Browsed by
Tag: research

I am the Lifespan – Video by Gennady Stolyarov II

I am the Lifespan – Video by Gennady Stolyarov II

logo_bg

Gennady Stolyarov II


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, discusses why longevity research is crucial, and how our generation stands on the threshold of finally dealing a decisive blow to the age-old enemies of aging and death, which have destroyed great human minds since the emergence of our species.

This video is part of the #IAmTheLifespan campaign, coordinated by Lifespan.io and the Life Extension Advocacy Foundation (LEAF) for Longevity Month, October 2017. Read more about this campaign here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

Induced Cell Turnover: A Proposed Modality for In Situ Tissue Regeneration and Repair – Press Release by Biogerontology Research Foundation

Induced Cell Turnover: A Proposed Modality for In Situ Tissue Regeneration and Repair – Press Release by Biogerontology Research Foundation

logo_bg

Biogerontology Research Foundation


Scientists at the Biogerontology Research FoundationFeinberg School of Medicine at Northwestern University and Swammerdam Institute of Life Sciences at the University of Amsterdam have published a paper on a proposed method of in situ tissue regeneration called Induced Cell Turnover (ICT) in the journal Human Gene Therapy. The proposed therapeutic modality would aim to coordinate the targeted ablation of endogenous cells with the administration of minimally-differentiated, hPSC-derived cells in a gradual and multi-phasic manner so as to extrinsically mediate the turnover and replacement of whole tissues and organs with stem-cell derived cells.

“One of the major hurdles limiting traditional cell therapies is low levels of engraftment and retention, which is caused in part by cells only being able to engraft at locations of existing cell loss, and by the fact that many of those vacancies have already become occupied by ECM and fibroblasts (i.e. scar tissue) by the time the cells are administered, long after the actual occurrence of cell loss. The crux underlying ICT is to coordinate endogenous cell ablation (i.e. induced apoptosis) with replacement cell administration so as to manually vacate niches for new cells to engraft, coordinating these two events in space and time so as to minimize the ability for sites of cell loss to become occupied by ECM and fibroblasts. This would be done in a gradual and multi-phasic manner so as to avoid acute tissue failure resulting from the transient absence of too many cells at any one time. While the notion of endogenous cell clearance prior to replacement cell administration has become routine for bone marrow transplants, it isn’t really on the horizon of researchers and clinicians working with solid tissues, and this is something we’d like to change,” said Franco Cortese, Deputy Director and Trustee of the Biogerontology Research Foundation, and lead author on the paper.

Cell-type and tissue-specific rates of induced turnover could be achieved using cell-type specific pro-apoptotic small molecule cocktails, peptide mimetics, and/or tissue-tropic AAV-delivered suicide genes driven by cell-type specific promoters. Because these sites of ablation would still be “fresh” when replacement cells are administered, the presumption is that the patterns of ablation will make administered cells more likely to engraft where they should, in freshly vacated niches where the signals promoting cell migration and engraftment are still active. By varying the dose of cell-type targeted ablative agents, cell type and tissue-specific rates of induced turnover could be achieved, allowing for the rate and spatial distribution of turnover to be tuned to the size of the tissue in order to avoid ablating too many cells at once and inadvertently inducing acute tissue failure.

“Cell therapies are limited by low levels of engraftment, and in principle their ability to improve clinical outcomes is limited by the fact that they can only engraft at locations of existing cell loss. Conversely, therapeutic tissue and organ engineering requires surgery, is more likely to introduce biochemical and mechanical abnormalities to tissue ultrastructure through the decellularization process, and is fundamentally incapable of replacing distributed tissues and structures with a high degree of interconnectivity to other tissues in the body. The aim of ICT is to form a bridge between these two main pillars of regenerative medicine, extending the efficacy of cell therapies beyond a patch for existing cell loss and accomplishing the aim of tissue and organ engineering (i.e. the replacement and regeneration of whole tissues and organs) while potentially remaining free of some of their present limitations,” said Giovanni Santostasi, co-author on the paper and a researcher at the Feinberg School of Medicine, Northwestern University.

While future iterations of the therapy could use patient-derived cells, such as ESCs derived via somatic cell nuclear transfer (SCNT) or iPSCs derived from nuclear reprogramming, shorter-term applications would likely use existing stem cell lines immunologically matched to the patient via HLA matching. The authors contend that the cloning of adult organisms with normal lifespans from adult somatic cells testifies to the fact that adult cells can be rejuvenated and used to produce a sufficient quantity of daughter cells to replace the sum of cells constituting adult organisms, and that serial cloning experiments (in which this process is done iteratively, using an adult cell of each subsequent generation to derive the next) attests to this fact even more strongly.

