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The Rise of Oisin Biotechnologies – Interview with Gary Hudson, CEO of Oisin Biotechnologies, by Ariel VA Feinerman

The Rise of Oisin Biotechnologies – Interview with Gary Hudson, CEO of Oisin Biotechnologies, by Ariel VA Feinerman

Ariel VA Feinerman
Gary Hudson


Gary Hudson

Preface

What is ageing? We can define ageing as a process of accumulation of the damage which is just a side-effect of normal metabolism. While researchers still poorly understand how metabolic processes cause damage accumulation, and how accumulated damage cause pathology, the damage itself — the structural difference between old tissue and young tissue — is categorized and understood pretty well. By repairing damage and restoring the previous undamaged — young — state of an organism, we can really rejuvenate it! Sounds very promising, and so it is. And for some types of damage (for example, for senescent cells) it is already proved to work!

Today in our virtual studio somewhere between cold rainy Saint-Petersburg and warm rainy Seattle, we meet Gary Hudson!

He has been involved in private space flight development for over 40 years. Hudson is best known as the founder of Rotary Rocket Company, which in spending ~$30 Million attempted to build a unique single stage to orbit launch vehicle known as the Roton. He helped found Transformational Space T/Space in 2004 and AirLaunch LLC which was awarded the DARPA/USAF FALCON project in 2003.

Previous projects included designs of the Phoenix SSTO, the Percheron, and other rockets, founder of Pacific American Launch Systems, and various consulting projects. Currently, he is the President and CEO of the Space Studies Institute.

Now Hudson brings his excellent engineering skills into rejuvenation biotechnology! He is a founding partner of Oisin Biotechnologies, who are developing a liposomally delivered DNA therapy for the removal of senescent cells from the body. Hudson provided an initial seed donation to help fund the creation of the Methuselah Foundation and SENS Research Foundation.

Interview

Feinerman: Hello, Mr Gary Hudson!

Hudson: Thanks for inviting us to this interview!

Feinerman: You have recently visited an amazing Undoing Aging 2018 conference, which took place in Berlin, 15–17 March, where your colleague, Matthew Scholz, was a speaker. What is your impression?

Hudson: It was a great conference with several important presentations. It put me in mind of the early SENS conferences in Cambridge, UK, which I helped to sponsor. I understand it will now become an annual event. Our CSO Dr. John Lewis also gave an important summary of our work to date.

Feinerman: Will Oisin’s presentations from conference be available for general public?

Hudson: I believe that the SENS Foundation will be posting them but I don’t have details about the timing.

FeinermanYour last interview was in July 2017, more than half a year ago. What has been accomplished?

Hudson: We have conducted many pre-clinical mouse experiments on both cancer and senescent cell removal. All have been successful and produce very remarkable results. We’ve also conducted a pilot toxicity and safety trial on non-human primates. The results of that trial were also successful and encourage us to proceed to human safety trials as soon as regulatory authorities approve them. We have also spun-out a cancer-focused company, Oisin Oncology, and raised a seed round for that venture.

Feinerman: Great to hear! However, when can we see some papers? People usually trust papers more than mere interviews or press releases. Of course, papers need many efforts not related to research but they will allow you attract more attention from general public, researchers, and investors.

Hudson: Papers are being prepared now for submission to major journals, but that process takes time, especially the peer review. For the moment, most of our data is only available to investors and partners in pharma and the biotech industry.

Feinerman: You planned human clinical trials, have you carried them out?

Hudson: It takes quite some time to organize a human trial and to get it approved. Before one can be conducted, we have to set up so-called “GMP (Good Manufacturing Practice) manufacture of our therapeutic, and then we have to conduct “GLP (Good Laboratory Practice) Tox” studies in two different species. Once that is all completed later this year, then we can begin a human safety trial, or a “Phase 1” trial. All this takes time, but we hope that first safety trials in oncology indications might begin this year, or in early 2019.

Feinerman: Does that mean we have a race between Unity Biotechnology and Oisin and you have all chances to win the race?

Hudson: I don’t see it as a race or a competition. I believe that future anti-aging treatment will require multiple complimentary approaches.

Feinerman: When we can expect your therapy available in the clinic?

Hudson: It’s very difficult to predict. I believe that our cancer treatment will make it to the clinic first, and that could happen in less than five years. Since the FDA doesn’t regard ageing as an indication, it may take longer for our SENSOlytic™ treatment to reach the public, since the regulatory environment will need to change.

Feinerman: As Michael Rae has said, we need not to wait when ageing will be recognised as a disease. You can mark your senolytics as a therapy for specific ageing pathology like fibrosis or chronic inflammation in the same way as Unity does.

Hudson: This is certainly true and is part of our strategy, but many of those endpoints are more difficult to ascertain than oncology endpoints. Additionally, going after oncology approvals can be faster and easier to get to clinic. But we will push forward on several fronts as funding permits.

Feinerman: In your previous interview you have said that you make some tweaks to both the promoter side and the effector side of the constructs that will provide even more interesting and useful extensions to the basic capability, but you can’t discuss those for IP reasons. Can you now say about them?

Hudson: I still can’t say too much about them, but we have conducted animal trials on some of these “tweaks” and they work quite well. The downside to the matter is that every “tweak” requires new trials, and our goal is to get something to the clinic as soon as possible, so many of the improvements will have to wait. Progress is limited based on available funds and personnel resources, of course, but we will move as quickly as we can.

Feinerman: Do you use any CAD software to design your constructs? Are you going to make them public so independent engineers will be able to help you identify new useful pairs of promoters and effectors? Your technology is so powerful that Open Source approach would be very helpful!

Hudson: No, the design of the current constructs are very straightforward and simple. As our patents are issued, their design will become public. If people wish to design their own constructs for particular applications they may contact us for collaboration, though we do have several collaborations active at the moment so we may already be working on similar ideas.

Feinerman: What do you think on targeting your machinery on cells with abnormal telomerase activity to kill cancer? Can you use several conditions — like in programming — several promoters to be more specific?

Hudson: If we targeted telomerase we’d also kill stem cells, just like the side effects of much of conventional chemotherapy. That’s probably not a good idea. But multiple promoters, or synthetic promoters, might be used to achieve the aims of killing only cancer cells. Our initial therapeutic will likely just employ p53 promoter targeting, since we have good data that works.

Feinerman: Yeah, the same issue as when we remove or break telomerase gene: there would be nice to do this only in compromised tissue, but as researchers say it is very difficult to make the removal selective. However, it is not a problem with ALT genes, which cause 15–20% of cancers. Are you going to collaborate with the OncoSENS lab? Also killing cells actively expressing telomerase will be very useful in WILT implementation.

Hudson: We’ve had conversations with the SENS Foundation about OncoSENS and cooperated in a preliminary fashion, but I don’t believe it is currently a research priority for them. We already have enough projects to keep us busy for some time, too!

Feinerman: Now you use only suicide gene as an effector, do you plan to use other genes? For example to enhance the cells, give them ability to produce new enzymes, or temporarily shut down telomerase to help anti-cancer therapy to be more effective.

Hudson: We believe we can express any gene under the control of any promoter we wish to use, so the possibilities are almost endless.

Feinerman: Now we know that epigenetic changes (shift) play a huge role in ageing. Even though there is no consensus among researchers whether they are a cause or a consequence of ageing, experiments show that temporal expression of OSKM transcription factors may have some health benefits by restoring “young” epigenetic profiles. You can remember the Belmonte work, for example. However, the problem in their work is that they used transgenic mice and express OSKM in every their cell. If you temporarily express OSKM in an “old” cell, that is OK, you can “rejuvenate” such a cell. While if you express OSKM in a stem cell which is already biologically “young”, you can force the cell into iPSC, which is a way to cancer. Using your machinery we can target only cells which have “old” expression profiles, and involving normal mice! Such a work will be much “cleaner” and safer than Belmonte’s work.

Hudson: With respect to your comments about reprogramming, Oisin is currently working with a university group on exactly this approach, but I can’t say more at this time. We also believe that first you have to clear existing senescent cells, then you can reprogram successfully.

Feinerman: How many resources, finances, and personnel do you need to move as quickly as possible? Do you have open positions? Maybe, some of our readers have enough finances or experience.

Hudson: We could effectively spend tens of millions or dollar or more, very easily, but it isn’t realistic to assume we could raise that amount — and if we did, we’d lose control of Oisin’s ageing focus, since investors would most likely want us to aim at quick returns. We are always interested in talking with “mission minded” investors, however. As for hiring, we have to do that slowly and judiciously, since labour is one of the biggest costs to a start-up company, and over-hiring can sink a project quickly. We already have more potential hires than we can bring on-board.

Feinerman: Now cryptocurrencies and blockchain technologies allow completely new and efficient ways for investments. We can see this as various no-name companies easily rise tens of millions dollars via ICOs for clearly doubtful projects. Would you like to make an ICO? Oisin shows real progress and can easily rise big sums! People say that they will be glad to buy your tokens if you issue them. You have said that you prefer to work with “mission minded” investors. There are thousands people out there who can invest from $1,000 to $100,000 in cryptocurrencies and who believe that radical extension of healthy life is possible!

If you are worried about legal issues, you can use various cryptocurrency investment funds who act like proxies between holders of cryptocurrencies and companies.

Hudson: We have investigated several of these financing options, but we are not expert in this area, so we have been reluctant to move too quickly. But we continue to have conversations with relevant parties. There is a lot of regulatory uncertainty surrounding ICOs, however, so we must move cautiously.

Feinerman: Now we know enough about ageing to defeat our main enemy. Do you agree that first comprehensive rejuvenation panel is not a scientific problem and even not an engineering problem, but a problem of engineering management?

Hudson: I wouldn’t say that there is no science left to do, but as an engineer myself I naturally agree that proper engineering management and program management skills must be brought to bear on the problem of ageing.

Feinerman: One person has said, we get what we ask for. Can we now aim high and publicly claim that our main goal is not additional five years of life but LEV — Longevity Escape Velocity and finally unlimited healthy life?

Hudson: This is a difficult “public relations” problem. Most investors, the scientific community, and the public are not yet ready to embrace the notion of longevity escape velocity. Thus at Oisin we do pitch health span as a primary goal. But personally I don’t believe that you can obtain health span improvements without making significant progress towards LEV. So in the end, I think we get LEV by targeting health span, and we reduce the controversy by doing so.

Feinerman: Some people ask me how to buy your stocks or invest in Oisin. What can you say?

Hudson: We do have a number of private investors (angel investors) who are “mission minded” or “mission focused” and we welcome discussions with qualified investors and firms who share our vision for dealing with ageing and cancer. Accredited investor candidates may contact us at info@oisinbio.com

Feinerman: David Gobel claims that “By advancing tissue engineering and regenerative medicine, we want to create a world where 90-year olds can be as healthy as 50-year olds by 2030.” And I secretly hope that 40 will become new 30 or even 20 by 2030! Can we achieve that — in principle?

Hudson: I certainly hope so! In 2030 I’ll be 80, so I’m looking forward to feeling like I’m 40…

Feinerman: Thank you very much for your amazing answers! That was a real pleasure to talk with such a great man like you. I hope we all will succeed in our goal and will have hundreds, thousands, and — who knows? — maybe even millions years of healthy life!

Hudson: It is kind of you to say so, but I only consider myself fortunate to be working with the really great men and women in the anti-aging community who are doing the real work. I’m only trying to facilitate their efforts and get treatments to the clinic as fast as possible. I don’t know what will be possible in the long term, but anything will be better than letting nature run its course, producing sickness and declining functional health.

Ariel VA Feinerman is a researcher, author, and photographer, who believes that people should not die from diseases and ageing, and whose main goal is to improve human health and achieve immortality.

Message from Ariel VA Feinerman: If you like my work, any help will be appreciated!

PayPal: arielfeinerman@gmail.com

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New FDA Regenerative Medicine Framework is Win-Win for Gene Therapies – Article by Keith Comito and Elena Milova

New FDA Regenerative Medicine Framework is Win-Win for Gene Therapies – Article by Keith Comito and Elena Milova

Elena Milova
Keith Comito


Editor’s Note: In this article, Keith Comito and Elena Milova positively discuss new a FDA regulatory framework on RMAT (regenerative medicine advanced therapies) and on how it benefits the healthy-life-extension community. This article was originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Kenneth Alum, Director of  Publication, U.S. Transhumanist Party, March 3, 2018

Back in November 2017, the FDA announced a comprehensive policy framework for the development and oversight of regenerative medicine products, including novel cellular therapies. Both draft guidance documents had 90-day comment periods, and we at LEAF joined forces with the Niskanen Center to submit comments to the FDA to ensure that the voice of the community for healthy life extension was heard. These new regulations could have considerable implications for the therapies and technologies being developed as part of the biomedical gerontology field.

The first draft guidance addresses how the FDA intends to optimize its regulatory requirements for devices used in the recovery, isolation, and delivery of RMATs (regenerative medicine advanced therapies), including combination products.

