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Category: Allied Projects

I am the Lifespan – Video by Gennady Stolyarov II

I am the Lifespan – Video by Gennady Stolyarov II

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Gennady Stolyarov II


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, discusses why longevity research is crucial, and how our generation stands on the threshold of finally dealing a decisive blow to the age-old enemies of aging and death, which have destroyed great human minds since the emergence of our species.

This video is part of the #IAmTheLifespan campaign, coordinated by Lifespan.io and the Life Extension Advocacy Foundation (LEAF) for Longevity Month, October 2017. Read more about this campaign here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

AgeMeter Crowdfunding Campaign On LifeSpan.io – Are You Getting Any Younger?

AgeMeter Crowdfunding Campaign On LifeSpan.io – Are You Getting Any Younger?

Martin van der Kroon


AgeMeter is a project that intends to develop a functional age test to validate interventions through a low-cost, modular touch screen device that would integrate multiple cognitive & biometric assessment technologies. At this moment AgeMeter is doing a crowdfunding campaign on Lifespan.io with the intended goal of raising $30,000. At the moment of writing the pledged amount for funding AgeMeter stands at $22,590, leaving $7,410 to go, with only 4 days left on the clock to reach the funding goal.

But why am I telling you this, and why would AgeMeter be an important tool to further longevity? Glad you asked!

The folks at AgeMeter explain clearly why it is important to realize this project:

“The AgeMeterTM device will measure functional biomarkers of participants, estimating the age at which a person physically functions, enabling researchers to validate measurements from genetic and biochemical aging interventions and reliably compare results across subjects, studies and approaches.

Many laboratories have published results indicating the reversal or delay of various biomarkers of aging in model organisms and human cells, including cellular biomarkers such as telomere length, epigenome methylation status, expression of proteins specific to senescent cells and others, as well as morphological and functional tests, such as appearance, gait and balance, memory tests, etc. Thus far, however, there has been no fully integrated approach that can easily collect a variety of different data points from human participants, reliably correlating the output to functional age and comparing this against chronological age.

Being able to easily evaluate the effectiveness of a potential aging treatment in this way will allow longevity research to proceed at a faster rate, because meaningful data in regards to lifespan effect can be gathered in the middle of a study, not just at the end.”

Elliot Small from the Center for Age Control gives a thorough explanation of what AgeMeter is:

Furthermore, the AgeMeter project has been endorsed as a reputable initiative by LongeCity ensuring, that if you wish to donate, your donation is used as intended.

Of course there are many spectacular developments in longevity, such as gene-editing, and so on. It is, however, important to remember that with insufficient research and data all these high-profile innovations are much less useful, and can even do harm. We might compare it to a patient going into surgery; The surgeon can only do his or her best work if the M.D. has correctly diagnosed the patient.

That is why AgeMeter is important, and needs your help with funding!

MouseAge: Using Artificial Intelligence to Determine Age and Assess Therapies Against Aging – Project by Lifespan.io

MouseAge: Using Artificial Intelligence to Determine Age and Assess Therapies Against Aging – Project by Lifespan.io

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United States Transhumanist Party


According to Article 3, Section V of the Constitution of the United States Transhumanist Party:

“The United States Transhumanist Party supports concerted research in effort to eradicate disease and illness that wreak havoc upon and cause death of sapient beings. We strongly advocate the increase and redirection of research funds to conduct research and experiments and to explore life, science, technology, medicine, and extraterrestrial realms to improve all sentient entities.”

Which is why the U.S. Transhumanist Party is pleased to announce the official launch of the fundraising campaign for the MouseAge project. MouseAge is a longevity-based project started by one of our Allied Organizations, Lifespan.io, of which we’ll provide relevant information below:

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A “Disease” Approach in Life-Extension Advocacy Can Facilitate Communication with the General Public – Infographic by Elena Milova and Keith Comito

A “Disease” Approach in Life-Extension Advocacy Can Facilitate Communication with the General Public – Infographic by Elena Milova and Keith Comito

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Elena Milova and Keith Comito


The U.S. Transhumanist Party is pleased to share this infographic from our friends at the Life Extension Advocacy Foundation (LEAF), one of the Transhumanist Party’s most active Allied Organizations. Life-extension advocates Elena Milova and Keith Comito have compiled a set of tips for communicating ideas regarding the progress of medical science and technology, for the pursuit of healthy life extension, in such a manner as to enable many in the general public to understand and sympathize with our goals and the science behind them. We encourage you to distribute this infographic to any activists and advocates who you think would benefit from the advice therein.

LEAF Interview with Dr. Aubrey de Grey: Controlling the Main Aging Damages

LEAF Interview with Dr. Aubrey de Grey: Controlling the Main Aging Damages

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Aubrey de Grey and Life Extension Advocacy Foundation


The U.S. Transhumanist Party is pleased to feature this interview of Dr. Aubrey de Grey, the Transhumanist Party’s Anti-Aging Advisor, conducted by Elena Milova of the Life Extension Advocacy Foundation (LEAF), one of the Transhumanist Party’s most active Allied Organizations. You can also see this interview on YouTube here.

Description by LEAF: Please enjoy this interview with Dr. Aubrey de Grey, Chief Science Officer and Co-founder of SENS Research Foundation — one of the most successful advocacy and fundraising initiatives supporting breakthrough research on the main mechanisms of aging and age-related diseases.

In this video Dr. de Grey speaks about the progress in developing interventions to tackle age-related damages identified by SENS as the main ones.

Interviewer – LEAF/Lifespan.io Board member Elena Milova.

Dr. de Grey received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. He is Editor-in-Chief of Rejuvenation Research , is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations.

Subscribe to Lifespan.io’s YouTube channel for more.

