Possible Options: academically, empirically, factually, objectively] verifiable evidence to serve its own agenda, including but not limited to [Candidate adjectives for inclusion in the list: scientific, historical, political, journalistic] evidence.

If so, which adverb should be applied before “verifiable evidence”?

Rank-order the options you support. “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesuse “academically”.

☐ Yesuse “empirically”.

☐ Yesuse “factually”.

☐ Yesuse “objectively”.

☐ No, do not include such a clause at all.

Question X. Additional Text of Section E2-B. Unfavorable View of Logical Fallacies.

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-3: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon – Same as choice for Question VI] any position or belief system that contains arguments built upon logical fallacies (with exemption granted to arguments containing both fallacious and logically defensible premises).

Select one of the following options.

Yes.

No.

Abstain.

Question XISection E2-C. Liberty to Innovate

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports maximum individual liberty to engage in scientific and technological innovation for the improvement of the self and the human species. In particular, the United States Transhumanist Party supports all rationally, scientifically grounded research efforts for curing diseases, lengthening lifespans, achieving functional, healthy augmentations of the body and brain, and increasing the durability and youthfulness of the human organism. The United States Transhumanist Party holds that all such research efforts should be rendered fully lawful and their products should be made fully available to the public, as long as no individual is physically harmed without that individual’s consent or defrauded by misrepresentation of the effects of a possible treatment or substance.”

Select one of the following options.

Yes.

No.

Abstain.

Question XIISection E2-D. Support for Emerging Technologies

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports all emerging technologies that have the potential to improve the human condition – including but not limited to autonomous vehicles, electric vehicles, economical solar power, safe nuclear power, hydroelectricity, geothermal power, applications for the sharing of durable goods, artificial intelligence, biotechnology, nanotechnology, robotics, rapid transit, 3D printing, vertical farming, electronic devices to detect and respond to trauma, and beneficial genetic modification of plants, animals, and human beings.”

Select one of the following options.

Yes.

No.

Abstain.

Question XIIISection E2-E. Smart Infrastructure

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party advocates the construction of a self-repairing, self-maintaining smart infrastructure which incorporates the distribution of energy, communications, and clean potable water to every building.”

Select one of the following options.

Yes.

No.

Abstain.

CellAge Fundraiser Update and Donation Matching from LongeCity

CellAge Fundraiser Update and Donation Matching from LongeCity

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Lifespan.io and CellAge


The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

Here is an update from Lifespan.io and CellAge:

If you haven’t already noticed, our latest Campaign, CellAge, has been having a bit of difficulty in reaching its funding goal. So, in order to solve that problem, we asked all our backers from previous campaigns for feedback on how we can improve the current CellAge campaign.

We’ve gotten a staggering number of responses (which we’re still personally replying to) and have compiled all the reasons into one big, dramatic “what could have gone better” spreadsheet.

One of those reasons was that CellAge did not have a fund match.

So we fixed that.


CellAge is now endorsed by LongeCity. And they’re running a Fund Match up to $3000.

For those who don’t know, LongeCity is one of the oldest, most respected international pro-longevity organizations. Their exclusive forum boasts thousands of individuals learning, discussing and sharing latest breakthroughs of anything that has to do with slowing down aging.

Apart from generously contributing $800 right away, LongeCity is also running an internal fund match: anything donated via this special page before the 18th of February, will be doubled up to $3000.

To have them support CellAge means that they understand the significance of its success.

What makes this even more exciting is that CellAge has managed to secure additional external funding for their project, which means that they will be able to achieve the same goals even sooner.

The initial goal will now be $20,000, with all stretch goals being reduced as well.

Having raised over $15,000 so far, along with the fund match, means we’re incredibly close to successfully funding CellAge’s exciting research.

Just a quick refresher: CellAge is using customised synthetic biology to develop cutting edge ways to detect and destroy senescent cells, which contribute to age-related diseases. By developing this technology we will be able to give researchers a superior tool for finding senescent cells, and improving the quality of stem cell therapies.

Ultimately this will lead to a better way to remove problem senescent cells without the side effects traditional small molecules inevitably cause. In short, this technology can help start a revolution in medical research and a leap in how we treat age-related diseases for a healthier future.

If you’re still undecided, remember, every dollar you put into the LongeCity match will become two for CellAge.

Click here for donation match.