The second document explains what expedited programs may be available to sponsors of regenerative medicine therapies and describes what therapies may be eligible for RMAT designation.

According to new FDA regulations, a drug is eligible for designation as an RMAT if:

  • The drug is a regenerative medicine therapy, which is defined as a cell therapy, therapeutic tissue engineering product, human cell and tissue product, or any combination product using such therapies or products, except for those regulated solely under Section 361 of the Public Health Service Act and part 1271 of Title 21, Code of Federal Regulations;
  • The drug is intended to treat, modify, reverse, or cure a serious or life-threatening disease or condition; and
  • Preliminary clinical evidence indicates that the drug has the potential to address unmet medical needs for such disease or condition

We hope that this joint project will support the improvement of US regulations that concern these innovative treatments and will make the overall regulatory landscape more friendly. Below, we cite the most important notes from our resulting paper.

Last week, the Niskanen Center joined with the Life Extension Advocacy Foundation in filing comments to the Food and Drug Administration (FDA), offering our support for the agency’s new regenerative medicine advanced therapy (RMAT) designation draft guidance for industry.

Although there are opportunities for marginal improvements to the guidance, and FDA approval processes more generally, we are happy to see that the agency chose to include gene therapies in its interpretation of what qualifies as a regenerative medicine therapy.

Under section 3033 of the 21st Century Cures Act, the FDA was tasked with developing an accelerated approval process for regenerative advanced therapies. Such therapies would qualify for expedited review and approval so long as the drug (a) met the definition of a regenerative medicine therapy, (b) was “intended to treat, modify, reverse, or cure a serious condition,” and (c) “has the potential to address unmet medical needs” for a serious disease or condition. Unfortunately, the bill’s definition of a regenerative medicine advanced therapy was unclear on whether gene therapies, in particular, would qualify. Luckily, the FDA clarified this point. As the RMAT guidance document notes:

gene therapies, including genetically modified cells, that lead to a durable modification of cells or tissues may meet the definition of a regenerative medicine therapy. Additionally, a combination product (biologic-device, biologic-drug, or biologic-device-drug) can be eligible for RMAT designation when the biological product component provides the greatest contribution to the overall intended therapeutic effects of the combination product.

This is an excellent development and one that portends immense benefits for future gene therapy applications submitted for FDA approval. According to the guidance, the new RMAT designation, unlike other fast-track approval and review processes, “does not require evidence to indicate that the drug may offer a substantial improvement over available therapies.” Liberalizing the threshold standards of evidence for RMAT designation ensures that future gene therapies will encounter fewer unnecessary roadblocks in delivering more effective and innovative treatments for individuals suffering from debilitating diseases.

As we note in our concluding remarks:

Overall, we consider the RMAT guidance to be a stellar improvement over other expedited programs, especially in its qualifying criteria. However, greater clarity is needed in order to capture the benefits of more advanced cell therapies that can help contribute to the healthy aging and well-being of American citizens. As FDA Commissioner Scott Gottlieb recently noted: “The benefits of [gene therapy] science—and the products that become available—are likely to accelerate. How we define the modern framework for safely advancing these opportunities will determine whether we’re able to fully realize the benefits that these new technologies can offer.”

We agree wholeheartedly. Developing a regulatory framework that accommodates safety and innovation will be a key determinant of how quickly the benefits of regenerative medicine, gene therapy, and anti-aging research revolutionize the lives of Americans. This guidance is an important and promising step in the right direction. With the right modifications, it can help usher in a new age of healthcare improvement for individuals from all walks of life.

Read the full comments submitted to the FDA here.

Source: Niskanen Center

About Elena Milova

As a devoted advocate of rejuvenation technologies since 2013, Elena is providing the community with a systemic vision how aging is affecting our society. Her research interests include global and local policies on aging, demographic changes, public perception of the application of rejuvenation technologies to prevent age-related diseases and extend life, and related public concerns. Elena is a co-author of the book “Aging prevention for all” (in Russian, 2015) and the organizer of multiple educational events helping the general public adopt the idea of eventually bringing aging under medical control.

About Keith Comito

Keith Comito is President of LEAF / Lifespan.io and a long-time advocate of longevity research. He is also a computer programmer, mathematician, musician, lover of life and perhaps a man with too many hobbies. He earned a B.S. in Mathematics, B.S. in Computer science, and M.S. in Applied Mathematics at Hofstra University, where his work included analysis of the LMNA protein.

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.

Alzheimer’s Drug Turns Back the Clock in Mitochondria – Article by Steve Hill

Alzheimer’s Drug Turns Back the Clock in Mitochondria – Article by Steve Hill

Steve Hill


Editor’s Note: In this article, Mr. Steve Hill discusses an experimental drug, J147, for treating Alzheimer’s disease and also how Alzheimer’s disease is closely linked to aging.  This article was originally published by the Life Extension Advocacy Foundation (LEAF).

                   ~ Kenneth Alum, Director of  Publication, U.S. Transhumanist Party, January 26, 2018

J147 is an experimental drug that has been shown to treat Alzheimer’s disease, and it also appears to reverse some aspects of aging. It is also poised to enter human clinical trials in the near future, although how it works has been somewhat of a puzzle.

A new study  published in the journal Aging Cell has changed all that, and the results are quite intriguing [1]. Researchers at the Salk Institute have solved the mystery of how J147 works and why it makes old flies, mice, and cells more youthful.

Rejuvenating mitochondria

The drug apparently works because it binds to a protein found in mitochondria, the powerhouses of cells; this, in turn, causes cells to function in a more youthful manner. Mitochondrial dysfunction is one of the hallmarks of aging and is thought to be a key reason why we age and develop age-related diseases [2]. This drug appears, at least partially, to address some of that dysfunction.

Finding the target of J147 was the key to revealing the link between Alzheimer’s disease and the aging process. It was the critical information the researchers needed and was holding the drug back from clinical trials.

Dave Schubert, head of Salk’s Cellular Neurobiology Laboratory, and his team originally developed the J147 drug in 2011. The team screened numerous plant-sourced compounds with the potential to reverse the cellular and molecular signs of aging in the brain. The drug was developed as a modified version of a molecule found in the spice curcumin, a common ingredient in Asian foods such as curry.

Since then, the researchers have shown that J147 can reverse memory deficits, increases the production of brain cells, and slows the progression of Alzheimer’s in mice [3]. However, at that point, they did not understand how J147 worked.

Finding the target

During the new study lead by Dave Schubert and Salk Research Associate Josh Goldberg, the researchers used a number of approaches to find out how J147 worked. They eventually identified that the target of J147 was the mitochondrial protein known as ATP synthase, specifically ATP5A, a subunit of that protein. ATP synthase is involved in the mitochondrial generation of ATP, which cells use for energy.

The researchers demonstrated that by reducing the activity of ATP synthase, they were able to protect neuronal cells from a number of toxicities associated with the aging of the brain. One reason for this neuroprotective effect is thought to be the role of excitotoxicity in neuronal cell damage.

Excitotoxicity is the pathological process by which neurons are damaged and killed by the overactivation of receptors for the excitatory neurotransmitter glutamate. Think of it being a bit like a light switch being turned on and off so rapidly that it ends up causing the light bulb to blow.

Recently, the role of ATP synthase inhibition for neuroprotection against excitotoxic damage was demonstrated in a mouse study [4]. The second study showed that mouse models expressing the human form of mutant ATPase inhibitory factor 1 (hIF1), which causes a sustained inhibition of ATP synthase, were more resilient to neuronal death after excitotoxic damage. This data is consistent with this new J147 study, in which an increase in IF1 in the mice reduced the activity of ATP synthase (specifically ATP5A) and was neuroprotective.

ATP synthase is implicated in aging

ATP synthase has previously been shown to influence aging in C. elegans worms and flies. Given that aging is the greatest risk factor for developing Alzheimer’s disease, it is no surprise that the target of the drug is also involved in the aging process.

The team also revealed that by modulating the activity of ATP synthase, they could influence the levels of ATP and other molecules and were able to encourage healthier, more stable mitochondria during aging. Mice given the compound showed profound changes, appearing to look younger at a cellular and molecular level.

The researchers believe that these results are not only encouraging for the treatment of Alzheimer’s, they suggest that J147 may also be useful in treating other age-related diseases.

“People have always thought that you need separate drugs for Alzheimer’s, Parkinson’s and stroke,” said Dave Schubert. “But it may be that by targeting aging we can treat or slow down many pathological conditions that are old-age-associated.”

With J147 having just completed the FDA required toxicology testing in animals, the next step is phase 1 human clinical trials, and the road to approval begins.

Conclusion

It is very heartening to hear important researchers suggesting that in order to treat age-related diseases, one needs to treat the aging processes themselves. This is the exactly what Dr. Aubrey de Grey and others have been saying for many years. It is good to hear more voices joining the call to tackle age-related diseases at their root: the hallmarks and damages where they all begin.

The process of age-related disease begins long before the familiar signs and diagnoses are made; by targeting the early processes that are not given specific disease names, we might yet defeat horrific diseases, such as Alzheimer’s, which rob us of who we are.

Literature

[1] Joshua Goldberg et al. The mitochondrial ATP synthase is a shared drug target for aging and dementia. Aging Cell, 2018 DOI: 10.1111/acel.12715
[2] López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.
[3] Prior, M., Dargusch, R., Ehren, J. L., Chiruta, C., & Schubert, D. (2013). The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice. Alzheimer’s research & therapy, 5(3), 25.
[4] Formentini, L., Pereira, M. P., Sánchez‐Cenizo, L., Santacatterina, F., Lucas, J. J., Navarro, C., … & Cuezva, J. M. (2014). In vivo inhibition of the mitochondrial H+‐ATP synthase in neurons promotes metabolic preconditioning. The EMBO journal, 33(7), 762-778.

About Steve Hill

As a scientific writer and a devoted advocate of healthy longevity technologies Steve has provided the community with multiple educational articles, interviews and podcasts, helping the general public to better understand aging and the means to modify its dynamics. His materials can be found at H+ Magazine, Longevity reporter, Psychology Today and Singularity Weblog. He is a co-author of the book “Aging Prevention for All” – a guide for the general public exploring evidence-based means to extend healthy life (in press).

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.

Results of Platform Vote #6 and Adopted Sections

Results of Platform Vote #6 and Adopted Sections

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Gennady Stolyarov II


The U.S. Transhumanist Party conducted its seventh vote of the members and the sixth vote on its platform planks on November 11 through November 17, 2017. Official ballot options can be found here.

Detailed results of the voting have been tabulated here. In two instances, where no majority was reached in the first round of voting, options were selected based on the ranked-preference method with instant runoffs.

As a result, the following new or amended sections of Article III of the U.S. Transhumanist Party Constitution were adopted.

Section II: The United States Transhumanist Party supports all acceptance, tolerance, and inclusivity of individuals and groups of all races, genders, classes, religions, creeds, and ideologies. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to enforce said restrictions regardless of cause or motivation thereof. Additionally, any institution that uses violence, suppression of free speech, or other unconstitutional or otherwise illegal methods will be disavowed and condemned by the United States Transhumanist Party, with an efficient, non-violent alternative to said institution being offered to achieve its goals if they align with the Party’s interests.

Section XXVII: The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President.

Section LIX: The United States Transhumanist Party considers it important for impartial, objective investigations of alleged police and other law-enforcement misconduct to be pursued. While law-enforcement agencies should not be prohibited from internally investigating potential abuses within their own ranks, such investigations should never be considered exclusive or conclusive, and further external checks and accountability should be instituted. As part of providing such checks and accountability, investigations regarding misconduct, negligence, abuse, criminal activity, felonies, and misdemeanors allegedly committed by police, district attorneys, and judges, should, in addition to any internal investigation, also be conducted by a civilian organization outside the justice system. The intent of this requirement is to limit the possibility of favorably biased or preferential treatment of a member of a given law-enforcement agency by that person’s colleagues, and to restore confidence by the public that an investigation into police misconduct is done as objectively as possible.

Section LXIV: The United States Transhumanist Party supports efforts to create a reasonable minimum timeframe between the proposal of a bill and the voting procedure. To ensure a reasonable timeframe is proportional to the number of pages of a proposed bill, a time period per each specified amount of pages could be adopted. For example, and without committing to specific numerical magnitudes, a 24-hour period within a working week per every 20 pages could be adopted to ensure all members of Congress involved have sufficient time to read through and study a proposed bill’s implications. Such measures would prevent a bill from being introduced shortly before the voting process. They would also have the added side effect that proposals might become more concise, as the length of a bill would influence the consideration time.

In addition to this, after the proposal has been submitted, any amendments must be explicitly discussed in a public forum with the same degree of thorough consideration and same rules pertaining to the timeframe of consideration as allowed for the original proposal.

Section LXV: The United States Transhumanist Party supports efforts to ensure a jury is fully informed on its rights and responsibilities, including jury nullification. The United States Transhumanist Party also supports efforts to prevent false claims being made regarding the rights and responsibilities of the jury.