“ICT could theoretically enable the controlled turnover and rejuvenation of aged tissues. The technique is particularly applicable to tissues that are not amenable to growth ex vivo and implantation (as with solid organs) – such as the vascular, lymphatic, and nervous systems. The method relies upon targeted ablation of old, damaged and/or senescent cells, coupled with a titrated replacement with patient-derived semi-differentiated stem and progenitor cells. By gradually replacing the old cells with new cells, entire tissues can be replaced in situ. The body naturally turns over tissues, but not all tissues and perhaps not optimally. I am reminded of the quote attributed to Heraclitus: ‘No man ever steps in the same river twice, for it’s not the same river and he’s not the same man,'” said Sebastian Aguiar, a coauthor on the paper and researcher at the Swammerdam Institute of Life Sciences, University of Amsterdam.

“Reversing aging in humans will require a multi-step approach at multiple levels of the organismal organization. In situ targeted ablation of the senescent cells and regeneration will be an important component of comprehensive anti-aging therapies,” said Alex Zhavoronkov, Chief Science Officer of the Biogerontology Research Foundation.

The researchers originally proposed ICT in 2016 in the context of biomedical gerontology as a possible means of preventing and/or negating age-related phenotypic deviation for the purposes of healthspan extension, and in this new paper they refine the methodological underpinnings of the approach, take a closer look at potential complications and strategies for their deterrence, and analyze ICT in the context of regenerative medicine as an intervention for a broader range of conditions based on disease or dysfunction at the cellular and intercellular level, with potential utilities absent from traditional cell therapies and tissue/organ engineering, the two main pillars of regenerative medicine. The intervention is still very much conceptual, and any potential utilities over other therapeutic modalities within regenerative medicine would need to be verified via preclinical studies, but their hope is to stimulate further research at this interface between geroscience and regenerative medicine.

###

The paper is available here.

About the Biogerontology Research Foundation:

The Biogerontology Research Foundation is a UK non-profit research foundation and public policy center seeking to fill a gap within the research community, whereby the current scientific understanding of the ageing process is not yet being sufficiently exploited to produce effective medical interventions. The BGRF funds and conducts research which, building on the body of knowledge about how ageing happens, aims to develop biotechnological interventions to remediate the molecular and cellular deficits which accumulate with age and which underlie the ill-health of old age. Addressing ageing damage at this most fundamental level will provide an important opportunity to produce the effective, lasting treatments for the diseases and disabilities of ageing, required to improve quality of life in the elderly. The BGRF seeks to use the entire scope of modern biotechnology to attack the changes that take place in the course of ageing, and to address not just the symptoms of age-related diseases but also the mechanisms of those diseases.

Being Excited About Failure – Article by Martin van der Kroon

Being Excited About Failure – Article by Martin van der Kroon

Martin van der Kroon


The much hyped CRISPR-Cas9 genome-editing technique often explained as being the ‘DNA scissors’ or the ‘cut and paste’ technique, has had a setback, and this has me excited.

CRISPR-Cas9 has has the scientific community, and in particular those involved in research and development of genome editing, raving over the roughly past 3 years. It is hailed as a cheap and fast way to edit genomes with great accuracy compared to other genome-editing techniques, and this is true. Now however, researchers have found CRISPR-Cas9 to have some annoying side-effects. The side-effects were found in mice who had their blindness corrected but also caused mutations in other parts of the DNA sequence, roughly 1500 mutations. It is unknown what the consequences of the mutations are at this moment.

“Why am I excited about this setback?” you might ask.

Read More Read More

LEAF Interview with Dr. Aubrey de Grey: Controlling the Main Aging Damages

LEAF Interview with Dr. Aubrey de Grey: Controlling the Main Aging Damages

logo_bg

Aubrey de Grey and Life Extension Advocacy Foundation


The U.S. Transhumanist Party is pleased to feature this interview of Dr. Aubrey de Grey, the Transhumanist Party’s Anti-Aging Advisor, conducted by Elena Milova of the Life Extension Advocacy Foundation (LEAF), one of the Transhumanist Party’s most active Allied Organizations. You can also see this interview on YouTube here.

Description by LEAF: Please enjoy this interview with Dr. Aubrey de Grey, Chief Science Officer and Co-founder of SENS Research Foundation — one of the most successful advocacy and fundraising initiatives supporting breakthrough research on the main mechanisms of aging and age-related diseases.

In this video Dr. de Grey speaks about the progress in developing interventions to tackle age-related damages identified by SENS as the main ones.

Interviewer – LEAF/Lifespan.io Board member Elena Milova.

Dr. de Grey received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. He is Editor-in-Chief of Rejuvenation Research , is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations.

Subscribe to Lifespan.io’s YouTube channel for more.

This interview is presented by LEAF. Please support its work by becoming a “Lifespan Hero“.

Results of Platform Vote #2 and Adopted Sections

Results of Platform Vote #2 and Adopted Sections

logo_bg

Gennady Stolyarov II


The U.S. Transhumanist Party conducted its third vote of the members and the second vote on its platform planks on February 16 through February 22, 2017. Official ballot options can be found here.

Detailed results of the voting have been tabulated here. Options were selected based on the ranked-preference method with instant runoffs.

As a result, the following sections of Article III of the U.S. Transhumanist Party Constitution were adopted.

Section VI: The United States Transhumanist Party upholds morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not directly harm others.