-The Lifespan Team

15-Day Exposure Period for Platform Vote #2 and Practice of Rolling Exposure Periods Going Forward

15-Day Exposure Period for Platform Vote #2 and Practice of Rolling Exposure Periods Going Forward

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Gennady Stolyarov II


Informal polling of U.S. Transhumanist Party members has indicated that the majority of respondents prefer ballots to be relatively concise, with five issues addressed per ballot. The U.S. Transhumanist Party will endeavor to respect this preference where it is reasonable to do so.

In order to enable members’ suggestions regarding platform planks to still be considered on a relatively expeditious timeframe, the U.S. Transhumanist Party will henceforth institute the practice of rolling exposure periods, where any potential plank (and the set of options that has been generated in connection with it) may be placed on the ballot if it has been publicly exposed for at least 15 days. This will still allow members at least 15 days to comment on any proposal and suggest alternative variants. Furthermore, some proposals may be exposed for longer than 15 days as a result of this, allowing for more discussion. Once any five potential planks have been exposed for at least 15 days each, the U.S. Transhumanist Party will endeavor to circulate ballots to enable members to vote on them, which will potentially enable multiple votes to be held in closer succession while still keeping each ballot concise.

The United States Transhumanist Party also hereby opens its exposure period for its second vote on platform planks, which will last at least until 12:01 a.m. on February 16, 2017. Comments from members, and at times specific wording suggestions, have motivated the presentation of the five potential planks below. In some instances, multiple options have already been generated based on available sources and suggestions, however additional options may still be proposed for consideration.

During the exposure period, please post your comments on this thread. If you post comments intended to be considered in voting and/or amending any of these planks in any other electronic medium, please note that you thereby give your consent to have your comments reproduced with attribution or linked within this discussion thread, in order to direct members’ attention and consideration to them.

After the exposure period, a 7-day electronic voting period will occur. Instructions for electronic voting will be sent to members of the U.S. Transhumanist Party via e-mail at that time. All individuals who are members of the U.S. Transhumanist Party as of the end of the exposure period and who have expressed agreement with its three Core Ideals will be eligible to vote thereafter. You can still vote if you become a member during the exposure period, so please apply here if you are interested. During the 7-day electronic voting period, you will still be able to become a member – but you will only be able to vote in subsequent elections, since we seek for voting on any given issue to be done by those members who have had an opportunity to thoroughly consider that issue and be involved in deliberations regarding it.

Electronic voting will be conducted by a ranked-preference method. Members will be able to rank-order their preferred selections on each individual Platform Section. The original text of each Section will be available for selection, as well as any reasonable amendments proposed by any member. Leadership of the Transhumanist Party reserves the right to edit any proposed amendment for correctness of spelling and grammar only – but not with regard to the substance, unless the person proposing the amendment requests or consents to a substantive edit. “No Section of this sort” will also be a choice, and any Section where a majority of votes favors this option will be not be adopted. Members will also be able to abstain from voting on any given Section.

The ranked-preference method has the advantage of eliminating a “winner-take-all” or “first-past-the-post” mentality and preventing people from being channeled into voting for sub-optimal choices (in their view) just because they fear an even less palatable alternative prevailing. Within the ranked-preference methodology, if no option obtains a clear majority as voters’ first choice, the option having the fewest first-choice votes is eliminated from consideration, and all those who voted for that option will have their votes assigned to their second-choice options. This process of elimination continues until one particular option has a clear majority of votes.

The Transhumanist Party encourages all members to participate in this process and for other transhumanists to sign up for membership during the exposure period. 

The Section titles below are provisional and will be replaced with official numbers for each plank that is adopted. The Section titles are informational only and will not be included in the adopted versions of the platform planks.


Section E2-A. Morphological Freedom.

Option E2-A-1.

[Based on Section VI of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party advocates for morphological freedom – the right of an individual to alter the appearance, composition, and prospects of his, her, or its organism, as long as such changes do not harm others.

 

Option E2-A-2.

[Platform Adaptation of Article X of the Transhumanist Bill of Rights, Version 2.0]

The United States Transhumanist Party upholds morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not harm others.

The United States Transhumanist Party considers morphological freedom to include the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient should be entitled to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

The United States Transhumanist Party also recognizes that morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

However, the United States Transhumanist Party holds that the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms inflicted upon others. Furthermore, the United States Transhumanist Party recognizes any sentient entity to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

Potential Add-On Language [Based on Transhuman National Committee Platform, Freedom of Self Policy Plank]

Clause E2-A-Add-1.  The United States Transhumanist Party is focused on the rights of all sapient individuals to do as they see fit with themselves and their own reproductive choices.