Section LXVI: As an intermediate step toward the goal of complete nuclear disarmament and a potential pragmatic compromise in any future negotiations for disarmament, the United States Transhumanist Party supports efforts to significantly reduce the United States nuclear stockpile, and to replace or transfer a small part (between 1 percent and 10 percent) of this stockpile, to mobile nuclear platforms such as submarines. An enemy may currently target the stationary nuclear bombs directly. Having a largely hidden mobile fleet of nuclear bombs would render it much more difficult for any enemy to target the nuclear arsenal, while still maintaining the nuclear deterrent option in sufficient capacity. This would further have the effect of lowering the budget required to maintain the nuclear stockpile, as it could be drastically downsized.

Section LXVII: The United States Transhumanist Party supports the right for individuals to have autonomy over, and utilize their bodies to earn money, including through activities such as prostitution, as long as such activities arise from a person’s own free will (e.g., not under duress), and the person is not endangering the health or well-being of others, including but not limited to the communication of sexually transmissible diseases.

Legalization would give those who wish to engage in prostitution the safety and protection of the law – for example, so that they may report abuse and would be prone to being exploited. It would also open the possibility for such individuals to unionize if they wish to do so. Furthermore, legalization would decrease government spending on what is ultimately a ‘moral crusade’.

However, the United States Transhumanist Party unequivocally condemns any manner of human trafficking, child exploitation, and other abuse that involves a violation of the autonomy and consent of any individual. The legalization of prostitution should be combined with stronger efforts to combat these dangerous and exploitative practices.

The legalization of prostitution could furthermore enable more effective action against human trafficking and involuntary exploitation, as, when prostitution is legalized, employees in this industry would become subject to the protections of the law. Legalization would help focus resources on combating the trafficking of humans rather than catching workers who chose this profession voluntarily.

Section LXVIII: The United States Transhumanist Party holds that any statement made by an elected official and/or public servant to members of the public in a public forum as part of that official’s or public servant’s job duties, and available to be heard, read, or otherwise understood in a public setting, physical or digital, should be considered a part of the public record and treated as an official statement of their office and position. This requirement does not extend to statements made by an elected official and/or public servant in the capacity of a private citizen or in the expression of a personal opinion or other position unrelated to the exercise of the official’s or public servant’s job duties.

Section LXIX: The United States Transhumanist Party holds that state and federal governments should establish an artificial intelligence (AI) analysis system for measuring risk of proposed legislation. Such a system could provide an impartial look at what legislation could cause harm or unintended consequences. Submitted policies would receive a score from 0 to 100, and the AI system would state what possible negative impacts may result. This system should be publicly accessible for submissions and for security audit. This is not intended to create or enact laws, but simply to serve as a tool to measure risk versus reward.

Section LXX: The United States Transhumanist Party strongly opposes the possibility for any political party to determine the boundaries and borders of any voting district. The United States Transhumanist Party supports measures that require any efforts to have the districts potentially redrawn, when necessary due to migration for example, to be left to an automated system such as an artificial intelligence (AI) designed for this task.

Section LXXI: The United States Transhumanist Party supports efforts to remove the possibility for a President to sign an international agreement among two or more nations by executive order. This would prevent a President from engaging in international affairs without support from the Congress, and likewise would make it more difficult to exit an international agreement, as support from Congress would need to exist in order for such an exit to occur. This would furthermore ensure that the United States becomes a more trustworthy nation in the eyes of the international community.

Section LXXII: The United States Transhumanist Party supports efforts to create a framework for an international or world passport. This framework could, for example, be administered through the United Nations, and the passport could be valid only for those countries who have proven to meet the standards, set by participating countries, required to ensure safety. Given that the European Union has an ID valid within its borders, and the United States has a similar agreement with Canada, imagining these forms of identification being combined shows that a world passport is not a farfetched or alien idea.

Section LXXIII:  The United States Transhumanist Party supports efforts to mandate that new firearms will be produced with an embedded registration chip, as well as the registration number engraved on the firearm. The chip would have a registration number, a ‘trace online’ code, and a ‘lost or stolen’ code. The firearm would be accompanied by a physical and digital certificate of ownership with a registration number, the ‘trace online’ number, and the ‘lost or stolen’ number. The embedded chip would render it much harder to make the firearm untraceable. The number and codes involved would have to be unique identifiers.

When a firearm would be lost or stolen, the owner of the firearm and holder of the certificate would report the firearm to the authorities as lost or stolen using the ‘lost or stolen’ number. The intent of having a separate reporting number is to ensure that, in the event that a firearm is stolen or taken without consent, the offender cannot report the firearm as stolen, or as found again. When a firearm owner suspects the firearm is simply mislocated – for example, in the car or in the house, or perhaps taken by a family member, the owner could trace the firearm online via GPS on an online map, using the ‘trace online’ code. The ‘trace online’ code would never be revealed to law enforcement.

Law enforcement would have a device that can confirm the registration number of a firearm in close proximity, similar to contactless payments. On the other hand the detection range would be greater when a firearm has been reported lost or stolen by the owner of the firearm in question with the ‘lost and stolen’ number. A firearm that would not have been reported lost or stolen to law enforcement by the owner of the firearm with the ‘lost or stolen’ number would not be traceable from a greater distance by law enforcement.

This would ensure the privacy, safety, and peace of mind of firearm owners who might otherwise feel law enforcement would trace firearms without legal justification. At the same time, this measure would decrease the probability of stolen firearms never being found, and possibly ending in the hands of people with ill intent.

Section LXXIV: The United States Transhumanist Party supports the creation of an office of a Public Civil-Rights Prosecutor. Our current justice system is flawed. Only people with substantial wealth can afford lawyers to take legal action against those who attack a person’s rights. While there are organizations like the American Civil Liberties Union (ACLU), which offer help for some cases, their ability to do so is severely limited and typically non-existent in the lower courts. A Public Civil-Rights Prosecutor’s office will help guarantee that, no matter who a person is or the position of the offending party, a person’s rights cannot be assailed without consequence.

Section LXXV: The United States Transhumanist Party supports lowering spending by the Department of Defense and the U.S. Military, which amounts to hundreds of billions of dollars per year and includes unchecked wastefulness. Reducing military spending would free up money for more important goals, such as curing disease, which collectively kills many more people than military conflict or war by an exponential degree.

Section LXXVI: The United States Transhumanist Party supports efforts to hold institutions, corporations, and states accountable for usage of federal money with a specific intended purpose. When an entity has been granted any form of funding with a specifically intended purpose, such as disaster relief or specific educational funds, and these funds are misappropriated or used for other purposes well outside of the scope of what they were intended for, the entity in question ought to restitute the funding that was made available.

Section LXXVII: The United States Transhumanist Party supports increases in the budget for the National Institutes of Health (NIH). Numerous biotech CEOs have recently made the case to increase the NIH budget, because the NIH conducts research that their companies would not be able to invest in, as investments not leading directly to a product would affect the bottom line. 33% of all the publications from NIH research are cited in corporate patents, so it stimulates new product development. A major driver for economic progress and reducing the suffering of those in pain, the NIH is essentially a public charity that brings us into the future. Whether one supports limited or expansive government, the NIH does not seek to regulate anything nor impose laws on anyone. It exclusively conducts medical research to help the sick.

Section LXXVIII: The U.S. Transhumanist Party supports efforts to reinstate the rights to vote for convicted felons who have received and served their punishment, in order to present them the opportunity to participate in society as otherwise normal citizens.

Section LXXIX: The United States Transhumanist Party supports repealing the current requirement in the United States that drugs or treatments may not be used, even on willing patients, unless approval for such drugs or treatments is received from the Food and Drug Administration. Such requirements are a profound violation of patient sovereignty; a person who is terminally ill is unable to choose to take a risk on an unapproved drug or treatment unless this person is fortunate enough to participate in a clinical trial. Even then, once the clinical trial ends, the treatment must be discontinued, even if it was actually successful at prolonging the person’s life. This is not only profoundly tragic, but morally unconscionable as well. The most critical reform needed is to allow unapproved drugs and treatments to be marketed and consumed. If the FDA wishes to strongly differentiate between approved and unapproved treatments, then a strongly worded warning label could be required for unapproved treatments, and patients could even be required to sign a consent form stating that they have been informed of the risks of an unapproved treatment. This reform to directly extend many lives and to redress a moral travesty should be the top political priority of advocates of indefinite life extension. Over the coming decades, its effect will be to allow cutting-edge treatments to reach a market sooner and thus to enable data about those treatments’ effects to be gathered more quickly and reliably. Because many treatments take 10-15 years to receive FDA approval, this reform could by itself speed up the real-world advent of indefinite life extension by over a decade.

Section LXXX: The United States Transhumanist Party supports efforts to increase opportunities for entry into the medical profession. The current system for licensing doctors is highly monopolistic and protectionist – the result of efforts by the American Medical Association in the early 20th century to limit entry into the profession in order to artificially boost incomes for its members. The medical system suffers today from too few doctors and thus vastly inflated patient costs and unacceptable waiting times for appointments. Instead of prohibiting the practice of medicine by all except a select few who have completed an extremely rigorous and cost-prohibitive formal medical schooling, governments in the Western world should allow the market to determine different tiers of medical care for which competing private certifications would emerge. For the most specialized and intricate tasks, high standards of certification would continue to exist, and a practitioner’s credentials and reputation would remain absolutely essential to convincing consumers to put their lives in that practitioner’s hands. But, with regard to routine medical care (e.g., annual check-ups, vaccinations, basic wound treatment), it is not necessary to receive attention from a person with a full-fledged medical degree. Furthermore, competition among certification providers would increase quality of training and lower its price, as well as accelerate the time needed to complete the training. Such a system would allow many more young medical professionals to practice without undertaking enormous debt or serving for years (if not decades) in roles that offer very little remuneration while entailing a great deal of subservience to the hierarchy of an established institution. Ultimately, without sufficient doctors to affordably deliver life-extending treatments when they become available, it would not be feasible to extend these treatments to the majority of people.

Section LXXXI: The United States Transhumanist Party supports reforms to the patent system that prevent the re-patenting of drugs and medical devices, or the acquisition of any exclusive or monopoly rights over those drugs and devices, once they have become generic or entered the public domain. Appallingly, many pharmaceutical companies today attempt to re-patent drugs that have already entered the public domain, simply because the drugs have been discovered to have effects on a disease different from the one for which they were originally patented. The result of this is that the price of the re-patented drug often spikes by orders of magnitude compared to the price level during the period the drug was subject to competition. Only a vibrant and competitive market, where numerous medical providers can experiment with how to improve particular treatments or create new ones, can allow for the rate of progress needed for the people alive today to benefit from radical life extension.

Section LXXXII: The United States Transhumanist Party supports reforms to reduce the lengths of times over which medical patents could be effective. Medical patents – in essence, legal grants of monopoly for limited periods of time – greatly inflate the cost of drugs and other treatments. Especially in today’s world of rapidly advancing biotechnology, a patent term of 20 years essentially means that no party other than the patent holder (or someone paying royalties to the patent holder) may innovate upon the patented medicine for a generation, all while the technological potential for such innovation becomes glaringly obvious. As much innovation consists of incremental improvements on what already exists, the lack of an ability to create derivative drugs and treatments that tweak current approaches implies that the entire medical field is, for some time, stuck at the first stages of a treatment’s evolution – with all of the expense and unreliability this entails. Even with shortened patent terms, the original developer of an innovation will still always benefit from a first-mover advantage, as it takes time for competitors to catch on. If the original developer can maintain high-quality service and demonstrate the ability to sell a safe product, then the brand-name advantage alone can secure a consistent revenue stream without the need for a patent monopoly.

Official Ballot Options for Platform Vote #6

Official Ballot Options for Platform Vote #6

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The 7-day electronic voting period on the sixth set of proposed platform planks of the U.S. Transhumanist Party (19 potential planks and 3 potential amendments in total) will occur from 12:01 a.m. U.S. Pacific Time on November 11, 2017, to 12:01 a.m.  U.S. Pacific Time on November 18, 2017. All members of the U.S. Transhumanist Party who have applied before 12:01 a.m. on November 11, 2017, will be eligible to vote, as long as they have expressed agreement with the three Core Ideals of the Transhumanist Party or have otherwise been rendered eligible to vote at the discretion of the Chairman.

All members who are eligible to vote will be sent a link to an electronic submission form whereby they will be able to cast their ballot.

When you are voting, it is strongly recommended that you keep this page of official ballot options and the submission form open simultaneously in different windows so that you can reference the relevant options as you vote on them. Due to space limitations, the submission form does not list the entire text of all the options.

It is also recommended that you set aside at least thirty minutes to consider and vote on all of the options and read their text closely, as some of the options contain minor variations upon other options. 

For some questions, electronic voting is  conducted by a ranked-preference method on individual articles where more options are possible than would be accommodated by a simple “Yes” or “No” vote. Members should keep in mind that the ranked-preference method eliminates the incentives for strategic voting – so members are encouraged to vote for the options that reflect their individual preferences as closely as possible, without regard for how other members might vote.

