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Category: Allied Projects

CellAge Fundraiser Update and Donation Matching from LongeCity

CellAge Fundraiser Update and Donation Matching from LongeCity

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Lifespan.io and CellAge


The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

Here is an update from Lifespan.io and CellAge:

If you haven’t already noticed, our latest Campaign, CellAge, has been having a bit of difficulty in reaching its funding goal. So, in order to solve that problem, we asked all our backers from previous campaigns for feedback on how we can improve the current CellAge campaign.

We’ve gotten a staggering number of responses (which we’re still personally replying to) and have compiled all the reasons into one big, dramatic “what could have gone better” spreadsheet.

One of those reasons was that CellAge did not have a fund match.

So we fixed that.


CellAge is now endorsed by LongeCity. And they’re running a Fund Match up to $3000.

For those who don’t know, LongeCity is one of the oldest, most respected international pro-longevity organizations. Their exclusive forum boasts thousands of individuals learning, discussing and sharing latest breakthroughs of anything that has to do with slowing down aging.

Apart from generously contributing $800 right away, LongeCity is also running an internal fund match: anything donated via this special page before the 18th of February, will be doubled up to $3000.

To have them support CellAge means that they understand the significance of its success.

What makes this even more exciting is that CellAge has managed to secure additional external funding for their project, which means that they will be able to achieve the same goals even sooner.

The initial goal will now be $20,000, with all stretch goals being reduced as well.

Having raised over $15,000 so far, along with the fund match, means we’re incredibly close to successfully funding CellAge’s exciting research.

Just a quick refresher: CellAge is using customised synthetic biology to develop cutting edge ways to detect and destroy senescent cells, which contribute to age-related diseases. By developing this technology we will be able to give researchers a superior tool for finding senescent cells, and improving the quality of stem cell therapies.

Ultimately this will lead to a better way to remove problem senescent cells without the side effects traditional small molecules inevitably cause. In short, this technology can help start a revolution in medical research and a leap in how we treat age-related diseases for a healthier future.

If you’re still undecided, remember, every dollar you put into the LongeCity match will become two for CellAge.

Click here for donation match.

-The Lifespan Team

Transhumanist Party Activism Project: Contributing Computing Power to The Longevity Meme Folding@home Team

Transhumanist Party Activism Project: Contributing Computing Power to The Longevity Meme Folding@home Team

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Gennady Stolyarov II


The Transhumanist Party is pleased to announce the revitalization of an ongoing official activism project – one that all members, irrespective of geographical location, can easily join. This is a project that utilizes our favored approach of direct, individually attainable action toward the creation of a brighter future.

You can personally help advance the fight against a multitude of diseases – such as Alzheimer’s Disease, Parkinson’s Disease, and many cancers.

The Longevity Meme Folding@home team – a group of volunteers who donate their computing power to perform protein-folding simulations that could one day result in cures for major diseases and the lengthening of human lifespans – has been operating for years, contributing otherwise idle computer resources to actual meaningful biological research.

To take part in this effort, just download the client for the Folding@home project at http://folding.stanford.edu/. Then join The Longevity Meme team here, and your computer will do the rest over time. I have personally been engaged in this effort for over six years.

If you would like a digital reward for contributing to this project, I am able to give five levels of digital Open Badges via Credly. Here is a page describing the various tiers of badges.  Once you have reached the requisite number of Folding@home points to claim each badge, just contact me via e-mail here with a message that includes your user name and an e-mail address.

Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

From Lifespan.io and CellAge:

Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases, including cancer, cardiovascular diseases and osteoarthritis. Not only does aging have a negative effect on the quality of life among the elderly but it also causes a significant financial strain on both private and public sectors. As the proportion of older people is increasing so is health care spending. According to a WHO analysis, the annual number of new cancer cases is projected to rise to 17 million by 2020, and reach 27 million by 2030. Similar trends are clearly visible in other age-related diseases such as cardiovascular disease. Few effective treatments addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to aging.

Recently a new approach which has the potential of significantly alleviating these problems has been validated by a number of in vivo and in vitro studies. It has been demonstrated that senescent cells (cells which have ceased to replicate due to stress or replicative capacity exhaustion) are linked to many age-related diseases. Furthermore, removing senescent cells from mice has been recently shown to drastically increase mouse healthspan (a period of life free of serious diseases).

Here at CellAge we are working hard to help translate these findings into humans!

CellAge, together with a leading synthetic biology partner, Synpromics, are poised to develop a technology allowing for the identification and removal of harmful senescent cells. Our breakthrough technology will benefit both the scientific community and the general public.

In short, CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies. The most prominently used p16 gene promoter has a number of limitations, for example. First, it is involved in cell cycle regulation, which poses a danger in targeting cells which are not diving but not senescent either, such as quiescent stem cells. Second, organism-wide administration of gene therapy might at present be too dangerous. This means senescent cells only in specific organs might need to be targeted and p16 promoter does not provide this level of specificity. Third, the p16 promoter is not active in all senescent cells. Thus, after therapies utilizing this promoter, a proportion of senescent cells would still remain. Moreover, the p16 promoter is relatively large (2.1kb), making it difficult to incorporate in present gene therapy vehicles. Lastly, to achieve the intended therapeutic effect the strength of p16 promoter to drive therapeutic effect might not be high enough.

CellAge will be constructing a synthetic promoter which has a potential to overcome all of the mentioned limitations. A number of gene therapy companies, including uniQure, AGTC and Avalanche Biotech have successfully targeted other types of cells using this technology. With your help, we will be able to use same technology to develop tools and therapies for accurate senescent cell targeting.