The United States Transhumanist Party considers morphological freedom to include the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient should be entitled to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

The United States Transhumanist Party also recognizes that morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

The United States Transhumanist Party is focused on the rights of all sapient individuals to do as they see fit with themselves and their own reproductive choices.

However, the United States Transhumanist Party holds that the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms directly inflicted upon others. Furthermore, the United States Transhumanist Party recognizes any sentient entity to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

The United States Transhumanist Party recognizes the ethical obligations of sapient beings to be the purview of those individual beings, and holds that no other group, individual, or government has the right to limit those choices – including genetic manipulation or other biological manipulation or any other modifications up to and including biological manipulation, mechanical manipulation, life extension, reproductive choice, reproductive manipulation, cryonics, or other possible modifications, enhancements, or morphological freedoms. It is only when such choices directly infringe upon the rights of other sapient beings that the United States Transhumanist Party will work to develop policies to avoid potential infringements.

Section VII:  The United States Transhumanist Party strongly supports and emphasizes all values and organized efforts related to the cultivation of science, reason, intelligence, and rational thinking.

The United States Transhumanist Party places no reliance upon any and all sources of information that cannot stand up to rational scrutiny.

The United States Transhumanist Party places no reliance upon any individual, organization, or belief system that intentionally distorts empirically verifiable evidence, including but not limited to scientific and historical evidence, to serve its own agenda.

The United States Transhumanist Party places no reliance upon any position or belief system that contains arguments built upon logical fallacies (with exemption granted to arguments containing both fallacious and logically defensible premises).

Section VIII: The United States Transhumanist Party supports maximum individual liberty to engage in scientific and technological innovation for the improvement of the self and the human species. In particular, the United States Transhumanist Party supports all rationally, scientifically grounded research efforts for curing diseases, lengthening lifespans, achieving functional, healthy augmentations of the body and brain, and increasing the durability and youthfulness of the human organism. The United States Transhumanist Party holds that all such research efforts should be rendered fully lawful and their products should be made fully available to the public, as long as no individual is physically harmed without that individual’s consent or defrauded by misrepresentation of the effects of a possible treatment or substance.

Section IX: The United States Transhumanist Party supports all emerging technologies that have the potential to improve the human condition – including but not limited to autonomous vehicles, electric vehicles, economical solar power, safe nuclear power, hydroelectricity, geothermal power, applications for the sharing of durable goods, artificial intelligence, biotechnology, nanotechnology, robotics, rapid transit, 3D printing, vertical farming, electronic devices to detect and respond to trauma, and beneficial genetic modification of plants, animals, and human beings.

Section X: The United States Transhumanist Party advocates the construction of a self-repairing, self-maintaining smart infrastructure which incorporates the distribution of energy, communications, and clean potable water to every building.

Official Ballot Options for Platform Vote #2

Official Ballot Options for Platform Vote #2

logo_bg


 

The 7-day electronic voting period on the second set of five proposed platform planks of the U.S. Transhumanist Party will occur from 12:01 a.m. U.S. Pacific Time on February 16, 2017, to 12:01 a.m.  U.S. Pacific Time on February 23, 2017. All members of the U.S. Transhumanist Party who have applied before 12:01 a.m. on February 16, 2017, will be eligible to vote, as long as they have expressed agreement with the three Core Ideals of the Transhumanist Party or have otherwise been rendered eligible to vote at the discretion of the Chairman.

All members who are eligible to vote will be sent a link to an electronic submission form whereby they will be able to cast their ballot.

When you are voting, it is strongly recommended that you keep this page of official ballot options and the submission form open simultaneously in different windows so that you can reference the relevant options as you vote on them. Due to space limitations, the submission form does not list the entire text of all the options.

It is also recommended that you set aside at least fifteen minutes to consider and vote on all of the options and read their text closely, as some of the options contain minor variations upon other options. 

For most questions, electronic voting is  conducted by a ranked-preference method on individual articles where more options are possible than would be accommodated by a simple “Yes” or “No” vote. Members should keep in mind that the ranked-preference method eliminates the incentives for strategic voting – so members are encouraged to vote for the options that reflect their individual preferences as closely as possible, without regard for how other members might vote.

Results of the voting will be tabulated during late February 2017, with the intent to announce the results approximately 7 days after all votes have been submitted.

NOTE: The titles of the questions and potential Sections are descriptive and informational only and will not appear in the final adopted platform planks (which will be incorporated into Article III of the U.S. Transhumanist Party Constitution). They are intended as concise guides to the subject matter of the questions and potential Sections. Likewise, the letters assigned to Sections within this ballot will not reflect the numbering of the final adopted provisions, which will depend on which Sections are selected by the membership.

NOTE II: The inclusion of any proposals on this ballot does not indicate any manner of endorsement for those proposals by the U.S. Transhumanist Party at this time – except to place those proposals before the members to determine the will of the members with regard to whether or not the U.S. Transhumanist Party Platform should incorporate any given proposal.