Results of the voting will be tabulated during late November 2017, with the intent to announce the results approximately 7 days after all votes have been submitted.

NOTE: The titles of the questions and potential Sections are descriptive and informational only and will not appear in the final adopted platform planks (which will be incorporated into Article III of the U.S. Transhumanist Party Constitution). They are intended as concise guides to the subject matter of the questions and potential Sections. Likewise, the letters assigned to Sections within this ballot will not reflect the numbering of the final adopted provisions, which will depend on which Sections are selected by the membership.

NOTE II: The inclusion of any proposals on this ballot does not indicate any manner of endorsement for those proposals by the U.S. Transhumanist Party at this time – except to place those proposals before the members to determine the will of the members with regard to whether or not the U.S. Transhumanist Party Platform should incorporate any given proposal.


Voter Identification

E-mail address

Provide the same e-mail address you used to register for U.S. Transhumanist Party membership. Your ballot will be cross-referenced to our membership rolls, and only ballots with matching e-mail addresses will be counted.

What is your name?

At minimum, first and last name are required, unless you are publicly known by a single-name pseudonym which is not itself a common name. Your identity will not be publicly disclosed by the Transhumanist Party, unless you choose and/or authorize its disclosure. Only other members of the Transhumanist Party will be able to see that you voted, but not how you voted. The nature of the selections made by the members may be disclosed, but, if they are, each individual vote will not be associated with the identity of the voter but rather will be presented in an anonymized manner.

Navigate the Options

Proposed Platform Sections

Question I. Section E6-A. Minimum Timeframe for Voting on a Bill

Question II. Section E6-A. Minimum Timeframe for Voting on a Bill – Ancillary Provision Options

Question III. Section E6-B. Fully Informed Juries

Question IV. Section E6-C. Elimination of Stationary Nuclear Stockpile

Question V. Section E6-D. Legalization of Prostitution

Question VI. Section E6-D. Legalization of Prostitution – Ancillary Provisions

Question VII. Section E6-E. Public Records of Official Statements

Question VIII. Section E6-F. Artificial Intelligence System to Analyze Risk of Proposed Legislation

Question IX. Section E6-G. Opposition to Partisan Determination of Voting Districts

Question X. Section E6-H. Limitation of Presidential Authority over International Agreements

Question XI. Section E6-I. International or World Passport

Question XII. Section E6-J. Registration Chip for New Firearms

Question XIII. Section E6-K. Public Civil-Rights Prosecutor

Question XIV. Section E6-L. Lowering Military Spending

Question XV. Section E6-M. Accountability for Use of Federal Grants

Question XVI. Section E6-N. Increased Funding for the National Institutes of Health

Question XVII. Section E6-O. Reinstatement of Voting Rights to Felons Who Have Served Their Punishment

Question XVIII. Section E6-P. Repeal of FDA Approval Requirements for Drug Tests on Willing Patients

Question XIX. Section E6-Q. Abolition of Medical Licensing Protectionism

Question XX. Section E6-R. Abolition of Ability to Re-Patent Generic Medicines and Devices

Question XIX. Section E6-Q. Abolition of Medical Licensing Protectionism

Proposed Amendments to Existing Planks

Question XXII. Amendments to Section II on Anti-Bigotry to Encompass “Alt-Left” Groups or Simplify / Generalize Section II

Question XXIII. Amendments to Section XXVII on Abolition of the Electoral College

Question XXIV. Amendments to Section LIX on External Investigations of Law-Enforcement Misconduct

 

Proposed Platform Sections

Question I. Section E6-A. Minimum Timeframe for Voting on a Bill

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to create a reasonable minimum timeframe between the proposal of a bill and the voting procedure. To ensure a reasonable timeframe is proportional to the number of pages of a proposed bill, a time period per each specified amount of pages could be adopted. For example, and without committing to specific numerical magnitudes, a 24-hour period within a working week per every 20 pages could be adopted to ensure all member of Congress involved have sufficient time to read through and study a proposed bill’s implications. Such measures would prevent a bill from being introduced shortly before the voting process. They would also have the added side effect that proposals might become more concise, as the length of a bill would influence the consideration time.”

Select one of the following options.

Yes.

No.

Abstain.

Question II. Section E6-A. Minimum Timeframe for Voting on a Bill – Ancillary Provision Options

If Section E6-A regarding the minimum timeframe for voting on a bill is adopted as part of the U.S. Transhumanist Party Platform, which one, if any, of the following ancillary provisions shall be appended to that Section?

Rank-order the Section E6-A Ancillary Provision Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Ancillary Provision Option of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Ancillary Provision Option E6-A-i. [Based on Proposal by Martin van der Kroon]  In addition to this, after the proposal has been submitted, no change may be made to the proposal to prevent changing the substance of a proposal.

☐ Ancillary Provision Option E6-A-ii. [Based on Proposal by Gennady Stolyarov II] In addition to this, after the proposal has been submitted, any amendments must be explicitly discussed in a public forum with the same degree of thorough consideration and same rules pertaining to the timeframe of consideration as allowed for the original proposal.

☐ Ancillary Provision Option E6-A-NO. No Ancillary Provision Option of this sort.

Question III. Section E6-B. Fully Informed Juries

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to ensure a jury is fully informed on its rights and responsibilities, including jury nullification. The United States Transhumanist Party also supports efforts to prevent false claims being made regarding the rights and responsibilities of the jury.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question IV. Section E6-C. Elimination of Stationary Nuclear Stockpile

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“As an intermediate step toward the goal of complete nuclear disarmament and a potential pragmatic compromise in any future negotiations for disarmament, the United States Transhumanist Party supports efforts to significantly reduce the United States nuclear stockpile, and to replace or transfer a small part (between 1 percent and 10 percent) of this stockpile, to mobile nuclear platforms such as submarines. An enemy may currently target the stationary nuclear bombs directly. Having a largely hidden mobile fleet of nuclear bombs would render it much more difficult for any enemy to target the nuclear arsenal, while still maintaining the nuclear deterrent option in sufficient capacity. This would further have the effect of lowering the budget required to maintain the nuclear stockpile, as it could be drastically downsized.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question V. Section E6-D. Legalization of Prostitution

Rank-order the Section E6-D Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E6-D-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports the right for individuals to have autonomy over, and utilize their bodies to earn money, including through activities such as prostitution, as long as such activities arise from a person’s own free will (e.g., not under duress), and the person is not endangering the health or well-being of others.

Legalization would give those who wish to engage in prostitution the safety and protection of the law – for example, so that they may report abuse and would be prone to being exploited. It would also open the possibility for such individuals to unionize if they wish to do so. Furthermore, legalization would decrease government spending on what is ultimately a ‘moral crusade’.

☐ Option E6-D-2. [Based on Proposal by Martin van der Kroon, with Added Wording by Ajay Davis]

The United States Transhumanist Party supports the right for individuals to have autonomy over, and utilize their bodies to earn money, including through activities such as prostitution, as long as such activities arise from a person’s own free will (e.g., not under duress), and the person is not endangering the health or well-being of others, including but not limited to the communication of sexually transmissible diseases.

Legalization would give those who wish to engage in prostitution the safety and protection of the law – for example, so that they may report abuse and would be prone to being exploited. It would also open the possibility for such individuals to unionize if they wish to do so. Furthermore, legalization would decrease government spending on what is ultimately a ‘moral crusade’.

☐ Option E6-D-NO. No Section of this sort.

Question VI. Section E6-D. Legalization of Prostitution – Ancillary Provisions

If Section E6-D regarding the legalization of prostitution is adopted as part of the U.S. Transhumanist Party Platform, shall any of the following ancillary provisions be appended to that Section?

Select all the options you support. (You can select multiple options for this question.)  Any option receiving the majority of votes cast will be included in the ultimately adopted plank, unless Option E6-D-NO prevails in the vote on Question V above. If you do not favor any of the options below, then you may leave this question blank.

☐ Ancillary Provision E6-D-i. Opposition to Human Trafficking and Exploitation. However, the United States Transhumanist Party unequivocally condemns any manner of human trafficking, child exploitation, and other abuse that involves a violation of the autonomy and consent of any individual. The legalization of prostitution should be combined with stronger efforts to combat these dangerous and exploitative practices.

☐ Ancillary Provision E6-D-ii. Legalization of Prostitution as Enabling More Effective Combating of Human Trafficking and Exploitation. The legalization of prostitution could furthermore enable more effective action against human trafficking and involuntary exploitation, as, when prostitution is legalized, employees in this industry would become subject to the protections of the law. Legalization would help focus resources on combating the trafficking of humans rather than catching workers who chose this profession voluntarily.

Question VII. Section E6-E. Public Records of Official Statements

Rank-order the Section E6-E Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E6-E-1. [Based on Proposal by Ryan Starr, with Clarifications Suggested by Martin van der Kroon]

The United States Transhumanist Party holds that any statement made by an elected official and/or public servant to members of the public in a public forum, and available to be heard, read, or otherwise understood in a public setting, physical or digital, should be considered a part of the public record and treated as an official statement of their office and position.

☐ Option E6-E-2. [Based on Proposal by Ryan Starr, with Further Clarifications Regarding the Capacity in Which the Official Acts]

The United States Transhumanist Party holds that any statement made by an elected official and/or public servant to members of the public in a public forum as part of that official’s or public servant’s job duties, and available to be heard, read, or otherwise understood in a public setting, physical or digital, should be considered a part of the public record and treated as an official statement of their office and position. This requirement does not extend to statements made by an elected official and/or public servant in the capacity of a private citizen or in the expression of a personal opinion or other position unrelated to the exercise of the official’s or public servant’s job duties.

☐ Option E6-E-NO. No Section of this sort.

Question VIII. Section E6-F. Artificial Intelligence System to Analyze Risk of Proposed Legislation

Rank-order the Section E6-F Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E6-F-1. [Based on Proposal by Ryan Starr]

The United States Transhumanist Party holds that state and federal governments should establish an artificial intelligence (AI) analysis system for measuring risk of proposed legislation. Such a system could provide an impartial look at what legislation could cause harm or unintended consequences. Submitted policies would receive a score from 0 to 100, and the AI system would state what possible negative impacts may result. This system should be publicly accessible for submissions and for security audit. This is not intended to create or enact laws, but simply to serve as a tool to measure risk versus reward.

☐ Option E6-F-2. [Based on Proposal by Ryan Starr, with Added Wording by Daniel Yeluashvili on Blocking Certain Laws]

The United States Transhumanist Party holds that state and federal governments should establish an artificial intelligence (AI) analysis system for measuring risk of proposed legislation. Such a system could provide an impartial look at what legislation could cause harm or unintended consequences. Submitted policies would receive a score from 0 to 100, and the AI system would state what possible negative impacts may result. This system should be publicly accessible for submissions and for security audit. This is not intended to create or enact laws, but simply to serve as a tool to measure risk versus reward. However, such an AI system should be used to block laws that have a 50% or greater probability of negatively affecting the majority of the population.

☐ Option E6-F-NO. No Section of this sort.

Question IX. Section E6-G. Opposition to Partisan Determination of Voting Districts

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party strongly opposes the possibility for any political party to determine the boundaries and borders of any voting district. The United States Transhumanist Party supports measures that require any efforts to have the districts potentially redrawn, when necessary due to migration for example, to be left to an automated system such as an artificial intelligence (AI) designed for this task.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question X. Section E6-H. Limitation of Presidential Authority over International Agreements

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to remove the possibility for a President to sign an international agreement among two or more nations by executive order. This would prevent a President from engaging in international affairs without support from the Congress, and likewise would make it more difficult to exit an international agreement, as support from Congress would need to exist in order for such an exit to occur. This would furthermore ensure that the United States becomes a more trustworthy nation in the eyes of the international community.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XI. Section E6-I. International or World Passport

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to create a framework for an international or world passport. This framework could, for example, be administered through the United Nations, and the passport could be valid only for those countries who have proven to meet the standards, set by participating countries, required to ensure safety. Given that the European Union has an ID valid within its borders, and the United States has a similar agreement with Canada, imagining these forms of identification being combined shows that a world passport is not a farfetched or alien idea.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XII. Section E6-J. Registration Chip for New Firearms

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to mandate that new firearms will be produced with an embedded registration chip, as well as the registration number engraved on the firearm. The chip would have a registration number, a ‘trace online’ code, and a ‘lost or stolen’ code. The firearm would be accompanied by a physical and digital certificate of ownership with a registration number, the ‘trace online’ number, and the ‘lost or stolen’ number. The embedded chip would render it much harder to make the firearm untraceable. The number and codes involved would have to be unique identifiers.

“When a firearm would be lost or stolen, the owner of the firearm and holder of the certificate would report the firearm to the authorities as lost or stolen using the ‘lost or stolen’ number. The intent of having a separate reporting number is to ensure that, in the event that a firearm is stolen or taken without consent, the offender cannot report the firearm as stolen, or as found again. When a firearm owner suspects the firearm is simply mislocated – for example, in the car or in the house, or perhaps taken by a family member, the owner could trace the firearm online via GPS on an online map, using the ‘trace online’ code. The ‘trace online’ code would never be revealed to law enforcement.