Clause E2-A-Add-2. The United States Transhumanist Party recognizes the ethical obligations of sapient beings to be the purview of those individual beings, and holds that no other group, individual, or government has the right to limit those choices – including genetic manipulation or other biological manipulation or any other modifications up to and including biological manipulation, mechanical manipulation, life extension, reproductive choice, reproductive manipulation, cryonics, or other possible modifications, enhancements, or morphological freedoms. It is only when such choices directly infringe upon the rights of other sapient beings that the United States Transhumanist Party will work to develop policies to avoid potential infringements.

Question E2-A-Add-3. If any option of the Morphological Freedom plank is adopted, shall any mention of not harming others be preceded by the word “directly”? For example, if members vote in the affirmative, then in Option E2-A-1, “as long as such changes do not harm others” would be revised to “as long as such changes do not directly harm others”. In Option E2-A-2, “so long as it does not harm others” would be revised to “so long as it does not directly harm others”.

☐ Yes, add the word “directly”.

☐ No, do not add the word “directly”.

Section E2-B. Pro-Intelligence / Pro-Science Position

Option E2-B-1.

[Based on Section II of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports the spread of a pro-science culture by emphasizing reason and secular values.

Option E2-B-2.

[Based on Proposal by Daniel Yeluashvili, Base Text]

The United States Transhumanist Party strongly supports and emphasizes all values and organized efforts related to the cultivation of science, reason, intelligence, and rational thinking.

Potential Add-On Language [Based on Proposals by Daniel Yeluashvili, with Additional Options Generated]

Note: It is intended for members to have the options to accept or reject any of the following add-on clauses and to select candidate language within each clause when multiple variants may be feasible.

Clause E2-B-Add-1: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, frowns upon, places no reliance upon] any and all sources of information that cannot stand up to [Possible Options: academic, rational, factually grounded, objective] scrutiny.

Clause E2-B-Add-2: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, frowns upon, places no reliance upon] any [Candidate entities for inclusion in the list: individual, organization, belief system] that intentionally distorts [Possible Options: academically, empirically, factually, objectively] verifiable evidence to serve its own agenda, including but not limited to [Candidate adjectives for inclusion in the list: scientific, historical, political, journalistic] evidence.

Clause E2-B-Add-3: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, frowns upon, places no reliance upon] any position or belief system that contains arguments built upon logical fallacies (with exemption granted to arguments containing both fallacious and logically defensible premises).

Section E2-C. Liberty to Innovate

Option E2-C-1.

[Based on Section III of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports maximum individual liberty to engage in scientific and technological innovation for the improvement of the self and the human species. In particular, the United States Transhumanist Party supports all rationally, scientifically grounded research efforts for curing diseases, lengthening lifespans, achieving functional, healthy augmentations of the body and brain, and increasing the durability and youthfulness of the human organism. The United States Transhumanist Party holds that all such research efforts should be rendered fully lawful and their products should be made fully available to the public, as long as no individual is physically harmed without that individual’s consent or defrauded by misrepresentation of the effects of a possible treatment or substance.

Section E2-D. Support for Emerging Technologies

Option E2-D-1.

[Based on Section XVII of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports all emerging technologies that have the potential to improve the human condition – including but not limited to autonomous vehicles, electric vehicles, economical solar power, safe nuclear power, hydroelectricity, geothermal power, applications for the sharing of durable goods, artificial intelligence, biotechnology, nanotechnology, robotics, rapid transit, 3D printing, vertical farming, electronic devices to detect and respond to trauma, and beneficial genetic modification of plants, animals, and human beings.

Section E2-E. Smart Infrastructure

Option E2-E-1.

[Based on Proposal by Jennifer Warren]

The United States Transhumanist Party advocates the construction of a self-repairing, self-maintaining smart infrastructure which incorporates the distribution of energy, communications, and clean potable water to every building.

The Transhumanist Party: New Politics for Life Extension and Technological Progress

The Transhumanist Party: New Politics for Life Extension and Technological Progress

 

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Gennady Stolyarov II


 

Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, discusses the progress made in late 2016 and early 2017 and the goals of transhumanist politics – how the advocacy of emerging technologies and life extension in a political context sets the Transhumanist Party’s approach apart from mainstream politics.

This presentation was delivered virtually on January 27, 2017, to a meeting of People Unlimited in Scottsdale, Arizona, as part of People Unlimited’s Ageless Education speaker series. After the conclusion of his remarks, Mr. Stolyarov answered several questions from the audience.