 


 

Voter Identification

E-mail address

Provide the same e-mail address you used to register for U.S. Transhumanist Party membership. Your ballot will be cross-referenced to our membership rolls, and only ballots with matching e-mail addresses will be counted.

What is your name?

At minimum, first and last name are required, unless you are publicly known by a single-name pseudonym which is not itself a common name. Your identity will not be publicly disclosed by the Transhumanist Party, unless you choose and/or authorize its disclosure. Only other members of the Transhumanist Party will be able to see *that* you voted, but not *how* you voted. The nature of the selections made by the members may be disclosed, but, if they are, each individual vote will not be associated with the identity of the voter but rather will be presented in an anonymized manner.

Navigate the Options

Question I. Section E2-A. Morphological Freedom
Question II. Additional Text of Section E2-A. Reproductive Choice
Question III. Additional Text of Section E2-A. Ethical Obligations as Individual, Not Collective Purview
Question IV. Preceding Mention of Not Harming Others by the Word “Directly”
Question V. Section E2-B. Pro-Intelligence / Pro-Science Position
Question VI. Additional Text of Section E2-B. Unfavorable Treatment of Sources That Cannot Stand Up to Scrutiny
Question VII. Additional Text of Section E2-B. Nature of Scrutiny to Be Used to Justify Reliance
Question VIII. Additional Text of Section E2-B. Unfavorable Treatment of Entities That Intentionally Distort Evidence
Question IX. Additional Text of Section E2-B. Manner of Verifiability of Evidence
Question X. Additional Text of Section E2-B. Unfavorable View of Logical Fallacies
Question XI. Section E2-C. Liberty to Innovate
Question XII. Section E2-D. Support for Emerging Technologies
Question XIII. Section E2-E. Smart Infrastructure

Proposed Platform Sections

Question I. Section E2-A. Morphological Freedom. 

Rank-order the Section E2-A Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E2-A-1. [Based on Section VI of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party advocates for morphological freedom – the right of an individual to alter the appearance, composition, and prospects of his, her, or its organism, as long as such changes do not harm others.

☐ Option E2-A-2. [Platform Adaptation of Article X of the Transhumanist Bill of Rights, Version 2.0]

The United States Transhumanist Party upholds morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not harm others.

The United States Transhumanist Party considers morphological freedom to include the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient should be entitled to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

The United States Transhumanist Party also recognizes that morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

However, the United States Transhumanist Party holds that the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms inflicted upon others. Furthermore, the United States Transhumanist Party recognizes any sentient entity to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

 Option E2-A-NO. No Section of this sort.

Question II. Additional Text of Section E2-A. Reproductive Choice.

If Section E2-A on morphological freedom is adopted, shall the following sentence be integrated into the article?

“The United States Transhumanist Party is focused on the rights of all sapient individuals to do as they see fit with themselves and their own reproductive choices.”

Select one of the following options.

Yes.

No.

Abstain.

Question III. Additional Text of Section E2-A. Ethical Obligations as Individual, Not Collective Purview

If Section E2-A on morphological freedom is adopted, shall the following sentence be integrated into the article?

“The United States Transhumanist Party recognizes the ethical obligations of sapient beings to be the purview of those individual beings, and holds that no other group, individual, or government has the right to limit those choices – including genetic manipulation or other biological manipulation or any other modifications up to and including biological manipulation, mechanical manipulation, life extension, reproductive choice, reproductive manipulation, cryonics, or other possible modifications, enhancements, or morphological freedoms. It is only when such choices directly infringe upon the rights of other sapient beings that the United States Transhumanist Party will work to develop policies to avoid potential infringements.”

Select one of the following options.

Yes.

No.

Abstain.

Question IV. Preceding Mention of Not Harming Others by the Word “Directly”

If any option for Section E2-A on morphological freedom is adopted, shall any mention of not harming others be preceded by the word “directly”? For example, if members vote in the affirmative, then in Option E2-A-1, “as long as such changes do not harm others” would be revised to “as long as such changes do not directly harm others”. In Option E2-A-2, “so long as it does not harm others” would be revised to “so long as it does not directly harm others”.

Select one of the following options.

☐ Yes, add the word “directly”.

☐ No, do not add the word “directly”.

Abstain.

Question VSection E2-B. Pro-Intelligence / Pro-Science Position

Rank-order the Section E2-B Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E2-B-1.  [Based on Section II of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports the spread of a pro-science culture by emphasizing reason and secular values.

☐ Option E2-B-2. [Based on Proposal by Daniel Yeluashvili, Base Text]

The United States Transhumanist Party strongly supports and emphasizes all values and organized efforts related to the cultivation of science, reason, intelligence, and rational thinking.

 Option E2-B-NO. No Section of this sort.

Question VI. Additional Text of Section E2-B. Unfavorable Treatment of Sources That Cannot Stand Up to Scrutiny 

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-1: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon] any and all sources of information that cannot stand up to [Possible Options: academic, rational, factually grounded, objective] scrutiny.

If so, which of the following wording options would you favor for the term to express the U.S. Transhumanist Party’s unfavorable outlook toward the aforementioned sources of information?