“Law enforcement would have a device that can confirm the registration number of a firearm in close proximity, similar to contactless payments. On the other hand the detection range would be greater when a firearm has been reported lost or stolen by the owner of the firearm in question with the ‘lost and stolen’ number. A firearm that would not have been reported lost or stolen to law enforcement by the owner of the firearm with the ‘lost or stolen’ number would not be traceable from a greater distance by law enforcement.

“This would ensure the privacy, safety, and peace of mind of firearm owners who might otherwise feel law enforcement would trace firearms without legal justification. At the same time, this measure would decrease the probability of stolen firearms never being found, and possibly ending in the hands of people with ill intent.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XIII. Section E6-K. Public Civil-Rights Prosecutor

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports the creation of an office of a Public Civil-Rights Prosecutor. Our current justice system is flawed. Only people with substantial wealth can afford lawyers to take legal action against those who attack a person’s rights. While there are organizations like the American Civil Liberties Union (ACLU), which offer help for some cases, their ability to do so is severely limited and typically non-existent in the lower courts. A Public Civil-Rights Prosecutor’s office will help guarantee that, no matter who a person is or the position of the offending party, a person’s rights cannot be assailed without consequence.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XIV. Section E6-L. Lowering Military Spending

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports lowering spending by the Department of Defense and the U.S. Military, which amounts to hundreds of billions of dollars per year and includes unchecked wastefulness. Reducing military spending would free up money for more important goals, such as curing disease, which collectively kills many more people than military conflict or war by an exponential degree.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XV. Section E6-M. Accountability for Use of Federal Grants

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to hold institutions, corporations, and states accountable for usage of federal money with a specific intended purpose. When an entity has been granted any form of funding with a specifically intended purpose, such as disaster relief or specific educational funds, and these funds are misappropriated or used for other purposes well outside of the scope of what they were intended for, the entity in question ought to restitute the funding that was made available.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XVI. Section E6-N. Increased Funding for the National Institutes of Health

Rank-order the Section E6-N Options that you support. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “No Section of this sort” in your rank-ordering, and it does not need to be your most favored option if you do so. (For instance, some voters might favor some options but think that no language is preferable to some of the other options.)

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Option E6-N-1. [Based on Proposal by John Marlowe]

The United States Transhumanist Party supports increases in the budget for the National Institutes of Health (NIH). Numerous biotech CEOs have recently made the case to increase the NIH budget, because the NIH conducts research that their companies would not be able to invest in, as investments not leading directly to a product would affect the bottom line. 33% of all the publications from NIH research are cited in corporate patents, so it stimulates new product development. A major driver for economic progress and reducing the suffering of those in pain, the NIH is essentially a public charity that brings us into the future. Whether one supports limited or expansive government, the NIH does not seek to regulate anything nor impose laws on anyone. It exclusively conducts medical research to help the sick.

☐ Option E6-N-2. [Based on Proposal by John Marlowe, with Modification to Require Offsetting Decreases in Military Spending]

The United States Transhumanist Party supports increases in the budget for the National Institutes of Health (NIH), provided that such increases are offset by equivalent or greater decreases in military spending. Numerous biotech CEOs have recently made the case to increase the NIH budget, because the NIH conducts research that their companies would not be able to invest in, as investments not leading directly to a product would affect the bottom line. 33% of all the publications from NIH research are cited in corporate patents, so it stimulates new product development. A major driver for economic progress and reducing the suffering of those in pain, the NIH is essentially a public charity that brings us into the future. Whether one supports limited or expansive government, the NIH does not seek to regulate anything nor impose laws on anyone. It exclusively conducts medical research to help the sick.

☐ Option E6-N-NO. No Section of this sort.

Question XVII. Section E6-O. Reinstatement of Voting Rights to Felons Who Have Served Their Punishment

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The U.S. Transhumanist Party supports efforts to reinstate the rights to vote for convicted felons who have received and served their punishment, in order to present them the opportunity to participate in society as otherwise normal citizens.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XVIII. Section E6-P. Repeal of FDA Approval Requirements for Drug Tests on Willing Patients

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports repealing the current requirement in the United States that drugs or treatments may not be used, even on willing patients, unless approval for such drugs or treatments is received from the Food and Drug Administration. Such requirements are a profound violation of patient sovereignty; a person who is terminally ill is unable to choose to take a risk on an unapproved drug or treatment unless this person is fortunate enough to participate in a clinical trial. Even then, once the clinical trial ends, the treatment must be discontinued, even if it was actually successful at prolonging the person’s life. This is not only profoundly tragic, but morally unconscionable as well. The most critical reform needed is to allow unapproved drugs and treatments to be marketed and consumed. If the FDA wishes to strongly differentiate between approved and unapproved treatments, then a strongly worded warning label could be required for unapproved treatments, and patients could even be required to sign a consent form stating that they have been informed of the risks of an unapproved treatment. This reform to directly extend many lives and to redress a moral travesty should be the top political priority of advocates of indefinite life extension. Over the coming decades, its effect will be to allow cutting-edge treatments to reach a market sooner and thus to enable data about those treatments’ effects to be gathered more quickly and reliably. Because many treatments take 10-15 years to receive FDA approval, this reform could by itself speed up the real-world advent of indefinite life extension by over a decade.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XIX. Section E6-Q. Abolition of Medical Licensing Protectionism

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports efforts to increase opportunities for entry into the medical profession. The current system for licensing doctors is highly monopolistic and protectionist – the result of efforts by the American Medical Association in the early 20th century to limit entry into the profession in order to artificially boost incomes for its members. The medical system suffers today from too few doctors and thus vastly inflated patient costs and unacceptable waiting times for appointments. Instead of prohibiting the practice of medicine by all except a select few who have completed an extremely rigorous and cost-prohibitive formal medical schooling, governments in the Western world should allow the market to determine different tiers of medical care for which competing private certifications would emerge. For the most specialized and intricate tasks, high standards of certification would continue to exist, and a practitioner’s credentials and reputation would remain absolutely essential to convincing consumers to put their lives in that practitioner’s hands. But, with regard to routine medical care (e.g., annual check-ups, vaccinations, basic wound treatment), it is not necessary to receive attention from a person with a full-fledged medical degree. Furthermore, competition among certification providers would increase quality of training and lower its price, as well as accelerate the time needed to complete the training. Such a system would allow many more young medical professionals to practice without undertaking enormous debt or serving for years (if not decades) in roles that offer very little remuneration while entailing a great deal of subservience to the hierarchy of an established institution. Ultimately, without sufficient doctors to affordably deliver life-extending treatments when they become available, it would not be feasible to extend these treatments to the majority of people.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XX. Section E6-R. Abolition of Ability to Re-Patent Generic Medicines and Devices

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports reforms to the patent system that prevent the re-patenting of drugs and medical devices, or the acquisition of any exclusive or monopoly rights over those drugs and devices, once they have become generic or entered the public domain. Appallingly, many pharmaceutical companies today attempt to re-patent drugs that have already entered the public domain, simply because the drugs have been discovered to have effects on a disease different from the one for which they were originally patented. The result of this is that the price of the re-patented drug often spikes by orders of magnitude compared to the price level during the period the drug was subject to competition. Only a vibrant and competitive market, where numerous medical providers can experiment with how to improve particular treatments or create new ones, can allow for the rate of progress needed for the people alive today to benefit from radical life extension.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Question XXI. Section E6-S. Reduction of Medical Patent Timeframes

Shall the following language be adopted as a new Section within the U.S. Transhumanist Party Platform?

“The United States Transhumanist Party supports reforms to reduce the lengths of times over which medical patents could be effective. Medical patents – in essence, legal grants of monopoly for limited periods of time – greatly inflate the cost of drugs and other treatments. Especially in today’s world of rapidly advancing biotechnology, a patent term of 20 years essentially means that no party other than the patent holder (or someone paying royalties to the patent holder) may innovate upon the patented medicine for a generation, all while the technological potential for such innovation becomes glaringly obvious. As much innovation consists of incremental improvements on what already exists, the lack of an ability to create derivative drugs and treatments that tweak current approaches implies that the entire medical field is, for some time, stuck at the first stages of a treatment’s evolution – with all of the expense and unreliability this entails. Even with shortened patent terms, the original developer of an innovation will still always benefit from a first-mover advantage, as it takes time for competitors to catch on. If the original developer can maintain high-quality service and demonstrate the ability to sell a safe product, then the brand-name advantage alone can secure a consistent revenue stream without the need for a patent monopoly.”

Select one of the following options.

 Yes.

 No.

 Abstain.

Proposed Amendments to Existing Planks

Question XXII. Amendments to Section II on Anti-Bigotry to Encompass “Alt-Left” Groups or Simplify / Generalize Section II

Rank-order the Options for Amendments to Section II that you support, if any. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “Current Version of Section II” in your rank-ordering, and it does not need to be your most favored option if you do so.

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Current Version of Section II. The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries.

☐ Amendment II-1. [Addition of New Paragraph on “Alt-Left” Movements, Reflecting Recommendation by Scott Jurgens]

The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries.

While opposing movements based on hostile discrimination on circumstantial attributes, the United States Transhumanist Party also condemns movements on the “alt-left” which attempt to stifle free speech, use violence to prevent the expression of “alt-right” or even non-left-wing sentiments, or promote retributive circumstantial discrimination, which should be rejected along with the original acts of circumstantial discrimination against which the “alt-left” is reacting. The United States Transhumanist Party unequivocally opposes the use of violence against lives and property and the disruption of the peaceful conduct of daily life by movements calling themselves “Antifa”, “By Any Means Necessary”, or “Black Lives Matter” – even as the United States Transhumanist Party remains strongly opposed to fascism and strongly supports efforts to protect black Americans and all other Americans from police brutality and all other forms of violence. It is imperative that only peaceful, rights-respecting tactics and reforms be used in the efforts to thwart fascism and prevent police brutality.

☐ Amendment II-2. [Addition of New Paragraph on “Alt-Left” Movements, Reflecting Suggestions by B.J. Murphy to Include Individual Supporters and Emphasize the Right of Self-Defense]

The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries – and individual supporters of those movements.

While opposing movements based on hostile discrimination on circumstantial attributes, the United States Transhumanist Party also condemns movements on the “alt-left” which attempt to stifle free speech, use violence to prevent the expression of “alt-right” or even non-left-wing sentiments, or promote retributive circumstantial discrimination, which should be rejected along with the original acts of circumstantial discrimination against which the “alt-left” is reacting. The United States Transhumanist Party unequivocally opposes the use of violence against lives and property and the disruption of the peaceful conduct of daily life by movements calling themselves “Antifa”, “By Any Means Necessary”, or “Black Lives Matter” and by individual supporters of those movements – even as the United States Transhumanist Party remains strongly opposed to fascism and strongly supports efforts to protect black Americans and all other Americans from police brutality and all other forms of violence. It is imperative that only peaceful, rights-respecting tactics and reforms be used in the efforts to thwart fascism and prevent police brutality.

However, the United States Transhumanist Party also recognizes the difference between committing violence for the sake of violence and committing violence as a means of self-defense – especially against fascism – and therefore does not condemn purely defensive violence.

☐ Amendment II-3. [Simplification, Reflecting Recommendation by Martin van der Kroon

The United States Transhumanist Party opposes any movement or group, and individual members of such movements or groups, that utilize and justify the use of violence, bullying, doxxing, intimidation, and other coercive or privacy-infringing tactics in a quest to force their goals or display dominance, regardless of political orientation, leaning, or ideology.

☐ Amendment II-4. [Simplification, Reflecting Recommendation by Daniel Yeluashvili

The United States Transhumanist Party supports all acceptance, tolerance, and inclusivity of individuals and groups of all races, genders, classes, religions, creeds, and ideologies. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to enforce said restrictions regardless of cause or motivation thereof. Additionally, any institution that uses violence, suppression of free speech, or other unconstitutional or otherwise illegal methods will be disavowed and condemned by the United States Transhumanist Party, with an efficient, non-violent alternative to said institution being offered to achieve its goals if they align with the Party’s interests.

Question XXIII. Amendments to Section XXVII on Abolition of the Electoral College

Rank-order the Options for Amendments to Section XXVII that you support, if any. Choose “1” for your most highly favored option, “2” for your second-most highly favored option, etc. You may include the option for “Current Version of Section XXVII” in your rank-ordering, and it does not need to be your most favored option if you do so.

If you choose “Abstain”, then do not rank-order any options, as you will be considered to have skipped this question.

☐ Current Version of Section XXVII. The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President. While the original intent of the Electoral College as a deliberative body to check the passions of the poorly informed masses and potentially overturn the election of a demagogue may have been noble, the reality has not reflected this intention. Instead, the Electoral College has enabled votes from less cosmopolitan, less tolerant, more culturally ossified and monolithic areas of the country to disproportionately sway the outcome of Presidential elections, to the detriment of individual liberty and progress.

