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The Good Sides of Aging? – Article by Nicola Bagalà

The Good Sides of Aging? – Article by Nicola Bagalà

Nicola Bagalà


Editor’s Note: Nicola Bagalà in this guest article elaborates upon aging as a topic distinguished in terms of Chronological Aging and Biological Aging. This article was originally published by the Life Extension Advocacy Foundation (LEAF).

~ Kenneth Alum, Director of Publication, U.S. Transhumanist Party, October 17, 2017

Sometimes, and especially in articles aimed at mitigating people’s fear of aging, it is said that aging doesn’t come just with downsides, such as frailty and diseases, but also with upsides — for example, wisdom and a long life experience.

It is often subtly implied that these two very different aspects are two sides of the same coin, that you can’t have one without the other, and perhaps even that the ill health of old age is a fair price to pay for the benefits that also come with it.

Nothing could be further from the truth.

Setting the record straight

There are plenty of good reasons to be afraid of aging, because the diseases and disabilities it causes are very real and far from being observed only in exceptional cases. It would be foolish not to fear cancer, for example, because it is an extremely serious and often fatal condition; in the same way, and for the same reasons, it is foolish not to fear aging; perhaps, an even stronger fear is justified, because aging can and does give rise to many diseases, including cancer itself.

There’s nothing wrong with fearing aging, because it may help us steer clear from its inherent dangers, just like the fear of any other harmful thing keeps us away from it. This is true so long as by ‘aging’ we mean biological aging, which is not at all the same as chronological aging. It is very important to draw a line between the two so that we don’t end up accepting the downsides of the former, which are neither necessary nor sufficient to enjoy the benefits of the latter.

What’s the difference?

Chronological aging is a rather fancy term to indicate a very mundane thing, namely the passing of time. For as long as time will keep passing, everything will age chronologically. This is obviously a good thing because if time did not pass, the universe would stand still and nothing at all, including ourselves, would ever happen.

However, it is easy to see how chronological and biological aging are not the same thing by means of a simple observation: Although time runs essentially uniformly everywhere on Earth, different life forms have different health- and lifespans. If time passes at the same rate for me and for a cat, and yet I’m (biologically) old at age 80 while a cat is (biologically) old already at age 15, clearly there must be something else than just the passing of time that accounts for this discrepancy.

This ‘something else’ is metabolism—the intricate set of chemical reactions the bodies of living creatures perform on a daily basis for the very purpose of staying alive. As we have discussed in other articles, what we call biological aging is really just a process of damage accumulation; this damage, which eventually leads to pathologies, is caused by metabolism itself, and therefore a faster metabolism means faster aging. Different species have different metabolic rates; as a rule of thumb, the smaller the species, the faster its metabolism and thus its aging, leading to shorter health- and lifespan. This is, in a nutshell, why a cat ages faster than I do.

As a confirmation of this fact, one may observe that species in a regimen of caloric restriction tend to live longer (sometimes much longer) than their normal lifespan, and the insurgence of age-related diseases is delayed accordingly: A lower caloric intake causes metabolism to slow down; consequently, the aging process follows suit.

Interestingly, some lucky species, the so-called negligibly senescent organisms, don’t show any signs of biological aging at all with the passing of time.

At this point, you don’t have to be clairvoyant to see that biological aging implies chronological aging, but not vice-versa. No chronological aging means no time passing, and no time passing means nothing takes place, metabolism included. However, since different creatures age differently (or not at all) despite time passing at the same rate for all of them, chronological aging doesn’t imply biological aging. Quite simply, they’re not the same thing.

Render unto Caesar the things which are Caesar’s

Having cleared the difference between chronological and biological aging, we must now correctly attribute the aforementioned pros and cons of old age to each of them.

From the very definition of biological aging above, it’s clear that it is the culprit responsible for the cons—the diseases of old age.

Speaking of the pros, all possible benefits of old age—life experience, wisdom, sense of accomplishment—certainly do not come from the damage that metabolism has wrecked throughout your body over the years. Clearly, they depend on the events of your life, and thus they’re not at all granted to happen, no matter how long you live. If you spent your life in isolation doing nothing, avoiding new experiences, and not learning anything new, your wisdom as an eighty-year-old would hardly compare to that of a well-traveled, seasoned scientist or philosopher of the same age, for example. Ultimately, the benefits traditionally attributed to old age obviously depend on the passing of time (i.e., chronological aging), and most of all on the use you made of your time. Just because you’re old, you’re not automatically wise, accomplished, or well-learned.

