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Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

The Transhumanist Party supports Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

From Lifespan.io and CellAge:

Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases, including cancer, cardiovascular diseases and osteoarthritis. Not only does aging have a negative effect on the quality of life among the elderly but it also causes a significant financial strain on both private and public sectors. As the proportion of older people is increasing so is health care spending. According to a WHO analysis, the annual number of new cancer cases is projected to rise to 17 million by 2020, and reach 27 million by 2030. Similar trends are clearly visible in other age-related diseases such as cardiovascular disease. Few effective treatments addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to aging.

Recently a new approach which has the potential of significantly alleviating these problems has been validated by a number of in vivo and in vitro studies. It has been demonstrated that senescent cells (cells which have ceased to replicate due to stress or replicative capacity exhaustion) are linked to many age-related diseases. Furthermore, removing senescent cells from mice has been recently shown to drastically increase mouse healthspan (a period of life free of serious diseases).

Here at CellAge we are working hard to help translate these findings into humans!

CellAge, together with a leading synthetic biology partner, Synpromics, are poised to develop a technology allowing for the identification and removal of harmful senescent cells. Our breakthrough technology will benefit both the scientific community and the general public.

In short, CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies. The most prominently used p16 gene promoter has a number of limitations, for example. First, it is involved in cell cycle regulation, which poses a danger in targeting cells which are not diving but not senescent either, such as quiescent stem cells. Second, organism-wide administration of gene therapy might at present be too dangerous. This means senescent cells only in specific organs might need to be targeted and p16 promoter does not provide this level of specificity. Third, the p16 promoter is not active in all senescent cells. Thus, after therapies utilizing this promoter, a proportion of senescent cells would still remain. Moreover, the p16 promoter is relatively large (2.1kb), making it difficult to incorporate in present gene therapy vehicles. Lastly, to achieve the intended therapeutic effect the strength of p16 promoter to drive therapeutic effect might not be high enough.

CellAge will be constructing a synthetic promoter which has a potential to overcome all of the mentioned limitations. A number of gene therapy companies, including uniQure, AGTC and Avalanche Biotech have successfully targeted other types of cells using this technology. With your help, we will be able to use same technology to develop tools and therapies for accurate senescent cell targeting.

A Transhumanist Opinion on Privacy

A Transhumanist Opinion on Privacy

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Ryan Starr

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Privacy is a favorite topic of mine. Maintaining individual privacy is a crucial element in free society. Yet there are many who want to invade it for personal or political gain. As our digital fingerprint becomes a part of our notion of self, how do we maintain our personal privacy on an inherently impersonal network of data? Where do we draw that line on what is private, and how do we enforce it? These are questions that are difficult to answer when looking at a short-term perspective. However, if we look further into the probable future, we can create a plan that helps protect the privacy of citizens today and for generations to come. By taking into account the almost certain physical merger of human biology and technology, the answer becomes clear. Our electronic data should be treated as part of our bodily autonomy.

The explosive success of social media has shown that we already view ourselves as partly digital entities. Where we go, what we eat, and who we are with is proudly displayed in cyberspace for eternity. But beyond that we store unique data about ourselves “securely” on the internet. Bank accounts, tax returns, even medical information are filed away on a server somewhere and specifically identified as us. It’s no longer solely what we chose to let people see. We are physical and digital beings, and it is time we view these two sides as one before we take the next step into enhanced humanity.

Subdermal storage of electronic data is here, and its storage capabilities will expand rapidly. Soon we will be able to store a lot more than just access codes for our doors. It is hard to speculate exactly what people will chose to keep stored this way, and there may even come a time when what we see and hear is automatically stored this way. But before we go too far into what will be stored, we must understand how this information is accessed in present time. These implants are currently based in NFC technology. Near-Field Communication is a method of storing and transmitting data wirelessly within a very short distance. Yes, “wireless” is the key word. It means that if I can connect my NFC tag to my smart phone by just waiving my hand close to it (usually within an inch or so), then technically someone else can, too. While current antenna limitations and the discreetness of where a person’s tag is implanted create a highly secure method of storage, advances in technology will eventually make it easier to access the individual. This is why it is urgent we develop a streamlined policy for privacy.

The current Transhumanist position is that personally collected intellectual property, whether stored digitally or organically, is the property of the individual. As such, it should be protected from unauthorized search and download. The current platform also states that each individual has the freedom to enhance their own body as they like so long as it doesn’t negatively impact others. However, it does not specify what qualifies as a negative impact or how to prevent it. Morphological freedom is a double-edged sword. A person can a person enhance their ability to access information on themselves, but they can also use it to access others. It is entirely feasible enhancements will be created that allow a person to hack another. And collecting personal data isn’t the only risk with that. What if the hacking victim has an artificial heart or an implanted insulin pump? The hacker could potentially access the code the medical device is operating with and change or delete it, ultimately leading to death. Another scenario might be hacking into someone’s enhanced sensory abilities. Much like in the novel Ender’s Game, a person can access another to see what they see. This ability can be abused countless ways ranging from government surveillance to sexual voyeurism. While this is still firmly within the realm of science fiction, a transhuman society will need to create laws to protect against these person-to-person invasions of privacy.

Now let’s consider mass data collection. Proximity beacons could easily and cheaply be scattered across stores and cities to function as passive collection points much like overhead cameras are today. Retail stands to gain significantly from this technology, especially if they are allowed access to intimate knowledge about customers. Government intelligence gathering also stands to benefit from this capability. Levels of adrenaline, dopamine, and oxytocin stored for personal health analysis could be taken and paired with location data to put together an invasive picture of how people are feeling in a certain situation. Far more can be learned and exploited when discreetly collected biodata is merged with publicly observable activity.

In my mind, these are concerns that should be addressed sooner than later. If we take the appropriate steps to preserve personal privacy in all domains, we can make a positive impact that will last into the 22nd century.

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Ryan Starr is the leader of the Transhumanist Party of Colorado. This article was originally published on his blog, and has been republished here with his permission.