☐ Amendment XXVII-1. [Removal of Last Sentence, Reflecting Recommendation by Scott Jurgens] The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President. While the original intent of the Electoral College as a deliberative body to check the passions of the poorly informed masses and potentially overturn the election of a demagogue may have been noble, the reality has not reflected this intention.

☐ Amendment XXVII-2. [Removal of Last Two Sentences, Reflecting Recommendation by Scott Jurgens] The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President.

Question XXIV. Amendments to Section LIX on External Investigations of Law-Enforcement Misconduct

Shall the current version of Section LIX be retained in the United States Transhumanist Party Platform, or shall Section LIX be amended as stated in Amendment LIX-1 below?

Select one of the following options.

☐ Current Version of Section LIX. The United States Transhumanist Party considers it important for impartial, objective investigations of alleged police and other law-enforcement misconduct to be pursued. While law-enforcement agencies should not be prohibited from internally investigating potential abuses within their own ranks, such investigations should never be considered exclusive or conclusive, and further external checks and accountability should be instituted. As part of providing such checks and accountability, investigations regarding police misconduct, criminal activity, felonies, and misdemeanors should, in addition to any internal investigation, also be investigated by a different source – for example, a different police department, or a district attorney for a different area assigned to lead the investigation. The intent of this requirement is to limit the possibility of favorably biased or preferential treatment of a member of a given law-enforcement agency by that person’s colleagues, and to restore confidence by the public that an investigation into police misconduct is done as objectively as possible.

☐ Amendment LIX-1. [Replacement of Second-to-Last Sentence to Require a Civilian Investigating Organization, Based on Recommendation by Ryan Starr] The United States Transhumanist Party considers it important for impartial, objective investigations of alleged police and other law-enforcement misconduct to be pursued. While law-enforcement agencies should not be prohibited from internally investigating potential abuses within their own ranks, such investigations should never be considered exclusive or conclusive, and further external checks and accountability should be instituted. As part of providing such checks and accountability, investigations regarding misconduct, negligence, abuse, criminal activity, felonies, and misdemeanors allegedly committed by police, district attorneys, and judges, should, in addition to any internal investigation, also be conducted by a civilian organization outside the justice system. The intent of this requirement is to limit the possibility of favorably biased or preferential treatment of a member of a given law-enforcement agency by that person’s colleagues, and to restore confidence by the public that an investigation into police misconduct is done as objectively as possible.

 Abstain.

Stem-Cell Clinical Trials Show Remarkable Results Against Age-Related Frailty – Article by Steve Hill

Stem-Cell Clinical Trials Show Remarkable Results Against Age-Related Frailty – Article by Steve Hill

Steve Hill


Editor’s Note: In this article, Mr. Steve Hill discusses two very promising human clinical trials using stem cell therapy for age-related frailty. This article was originally published by the Life Extension Advocacy Foundation (LEAF) .

~ Kenneth Alum, Director of Publication, U.S. Transhumanist Party, October 29, 2017

The first results of two human clinical trials using stem cell therapy for age-related frailty have been published, and the results are very impressive indeed. The studies show that the approach used is effective in tackling multiple key age-related factors.

Aging research has made significant progress in the last few years, with senescent-cell-clearing therapies entering human trials this year, DNA repair in human trials, and a number of other exciting therapies nearing human testing. We are reaching the point where therapies that target aging processes are no longer a matter of speculation; they are now an undeniable matter of fact.

What are mesenchymal stem cells?

Mesenchymal stem cells (MSCs) are one of the most commonly used types of stem cells in therapy. MSCs are adult stem cells that can become other types of cells, depending on stimulus; this ability to become a variety of other cell types is known as multipotency. [1]

The cells into which MSCs can transform (differentiate) include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells), and adipocytes (fat cells). MSCs are of great interest to aging researchers and are arguably one of the most well studied and understood types of stem cells. [2]

MSCs are currently in various trials to treat conditions such as cancer, heart disease, and arthritis. [3] The potential of MSCs for treating neurodegenerative diseases, such as Alzheimer’s, are also being explored in preclinical testing. [4-5]

A therapy for age-related frailty

The focus of the MSC therapy in the case of these two clinical trials is to reduce the effects of age-related frailty on senior citizens. This also marks an important step for rejuvenation biotechnology, as this is the first stem-cell treatment that is close to final FDA approval for specifically targeting age-related frailty. Should this be approved, then it opens the door for other similar approaches and the potential treatment of many age-related diseases.

The therapy itself uses MSCs taken from adult donor bone marrow and is infused into patients with an average age of 76 years old. The good news is that patients in both the phase 1 and phase 2 clinical trials have shown no adverse effects to treatment.

This is excellent news and now paves the way to move to phase 3 clinical trials, which are larger-scale tests to further determine the efficacy and compare it to the best currently available treatments, for which there are basically none beyond simple coping approaches, such as walking sticks and frames to compensate for frailty.

It is also important to note that at this at this point, the drug or therapy is accepted as having some effect. You can read more about the clinical trial process and what each phase means here.

In the first trial, 15 patients with age-related frailty were given a single transplant of MSCs from donors aged between 20 and 45. [6] Six months later, all patients in the trial showed an improved level of fitness, lower levels of inflammatory tumor necrosis factor (TNF), and improved quality of life in general. TNF is one of the regulators of inflammation and contributes to the chronic age-related inflammation known as “inflammaging”, which drives a number of age-related diseases. [7]

The second trial was a randomized, double-blind study including a placebo group. An improved physical performance level was observed in patients, and, again, the level of systemic TNF, and thus inflammation, was reduced. [8] Once again, there were no adverse effects observed in the patients, and the researchers wrote:

Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome.

David G. Le Couter and colleagues have written about the clinical trials in a guest editorial in The Journals of Gerontology:

There are always caveats associated with interpreting efficacy in small numbers of subjects, yet it is remarkable that a single treatment seems to have generated improvement in key features of frailty that are sustained for many months.

The next step for the researchers here is to begin a phase 2b clinical trial with 120 patients in ten different locations. Following the conclusion of this, a large randomized phase 3 trial will be launched, and this will be the final barrier to public approval for the therapy.

Conclusion

With an ever-increasing number of aged people in our population, stem cells hold great potential for treating a number of age-related diseases and combating the disability and frailty that accompany the aging process. Developing therapies like these could potentially help older people to enjoy an improved level of physical performance and a better quality of life. Being able to remain mobile and independent as we grow older would be of huge benefit to not only the individual but also to families and society as a whole.

There are currently no FDA-approved treatments for age-related frailty, so this represents a huge unmet need that will only worsen with an increasingly aging population if those needs are not met by new medicines.

Seeing such tangible results in humans is a clear indication of the potential of rejuvenation biotechnology, and how we regard and treat aging will be changing in the near future.

Literature

[1] Nardi, N. B., & da Silva Meirelles, L. (2008). Mesenchymal stem cells: isolation, in vitro expansion and characterization. In Stem cells (pp. 249-282). Springer Berlin Heidelberg.

[2] Stolzing, A., Jones, E., McGonagle, D., & Scutt, A. (2008). Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mechanisms of ageing and development, 129(3), 163-173.

[3] Wang, S., Qu, X., & Zhao, R. C. (2012). Clinical applications of mesenchymal stem cells. Journal of hematology & oncology, 5(1), 19.

[4] Danielyan, L., Beer-Hammer, S., Stolzing, A., Schäfer, R., Siegel, G., Fabian, C., … & Novakovic, A. (2014). Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer’s and Parkinson’s disease. Cell transplantation, 23(1), S123-S139.

[5] Naaldijk, Y., Jaeger, C., Fabian, C., Leovsky, C., Blüher, A., Rudolph, L., … & Stolzing, A. (2017). Effect of systemic transplantation of bone marrow‐derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice. Neuropathology and applied neurobiology, 43(4), 299-314.

[6] Golpanian, S., DiFede, D. L., Khan, A., Schulman, I. H., Landin, A. M., Tompkins, B. A., … & Levis-Dusseau, S. (2017). Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, glx056.

[7] Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017). Inflammaging and ‘Garb-aging’. Trends in Endocrinology & Metabolism, 28(3), 199-212.

[8] Tompkins, B. A., DiFede, D. L., Khan, A., Landin, A. M., Schulman, I. H., Pujol, M. V., … & Mushtaq, M. (2017). Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 72(11), 1513-1522.

 

About Steve Hill

As a scientific writer and a devoted advocate of healthy longevity technologies, Steve has provided the community with multiple educational articles, interviews, and podcasts, helping the general public to better understand aging and the means to modify its dynamics. His materials can be found at H+ Magazine, Longevity Reporter, Psychology Today, and Singularity Weblog. He is a co-author of the book Aging Prevention for All – a guide for the general public exploring evidence-based means to extend healthy life (in press).

About LIFE EXTENSION ADVOCACY FOUNDATION (LEAF)

In 2014, the Life Extension Advocacy Foundation was established as a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects and raising awareness regarding the societal benefits of life extension. In 2015 they launched Lifespan.io, the first nonprofit crowdfunding platform focused on the biomedical research of aging.

They believe that this will enable the general public to influence the pace of research directly. To date they have successfully supported four research projects aimed at investigating different processes of aging and developing therapies to treat age-related diseases.

The LEAF team organizes educational events, takes part in different public and scientific conferences, and actively engages with the public on social media in order to help disseminate this crucial information. They initiate public dialogue aimed at regulatory improvement in the fields related to rejuvenation biotechnology.

21-Day Exposure Period for Platform Vote #6

21-Day Exposure Period for Platform Vote #6

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Gennady Stolyarov II


For its upcoming sixth Platform vote, the U.S. Transhumanist Party has receive a large volume of suggestions from members during the past four months. This exposure period is intended to encompass as many of these suggestions as possible. A vote will be scheduled on some or all of these items once they have been exposed for at least 21 days. For each item, a 7-day voting period is expected to be opened at the earliest at 12:01 a.m. on Saturday, November 11, 2017.

During the exposure period, please post your comments on this thread. If you post comments intended to be considered in voting and/or amending any of these planks in any other electronic medium, please note that you thereby give your consent to have your comments reproduced with attribution or linked within this discussion thread, in order to direct members’ attention and consideration to them.

After the exposure period, a 7-day electronic voting period will occur. Instructions for electronic voting will be sent to members of the U.S. Transhumanist Party via e-mail at that time. All individuals who are members of the U.S. Transhumanist Party as of the end of the exposure period and who have expressed agreement with its three Core Ideals will be eligible to vote thereafter. You can still vote if you become a member during the exposure period, so please apply here if you are interested. During the 7-day electronic voting period, you will still be able to become a member – but you will only be able to vote in subsequent elections, since we seek for voting on any given issue to be done by those members who have had an opportunity to thoroughly consider that issue and be involved in deliberations regarding it.

Electronic voting will be conducted by a ranked-preference method if more than a single option is presented for the wording of a particular plank or segment of a plank. Members will be able to rank-order their preferred selections on each individual Platform Section. The original text of each Section will be available for selection, as well as any reasonable amendments proposed by any member. Leadership of the Transhumanist Party reserves the right to edit any proposed amendment for correctness of spelling and grammar only – but not with regard to the substance, unless the person proposing the amendment requests or consents to a substantive edit. “No Section of this sort” will also be a choice, and any Section where a majority of votes favors this option will be not be adopted. Members will also be able to abstain from voting on any given Section.

The ranked-preference method has the advantage of eliminating a “winner-take-all” or “first-past-the-post” mentality and preventing people from being channeled into voting for sub-optimal choices (in their view) just because they fear an even less palatable alternative prevailing. Within the ranked-preference methodology, if no option obtains a clear majority as voters’ first choice, the option having the fewest first-choice votes is eliminated from consideration, and all those who voted for that option will have their votes assigned to their second-choice options. This process of elimination continues until one particular option has a clear majority of votes.

The Transhumanist Party encourages all members to participate in this process and for other transhumanists to sign up for membership during the exposure period. 

The Section titles below are provisional and will be replaced with official numbers for each plank that is adopted. The Section titles are informational only and will not be included in the adopted versions of the platform planks.


Section E6-A. Minimum Timeframe for Voting on a Bill

Option E6-A-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports efforts to create a reasonable minimum timeframe between the proposal of a bill and the voting procedure. To ensure a reasonable timeframe is proportional to the number of pages of a proposed bill, a time period per each specified amount of pages could be adopted. For example, and without committing to specific numerical magnitudes, a 24-hour period within a working week per every 20 pages could be adopted to ensure all member of Congress involved have sufficient time to read through and study a proposed bill’s implications. Such measures would prevent a bill from being introduced shortly before the voting process. They would also have the added side effect that proposals might become more concise, as the length of a bill would influence the consideration time.

[The question will allow members to select one or none of the ancillary provisions below, with any measure receiving a majority of the votes being included in the ultimately adopted plank. The ancillary provisions are compatible with each of the main options above.]