Rank-order the options you support. “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesuse “condemns”.

☐ Yes, use “disavows”.

☐ Yes, use “disregards”.

☐ Yes, use “disapproves of”.

☐ Yes, use “frowns upon”.

☐ Yes, use “places no reliance upon”.

☐ No, do not include such a clause at all.

Question VII. Additional Text of Section E2-B. Nature of Scrutiny to Be Used to Justify Reliance

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-1: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon] any and all sources of information that cannot stand up to [Possible Options: academic, rational, factually grounded, objective] scrutiny.

If so, which of the following wording options would you favor for the term to express the kind of scrutiny to which information should be able to stand up?

Rank-order the options you support. “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesuse “academic”.

☐ Yesuse “rational”.

☐ Yesuse “factually grounded”.

☐ Yesuse “objective”.

☐ No, do not include such a clause at all.

Question VIII. Additional Text of Section E2-B. Unfavorable Treatment of Entities That Intentionally Distort Evidence

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-2: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon – Same as choice for Question VI] any [Candidate entities for inclusion in the list: individual, organization, belief system] that intentionally distorts [Possible Options: academically, empirically, factually, objectively] verifiable evidence to serve its own agenda, including but not limited to [Candidate adjectives for inclusion in the list: scientific, historical, political, journalistic] evidence.

If so, which of the following entities do think should be included in the list of entities to be considered unfavorably if they engage in the distortion being described, and what sort of evidence do you think should be included in the list of evidence whose distortion the U.S. Transhumanist Party would oppose?

Select all the options you support. (You can select multiple options for this question.) “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesinclude “individual”.

☐ Yesinclude “organization”.

☐ Yesinclude “belief system”.

☐ Yesinclude “scientific” evidence.

☐ Yesinclude “historical” evidence.

☐ Yesinclude “political” evidence.

☐ Yesinclude “journalistic” evidence.

☐ No, do not include such a clause at all.

Question IX. Additional Text of Section E2-B. Manner of Verifiability of Evidence

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-2: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon – Same as choice for Question VI] any [Candidate entities for inclusion in the list: individual, organization, belief system] that intentionally distorts [Possible Options: academically, empirically, factually, objectively] verifiable evidence to serve its own agenda, including but not limited to [Candidate adjectives for inclusion in the list: scientific, historical, political, journalistic] evidence.

If so, which adverb should be applied before “verifiable evidence”?

Rank-order the options you support. “Yes” favors including the above language, whereas “No” favors omitting it in entirety.

☐ Yesuse “academically”.

☐ Yesuse “empirically”.

☐ Yesuse “factually”.

☐ Yesuse “objectively”.

☐ No, do not include such a clause at all.

Question X. Additional Text of Section E2-B. Unfavorable View of Logical Fallacies.

If Section E2-B regarding a pro-intelligence / pro-science position is adopted, shall additional language be included to the following effect?

Clause E2-B-Add-3: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, disapproves of, frowns upon, places no reliance upon – Same as choice for Question VI] any position or belief system that contains arguments built upon logical fallacies (with exemption granted to arguments containing both fallacious and logically defensible premises).

Select one of the following options.

Yes.

No.

Abstain.

Question XISection E2-C. Liberty to Innovate

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports maximum individual liberty to engage in scientific and technological innovation for the improvement of the self and the human species. In particular, the United States Transhumanist Party supports all rationally, scientifically grounded research efforts for curing diseases, lengthening lifespans, achieving functional, healthy augmentations of the body and brain, and increasing the durability and youthfulness of the human organism. The United States Transhumanist Party holds that all such research efforts should be rendered fully lawful and their products should be made fully available to the public, as long as no individual is physically harmed without that individual’s consent or defrauded by misrepresentation of the effects of a possible treatment or substance.”

Select one of the following options.

Yes.

No.

Abstain.

Question XIISection E2-D. Support for Emerging Technologies

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports all emerging technologies that have the potential to improve the human condition – including but not limited to autonomous vehicles, electric vehicles, economical solar power, safe nuclear power, hydroelectricity, geothermal power, applications for the sharing of durable goods, artificial intelligence, biotechnology, nanotechnology, robotics, rapid transit, 3D printing, vertical farming, electronic devices to detect and respond to trauma, and beneficial genetic modification of plants, animals, and human beings.”

Select one of the following options.

Yes.

No.

Abstain.

Question XIIISection E2-E. Smart Infrastructure

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party advocates the construction of a self-repairing, self-maintaining smart infrastructure which incorporates the distribution of energy, communications, and clean potable water to every building.”

Select one of the following options.

Yes.

No.

Abstain.

CellAge Fundraiser Update and Donation Matching from LongeCity

CellAge Fundraiser Update and Donation Matching from LongeCity

logo_bg

Lifespan.io and CellAge


The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

Here is an update from Lifespan.io and CellAge:

If you haven’t already noticed, our latest Campaign, CellAge, has been having a bit of difficulty in reaching its funding goal. So, in order to solve that problem, we asked all our backers from previous campaigns for feedback on how we can improve the current CellAge campaign.