This interview is presented by LEAF. Please support its work by becoming a “Lifespan Hero“.

CellAge Fundraiser Update and Donation Matching from LongeCity

CellAge Fundraiser Update and Donation Matching from LongeCity

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Lifespan.io and CellAge


The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

Here is an update from Lifespan.io and CellAge:

If you haven’t already noticed, our latest Campaign, CellAge, has been having a bit of difficulty in reaching its funding goal. So, in order to solve that problem, we asked all our backers from previous campaigns for feedback on how we can improve the current CellAge campaign.

We’ve gotten a staggering number of responses (which we’re still personally replying to) and have compiled all the reasons into one big, dramatic “what could have gone better” spreadsheet.

One of those reasons was that CellAge did not have a fund match.

So we fixed that.


CellAge is now endorsed by LongeCity. And they’re running a Fund Match up to $3000.

For those who don’t know, LongeCity is one of the oldest, most respected international pro-longevity organizations. Their exclusive forum boasts thousands of individuals learning, discussing and sharing latest breakthroughs of anything that has to do with slowing down aging.

Apart from generously contributing $800 right away, LongeCity is also running an internal fund match: anything donated via this special page before the 18th of February, will be doubled up to $3000.

To have them support CellAge means that they understand the significance of its success.

What makes this even more exciting is that CellAge has managed to secure additional external funding for their project, which means that they will be able to achieve the same goals even sooner.

The initial goal will now be $20,000, with all stretch goals being reduced as well.

Having raised over $15,000 so far, along with the fund match, means we’re incredibly close to successfully funding CellAge’s exciting research.

Just a quick refresher: CellAge is using customised synthetic biology to develop cutting edge ways to detect and destroy senescent cells, which contribute to age-related diseases. By developing this technology we will be able to give researchers a superior tool for finding senescent cells, and improving the quality of stem cell therapies.

Ultimately this will lead to a better way to remove problem senescent cells without the side effects traditional small molecules inevitably cause. In short, this technology can help start a revolution in medical research and a leap in how we treat age-related diseases for a healthier future.

If you’re still undecided, remember, every dollar you put into the LongeCity match will become two for CellAge.

Click here for donation match.

-The Lifespan Team

Transhumanist Party Activism Project: Contributing Computing Power to The Longevity Meme Folding@home Team

Transhumanist Party Activism Project: Contributing Computing Power to The Longevity Meme Folding@home Team

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Gennady Stolyarov II


The Transhumanist Party is pleased to announce the revitalization of an ongoing official activism project – one that all members, irrespective of geographical location, can easily join. This is a project that utilizes our favored approach of direct, individually attainable action toward the creation of a brighter future.

You can personally help advance the fight against a multitude of diseases – such as Alzheimer’s Disease, Parkinson’s Disease, and many cancers.

The Longevity Meme Folding@home team – a group of volunteers who donate their computing power to perform protein-folding simulations that could one day result in cures for major diseases and the lengthening of human lifespans – has been operating for years, contributing otherwise idle computer resources to actual meaningful biological research.

To take part in this effort, just download the client for the Folding@home project at http://folding.stanford.edu/. Then join The Longevity Meme team here, and your computer will do the rest over time. I have personally been engaged in this effort for over six years.

If you would like a digital reward for contributing to this project, I am able to give five levels of digital Open Badges via Credly. Here is a page describing the various tiers of badges.  Once you have reached the requisite number of Folding@home points to claim each badge, just contact me via e-mail here with a message that includes your user name and an e-mail address.

Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

From Lifespan.io and CellAge:

Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases, including cancer, cardiovascular diseases and osteoarthritis. Not only does aging have a negative effect on the quality of life among the elderly but it also causes a significant financial strain on both private and public sectors. As the proportion of older people is increasing so is health care spending. According to a WHO analysis, the annual number of new cancer cases is projected to rise to 17 million by 2020, and reach 27 million by 2030. Similar trends are clearly visible in other age-related diseases such as cardiovascular disease. Few effective treatments addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to aging.

Recently a new approach which has the potential of significantly alleviating these problems has been validated by a number of in vivo and in vitro studies. It has been demonstrated that senescent cells (cells which have ceased to replicate due to stress or replicative capacity exhaustion) are linked to many age-related diseases. Furthermore, removing senescent cells from mice has been recently shown to drastically increase mouse healthspan (a period of life free of serious diseases).

Here at CellAge we are working hard to help translate these findings into humans!

CellAge, together with a leading synthetic biology partner, Synpromics, are poised to develop a technology allowing for the identification and removal of harmful senescent cells. Our breakthrough technology will benefit both the scientific community and the general public.

In short, CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies. The most prominently used p16 gene promoter has a number of limitations, for example. First, it is involved in cell cycle regulation, which poses a danger in targeting cells which are not diving but not senescent either, such as quiescent stem cells. Second, organism-wide administration of gene therapy might at present be too dangerous. This means senescent cells only in specific organs might need to be targeted and p16 promoter does not provide this level of specificity. Third, the p16 promoter is not active in all senescent cells. Thus, after therapies utilizing this promoter, a proportion of senescent cells would still remain. Moreover, the p16 promoter is relatively large (2.1kb), making it difficult to incorporate in present gene therapy vehicles. Lastly, to achieve the intended therapeutic effect the strength of p16 promoter to drive therapeutic effect might not be high enough.

CellAge will be constructing a synthetic promoter which has a potential to overcome all of the mentioned limitations. A number of gene therapy companies, including uniQure, AGTC and Avalanche Biotech have successfully targeted other types of cells using this technology. With your help, we will be able to use same technology to develop tools and therapies for accurate senescent cell targeting.