Ancillary Provision Option E6-A-i. [Based on Proposal by Martin van der Kroon]  In addition to this, after the proposal has been submitted, no change may be made to the proposal to prevent changing the substance of a proposal.

Ancillary Provision Option E6-A-ii. [Based on Proposal by Gennady Stolyarov II] In addition to this, after the proposal has been submitted, any amendments must be explicitly discussed in a public forum with the same degree of thorough consideration and same rules pertaining to the timeframe of consideration as allowed for the original proposal.

 

Section E6-B. Fully Informed Juries

Option E6-B-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports efforts to ensure a jury is fully informed on its rights and responsibilities, including jury nullification. The United States Transhumanist Party also supports efforts to prevent false claims being made regarding the rights and responsibilities of the jury.

 

Section E6-C. Elimination of Stationary Nuclear Stockpile

Option E6-C-1. [Based on Proposal by Martin van der Kroon]

As an intermediate step toward the goal of complete nuclear disarmament and a potential pragmatic compromise in any future negotiations for disarmament, the United States Transhumanist Party supports efforts to significantly reduce the United States nuclear stockpile, and to replace or transfer a small part (between 1 percent and 10 percent) of this stockpile, to mobile nuclear platforms such as submarines. An enemy may currently target the stationary nuclear bombs directly. Having a largely hidden mobile fleet of nuclear bombs would render it much more difficult for any enemy to target the nuclear arsenal, while still maintaining the nuclear deterrent option in sufficient capacity. This would further have the effect of lowering the budget required to maintain the nuclear stockpile, as it could be drastically downsized.

 

Section E6-D. Legalization of Prostitution

Option E6-D-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports the right for individuals to have autonomy over, and utilize their bodies to earn money, including through activities such as prostitution, as long as such activities arise from a person’s own free will (e.g., not under duress), and the person is not endangering the health or well-being of others.

Legalization would give those who wish to engage in prostitution the safety and protection of the law – for example, so that they may report abuse and would be prone to being exploited. It would also open the possibility for such individuals to unionize if they wish to do so. Furthermore, legalization would decrease government spending on what is ultimately a ‘moral crusade’.

Option E6-D-2. [Based on Proposal by Martin van der Kroon, with Added Wording by Ajay Davis]

The United States Transhumanist Party supports the right for individuals to have autonomy over, and utilize their bodies to earn money, including through activities such as prostitution, as long as such activities arise from a person’s own free will (e.g., not under duress), and the person is not endangering the health or well-being of others, including but not limited to the communication of sexually transmissible diseases.

Legalization would give those who wish to engage in prostitution the safety and protection of the law – for example, so that they may report abuse and would be prone to being exploited. It would also open the possibility for such individuals to unionize if they wish to do so. Furthermore, legalization would decrease government spending on what is ultimately a ‘moral crusade’.

[The question will allow members to select one or none of the ancillary provisions below, with any measure receiving a majority of the votes being included in the ultimately adopted plankThe ancillary provisions are compatible with each of the main options above.]

Ancillary Provision E6-D-i. [Based on Proposal by Ryan Starr]

However, the United States Transhumanist Party unequivocally condemns any manner of human trafficking, child exploitation, and other abuse that involves a violation of the autonomy and consent of any individual. The legalization of prostitution should be combined with stronger efforts to combat these dangerous and exploitative practices.

Ancillary Provision E6-D-ii. [Based on Proposal by Martin van der Kroon]

The legalization of prostitution could furthermore enable more effective action against human trafficking and involuntary exploitation, as, when prostitution is legalized, employees in this industry would become subject to the protections of the law. Legalization would help focus resources on combating the trafficking of humans rather than catching workers who chose this profession voluntarily.

 

Section E6-E. Public Records of Official Statements

Option E6-E-1. [Based on Proposal by Ryan Starr, with Clarifications Suggested by Martin van der Kroon]

The United States Transhumanist Party holds that any statement made by an elected official and/or public servant to members of the public in a public forum, and available to be heard, read, or otherwise understood in a public setting, physical or digital, should be considered a part of the public record and treated as an official statement of their office and position.

Option E6-E-2. [Based on Proposal by Ryan Starr, with Further Clarifications Regarding the Capacity in Which the Official Acts]

The United States Transhumanist Party holds that any statement made by an elected official and/or public servant to members of the public in a public forum as part of that official’s or public servant’s job duties, and available to be heard, read, or otherwise understood in a public setting, physical or digital, should be considered a part of the public record and treated as an official statement of their office and position. This requirement does not extend to statements made by an elected official and/or public servant in the capacity of a private citizen or in the expression of a personal opinion or other position unrelated to the exercise of the official’s or public servant’s job duties.

 

Section E6-F. Artificial Intelligence System to Analyze Risk of Proposed Legislation

Option E6-F-1. [Based on Proposal by Ryan Starr]

The United States Transhumanist Party holds that state and federal governments should establish an artificial intelligence (AI) analysis system for measuring risk of proposed legislation. Such a system could provide an impartial look at what legislation could cause harm or unintended consequences. Submitted policies would receive a score from 0 to 100, and the AI system would state what possible negative impacts may result. This system should be publicly accessible for submissions and for security audit. This is not intended to create or enact laws, but simply to serve as a tool to measure risk versus reward.

Option E6-F-2. [Based on Proposal by Ryan Starr, with Added Wording by Daniel Yeluashvili on Blocking Certain Laws]

The United States Transhumanist Party holds that state and federal governments should establish an artificial intelligence (AI) analysis system for measuring risk of proposed legislation. Such a system could provide an impartial look at what legislation could cause harm or unintended consequences. Submitted policies would receive a score from 0 to 100, and the AI system would state what possible negative impacts may result. This system should be publicly accessible for submissions and for security audit. This is not intended to create or enact laws, but simply to serve as a tool to measure risk versus reward. However, such an AI system should be used to block laws that have a 50% or greater probability of negatively affecting the majority of the population.

 

Section E6-G. Opposition to Partisan Determination of Voting Districts

Option E6-G-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party strongly opposes the possibility for any political party to determine the boundaries and borders of any voting district. The United States Transhumanist Party supports measures that require any efforts to have the districts potentially redrawn, when necessary due to migration for example, to be left to an automated system such as an artificial intelligence (AI) designed for this task.

 

Section E6-H. Limitation of Presidential Authority over International Agreements

Option E6-H-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports efforts to remove the possibility for a President to sign an international agreement among two or more nations by executive order. This would prevent a President from engaging in international affairs without support from the Congress, and likewise would make it more difficult to exit an international agreement, as support from Congress would need to exist in order for such an exit to occur. This would furthermore ensure that the United States becomes a more trustworthy nation in the eyes of the international community.

 

Section E6-I. International or World Passport

Option E6-I-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports efforts to create a framework for an international or world passport. This framework could, for example, be administered through the United Nations, and the passport could be valid only for those countries who have proven to meet the standards, set by participating countries, required to ensure safety. Given that the European Union has an ID valid within its borders, and the United States has a similar agreement with Canada, imagining these forms of identification being combined shows that a world passport is not a farfetched or alien idea.

 

Section E6-J. Registration Chip for New Firearms

Option E6-J-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports efforts to mandate that new firearms will be produced with an embedded registration chip, as well as the registration number engraved on the firearm. The chip would have a registration number, a ‘trace online’ code, and a ‘lost or stolen’ code. The firearm would be accompanied by a physical and digital certificate of ownership with a registration number, the ‘trace online’ number, and the ‘lost or stolen’ number. The embedded chip would render it much harder to make the firearm untraceable. The number and codes involved would have to be unique identifiers.

When a firearm would be lost or stolen, the owner of the firearm and holder of the certificate would report the firearm to the authorities as lost or stolen using the ‘lost or stolen’ number. The intent of having a separate reporting number is to ensure that, in the event that a firearm is stolen or taken without consent, the offender cannot report the firearm as stolen, or as found again. When a firearm owner suspects the firearm is simply mislocated – for example, in the car or in the house, or perhaps taken by a family member, the owner could trace the firearm online via GPS on an online map, using the ‘trace online’ code. The ‘trace online’ code would never be revealed to law enforcement.

Law enforcement would have a device that can confirm the registration number of a firearm in close proximity, similar to contactless payments. On the other hand the detection range would be greater when a firearm has been reported lost or stolen by the owner of the firearm in question with the ‘lost and stolen’ number. A firearm that would not have been reported lost or stolen to law enforcement by the owner of the firearm with the ‘lost or stolen’ number would not be traceable from a greater distance by law enforcement.

This would ensure the privacy, safety, and peace of mind of firearm owners who might otherwise feel law enforcement would trace firearms without legal justification. At the same time, this measure would decrease the probability of stolen firearms never being found, and possibly ending in the hands of people with ill intent.

 

Section E6-K. Public Civil-Rights Prosecutor

Option E6-K-1. [Based on Proposal by Ryan Starr]

The United States Transhumanist Party supports the creation of an office of a Public Civil-Rights Prosecutor. Our current justice system is flawed. Only people with substantial wealth can afford lawyers to take legal action against those who attack a person’s rights. While there are organizations like the American Civil Liberties Union (ACLU), which offer help for some cases, their ability to do so is severely limited and typically non-existent in the lower courts. A Public Civil-Rights Prosecutor’s office will help guarantee that, no matter who a person is or the position of the offending party, a person’s rights cannot be assailed without consequence.

 

Section E6-L. Lowering Military Spending

Option E6-L-1. [Based on Proposal by John M.]

The United States Transhumanist Party supports lowering spending by the Department of Defense and the U.S. Military, which amounts to hundreds of billions of dollars per year and includes unchecked wastefulness. Reducing military spending would free up money for more important goals, such as curing disease, which collectively kills many more people than military conflict or war by an exponential degree.

 

Section E6-M. Accountability for Use of Federal Grants

Option E6-M-1. [Based on Proposal by Martin van der Kroon]

The United States Transhumanist Party supports efforts to hold institutions, corporations, and states accountable for usage of federal money with a specific intended purpose. When an entity has been granted any form of funding with a specifically intended purpose, such as disaster relief or specific educational funds, and these funds are misappropriated or used for other purposes well outside of the scope of what they were intended for, the entity in question ought to restitute the funding that was made available.

 

Section E6-N. Increased Funding for the National Institutes of Health

Option E6-N-1. [Based on Proposal by John Marlowe]

The United States Transhumanist Party supports increases in the budget for the National Institutes of Health (NIH). Numerous biotech CEOs have recently made the case to increase the NIH budget, because the NIH conducts research that their companies would not be able to invest in, as investments not leading directly to a product would affect the bottom line. 33% of all the publications from NIH research are cited in corporate patents, so it stimulates new product development. A major driver for economic progress and reducing the suffering of those in pain, the NIH is essentially a public charity that brings us into the future. Whether one supports limited or expansive government, the NIH does not seek to regulate anything nor impose laws on anyone. It exclusively conducts medical research to help the sick.

Option E6-N-2. [Based on Proposal by John Marlowe, with Modification to Require Offsetting Decreases in Military Spending]

The United States Transhumanist Party supports increases in the budget for the National Institutes of Health (NIH), provided that such increases are offset by equivalent or greater decreases in military spending. Numerous biotech CEOs have recently made the case to increase the NIH budget, because the NIH conducts research that their companies would not be able to invest in, as investments not leading directly to a product would affect the bottom line. 33% of all the publications from NIH research are cited in corporate patents, so it stimulates new product development. A major driver for economic progress and reducing the suffering of those in pain, the NIH is essentially a public charity that brings us into the future. Whether one supports limited or expansive government, the NIH does not seek to regulate anything nor impose laws on anyone. It exclusively conducts medical research to help the sick.

 

Section E6-O. Reinstatement of Voting Rights to Felons Who Have Served Their Punishment

Option E6-O-1. [Based on Proposal by Martin van der Kroon]

The U.S. Transhumanist Party supports efforts to reinstate the rights to vote for convicted felons who have received and served their punishment, in order to present them the opportunity to participate in society as otherwise normal citizens.

 

Section E6-P. Repeal of FDA Approval Requirements for Drug Tests on Willing Patients

Option E6-P-1. [Based on Proposal by Gennady Stolyarov II]

The United States Transhumanist Party supports repealing the current requirement in the United States that drugs or treatments may not be used, even on willing patients, unless approval for such drugs or treatments is received from the Food and Drug Administration. Such requirements are a profound violation of patient sovereignty; a person who is terminally ill is unable to choose to take a risk on an unapproved drug or treatment unless this person is fortunate enough to participate in a clinical trial. Even then, once the clinical trial ends, the treatment must be discontinued, even if it was actually successful at prolonging the person’s life. This is not only profoundly tragic, but morally unconscionable as well. The most critical reform needed is to allow unapproved drugs and treatments to be marketed and consumed. If the FDA wishes to strongly differentiate between approved and unapproved treatments, then a strongly worded warning label could be required for unapproved treatments, and patients could even be required to sign a consent form stating that they have been informed of the risks of an unapproved treatment. This reform to directly extend many lives and to redress a moral travesty should be the top political priority of advocates of indefinite life extension. Over the coming decades, its effect will be to allow cutting-edge treatments to reach a market sooner and thus to enable data about those treatments’ effects to be gathered more quickly and reliably. Because many treatments take 10-15 years to receive FDA approval, this reform could by itself speed up the real-world advent of indefinite life extension by over a decade.