We’ve gotten a staggering number of responses (which we’re still personally replying to) and have compiled all the reasons into one big, dramatic “what could have gone better” spreadsheet.

One of those reasons was that CellAge did not have a fund match.

So we fixed that.


CellAge is now endorsed by LongeCity. And they’re running a Fund Match up to $3000.

For those who don’t know, LongeCity is one of the oldest, most respected international pro-longevity organizations. Their exclusive forum boasts thousands of individuals learning, discussing and sharing latest breakthroughs of anything that has to do with slowing down aging.

Apart from generously contributing $800 right away, LongeCity is also running an internal fund match: anything donated via this special page before the 18th of February, will be doubled up to $3000.

To have them support CellAge means that they understand the significance of its success.

What makes this even more exciting is that CellAge has managed to secure additional external funding for their project, which means that they will be able to achieve the same goals even sooner.

The initial goal will now be $20,000, with all stretch goals being reduced as well.

Having raised over $15,000 so far, along with the fund match, means we’re incredibly close to successfully funding CellAge’s exciting research.

Just a quick refresher: CellAge is using customised synthetic biology to develop cutting edge ways to detect and destroy senescent cells, which contribute to age-related diseases. By developing this technology we will be able to give researchers a superior tool for finding senescent cells, and improving the quality of stem cell therapies.

Ultimately this will lead to a better way to remove problem senescent cells without the side effects traditional small molecules inevitably cause. In short, this technology can help start a revolution in medical research and a leap in how we treat age-related diseases for a healthier future.

If you’re still undecided, remember, every dollar you put into the LongeCity match will become two for CellAge.

Click here for donation match.

-The Lifespan Team

Discussion on Life-Extension Advocacy – Gennady Stolyarov II Answers Audience Questions

Discussion on Life-Extension Advocacy – Gennady Stolyarov II Answers Audience Questions

logo_bg

Gennady Stolyarov II


 

Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, answers audience questions regarding life-extension advocacy and possibilities for broadening the reach of transhumanist and life-extensionist ideas.

While we were unable to get into contact with our intended guest, Chris Monteiro, we were nonetheless able to have a productive, wide-ranging discussion that addressed many areas of emerging technologies, as well as trends in societal attitudes towards them and related issues of cosmopolitanism, ideology, and the need for a new comprehensive philosophical paradigm of transmodernism or hypermodernism that would build off of the legacy of the 18th-century Age of Enlightenment.

Become a member of the U.S. Transhumanist Party for free. Apply here.

The user comments submitted contemporaneously with this discussion are presented below.

User Comments

15-Day Exposure Period for Platform Vote #2 and Practice of Rolling Exposure Periods Going Forward

15-Day Exposure Period for Platform Vote #2 and Practice of Rolling Exposure Periods Going Forward

logo_bg

Gennady Stolyarov II


Informal polling of U.S. Transhumanist Party members has indicated that the majority of respondents prefer ballots to be relatively concise, with five issues addressed per ballot. The U.S. Transhumanist Party will endeavor to respect this preference where it is reasonable to do so.

In order to enable members’ suggestions regarding platform planks to still be considered on a relatively expeditious timeframe, the U.S. Transhumanist Party will henceforth institute the practice of rolling exposure periods, where any potential plank (and the set of options that has been generated in connection with it) may be placed on the ballot if it has been publicly exposed for at least 15 days. This will still allow members at least 15 days to comment on any proposal and suggest alternative variants. Furthermore, some proposals may be exposed for longer than 15 days as a result of this, allowing for more discussion. Once any five potential planks have been exposed for at least 15 days each, the U.S. Transhumanist Party will endeavor to circulate ballots to enable members to vote on them, which will potentially enable multiple votes to be held in closer succession while still keeping each ballot concise.

The United States Transhumanist Party also hereby opens its exposure period for its second vote on platform planks, which will last at least until 12:01 a.m. on February 16, 2017. Comments from members, and at times specific wording suggestions, have motivated the presentation of the five potential planks below. In some instances, multiple options have already been generated based on available sources and suggestions, however additional options may still be proposed for consideration.

During the exposure period, please post your comments on this thread. If you post comments intended to be considered in voting and/or amending any of these planks in any other electronic medium, please note that you thereby give your consent to have your comments reproduced with attribution or linked within this discussion thread, in order to direct members’ attention and consideration to them.

After the exposure period, a 7-day electronic voting period will occur. Instructions for electronic voting will be sent to members of the U.S. Transhumanist Party via e-mail at that time. All individuals who are members of the U.S. Transhumanist Party as of the end of the exposure period and who have expressed agreement with its three Core Ideals will be eligible to vote thereafter. You can still vote if you become a member during the exposure period, so please apply here if you are interested. During the 7-day electronic voting period, you will still be able to become a member – but you will only be able to vote in subsequent elections, since we seek for voting on any given issue to be done by those members who have had an opportunity to thoroughly consider that issue and be involved in deliberations regarding it.