What’s more, the debilitation that comes with biological aging makes it harder for you to relish and expand the wisdom and experience you’ve accrued over the years. So, not only does biological aging bring no benefits; it is a hindrance as well.

In conclusion, the pros and cons of old age are due to different causes, and, as such, they aren’t interdependent. The diseases of old age are not a currency you can use to buy yourself the wisdom of the aged, and thanks to the emergence of rejuvenation biotechnologies, you might relatively soon be able to enjoy the pros of old age without having to pay any undue and unfair tolls.

 

About Nicola Bagalà

Nicola Bagalà has been an enthusiastic supporter and advocate of rejuvenation science since 2011. Although his preferred approach to treating age-related diseases is Aubrey de Grey’s suggested SENS platform, he is very interested in any other potential approach as well. In 2015, he launched the blog Rejuvenaction to advocate for rejuvenation and to answer common concerns that generally come with the prospect of vastly extended healthy lifespans. Originally a mathematician graduated from Helsinki University, his scientific interests range from cosmology to AI, from drawing and writing to music, and he always complains he doesn’t have enough time to dedicate to all of them—which is one of the reasons he’s into life extension. He’s also a computer programmer and web developer. All the years spent learning about the science of rejuvenation have sparked his interest in biology, in which he’s planning to get a university degree.

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.

Jim Mellon Announces Launch of New Book – Juvenescence: Investing in the Age of Longevity – Press Release by Biogerontology Research Foundation

Jim Mellon Announces Launch of New Book – Juvenescence: Investing in the Age of Longevity – Press Release by Biogerontology Research Foundation

Biogerontology Research Foundation


London, UK: Biogerontology Research Foundation Trustee Jim Mellon announces the publication of his newest book, Juvenescence: Investing in the Age of Longevity.

The book is a comprehensive summary of the emerging longevity industry, including profiles of longevity companies, investment opportunities, and aims to chart the major ideas of the geroscience’s thought-leaders and the vast implications this will have on economies and societies.

Often referred to as the British Warren Buffett, Billionaire Jim Mellon is well known for identifying major emerging trends before they become mainstream. Mellon made his wealth by investing in emerging markets throughout the 1990s. After many years of research and investing in the life science sector, Jim announced his vision for the emergence of the nascent longevity industry at Master Investor, one of the UK’s leading investor show in March of 2017, which was attended by over five thousand investors and entrepreneurs.

“The Biogerontology Research Foundation is proud to support what we feel will come to be seen as a landmark publication in the modern history of biogerontology. Jim has put an enormous amount of thought and effort into this new book, and has interviewed many of the field’s leading scientists in his research. The field of geroscience and the emerging longevity industry are both sure to prosper from very well-respected business personalities like Jim Mellon championing the longevity industry and projecting that it will become the world’s largest industry. Further, governments and policy makers should note the pressing need for a paradigm shift in medicine and healthcare away from ‘sick care’ toward comprehensive and disease-preventative healthspan extension. We are proud to have Jim as a Trustee of the Biogerontology Research Foundation and look forward to helping him lend mainstream credibility to the field and actionability to the dawning longevity industry” said Franco Cortese, Deputy Director & Trustee of the Biogerontology Research Foundation.

In 2012, Jim published his best-seller Cracking the Code, which summarized his vision for the future of the life science sector. In 2017, he announced his intention to focus much of his time and assets on the emerging longevity industry and make substantial investments into this area.

Jim and long-time co-author Al Chalabi toured many academic institutions, biopharmaceutical companies, and Silicon Valley tech companies to learn about the latest research and to understand the rapidly advancing field of longevity. Juvenescence highlights the technologies they deem the most likely to generate substantial longevity dividends and create sustainable and profitable industries. They travelled through the US and Europe, interviewing geroscience’s leading scientists and thought-leaders and provide an objective survey of their findings well as a detailed vision for the industry’s future and the most appropriate investment opportunities within the dawning longevity industry.

 

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Earlier this year Jim Mellon announced the formation of Juvenescence Limited, a company investing in the longevity biotechnology. Since then the company announced investments in several high-profile longevity companies including Insilico Medicine, Inc, a Baltimore-based leader in artificial intelligence for drug discovery, biomarker development, and aging research.