 

Section E6-Q. Abolition of Medical Licensing Protectionism

Option E6-Q-1. [Based on Proposal by Gennady Stolyarov II]

The United States Transhumanist Party supports efforts to increase opportunities for entry into the medical profession. The current system for licensing doctors is highly monopolistic and protectionist – the result of efforts by the American Medical Association in the early 20th century to limit entry into the profession in order to artificially boost incomes for its members. The medical system suffers today from too few doctors and thus vastly inflated patient costs and unacceptable waiting times for appointments. Instead of prohibiting the practice of medicine by all except a select few who have completed an extremely rigorous and cost-prohibitive formal medical schooling, governments in the Western world should allow the market to determine different tiers of medical care for which competing private certifications would emerge. For the most specialized and intricate tasks, high standards of certification would continue to exist, and a practitioner’s credentials and reputation would remain absolutely essential to convincing consumers to put their lives in that practitioner’s hands. But, with regard to routine medical care (e.g., annual check-ups, vaccinations, basic wound treatment), it is not necessary to receive attention from a person with a full-fledged medical degree. Furthermore, competition among certification providers would increase quality of training and lower its price, as well as accelerate the time needed to complete the training. Such a system would allow many more young medical professionals to practice without undertaking enormous debt or serving for years (if not decades) in roles that offer very little remuneration while entailing a great deal of subservience to the hierarchy of an established institution. Ultimately, without sufficient doctors to affordably deliver life-extending treatments when they become available, it would not be feasible to extend these treatments to the majority of people.

 

Section E6-R. Abolition of Ability to Re-Patent Generic Medicines and Devices

Option E6-R-1. [Based on Proposal by Gennady Stolyarov II]

The United States Transhumanist Party supports reforms to the patent system that prevent the re-patenting of drugs and medical devices, or the acquisition of any exclusive or monopoly rights over those drugs and devices, once they have become generic or entered the public domain. Appallingly, many pharmaceutical companies today attempt to re-patent drugs that have already entered the public domain, simply because the drugs have been discovered to have effects on a disease different from the one for which they were originally patented. The result of this is that the price of the re-patented drug often spikes by orders of magnitude compared to the price level during the period the drug was subject to competition. Only a vibrant and competitive market, where numerous medical providers can experiment with how to improve particular treatments or create new ones, can allow for the rate of progress needed for the people alive today to benefit from radical life extension.

 

Section E6-S. Reduction of Medical Patent Timeframes

Option E6-S-1. [Based on Proposal by Gennady Stolyarov II]

The United States Transhumanist Party supports reforms to reduce the lengths of times over which medical patents could be effective. Medical patents – in essence, legal grants of monopoly for limited periods of time – greatly inflate the cost of drugs and other treatments. Especially in today’s world of rapidly advancing biotechnology, a patent term of 20 years essentially means that no party other than the patent holder (or someone paying royalties to the patent holder) may innovate upon the patented medicine for a generation, all while the technological potential for such innovation becomes glaringly obvious. As much innovation consists of incremental improvements on what already exists, the lack of an ability to create derivative drugs and treatments that tweak current approaches implies that the entire medical field is, for some time, stuck at the first stages of a treatment’s evolution – with all of the expense and unreliability this entails. Even with shortened patent terms, the original developer of an innovation will still always benefit from a first-mover advantage, as it takes time for competitors to catch on. If the original developer can maintain high-quality service and demonstrate the ability to sell a safe product, then the brand-name advantage alone can secure a consistent revenue stream without the need for a patent monopoly.

 

Proposed Amendments to Existing Planks

Members will be given the option to either retain existing language of a plank or to adopt any of the listed proposed amendments. Ranked-preference voting will be conducted for any Section for which more than one amendment has been proposed. Members will also be able to abstain from each vote.

 1. Amendments to Section II on Anti-Bigotry to Encompass “Alt-Left” Groups

Current Version of Section II. The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries.

Amendment II-1. [Addition of New Paragraph on “Alt-Left” Movements, Reflecting Recommendation by Scott Jurgens]

The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries.

While opposing movements based on hostile discrimination on circumstantial attributes, the United States Transhumanist Party also condemns movements on the “alt-left” which attempt to stifle free speech, use violence to prevent the expression of “alt-right” or even non-left-wing sentiments, or promote retributive circumstantial discrimination, which should be rejected along with the original acts of circumstantial discrimination against which the “alt-left” is reacting. The United States Transhumanist Party unequivocally opposes the use of violence against lives and property and the disruption of the peaceful conduct of daily life by movements calling themselves “Antifa”, “By Any Means Necessary”, or “Black Lives Matter” – even as the United States Transhumanist Party remains strongly opposed to fascism and strongly supports efforts to protect black Americans and all other Americans from police brutality and all other forms of violence. It is imperative that only peaceful, rights-respecting tactics and reforms be used in the efforts to thwart fascism and prevent police brutality.

Amendment II-2. [Addition of New Paragraph on “Alt-Left” Movements, Reflecting Suggestions by B.J. Murphy to Include Individual Supporters and Emphasize the Right of Self-Defense]

The United States Transhumanist Party abhors all racism, nativism, xenophobia, and sexism. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to close national borders, restrict immigration of peaceful individuals, or deny opportunities to individuals on the basis of ethnicity, race, or national origin. The United States Transhumanist Party unequivocally condemns all demagogues who seek to segregate individuals on the basis of national origin, race, or ethnicity. In particular, The United States Transhumanist Party opposes movements describing themselves as “white nationalism”, “America First”, “race realism”, and the “alt-right” – as well as the counterparts of those movements in other countries – and individual supporters of those movements.

While opposing movements based on hostile discrimination on circumstantial attributes, the United States Transhumanist Party also condemns movements on the “alt-left” which attempt to stifle free speech, use violence to prevent the expression of “alt-right” or even non-left-wing sentiments, or promote retributive circumstantial discrimination, which should be rejected along with the original acts of circumstantial discrimination against which the “alt-left” is reacting. The United States Transhumanist Party unequivocally opposes the use of violence against lives and property and the disruption of the peaceful conduct of daily life by movements calling themselves “Antifa”, “By Any Means Necessary”, or “Black Lives Matter” and by individual supporters of those movements – even as the United States Transhumanist Party remains strongly opposed to fascism and strongly supports efforts to protect black Americans and all other Americans from police brutality and all other forms of violence. It is imperative that only peaceful, rights-respecting tactics and reforms be used in the efforts to thwart fascism and prevent police brutality.

However, the United States Transhumanist Party also recognizes the difference between committing violence for the sake of violence and committing violence as a means of self-defense – especially against fascism – and therefore does not condemn purely defensive violence.

Amendment II-3. [Simplification, Reflecting Recommendation by Martin van der Kroon

The United States Transhumanist Party opposes any movement or group, and individual members of such movements or groups, that utilize and justify the use of violence, bullying, doxxing, intimidation, and other coercive or privacy-infringing tactics in a quest to force their goals or display dominance, regardless of political orientation, leaning, or ideology.

Amendment II-4. [Simplification, Reflecting Recommendation by Daniel Yeluashvili

The United States Transhumanist Party supports all acceptance, tolerance, and inclusivity of individuals and groups of all races, genders, classes, religions, creeds, and ideologies. Accordingly, the United States Transhumanist Party condemns any hostile discrimination or legal restrictions on the basis of national origin, skin color, birthplace, ancestry, gender identity, or any manner of circumstantial attribute tied to a person’s lineage or accident of birth. Furthermore, the United States Transhumanist Party strongly opposes any efforts to enforce said restrictions regardless of cause or motivation thereof. Additionally, any institution that uses violence, suppression of free speech, or other unconstitutional or otherwise illegal methods will be disavowed and condemned by the United States Transhumanist Party, with an efficient, non-violent alternative to said institution being offered to achieve its goals if they align with the Party’s interests.

 

2. Amendments to Section XVII on Abolition of the Electoral College

Current Version of Section XXVII. The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President. While the original intent of the Electoral College as a deliberative body to check the passions of the poorly informed masses and potentially overturn the election of a demagogue may have been noble, the reality has not reflected this intention. Instead, the Electoral College has enabled votes from less cosmopolitan, less tolerant, more culturally ossified and monolithic areas of the country to disproportionately sway the outcome of Presidential elections, to the detriment of individual liberty and progress.

Amendment XXVII-1. [Removal of Last Sentence, Reflecting Recommendation by Scott Jurgens] The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President. While the original intent of the Electoral College as a deliberative body to check the passions of the poorly informed masses and potentially overturn the election of a demagogue may have been noble, the reality has not reflected this intention.

Amendment XXVII-2. [Removal of Last Two Sentences, Reflecting Recommendation by Scott Jurgens] The United States Transhumanist Party advocates Constitutional reform to abolish the Electoral College in the United States Presidential elections and render the plurality of the popular vote the sole criterion for the election of President.

 

 3. Amendments to Section LIX on External Investigations of Law-Enforcement Misconduct

Current Version of Section LIX. The United States Transhumanist Party considers it important for impartial, objective investigations of alleged police and other law-enforcement misconduct to be pursued. While law-enforcement agencies should not be prohibited from internally investigating potential abuses within their own ranks, such investigations should never be considered exclusive or conclusive, and further external checks and accountability should be instituted. As part of providing such checks and accountability, investigations regarding police misconduct, criminal activity, felonies, and misdemeanors should, in addition to any internal investigation, also be investigated by a different source – for example, a different police department, or a district attorney for a different area assigned to lead the investigation. The intent of this requirement is to limit the possibility of favorably biased or preferential treatment of a member of a given law-enforcement agency by that person’s colleagues, and to restore confidence by the public that an investigation into police misconduct is done as objectively as possible.

Amendment LIX-1. [Replacement of Second-to-Last Sentence to Require a Civilian Investigating Organization, Based on Recommendation by Ryan Starr] The United States Transhumanist Party considers it important for impartial, objective investigations of alleged police and other law-enforcement misconduct to be pursued. While law-enforcement agencies should not be prohibited from internally investigating potential abuses within their own ranks, such investigations should never be considered exclusive or conclusive, and further external checks and accountability should be instituted. As part of providing such checks and accountability, investigations regarding misconduct, negligence, abuse, criminal activity, felonies, and misdemeanors allegedly committed by police, district attorneys, and judges, should, in addition to any internal investigation, also be conducted by a civilian organization outside the justice system. The intent of this requirement is to limit the possibility of favorably biased or preferential treatment of a member of a given law-enforcement agency by that person’s colleagues, and to restore confidence by the public that an investigation into police misconduct is done as objectively as possible.

MILE / U.S. Transhumanist Party Interview with Ira Pastor of Bioquark, Inc.

MILE / U.S. Transhumanist Party Interview with Ira Pastor of Bioquark, Inc.

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Gennady Stolyarov II 


 

Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, was honored to interview entrepreneur and pharmaceutical industry veteran Ira Pastor for MILE – the Movement for Indefinite Life Extension – the U.S. Transhumanist Party, and the Nevada Transhumanist Party. The hour-long conversation delved into a variety of interrelated subject areas, including regeneration and repair mechanisms in animals, potential applications in humans, development of substances and treatments that could achieve victories against diseases and lead to longer lifespans, political and regulatory implications for the development of such substances, the importance of awareness of this research within the broader society, and even a “moonshot” project called ReAnima for repairing traumatic injury to organs and tissues that would otherwise cause irreversible death in accident victims.

This interview took place on Saturday, February 11, 2017, at 10 a.m. U.S. Pacific Time.

Read about Bioquark here.

Read about Mr. Pastor here.

Join the U.S. Transhumanist Party for free here.

Visit and like the MILE – Movement for Indefinite Life Extension – Facebook page here.

Discussion on Life-Extension Advocacy – Gennady Stolyarov II Answers Audience Questions

Discussion on Life-Extension Advocacy – Gennady Stolyarov II Answers Audience Questions

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Gennady Stolyarov II


 

Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, answers audience questions regarding life-extension advocacy and possibilities for broadening the reach of transhumanist and life-extensionist ideas.

While we were unable to get into contact with our intended guest, Chris Monteiro, we were nonetheless able to have a productive, wide-ranging discussion that addressed many areas of emerging technologies, as well as trends in societal attitudes towards them and related issues of cosmopolitanism, ideology, and the need for a new comprehensive philosophical paradigm of transmodernism or hypermodernism that would build off of the legacy of the 18th-century Age of Enlightenment.

Become a member of the U.S. Transhumanist Party for free. Apply here.

The user comments submitted contemporaneously with this discussion are presented below.

User Comments