Electronic voting will be conducted by a ranked-preference method. Members will be able to rank-order their preferred selections on each individual Platform Section. The original text of each Section will be available for selection, as well as any reasonable amendments proposed by any member. Leadership of the Transhumanist Party reserves the right to edit any proposed amendment for correctness of spelling and grammar only – but not with regard to the substance, unless the person proposing the amendment requests or consents to a substantive edit. “No Section of this sort” will also be a choice, and any Section where a majority of votes favors this option will be not be adopted. Members will also be able to abstain from voting on any given Section.

The ranked-preference method has the advantage of eliminating a “winner-take-all” or “first-past-the-post” mentality and preventing people from being channeled into voting for sub-optimal choices (in their view) just because they fear an even less palatable alternative prevailing. Within the ranked-preference methodology, if no option obtains a clear majority as voters’ first choice, the option having the fewest first-choice votes is eliminated from consideration, and all those who voted for that option will have their votes assigned to their second-choice options. This process of elimination continues until one particular option has a clear majority of votes.

The Transhumanist Party encourages all members to participate in this process and for other transhumanists to sign up for membership during the exposure period. 

The Section titles below are provisional and will be replaced with official numbers for each plank that is adopted. The Section titles are informational only and will not be included in the adopted versions of the platform planks.


Section E2-A. Morphological Freedom.

Option E2-A-1.

[Based on Section VI of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party advocates for morphological freedom – the right of an individual to alter the appearance, composition, and prospects of his, her, or its organism, as long as such changes do not harm others.

 

Option E2-A-2.

[Platform Adaptation of Article X of the Transhumanist Bill of Rights, Version 2.0]

The United States Transhumanist Party upholds morphological freedom—the right to do with one’s physical attributes or intelligence whatever one wants so long as it does not harm others.

The United States Transhumanist Party considers morphological freedom to include the prerogative for a sentient intelligence to set forth in advance provisions for how to handle its physical manifestation, should that intelligence enter into a vegetative, unconscious, or similarly inactive state, notwithstanding any legal definition of death. For instance, a cryonics patient should be entitled to determine in advance that the patient’s body shall be cryopreserved and kept under specified conditions, in spite of any legal definition of death that might apply to that patient under cryopreservation.

The United States Transhumanist Party also recognizes that morphological freedom entails the duty to treat all sapients as individuals instead of categorizing them into arbitrary subgroups or demographics, including as yet undefined subcategorizations that may arise as sapience evolves.

However, the United States Transhumanist Party holds that the proper exercise of morphological freedom must also ensure that any improvement of the self should not result in involuntary harms inflicted upon others. Furthermore, the United States Transhumanist Party recognizes any sentient entity to have the freedom not to modify itself without being subject to negative political repercussions, which include but are not limited to legal and/or socio-economic repercussions.

Potential Add-On Language [Based on Transhuman National Committee Platform, Freedom of Self Policy Plank]

Clause E2-A-Add-1.  The United States Transhumanist Party is focused on the rights of all sapient individuals to do as they see fit with themselves and their own reproductive choices.

Clause E2-A-Add-2. The United States Transhumanist Party recognizes the ethical obligations of sapient beings to be the purview of those individual beings, and holds that no other group, individual, or government has the right to limit those choices – including genetic manipulation or other biological manipulation or any other modifications up to and including biological manipulation, mechanical manipulation, life extension, reproductive choice, reproductive manipulation, cryonics, or other possible modifications, enhancements, or morphological freedoms. It is only when such choices directly infringe upon the rights of other sapient beings that the United States Transhumanist Party will work to develop policies to avoid potential infringements.

Question E2-A-Add-3. If any option of the Morphological Freedom plank is adopted, shall any mention of not harming others be preceded by the word “directly”? For example, if members vote in the affirmative, then in Option E2-A-1, “as long as such changes do not harm others” would be revised to “as long as such changes do not directly harm others”. In Option E2-A-2, “so long as it does not harm others” would be revised to “so long as it does not directly harm others”.

☐ Yes, add the word “directly”.

☐ No, do not add the word “directly”.

Section E2-B. Pro-Intelligence / Pro-Science Position

Option E2-B-1.

[Based on Section II of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports the spread of a pro-science culture by emphasizing reason and secular values.

Option E2-B-2.

[Based on Proposal by Daniel Yeluashvili, Base Text]

The United States Transhumanist Party strongly supports and emphasizes all values and organized efforts related to the cultivation of science, reason, intelligence, and rational thinking.

Potential Add-On Language [Based on Proposals by Daniel Yeluashvili, with Additional Options Generated]

Note: It is intended for members to have the options to accept or reject any of the following add-on clauses and to select candidate language within each clause when multiple variants may be feasible.

Clause E2-B-Add-1: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, frowns upon, places no reliance upon] any and all sources of information that cannot stand up to [Possible Options: academic, rational, factually grounded, objective] scrutiny.