About the Biogerontology Research Foundation:

The Biogerontology Research Foundation is a UK non-profit research foundation and public policy center seeking to fill a gap within the research community, whereby the current scientific understanding of the ageing process is not yet being sufficiently exploited to produce effective medical interventions. The BGRF funds and conducts research which, building on the body of knowledge about how ageing happens, aims to develop biotechnological interventions to remediate the molecular and cellular deficits which accumulate with age and which underlie the ill-health of old age. Addressing ageing damage at this most fundamental level will provide an important opportunity to produce the effective, lasting treatments for the diseases and disabilities of ageing, required to improve quality of life in the elderly. The BGRF seeks to use the entire scope of modern biotechnology to attack the changes that take place in the course of ageing, and to address not just the symptoms of age-related diseases but also the mechanisms of those diseases.

Our Moral Obligation to Cure Aging – Aubrey de Grey Interviewed by Why? Radio

Our Moral Obligation to Cure Aging – Aubrey de Grey Interviewed by Why? Radio

Dr. Aubrey de Grey

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Dr. Aubrey de Grey in this interview explains and advocates for curing of aging, i.e., rejuvenation of the old to become youthful; preventing the youth from being old biologically, and other related points.

Aubrey de Grey is the U.S. Transhumanist Party’s Anti-Aging Advisor. He is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) charity dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging.

This interview was conducted by Why? Radio, a program of the Institute for Philosophy in Public Life. You can also find it here.

 

 

 

I am the Lifespan – Video by Gennady Stolyarov II

I am the Lifespan – Video by Gennady Stolyarov II

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Gennady Stolyarov II


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, discusses why longevity research is crucial, and how our generation stands on the threshold of finally dealing a decisive blow to the age-old enemies of aging and death, which have destroyed great human minds since the emergence of our species.

This video is part of the #IAmTheLifespan campaign, coordinated by Lifespan.io and the Life Extension Advocacy Foundation (LEAF) for Longevity Month, October 2017. Read more about this campaign here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

Transhumanism: Contemporary Issues – Presentation by Gennady Stolyarov II at VSIM:17 Conference in Ravda, Bulgaria

Transhumanism: Contemporary Issues – Presentation by Gennady Stolyarov II at VSIM:17 Conference in Ravda, Bulgaria

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Gennady Stolyarov II


Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, outlines common differences in perspectives in three key areas of contemporary transhumanist discourse: artificial intelligence, religion, and privacy. Mr. Stolyarov follows his presentation of each issue with the U.S. Transhumanist Party’s official stances, which endeavor to resolve commonplace debates and find new common ground in these areas. Watch the video of Mr. Stolyarov’s presentation here.

This presentation was delivered by Mr. Stolyarov on September 14, 2017, virtually to the Vanguard Scientific Instruments in Management 2017 (VSIM:17) Conference in Ravda, Bulgaria. Mr. Stolyarov was introduced by Professor Angel Marchev, Sr. –  the organizer of the conference and the U.S. Transhumanist Party’s Ambassador to Bulgaria.

After his presentation, Mr. Stolyarov answered questions from the audience on the subjects of the political orientation of transhumanism, what the institutional norms of a transhuman society would look like, and how best to advance transhumanist ideas.

Download and view the slides of Mr. Stolyarov’s presentation (with hyperlinks) here.

Listen to the Transhumanist March (March #12, Op. 78), composed by Mr. Stolyarov in 2014, here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

U.S. Transhumanist Party Discussion on Prosthetics, Neuroscience, and the Future of Human Potential

U.S. Transhumanist Party Discussion on Prosthetics, Neuroscience, and the Future of Human Potential

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Gennady Stolyarov II

Bobby Ridge

Scott Jurgens


U.S. Transhumanist Party Chairman Gennady Stolyarov II speaks with Secretary-Treasurer Bobby Ridge and Director of Applied Innovation Scott Jurgens regarding their areas of interest in research and study. Topics addressed include emerging advances in prosthetics, orthotics, 3D printing, 3D scanning, the science behind neuroplasticity, brain-computer interfaces (BCIs), artificial intelligence, and the societal implications of these technologies – including the extent to which they, combined with a universal basic income, may facilitate increased self-actualization by more people.

Conversations such as this one are prime examples of why the U.S. Transhumanist Party and the transhumanist movement are positioned to be the vanguard of the next era of our civilization, ready to rebuild it and take it to new heights, given sufficient recognition from and collaboration with the general public.

References

– Hugh Herr – “The new bionics that let us run, climb, and dance” – TED – March 2014
LimbForge – Enable Community Foundation
Autodesk Fusion 360
Thingiverse
– “Metal Gear Solid 5 Inspires an Amazing Prosthetic Arm” – Kendall Ashley – Nerdist – May 23, 2016

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

Zoltan Istvan Advocates for The Future at RAAD Fest 2017

Zoltan Istvan Advocates for The Future at RAAD Fest 2017

Zoltan Istvan

Introduction by U.S. Transhumanist Party Chairman Gennady Stolyarov II

Post by Martin van der Kroon


Zoltan Istvan, founder of the United States Transhumanist Party, discusses his 2016 Presidential campaign, his Immortality Bus tour, and his ambitions to spread the ideas of the transhumanist movement and forward the goal of defeating death. Zoltan delivered this speech at RAAD Fest 2017 in San Diego on August 11, 2017, as part of the panel entitled “Advocating for the Future”. He was introduced by the current U.S. Transhumanist Party Chairman, Gennady Stolyarov II.

The U.S. Transhumanist Party – Pursuing a Peaceful Political Revolution for Longevity – RAAD Fest 2017 Presentation by Gennady Stolyarov II

The U.S. Transhumanist Party – Pursuing a Peaceful Political Revolution for Longevity – RAAD Fest 2017 Presentation by Gennady Stolyarov II

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Gennady Stolyarov II


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, delivered this presentation as the initial speech in the panel discussion he moderated at RAAD Fest 2017, entitled “Advocating for the Future”. The audience consisted of approximately 700 in-person attendees.

Other speakers in the panel included Zoltan Istvan, Ben Goertzel, Max More, and Natasha Vita-More.

Gennady Stolyarov II Prepares to Present and Moderate Panel at RAAD Fest 2017

Gennady Stolyarov II Presents at RAAD Fest 2017

Gennady Stolyarov II Moderates Question-and-Answer Session for Panel: “Advocating for the Future” – RAAD Fest 2017

From left to right, Zoltan Istvan, Gennady Stolyarov II, Max More, Ben Goertzel, and Natasha Vita-More

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Fill out our Application Form here.

LEAF Panel: How to Promote Longevity? ft. Drs. Aubrey de Grey, Alexandra Stolzing, Oliver Medvedik

LEAF Panel: How to Promote Longevity? ft. Drs. Aubrey de Grey, Alexandra Stolzing, Oliver Medvedik

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Keith Comito
Oliver Medvedik
Steve Hill
Elena Milova
Aubrey de Grey
Alexandra Stolzing
Alen Akhabaev


The U.S. Transhumanist Party is pleased to feature this extensive discussion, hosted by our allies at LEAF – the Life Extension Advocacy Foundation.

Description by LEAF: Dr. Alexandra Stolzing, Dr. Aubrey de Grey, Dr. Oliver Medvedik and a number of other guests discuss longevity, advocacy and rejuvenation biotechnology in an exclusive panel hosted by the Life Extension Advocacy Foundation (LEAF). This panel, moderated by LEAF president Keith Comito, talks about the latest progress in rejuvenation biotechnology and about how to engage, educate and excite the public regarding cutting-edge medicine.

Panel: Dr. Alexandra Stolzing, Dr. Aubrey de Grey, Dr. Oliver Medvedik , Elena Milova, Keith Comito, Steve Hill and Alen Akhabaev.

Subscribe to LEAF’s video channel for more.

Support LEAF’s work by becoming a “Lifespan Hero”: http://lifespan.io/hero

The Great Transhumanist Game – How to Win; How to Play and Not to Play – Videos by Gennady Stolyarov II

The Great Transhumanist Game – How to Win; How to Play and Not to Play – Videos by Gennady Stolyarov II

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Gennady Stolyarov II


This two-part video series was created by Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, to serve as pieces in the Great Transhumanist Game orchestrated by Professor Angel Marchev, Sr., Ph.D., of the University of National and World Economy in Sofia, Bulgaria.

The Great Transhumanist Game – Part 1 – How to Win

What would it mean to win in the Great Transhumanist Game? Mr. Stolyarov answers that winning would be inaugurating the next great era of human civilization, and living to see it.

The Great Transhumanist Game – Part 2 – How to Play and Not to Play

Now that we know what it would mean to win the Great Transhumanist Game, how do we get from here to there? Mr. Stolyarov discusses the importance of knowing which game one is playing, and whose, and abstaining from playing the wrong, counterproductive political or insurrectionary games.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Fill out our Application Form here.