Clause E2-B-Add-2: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, frowns upon, places no reliance upon] any [Candidate entities for inclusion in the list: individual, organization, belief system] that intentionally distorts [Possible Options: academically, empirically, factually, objectively] verifiable evidence to serve its own agenda, including but not limited to [Candidate adjectives for inclusion in the list: scientific, historical, political, journalistic] evidence.

Clause E2-B-Add-3: The United States Transhumanist Party [Possible Options: condemns, disavows, disregards, frowns upon, places no reliance upon] any position or belief system that contains arguments built upon logical fallacies (with exemption granted to arguments containing both fallacious and logically defensible premises).

Section E2-C. Liberty to Innovate

Option E2-C-1.

[Based on Section III of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports maximum individual liberty to engage in scientific and technological innovation for the improvement of the self and the human species. In particular, the United States Transhumanist Party supports all rationally, scientifically grounded research efforts for curing diseases, lengthening lifespans, achieving functional, healthy augmentations of the body and brain, and increasing the durability and youthfulness of the human organism. The United States Transhumanist Party holds that all such research efforts should be rendered fully lawful and their products should be made fully available to the public, as long as no individual is physically harmed without that individual’s consent or defrauded by misrepresentation of the effects of a possible treatment or substance.

Section E2-D. Support for Emerging Technologies

Option E2-D-1.

[Based on Section XVII of the Nevada Transhumanist Party Platform]

The United States Transhumanist Party supports all emerging technologies that have the potential to improve the human condition – including but not limited to autonomous vehicles, electric vehicles, economical solar power, safe nuclear power, hydroelectricity, geothermal power, applications for the sharing of durable goods, artificial intelligence, biotechnology, nanotechnology, robotics, rapid transit, 3D printing, vertical farming, electronic devices to detect and respond to trauma, and beneficial genetic modification of plants, animals, and human beings.

Section E2-E. Smart Infrastructure

Option E2-E-1.

[Based on Proposal by Jennifer Warren]

The United States Transhumanist Party advocates the construction of a self-repairing, self-maintaining smart infrastructure which incorporates the distribution of energy, communications, and clean potable water to every building.

Results of Platform Vote #1 and Adopted Sections

Results of Platform Vote #1 and Adopted Sections

logo_bg

Gennady Stolyarov II


The U.S. Transhumanist Party conducted its second vote of the members and the first vote on its platform planks on January 15 through January 21, 2017. Official ballot options can be found here.

Detailed results of the voting have been tabulated here. Options were selected based on the ranked-preference method with instant runoffs.

As a result, the following sections of Article III of the U.S. Transhumanist Party Constitution were adopted.

Section I: The United States Transhumanist Party strongly supports individual privacy and liberty over how to apply technology to one’s personal life. The United States Transhumanist Party holds that each individual should remain completely sovereign in the choice to disclose or not disclose personal activities, preferences, and beliefs within the public sphere. As such, the United States Transhumanist Party opposes all forms of mass surveillance and any intrusion by governmental or private institutions upon non-coercive activities that an individual has chosen to retain within his, her, or its private sphere. However, the United States Transhumanist Party also recognizes that no individuals should be protected from peaceful criticism of any matters that those individuals have chosen to disclose within the sphere of public knowledge and discourse.

Section II: The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries.

Section III: The United States Transhumanist Party holds that the vast majority of technologies are beneficial to human well-being and should be enthusiastically advocated for and developed further. However, a minority of technologies could be detrimental to human well-being and, as such, their application, when it results in detrimental consequences, should be opposed. Examples of such detrimental technologies include nuclear, chemical, and biological weapons, mass-surveillance systems such as those deployed by the National Security Agency in the United States, and backscatter X-ray full-body scanners such as those used until 2013 by the Transportation Security Administration in the United States. Furthermore, the United States Transhumanist Party is opposed to the deliberate engineering of new active pathogens or the resurrection of once-existing pathogens, whose spread might not be able to be contained within laboratory settings. While it is impossible to un-learn the knowledge utilized in the creation of such technologies, the United States Transhumanist Party holds that all such knowledge should only be devoted toward peaceful, life-affirming, rights-respecting purposes, going forward.

Section IV: In recognition of the dire existential threat that nuclear weapons pose to sapient life on Earth – including as a result of such weapons’ accidental deployment due to system failures or human misunderstanding – the United States Transhumanist Party advocates the complete dismantlement and abolition of all nuclear weapons everywhere, as rapidly as possible. If necessary for geopolitical stability, synchronized multilateral disarmament and non-proliferation treaties should be pursued, strengthened, and accelerated in the most expeditious manner. If, however, multilateral agreements among nations are not reached, then the United States Transhumanist Party advocates that all nuclear powers, especially the United States and Russia, should undertake unilateral nuclear disarmament at the earliest opportunity in order to preserve civilization from accidental annihilation.

Section V: The United States Transhumanist Party supports concerted research in effort to eradicate disease and illness that wreak havoc upon and cause death of sapient beings. We strongly advocate the increase and redirection of research funds to conduct research and experiments and to explore life, science, technology, medicine, and extraterrestrial realms to improve all sentient entities.